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Select item 110150571.

Interactions between Gepotidacin and Escherichia coli Gyrase and Topoisomerase IV: Genetic and Biochemical Evidence for Well-Balanced Dual-Targeting

Alexandria A. Oviatt, Elizabeth G. Gibson, Jianzhong Huang, Karen Mattern, Keir C. Neuman, Pan F. Chan, Neil Osheroff

ACS Infect Dis. 2024 Apr 12; 10(4): 1137–1151. Published online 2024 Mar 5. doi: 10.1021/acsinfecdis.3c00346

PMCID:: PMC11015057

Article PDF–3.8M

Select item 108107862.

Structural analysis of the Trypanosoma brucei EIF4E6/EIF4G5 complex reveals details of the interaction between unusual eIF4F subunits

Renato Ferras Penteado, Renata Santana da Silva, Danielle Maria Nascimento Moura, Gustavo Barbosa de Lima, Amaranta Muniz Malvezzi, Tallyta Tâmara da Silva Monteiro, Camila Cavalcanti Xavier, Sophie Vichier-Guerre, Laurence Dugué, Sylvie Pochet, Nilson Ivo Tonin Zanchin, Christian Robson de Souza Reis, Osvaldo Pompílio de Melo Neto, Beatriz Gomes Guimarães

Sci Rep. 2024; 14: 2178. Published online 2024 Jan 25. doi: 10.1038/s41598-024-52364-1

PMCID:: PMC10810786

Article PDF–13M

Select item 107789313.

Structure–Functional Examination of Novel Ribonucleoside Hydrolase C (RihC) from Limosilactobacillus reuteri LR1

Leonid A. Shaposhnikov, Natalia Yu. Chikurova, Denis L. Atroshenko, Svyatoslav S. Savin, Sergei Yu. Kleymenov, Alla V. Chernobrovkina, Evgenii V. Pometun, Mikhail E. Minyaev, Ilya O. Matyuta, Dmitry M. Hushpulian, Konstantin M. Boyko, Vladimir I. Tishkov, Anastasia A. Pometun

Int J Mol Sci. 2024 Jan; 25(1): 538. Published online 2023 Dec 30. doi: 10.3390/ijms25010538

PMCID:: PMC10778931

Article PDF–4.7M

Select item 104578694.

Parasite Detection in Visceral Leishmaniasis Samples by Dye-Based qPCR Using New Gene Targets of Leishmania infantum and Crithidia

Nayore Tamie Takamiya, Luana Aparecida Rogerio, Caroline Torres, João Augusto Franco Leonel, Geovanna Vioti, Tricia Maria Ferreira de Sousa Oliveira, Karoline Camila Valeriano, Gabriane Nascimento Porcino, Isabel Kinney Ferreira de Miranda Santos, Carlos H. N. Costa, Dorcas Lamounier Costa, Tauana Sousa Ferreira, Rodrigo Gurgel-Gonçalves, João Santana da Silva, Felipe Roberti Teixeira, Roque Pacheco De Almeida, José M. C. Ribeiro, Sandra Regina Maruyama

Trop Med Infect Dis. 2023 Aug; 8(8): 405. Published online 2023 Aug 8. doi: 10.3390/tropicalmed8080405

PMCID:: PMC10457869

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Select item 103740595.

Characterization of two novel proteins involved in mitochondrial DNA anchoring in Trypanosoma brucei

Simona Amodeo, Irina Bregy, Anneliese Hoffmann, Albert Fradera-Sola, Mara Kern, Hélène Baudouin, Benoît Zuber, Falk Butter, Torsten Ochsenreiter

PLoS Pathog. 2023 Jul; 19(7): e1011486. Published online 2023 Jul 17. doi: 10.1371/journal.ppat.1011486

PMCID:: PMC10374059

Article PDF–2.7M

Select item 102167576.

Biological Catalysis and Information Storage Have Relied on N-Glycosyl Derivatives of β-D-Ribofuranose since the Origins of Life

Katarzyna Wozniak, Krzysztof Brzezinski

Biomolecules. 2023 May; 13(5): 782. Published online 2023 Apr 30. doi: 10.3390/biom13050782

PMCID:: PMC10216757

Article PDF–2.6M

Select item 101479287.

In-vitro biological evaluation of 3,3′,5,5′-tetramethoxy-biphenyl-4,4′-diol and molecular docking studies on trypanothione reductase and Gp63 from Leishmania amazonensis demonstrated anti-leishmania potential

Jéseka G. Schirmann, Bruna T. S. Bortoleti, Manoela D. Gonçalves, Fernanda Tomiotto-Pellissier, Priscila G. Camargo, Milena M. Miranda-Sapla, Camilo H. S. Lima, Marcelle L. F. Bispo, Idessania N. Costa, Ivete Conchon-Costa, Wander R. Pavanelli, Robert F. H. Dekker, Aneli M. Barbosa-Dekker

Sci Rep. 2023; 13: 6928. Published online 2023 Apr 28. doi: 10.1038/s41598-023-34124-9

PMCID:: PMC10147928

Article PDF–1.8M

Select item 101183048.

Hydrophobicity-Driven Increases in Editing in Mitochondrial mRNAs during the Evolution of Kinetoplastids

Fanny Rusman, Noelia Floridia-Yapur, Anahí G Díaz, Tatiana Ponce, Patricio Diosque, Nicolás Tomasini

Mol Biol Evol. 2023 Apr; 40(4): msad081. Published online 2023 Apr 8. doi: 10.1093/molbev/msad081

PMCID:: PMC10118304

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Select item 101170399.

A Picture is Worth 1000 Words: Teaching Science Communication with Graphical Abstract Assignments

Swati Agrawal, Paul Ulrich

J Microbiol Biol Educ. 2023 Apr; 24(1): e00208-22. Published online 2023 Mar 15. doi: 10.1128/jmbe.00208-22

PMCID:: PMC10117039

Article PDF–987K

Select item 993078110.

Design, synthesis, docking, and anticancer evaluations of new thiazolo[3,2-a] pyrimidines as topoisomerase II inhibitors

Mona S. El-Zoghbi, Samiha A. El-Sebaey, Hanan A. AL-Ghulikah, Eman A. Sobh

J Enzyme Inhib Med Chem. 2023; 38(1): 2175209. Published online 2023 Feb 12. doi: 10.1080/14756366.2023.2175209

PMCID:: PMC9930781

Article PDF–5.7M

Select item 988869611.

TriTrypDB: An integrated functional genomics resource for kinetoplastida

Achchuthan Shanmugasundram, David Starns, Ulrike Böhme, Beatrice Amos, Paul A. Wilkinson, Omar S. Harb, Susanne Warrenfeltz, Jessica C. Kissinger, Mary Ann McDowell, David S. Roos, Kathryn Crouch, Andrew R. Jones

PLoS Negl Trop Dis. 2023 Jan; 17(1): e0011058. Published online 2023 Jan 19. doi: 10.1371/journal.pntd.0011058

PMCID:: PMC9888696

Article PDF–2.2M

Select item 974579712.

Insights into the Spectrum of Activity and Mechanism of Action of MGB-BP-3

Charlotte Hind, Melanie Clifford, Charlotte Woolley, Jane Harmer, Leah M. C. McGee, Izaak Tyson-Hirst, Henry J. Tait, Daniel P. Brooke, Stephanie J. Dancer, Iain S. Hunter, Colin J. Suckling, Rebecca Beveridge, John A. Parkinson, J. Mark Sutton, Fraser J. Scott

ACS Infect Dis. 2022 Dec 9; 8(12): 2552–2563. Published online 2022 Nov 29. doi: 10.1021/acsinfecdis.2c00445

PMCID:: PMC9745797

Article PDF–3.9M

Select item 971991313.

The catalytic mechanism, metal dependence, substrate specificity, and biodiversity of ribonuclease H

Jing Pang, Qinyu Guo, Zheng Lu

Front Microbiol. 2022; 13: 1034811. Published online 2022 Nov 21. doi: 10.3389/fmicb.2022.1034811

PMCID:: PMC9719913

Article PDF–4.4M

Select item 954832414.

Recognition of DNA Supercoil Handedness during Catenation Catalyzed by Type II Topoisomerases

Esha D. Dalvie, Jordan C. Stacy, Keir C. Neuman, Neil Osheroff

Biochemistry. Author manuscript; available in PMC 2022 Oct 9.

Published in final edited form as: Biochemistry. 2022 Oct 4; 61(19): 2148–2158. Published online 2022 Sep 19. doi: 10.1021/acs.biochem.2c00370

PMCID:: PMC9548324

Article PDF–1.9M

Select item 951207315.

Delineating transitions during the evolution of specialised peroxisomes: Glycosome formation in kinetoplastid and diplonemid protists

Diego Andrade-Alviárez, Alejandro D. Bonive-Boscan, Ana J. Cáceres, Wilfredo Quiñones, Melisa Gualdrón-López, Michael L. Ginger, Paul A. M. Michels

Front Cell Dev Biol. 2022; 10: 979269. Published online 2022 Sep 12. doi: 10.3389/fcell.2022.979269

PMCID:: PMC9512073

Article PDF–4.8M

Select item 936261716.

An insight into differential protein abundance throughout Leishmania donovani promastigote growth and differentiation

Pedro J. Alcolea, Ana Alonso, Francisco García-Tabares, Jaime Larraga, Luis T. C. Martins, Franciso J. Loayza, Silvia Ruiz-García, Vicente Larraga

Int Microbiol. 2023; 26(1): 25–42. Published online 2022 Aug 5. doi: 10.1007/s10123-022-00259-4

PMCID:: PMC9362617

Article PDF–3.4M

Select item 936634717.

Broadening the spectrum of ivermectin: Its effect on Trypanosoma cruzi and related trypanosomatids

Laura Fraccaroli, María Daniela Ruiz, Virginia Gabriela Perdomo, Agustina Nicole Clausi, Darío Emmanuel Balcazar, Luciana Larocca, Carolina Carrillo

Front Cell Infect Microbiol. 2022; 12: 885268. Published online 2022 Jul 28. doi: 10.3389/fcimb.2022.885268

PMCID:: PMC9366347

Article PDF–1.4M

Select item 900625218.

Crystal structure of plasmoredoxin, a redox-active protein unique for malaria parasites

Karin Fritz-Wolf, Jochen Bathke, Stefan Rahlfs, Katja Becker

Curr Res Struct Biol. 2022; 4: 87–95. Published online 2022 Apr 1. doi: 10.1016/j.crstbi.2022.03.004

PMCID:: PMC9006252

Article PDF–3.0M

Select item 890623619.

TbKINX1B: a novel BILBO1 partner and an essential protein in bloodstream form Trypanosoma brucei

Doranda Perdomo, Elodie Berdance, Gertrud Lallinger-Kube, Annelise Sahin, Denis Dacheux, Nicolas Landrein, Anne Cayrel, Klaus Ersfeld, Mélanie Bonhivers, Linda Kohl, Derrick R. Robinson

Parasite. 2022; 29: 14. Published online 2022 Mar 9. doi: 10.1051/parasite/2022015

PMCID:: PMC8906236

Article PDF–7.5M

Select item 889875320.

Dihydrofolate reductase, thymidylate synthase, and serine hydroxy methyltransferase: successful targets against some infectious diseases

Hina Shamshad, Rowaida Bakri, Agha Zeeshan Mirza

Mol Biol Rep. 2022; 49(7): 6659–6691. Published online 2022 Mar 7. doi: 10.1007/s11033-022-07266-8

PMCID:: PMC8898753

Article PDF–8.3M

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