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Select item 56410851.

UBE2J2 promotes hepatocellular carcinoma cell epithelial-mesenchymal transition and invasion in vitro

Shaopeng Chen, Ying Tan, Haihua Deng, Zhifa Shen, Yanhong Liu, Pan Wu, Chunyan Tan, Yuyang Jiang

Oncotarget. 2017 Sep 22; 8(42): 71736–71749. Published online 2017 May 3. doi: 10.18632/oncotarget.17601

PMCID:: PMC5641085

Article PDF–10M

Select item 56122282.

Multiple E2 ubiquitin-conjugating enzymes regulate human cytomegalovirus US2-mediated immunoreceptor downregulation

Michael L. van de Weijer, Anouk B. C. Schuren, Dick J. H. van den Boomen, Arend Mulder, Frans H. J. Claas, Paul J. Lehner, Robert Jan Lebbink, Emmanuel J. H. J. Wiertz

J Cell Sci. 2017 Sep 1; 130(17): 2883–2892. doi: 10.1242/jcs.206839

PMCID:: PMC5612228

Article

Select item 59347663.

MARCH6 and TRC8 facilitate the quality control of cytosolic and tail‐anchored proteins

Sandra Stefanovic‐Barrett, Anna S Dickson, Stephen P Burr, James C Williamson, Ian T Lobb, Dick JH van den Boomen, Paul J Lehner, James A Nathan

EMBO Rep. 2018 May; 19(5): e45603. Published online 2018 Mar 8. doi: 10.15252/embr.201745603

PMCID:: PMC5934766

Article PDF–4.7M

Select item 40247464.

A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation

Michael L. van de Weijer, Michael C. Bassik, Rutger D. Luteijn, Cornelia M. Voorburg, Mirjam A.M. Lohuis, Elisabeth Kremmer, Rob C. Hoeben, Emily M. LeProust, Siyuan Chen, Hanneke Hoelen, Maaike E. Ressing, Weronika Patena, Jonathan S. Weissman, Michael T. McManus, Emmanuel J.H.J. Wiertz, Robert Jan Lebbink

Nat Commun. 2014 May 8; 5: 3832. Published online 2014 May 8. doi: 10.1038/ncomms4832

PMCID:: PMC4024746

Article PDF–3.2M

Select item 38294295.

RNF185 Is a Novel E3 Ligase of Endoplasmic Reticulum-associated Degradation (ERAD) That Targets Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)

Elma El Khouri, Gwenaëlle Le Pavec, Michel B. Toledano, Agnès Delaunay-Moisan

J Biol Chem. 2013 Oct 25; 288(43): 31177–31191. Published online 2013 Sep 9. doi: 10.1074/jbc.M113.470500

PMCID:: PMC3829429

Article PDF–3.7M

Select item 110277936.

Ring domains are essential for GATOR2-dependent mTORC1 activation

Cong Jiang, Xiaoming Dai, Shaohui He, Hongfei Zhou, Lan Fang, Jianping Guo, Songlei Liu, Tao Zhang, Weijuan Pan, Haihong Yu, Tianmin Fu, Dali Li, Hiroyuki Inuzuka, Ping Wang, Jianru Xiao, Wenyi Wei

Mol Cell. Author manuscript; available in PMC 2024 Apr 19.

Published in final edited form as: Mol Cell. 2023 Jan 5; 83(1): 74–89.e9. Published online 2022 Dec 16. doi: 10.1016/j.molcel.2022.11.021

PMCID:: PMC11027793

Article PDF–3.0M

Select item 34129657.

A Human Ubiquitin Conjugating Enzyme (E2)-HECT E3 Ligase Structure-function Screen

Yi Sheng, Jenny H. Hong, Ryan Doherty, Tharan Srikumar, Jonathan Shloush, George V. Avvakumov, John R. Walker, Sheng Xue, Dante Neculai, Janet W. Wan, Sung K. Kim, Cheryl H. Arrowsmith, Brian Raught, Sirano Dhe-Paganon

Mol Cell Proteomics. 2012 Aug; 11(8): 329–341. Published online 2012 Apr 10. doi: 10.1074/mcp.O111.013706

PMCID:: PMC3412965

Article PDF–2.4M

Select item 98604968.

Elucidation of ubiquitin-conjugating enzymes that interact with RBR-type ubiquitin ligases using a liquid–liquid phase separation–based method

Ryota Hayashida, Reika Kikuchi, Kenichiro Imai, Waka Kojima, Tatsuya Yamada, Miho Iijima, Hiromi Sesaki, Keiji Tanaka, Noriyuki Matsuda, Koji Yamano

J Biol Chem. 2023 Feb; 299(2): 102822. Published online 2022 Dec 21. doi: 10.1016/j.jbc.2022.102822

PMCID:: PMC9860496

Article PDF–6.6M

Select item 49674789.

Synthesis of Isomeric Phosphoubiquitin Chains Reveals that Phosphorylation Controls Deubiquitinase Activity and Specificity

Nicolas Huguenin-Dezot, Virginia De Cesare, Julien Peltier, Axel Knebel, Yosua Adi Kristaryianto, Daniel T. Rogerson, Yogesh Kulathu, Matthias Trost, Jason W. Chin

Cell Rep. 2016 Jul 26; 16(4): 1180–1193. Published online 2016 Jul 14. doi: 10.1016/j.celrep.2016.06.064

PMCID:: PMC4967478

Article

Select item 616234610.

The MALDI-TOF E2/E3 Ligase Assay as Universal Tool for Drug Discovery in the Ubiquitin Pathway

Virginia De Cesare, Clare Johnson, Victoria Barlow, James Hastie, Axel Knebel, Matthias Trost

Cell Chem Biol. 2018 Sep 20; 25(9): 1117–1127.e4. doi: 10.1016/j.chembiol.2018.06.004

PMCID:: PMC6162346

Article

Select item 397140711.

Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity

Agne Kazlauskaite, Van Kelly, Clare Johnson, Carla Baillie, C. James Hastie, Mark Peggie, Thomas Macartney, Helen I. Woodroof, Dario R. Alessi, Patrick G. A. Pedrioli, Miratul M. K. Muqit

Open Biol. 2014 Mar; 4(3): 130213. Published online 2014 Mar 19. doi: 10.1098/rsob.130213

PMCID:: PMC3971407

Article PDF–1.7M

Select item 498812512.

System-wide modulation of HECT E3 ligases with selective ubiquitin variant probes

Wei Zhang, Kuen-Phon Wu, Maria A. Sartori, Hari B. Kamadurai, Alban Ordureau, Chong Jiang, Peter Y. Mercredi, Ryan Murchie, Jicheng Hu, Avinash Persaud, Manjeet Mukherjee, Nan Li, Anne Doye, John R. Walker, Yi Sheng, Zhenyue Hao, Yanjun Li, Kevin R. Brown, Emmanuel Lemichez, Junjie Chen, Yufeng Tong, J. Wade Harper, Jason Moffat, Daniela Rotin, Brenda A. Schulman, Sachdev S. Sidhu

Mol Cell. Author manuscript; available in PMC 2017 Apr 7.

Published in final edited form as: Mol Cell. 2016 Apr 7; 62(1): 121–136. Published online 2016 Mar 3. doi: 10.1016/j.molcel.2016.02.005

PMCID:: PMC4988125

Article PDF–1.2M

Select item 341237813.

Identification of novel ATP13A2 interactors and their role in α-synuclein misfolding and toxicity

Marija Usenovic, Adam L. Knight, Arpita Ray, Victoria Wong, Kevin R. Brown, Guy A. Caldwell, Kim A. Caldwell, Igor Stagljar, Dimitri Krainc

Hum Mol Genet. 2012 Sep 1; 21(17): 3785–3794. Published online 2012 May 29. doi: 10.1093/hmg/dds206

PMCID:: PMC3412378

Article PDF–534K

Select item 283828114.

The E2 Ubiquitin-conjugating Enzymes Direct Polyubiquitination to Preferred Lysines

Yael David, Tamar Ziv, Arie Admon, Ami Navon

J Biol Chem. 2010 Mar 19; 285(12): 8595–8604. Published online 2010 Jan 8. doi: 10.1074/jbc.M109.089003

PMCID:: PMC2838281

Article PDF–1.0M

Select item 584108615.

High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy

Samuel A. Hasson, Lesley A. Kane, Koji Yamano, Chiu-Hui Huang, Danielle A. Sliter, Eugen Buehler, Chunxin Wang, Sabrina M. Heman-Ackah, Tara Hessa, Rajarshi Guha, Scott E. Martin, Richard J. Youle

Nature. Author manuscript; available in PMC 2018 Mar 7.

Published in final edited form as: Nature. 2013 Dec 12; 504(7479): 291–295. Published online 2013 Nov 24. doi: 10.1038/nature12748

PMCID:: PMC5841086

Article PDF–5.3M

Select item 276528016.

Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network

Gabriel Markson, Christina Kiel, Russell Hyde, Stephanie Brown, Panagoula Charalabous, Anja Bremm, Jennifer Semple, Jonathan Woodsmith, Simon Duley, Kourosh Salehi-Ashtiani, Marc Vidal, David Komander, Luis Serrano, Paul Lehner, Christopher M. Sanderson

Genome Res. 2009 Oct; 19(10): 1905–1911. doi: 10.1101/gr.093963.109

PMCID:: PMC2765280

Article PDF–425K

Select item 526093917.

Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease

Felipe Roberti Teixeira, Suzanne J. Randle, Shachi P. Patel, Tycho E.T. Mevissen, Grasilda Zenkeviciute, Tie Koide, David Komander, Heike Laman

Biochem J. 2016 Oct 15; 473(20): 3563–3580. Prepublished online 2016 Aug 8. Published online 2016 Oct 11. doi: 10.1042/BCJ20160387

PMCID:: PMC5260939

Article PDF–1.1M

Select item 484160718.

High-throughput analyses of hnRNP H1 dissects its multi-functional aspect

Philip J. Uren, Emad Bahrami-Samani, Patricia Rosa de Araujo, Christine Vogel, Mei Qiao, Suzanne C. Burns, Andrew D. Smith, Luiz O. F. Penalva

RNA Biol. 2016 Apr; 13(4): 400–411. Published online 2016 Jan 13. doi: 10.1080/15476286.2015.1138030

PMCID:: PMC4841607

Article PDF–1.6M

Select item 756688119.

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism

Michael Aregger, Keith A. Lawson, Maximillian Billmann, Michael Costanzo, Amy H. Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiss, Patricia Mero, James W. Dennis, Anne-Claude Gingras, Chad L. Myers, Brenda J. Andrews, Charles Boone, Jason Moffat

Nat Metab. Author manuscript; available in PMC 2020 Dec 1.

Published in final edited form as: Nat Metab. 2020 Jun; 2(6): 499–513. Published online 2020 Jun 1. doi: 10.1038/s42255-020-0211-z

PMCID:: PMC7566881

Article PDF–4.8M

Select item 549522520.

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing

Teng Fei, Yiwen Chen, Tengfei Xiao, Wei Li, Laura Cato, Peng Zhang, Maura B. Cotter, Michaela Bowden, Rosina T. Lis, Shuang G. Zhao, Qiu Wu, Felix Y. Feng, Massimo Loda, Housheng Hansen He, X. Shirley Liu, Myles Brown

Proc Natl Acad Sci U S A. 2017 Jun 27; 114(26): E5207–E5215. Published online 2017 Jun 13. doi: 10.1073/pnas.1617467114

PMCID:: PMC5495225

Article PDF–1.3M

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