PMC Links for Gene (Select 1147) - PMC

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Select item 91742201.

Spatial expression of IKK-alpha is associated with a differential mutational landscape and survival in primary colorectal cancer

Meera Patel, Kathryn A. F. Pennel, Jean A. Quinn, Hannah Hood, David K. Chang, Andrew V. Biankin, Selma Rebus, Antonia K. Roseweir, James H. Park, Paul G. Horgan, Donald C. McMillan, Joanne Edwards

Br J Cancer. 2022 Jun 1; 126(12): 1704–1714. Published online 2022 Feb 16. doi: 10.1038/s41416-022-01729-2

PMCID:: PMC9174220

Article PDF–7.7M

Select item 89300782.

Combined immunodeficiency with autoimmunity caused by a homozygous missense mutation in inhibitor of nuclear factor κB kinase alpha (IKKα)

Wayne Bainter, Vassilios Lougaris, Jacqueline G. Wallace, Yousef Badran, Rodrigo Hoyos-Bachiloglu, Zachary Peters, Hazel Wilkie, Mrinmoy Das, Erin Janssen, Abdallah Beano, Khaoula Ben Farhat, Christy Kam, Luisa Bercich, Paolo Incardona, Vincenzo Villanacci, Maria Pia Bondioni, Antonella Meini, Manuela Baronio, Phammela Abarzua, Silvia Parolini, Giovanna Tabellini, Stefano Maio, Birgitta Schmidt, Jeffrey D. Goldsmith, George Murphy, Georg Hollander, Alessandro Plebani, Janet Chou, Raif S. Geha

Sci Immunol. Author manuscript; available in PMC 2022 Mar 17.

Published in final edited form as: Sci Immunol. 2021 Sep 17; 6(63): eabf6723. Published online 2021 Sep 17. doi: 10.1126/sciimmunol.abf6723

PMCID:: PMC8930078

Article PDF–3.5M

Select item 88834993.

IKKα plays a major role in canonical NF-κB signalling in colorectal cells

Jack A. Prescott, Kathryn Balmanno, Jennifer P. Mitchell, Hanneke Okkenhaug, Simon J. Cook

Biochem J. 2022 Feb 11; 479(3): 305–325. Prepublished online 2022 Jan 14. Published online 2022 Feb 4. doi: 10.1042/BCJ20210783

PMCID:: PMC8883499

Article PDF–40M

Select item 72438754.

Critical role of IκB kinase alpha in embryonic skin development and skin carcinogenesis

Feng Zhu, Eunmi Park, Bigang Liu, Xiaojun Xia, Susan M. Fischer, Yinling Hu

Histol Histopathol. Author manuscript; available in PMC 2020 May 22.

Published in final edited form as: Histol Histopathol. 2009 Feb; 24(2): 265–271. doi: 10.14670/HH-24.265

PMCID:: PMC7243875

Article PDF–1.3M

Select item 71388255.

Selective degradation of IKKα by autophagy is essential for arsenite-induced cancer cell apoptosis

Qixing Tan, Shuxian Zou, Rui Jin, Yongliang Hu, Huan Xu, Hongli Wang, Mengnan Ding, Meiru Hu, Changyuan Wei, Lun Song

Cell Death Dis. 2020 Apr; 11(4): 222. Published online 2020 Apr 7. doi: 10.1038/s41419-020-2420-5

PMCID:: PMC7138825

Article PDF–3.2M

Select item 67157756.

IKKα Kinase Regulates the DNA Damage Response and Drives Chemo-resistance in Cancer

Carlota Colomer, Pol Margalef, Alberto Villanueva, Anna Vert, Irene Pecharroman, Laura Solé, Mónica González-Farré, Josune Alonso, Clara Montagut, Maria Martinez-Iniesta, Joan Bertran, Eva Borràs, Mar Iglesias, Eduard Sabidó, Anna Bigas, Simon J. Boulton, Lluís Espinosa

Mol Cell. 2019 Aug 22; 75(4): 669–682.e5. doi: 10.1016/j.molcel.2019.05.036

PMCID:: PMC6715775

Article PDF–6.7M

Select item 55085157.

Structural Basis for the Activation of IKK1/a

Smarajit Polley, Dario Oliveira Passos, De-Bin Huang, Maria Carmen Mulero, Anup Mazumder, Tapan Biswas, Inder M. Verma, Dmitry Lyumkis, Gourisankar Ghosh

Cell Rep. Author manuscript; available in PMC 2017 Jul 13.

Published in final edited form as: Cell Rep. 2016 Nov 15; 17(8): 1907–1914. doi: 10.1016/j.celrep.2016.10.067

PMCID:: PMC5508515

Article PDF–644K

Select item 46948478.

Opposed expression of IKKα: loss in keratinizing carcinomas and gain in non-keratinizing carcinomas

Desheng Xiao, Jiantao Jia, Ying Shi, Chunyan Fu, Ling Chen, Yiqun Jiang, Li Zhou, Shuang Liu, Yongguang Tao

Oncotarget. 2015 Sep 22; 6(28): 25499–25505. Published online 2015 Aug 6. doi: 10.18632/oncotarget.4548

PMCID:: PMC4694847

Article PDF–1.4M

Select item 44068779.

Blocking IKKα Expression Inhibits Prostate Cancer Invasiveness

Rubi Mahato, Bin Qin, Kun Cheng

Pharm Res. Author manuscript; available in PMC 2015 Apr 22.

Published in final edited form as: Pharm Res. 2011 Jun; 28(6): 1357–1369. Published online 2010 Dec 30. doi: 10.1007/s11095-010-0351-z

PMCID:: PMC4406877

Article PDF–3.4M

Select item 413118510.

Phosphorylation of H3 serine 10 by IKKα governs cyclical production of ROS in estrogen-induced transcription and ensures DNA wholeness

B Perillo, A Di Santi, G Cernera, M N Ombra, G Castoria, A Migliaccio

Cell Death Differ. 2014 Sep; 21(9): 1503. Published online 2014 Jun 27. doi: 10.1038/cdd.2014.91

PMCID:: PMC4131185

Article PDF–119K

Select item 367672711.

Hepatitis C Virus Infection Activates a Novel Innate Pathway Involving IKKa in Lipogenesis and Viral Assembly

Qisheng Li, Véronique Pène, Siddharth Krishnamurthy, Helen Cha, T. Jake Liang

Nat Med. Author manuscript; available in PMC 2013 Dec 1.

Published in final edited form as: Nat Med. 2013 Jun; 19(6): 722–729. Published online 2013 May 26. doi: 10.1038/nm.3190

PMCID:: PMC3676727

Article PDF–3.8M

Select item 356348512.

Beyond NF-κB activation: nuclear functions of IκB kinase α

Wei-Chien Huang, Mien-Chie Hung

J Biomed Sci. 2013; 20(1): 3. Published online 2013 Jan 23. doi: 10.1186/1423-0127-20-3

PMCID:: PMC3563485

Article PDF–1.2M

Select item 331992913.

IκB Kinase Alpha and Cancer

Shuang Liu, Zhisong Chen, Feng Zhu, Yinling Hu

J Interferon Cytokine Res. 2012 Apr; 32(4): 152–158. doi: 10.1089/jir.2011.0107

PMCID:: PMC3319929

Article PDF–237K

Select item 324827714.

Defective nuclear IKKα function in patients with ectodermal dysplasia with immune deficiency

Stephane T. Temmerman, Chi A. Ma, Yongge Zhao, Jeffrey Keenan, Ivona Aksentijevich, Margaret Fessler, Margaret R. Brown, Alan Knutsen, Ralph Shapiro, Ashish Jain

J Clin Invest. 2012 Jan 3; 122(1): 315–326. Published online 2011 Dec 12. doi: 10.1172/JCI42534