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Select item 109432471.

Structural insights into the ubiquitylation strategy of the oligomeric CRL2^FEM1B E3 ubiquitin ligase

Zonglin Dai, Ling Liang, Weize Wang, Peng Zuo, Shang Yu, Yaqi Liu, Xuyang Zhao, Yishuo Lu, Yan Jin, Fangting Zhang, Dian Ding, Weiwei Deng, Yuxin Yin

EMBO J. 2024 Mar; 43(6): 1089–1109. Published online 2024 Feb 15. doi: 10.1038/s44318-024-00047-y

PMCID:: PMC10943247

Abstract Article PDF–6.4M

Select item 64135082.

Fem1b promotes ubiquitylation and suppresses transcriptional activity of Gli1

Andrew S. Gilder, Yong-Bin Chen, Ramon J. Jackson, III, Jin Jiang, Joseph F. Maher

Biochem Biophys Res Commun. Author manuscript; available in PMC 2019 Mar 12.

Published in final edited form as: Biochem Biophys Res Commun. 2013 Oct 25; 440(3): 431–436. Published online 2013 Sep 25. doi: 10.1016/j.bbrc.2013.09.090

PMCID:: PMC6413508

Abstract Article PDF–521K

Select item 77258233.

BEX2 suppresses mitochondrial activity and is required for dormant cancer stem cell maintenance in intrahepatic cholangiocarcinoma

Keiichi Tamai, Mao Nakamura-Shima, Rie Shibuya-Takahashi, Shin-Ichiro Kanno, Akira Yasui, Mai Mochizuki, Wataru Iwai, Yuta Wakui, Makoto Abue, Kuniharu Yamamoto, Koh Miura, Masamichi Mizuma, Michiaki Unno, Sadafumi Kawamura, Ikuro Sato, Jun Yasuda, Kazunori Yamaguchi, Kazuo Sugamura, Kennichi Satoh

Sci Rep. 2020; 10: 21592. Published online 2020 Dec 9. doi: 10.1038/s41598-020-78539-0

PMCID:: PMC7725823

Abstract Article PDF–3.4M

Select item 25839414.

FEM1A and FEM1B: novel candidate genes for polycystic ovary syndrome

M.O. Goodarzi, J.F. Maher, J. Cui, X. Guo, K.D. Taylor, R. Azziz

Hum Reprod. 2008 Dec; 23(12): 2842–2849. Published online 2008 Aug 29. doi: 10.1093/humrep/den324

PMCID:: PMC2583941

Abstract Article PDF–200K

Select item 60038815.

The Eukaryotic Proteome is Shaped by E3 Ubiquitin Ligases Targeting C-terminal Degrons

Itay Koren, Richard T. Timms, Tomasz Kula, Qikai Xu, Mamie Z. Li, Stephen J. Elledge

Cell. Author manuscript; available in PMC 2019 Jun 14.

Published in final edited form as: Cell. 2018 Jun 14; 173(7): 1622–1635.e14. Published online 2018 May 17. doi: 10.1016/j.cell.2018.04.028

PMCID:: PMC6003881

Abstract Article PDF–933K

Select item 15785046.

Posttranslational hydroxylation of ankyrin repeats in IκB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)

Matthew E. Cockman, David E. Lancaster, Ineke P. Stolze, Kirsty S. Hewitson, Michael A. McDonough, Mathew L. Coleman, Charlotte H. Coles, Xiaohong Yu, Ronald T. Hay, Steven C. Ley, Christopher W. Pugh, Neil J. Oldham, Norma Masson, Christopher J. Schofield, Peter J. Ratcliffe

Proc Natl Acad Sci U S A. 2006 Oct 3; 103(40): 14767–14772. Published online 2006 Sep 26. doi: 10.1073/pnas.0606877103

PMCID:: PMC1578504

Abstract Article PDF–1.1M

Select item 53845797.

FEM1 proteins are ancient regulators of SLBP degradation

John F. Dankert, Julia K. Pagan, Natalia G. Starostina, Edward T. Kipreos, Michele Pagano

Cell Cycle. 2017; 16(6): 556–564. Published online 2017 Jan 24. doi: 10.1080/15384101.2017.1284715

PMCID:: PMC5384579

Abstract Article PDF–724K

Select item 54951198.

USP25 regulates Wnt signaling by controlling the stability of tankyrases

Daichao Xu, Jianping Liu, Tao Fu, Bing Shan, Lihui Qian, Lifeng Pan, Junying Yuan

Genes Dev. 2017 May 15; 31(10): 1024–1035. doi: 10.1101/gad.300889.117

PMCID:: PMC5495119

Abstract Article PDF–666K

Select item 28695379.

Family-Based Analysis of Candidate Genes for Polycystic Ovary Syndrome

Kathryn G. Ewens, Douglas R. Stewart, Wendy Ankener, Margrit Urbanek, Jan M. McAllister, Chen Chen, K. Maravet Baig, Stephen C. J. Parker, Elliot H. Margulies, Richard S. Legro, Andrea Dunaif, Jerome F. Strauss, III, Richard S. Spielman

J Clin Endocrinol Metab. 2010 May; 95(5): 2306–2315. Published online 2010 Mar 3. doi: 10.1210/jc.2009-2703

PMCID:: PMC2869537

Abstract Article

Select item 277985710.

Mouse Fem1b interacts with the Nkx3.1 homeoprotein and is required for proper male secondary sexual development

Xi Wang, Nishita Desai, Ya-Ping Hu, Sandy M. Price, Cory Abate-Shen, Michael M. Shen

Dev Dyn. Author manuscript; available in PMC 2009 Nov 20.

Published in final edited form as: Dev Dyn. 2008 Oct; 237(10): 2963–2972. doi: 10.1002/dvdy.21694

PMCID:: PMC2779857

Abstract Article PDF–2.2M

Select item 53591611.

VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases

Takumi Kamura, Katsumi Maenaka, Shuhei Kotoshiba, Masaki Matsumoto, Daisuke Kohda, Ronald C. Conaway, Joan Weliky Conaway, Keiichi I. Nakayama

Genes Dev. 2004 Dec 15; 18(24): 3055–3065. doi: 10.1101/gad.1252404

PMCID:: PMC535916

Abstract Article PDF–465K

Select item 1041608912.

Common Genetic Variation and Antidepressant Efficacy in Major Depressive Disorder: A Meta-Analysis of Three Genome-Wide Pharmacogenetic Studies

GENDEP Investigators, Rudolf Uher, Katherine E. Tansey, Marcella Rietschel, Neven Henigsberg, Wolfgang Maier, Ole Mors, Joanna Hauser, Anna Placentino, Daniel Souery, Anne Farmer, Katherine J. Aitchison, Ian Craig, Peter McGuffin, Cathryn M. Lewis, MARS Investigators, Marcus Ising, Susanne Lucae, Elisabeth B. Binder, Stefan Kloiber, Florian Holsboer, Bertram Müller-Myhsok, STAR*D Investigators, Stephan Ripke, Steven P. Hamilton, Jared Soundy, Gonzalo Laje, Francis J. McMahon, Maurizio Fava, A. John Rush, Roy H. Perlis

Am J Psychiatry. Author manuscript; available in PMC 2023 Aug 11.

Published in final edited form as: Am J Psychiatry. 2013 Feb; 170(2): 207–217. doi: 10.1176/appi.ajp.2012.12020237

PMCID:: PMC10416089

Abstract Article PDF–1.4M

Select item 818499813.

Tumor-associated antigen Prame targets tumor suppressor p14/ARF for degradation as the receptor protein of CRL2^Prame complex

Wenjuan Zhang, Lihui Li, Lili Cai, Yupei Liang, Junfeng Xu, Yue Liu, Lisha Zhou, Chen Ding, Yanmei Zhang, Hu Zhao, Jun Qin, Zhimin Shao, Wenyi Wei, Lijun Jia

Cell Death Differ. 2021 Jun; 28(6): 1926–1940. Published online 2021 Jan 27. doi: 10.1038/s41418-020-00724-5

PMCID:: PMC8184998

Abstract Article PDF–4.0M

Select item 272093314.

An interaction network of the mammalian COP9 signalosome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases

Michael Hans Olma, Marcia Roy, Thierry Le Bihan, Izabela Sumara, Sarah Maerki, Brett Larsen, Manfredo Quadroni, Matthias Peter, Mike Tyers, Lionel Pintard

J Cell Sci. 2009 Apr 1; 122(7): 1035–1044. Published online 2009 Mar 18. doi: 10.1242/jcs.043539

PMCID:: PMC2720933

Abstract Article

Select item 18754215.

Protein–Protein Interactions Between Large Proteins: Two-Hybrid Screening Using a Functionally Classified Library Composed of Long cDNAs

Manabu Nakayama, Reiko Kikuno, Osamu Ohara

Genome Res. 2002 Nov; 12(11): 1773–1784. doi: 10.1101/gr.406902

PMCID:: PMC187542

Abstract Article PDF–374K

Select item 729913016.

IKK-mediated Regulation of the COP9 Signalosome via Phosphorylation of CSN5

Jingzi Zhang, Ruoyu Zhao, Christine L. N. Bryant, Kenneth Wu, Zhihong Liu, Yibing Ding, Yue Zhao, Bin Xue, Zhen-Qiang Pan, Chaojun Li, Lan Huang, Lei Fang

J Proteome Res. Author manuscript; available in PMC 2020 Jun 17.

Published in final edited form as: J Proteome Res. 2020 Mar 6; 19(3): 1119–1130. Published online 2020 Feb 3. doi: 10.1021/acs.jproteome.9b00626

PMCID:: PMC7299130

Abstract Article PDF–2.2M

Select item 281034417.

An Integrative Predictive Model of Coronary Artery Calcification in Arteriosclerosis

Michael McGeachie, Rachel L Badovinac Ramoni, Josyf C. Mychaleckyj, Karen L Furie, Jonathan M. Dreyfuss, Yongmei Liu, David Herrington, Xiuqing Guo, João A. Lima, Wendy Post, Jerome I. Rotter, Stephen Rich, Michèle Sale, Marco F. Ramoni

Circulation. Author manuscript; available in PMC 2010 Dec 15.

Published in final edited form as: Circulation. 2009 Dec 15; 120(24): 2448–2454. doi: 10.1161/CIRCULATIONAHA.109.865501

PMCID:: PMC2810344

Abstract Article PDF–448K

Select item 715369518.

ARIH2 is a Vif-dependent regulator of CUL5-mediated APOBEC3G degradation in HIV infection

Ruth Hüttenhain, Jiewei Xu, Lily A. Burton, David E. Gordon, Judd F. Hultquist, Jeffrey R. Johnson, Laura Satkamp, Joseph Hiatt, David Y. Rhee, Kheewoong Baek, David C. Crosby, Alan D. Frankel, Alexander Marson, J. Wade Harper, Arno F. Alpi, Brenda A. Schulman, John D. Gross, Nevan J. Krogan

Cell Host Microbe. Author manuscript; available in PMC 2020 Jul 10.

Published in final edited form as: Cell Host Microbe. 2019 Jul 10; 26(1): 86–99.e7. Published online 2019 Jun 25. doi: 10.1016/j.chom.2019.05.008

PMCID:: PMC7153695

Abstract Article PDF–2.6M

Select item 895155619.

A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins

Danielle G. May, Laura Martin-Sancho, Valesca Anschau, Sophie Liu, Rachel J. Chrisopulos, Kelsey L. Scott, Charles T. Halfmann, Ramon Díaz Peña, Dexter Pratt, Alexandre R. Campos, Kyle J. Roux

Viruses. 2022 Mar; 14(3): 611. Published online 2022 Mar 15. doi: 10.3390/v14030611

PMCID:: PMC8951556

Abstract Article PDF–4.4M

Select item 271642220.

Defining the Human Deubiquitinating Enzyme Interaction Landscape

Mathew E. Sowa, Eric J. Bennett, Steven P. Gygi, J. Wade Harper

Cell. Author manuscript; available in PMC 2010 Jul 23.

Published in final edited form as: Cell. 2009 Jul 23; 138(2): 389–403. Published online 2009 Jul 16. doi: 10.1016/j.cell.2009.04.042

PMCID:: PMC2716422

Abstract Article PDF–6.1M

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