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Select item 110336931.

Cleavage of von Willebrand Factor Requires the Spacer Domain of the Metalloprotease ADAMTS13

Xinglong Zheng, Kenji Nishio, Elaine M. Majerus, J. Evan Sadler

J Biol Chem. Author manuscript; available in PMC 2024 Apr 22.

Published in final edited form as: J Biol Chem. 2003 Aug 8; 278(32): 30136–30141. Published online 2003 Jun 5. doi: 10.1074/jbc.M305331200

PMCID:: PMC11033693

Article PDF–1.2M

Select item 110182072.

Evaluating the potential mediating role of ADAMTS13 activity in the relationship between obesity and the severity of COVID-19: A retrospective cohort study

Wael Hafez, Asrar Rashid, Hesham Mohamed Abuelsaoud, Mohan Jose, Samy Kishk, Muneir Gador, Tesfalidet Emoshe, Fatema Abdulaal, Nivedita Nair, Muhammad Ahmad, Vanya Jalal Rashid, Youmna Faheem, Steffi John, Sabah Ahmed, Ahmed Daraghmi, Rami Soliman, Ahmed Abdelrahman, Ahmed Ali Mohamed, Mirvat Ghanem

Medicine (Baltimore) 2024 Apr 12; 103(15): e37806. Published online 2024 Apr 12. doi: 10.1097/MD.0000000000037806

PMCID:: PMC11018207

Article PDF–564K

Select item 110179553.

Robust thrombolytic and anti-inflammatory action of a constitutively active ADAMTS13 variant in murine stroke models

Kieron South, Ohud Saleh, Eloise Lemarchand, Graham Coutts, Craig J. Smith, Ingo Schiessl, Stuart M. Allan

Blood. 2022 Mar 10; 139(10): 1575–1587. Published online 2021 Nov 17. doi: 10.1182/blood.2021012787

PMCID:: PMC11017955

Article

Select item 107669544.

ADAMTS13 regulates angiogenic markers via Ephrin/Eph signaling in human mesenchymal stem cells under serum-deprivation stress

Srishti Dutta Gupta, Malancha Ta

Sci Rep. 2024; 14: 560. Published online 2024 Jan 4. doi: 10.1038/s41598-023-51079-z

PMCID:: PMC10766954

Article PDF–6.1M

Select item 106692225.

A Moderate Decrease in ADAMTS13 Activity Correlates with the Severity of STEC-HUS

Khadizha M. Emirova, Olga M. Orlova, Ekaterina M. Chichuga, Alexander L. Muzurov, Piotr P. Avdonin, Pavel V. Avdonin

Biomolecules. 2023 Nov; 13(11): 1671. Published online 2023 Nov 20. doi: 10.3390/biom13111671

PMCID:: PMC10669222

Article PDF–251K

Select item 104601196.

Contribution of ADAMTS13-independent VWF regulation in sickle cell disease

Ryan C. Hunt, Upendra Katneni, Ayla Yalamanoglu, Fred E. Indig, Juan C. Ibla, Chava Kimchi-Sarfaty

J Thromb Haemost. Author manuscript; available in PMC 2023 Sep 1.

Published in final edited form as: J Thromb Haemost. 2022 Sep; 20(9): 2098–2108. Published online 2022 Jul 12. doi: 10.1111/jth.15804

PMCID:: PMC10460119

Article PDF–1.3M

Select item 98928497.

ADAMTS13 conformation is closed in non-immune acquired thrombotic thrombocytopenic purpura of unidentified pathophysiology

Bérangère S. Joly, Elien Roose, Paul Coppo, Karen Vanhoorelbeke, Agnès Veyradier

Haematologica. 2023 Feb 1; 108(2): 638–644. Published online 2022 Apr 28. doi: 10.3324/haematol.2022.280768

PMCID:: PMC9892849

Article PDF–592K

Select item 98301688.

ADAMTS13 conformation and immunoprofiles in Japanese patients with immune-mediated thrombotic thrombocytopenic purpura

Kazuya Sakai, Masanori Matsumoto, Laure De Waele, Charlotte Dekimpe, Eriko Hamada, Masayuki Kubo, Claudia Tersteeg, Simon F. De Meyer, Karen Vanhoorelbeke

Blood Adv. 2023 Jan 10; 7(1): 131–140. Published online 2022 Nov 2. doi: 10.1182/bloodadvances.2022008885

PMCID:: PMC9830168

Article PDF–844K

Select item 96355279.

N-glycan–mediated shielding of ADAMTS13 prevents binding of pathogenic autoantibodies in immune-mediated TTP

Bogac Ercig, Nuno A. G. Graça, Kadri Kangro, Tom Arfman, Kanin Wichapong, Johana Hrdinová, Paul Kaijen, Floris P. J. van Alphen, Maartje van den Biggelaar, Karen Vanhoorelbeke, Agnès Veyradier, Paul Coppo, Chris Reutelingsperger, Gerry A. F. Nicolaes, Andres Männik, Jan Voorberg

Blood. 2021 May 13; 137(19): 2694–2698. doi: 10.1182/blood.2020007972

PMCID:: PMC9635527

Article

Select item 963168910.

Synonymous ADAMTS13 variants impact molecular characteristics and contribute to variability in active protein abundance

Katarzyna I. Jankowska, Douglas Meyer, David D. Holcomb, Jacob Kames, Nobuko Hamasaki-Katagiri, Upendra K. Katneni, Ryan C. Hunt, Juan C. Ibla, Chava Kimchi-Sarfaty

Blood Adv. 2022 Sep 27; 6(18): 5364–5378. Published online 2022 Sep 21. doi: 10.1182/bloodadvances.2022007065

PMCID:: PMC9631689

Article PDF–2.3M

Select item 958749911.

ADAMTS13 conformations and mechanism of inhibition in immune thrombotic thrombocytopenic purpura

Konstantine Halkidis, X. Long Zheng

J Thromb Haemost. Author manuscript; available in PMC 2023 Oct 1.

Published in final edited form as: J Thromb Haemost. 2022 Oct; 20(10): 2197–2203. Published online 2022 Aug 3. doi: 10.1111/jth.15822

PMCID:: PMC9587499

Article PDF–416K

Select item 954060512.

Anti-inflammatory protective effect of ADAMTS-13 in murine arthritis models

Shoichi Fukui, Sarah Gutch, Saeko Fukui, Long Chu, Denisa D. Wagner

J Thromb Haemost. Author manuscript; available in PMC 2022 Oct 7.

Published in final edited form as: J Thromb Haemost. 2022 Oct; 20(10): 2386–2393. Published online 2022 Aug 4. doi: 10.1111/jth.15828

PMCID:: PMC9540605

Article PDF–1.7M

Select item 922910013.

Lombardy diagnostic and therapeutic network of thrombotic microangiopathy

I. Mancini, P. Agosti, M. Boscarino, B. Ferrari, A. Artoni, R. Palla, M. Spreafico, G. Crovetti, E. Volpato, S. Rossini, C. Novelli, S. Gattillo, L. Barcella, M. Salmoiraghi, A. Falanga, F. Peyvandi, Lombardy AREU TMA Network

Orphanet J Rare Dis. 2022; 17: 246. Published online 2022 Jun 23. doi: 10.1186/s13023-022-02400-y

PMCID:: PMC9229100

Article PDF–752K

Select item 922726914.

Carriers of ADAMTS13 Rare Variants Are at High Risk of Life-Threatening COVID-19

Kristina Zguro, Margherita Baldassarri, Francesca Fava, Giada Beligni, Sergio Daga, Roberto Leoncini, Lucrezia Galasso, Michele Cirianni, Stefano Rusconi, Matteo Siano, Daniela Francisci, Elisabetta Schiaroli, Sauro Luchi, Giovanna Morelli, Enrico Martinelli, Massimo Girardis, Stefano Busani, Saverio Giuseppe Parisi, Sandro Panese, Carmelo Piscopo, Mario Capasso, Danilo Tacconi, Chiara Spertilli Raffaelli, Annarita Giliberti, Giulia Gori, Peter D. Katsikis, Maria Lorubbio, Paola Calzoni, Agostino Ognibene, Monica Bocchia, Monica Tozzi, Alessandro Bucalossi, Giuseppe Marotta, Simone Furini, GEN-COVID Multicenter Study, Alessandra Renieri, Chiara Fallerini

Viruses. 2022 Jun; 14(6): 1185. Published online 2022 May 29. doi: 10.3390/v14061185

PMCID:: PMC9227269

Article PDF–1011K

Select item 898317215.

Circulating ADAMTS13 Levels Are Associated with an Increased Occurrence of Obstructive Sleep Apnea

Mengling Huang, Sheng Liu, Shuang Liu, Wanwan Wen, Yu Ning, Yifan Jia, Yunxiao Yang, Xiaolu Jiao, Weiping Zheng, Ming Zhang

Dis Markers. 2022; 2022: 1504137. Published online 2022 Mar 29. doi: 10.1155/2022/1504137

PMCID:: PMC8983172

Article PDF–677K

Select item 893864716.

COVID-19 microthrombosis: unusually large VWF multimers are a platform for activation of the alternative complement pathway under cytokine storm

Yoshihiro Fujimura, Linda Z. Holland

Int J Hematol. 2022; 115(4): 457–469. Published online 2022 Mar 22. doi: 10.1007/s12185-022-03324-w

PMCID:: PMC8938647

Article PDF–1.4M

Select item 871482117.

The activity of the intrinsically water-soluble enzyme ADAMTS13 correlates with the membrane state when bound to a phospholipid bilayer

Andrej Kamenac, Tobias Obser, Achim Wixforth, Matthias F. Schneider, Christoph Westerhausen

Sci Rep. 2021; 11: 24476. Published online 2021 Dec 28. doi: 10.1038/s41598-021-04083-0

PMCID:: PMC8714821

Article PDF–3.0M

Select item 870343818.

Residues R1075, D1090, R1095, and C1130 Are Critical in ADAMTS13 TSP8-Spacer Interaction Predicted by Molecular Dynamics Simulation

Zhiwei Wu, Junxian Yang, Xubin Xie, Guangjian Liu, Ying Fang, Jianhua Wu, Jiangguo Lin

Molecules. 2021 Dec; 26(24): 7525. Published online 2021 Dec 12. doi: 10.3390/molecules26247525

PMCID:: PMC8703438

Article PDF–2.8M

Select item 857926819.

Anti-cysteine/spacer antibodies that open ADAMTS13 are a common feature in iTTP

Laure De Waele, Alexandre Curie, Kadri Kangro, Edwige Tellier, Gilles Kaplanski, Andres Männik, Claudia Tersteeg, Bérangère S. Joly, Paul Coppo, Agnès Veyradier, Simon F. De Meyer, Elien Roose, Karen Vanhoorelbeke

Blood Adv. 2021 Nov 9; 5(21): 4480–4484. Published online 2021 Nov 8. doi: 10.1182/bloodadvances.2021004971

PMCID:: PMC8579268

Article PDF–754K

Select item 852791220.

A mild deficiency of ADAMTS13 is associated with severity in COVID-19: comparison of the coagulation profile in critically and noncritically ill patients

Reyes María Martín-Rojas, Maite Chasco-Ganuza, Sara Casanova-Prieto, Valeria Estefanía Delgado-Pinos, Gloria Pérez-Rus, Patricia Duque-González, Milagros Sancho, José Luis Díez-Martín, Cristina Pascual-Izquierdo

Blood Coagul Fibrinolysis. 2021 Oct; 32(7): 458–467. Published online 2021 Jul 23. doi: 10.1097/MBC.0000000000001068

PMCID:: PMC8527912

Article PDF–414K

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