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Select item 87762541.

Molecular structures and conformations of protocadherin-15 and its complexes on stereocilia elucidated by cryo-electron tomography

Johannes Elferich, Sarah Clark, Jingpeng Ge, April Goehring, Aya Matsui, Eric Gouaux

eLife. 2021; 10: e74512. Published online 2021 Dec 29. doi: 10.7554/eLife.74512

PMCID:: PMC8776254

Article PDF–8.3M

Select item 85778402.

Proposed therapy, developed in a Pcdh15-deficient mouse, for progressive loss of vision in human Usher syndrome

Saumil Sethna, Wadih M Zein, Sehar Riaz, Arnaud PJ Giese, Julie M Schultz, Todd Duncan, Robert B Hufnagel, Carmen C Brewer, Andrew J Griffith, T Michael Redmond, Saima Riazuddin, Thomas B Friedman, Zubair M Ahmed

eLife. 2021; 10: e67361. Published online 2021 Nov 9. doi: 10.7554/eLife.67361

PMCID:: PMC8577840

Article PDF–9.7M

Select item 58921933.

Tuning Inner-Ear Tip-Link Affinity Through Alternatively Spliced Variants of Protocadherin-15

Yoshie Narui, Marcos Sotomayor

Biochemistry. Author manuscript; available in PMC 2019 Mar 20.

Published in final edited form as: Biochemistry. 2018 Mar 20; 57(11): 1702–1710. Published online 2018 Mar 6. doi: 10.1021/acs.biochem.7b01075

PMCID:: PMC5892193

Article PDF–798K

Select item 44365914.

Quantitative trait loci mapping and gene network analysis implicate protocadherin-15 as a determinant of brain serotonin transporter expression

R. Ye, A. M. D. Carneiro, Q. Han, D. Airey, E. Sanders-Bush, B. Zhang, L. Lu, R. Williams, R. D. Blakely

Genes Brain Behav. Author manuscript; available in PMC 2015 May 19.

Published in final edited form as: Genes Brain Behav. 2014 Mar; 13(3): 261–275. Published online 2014 Feb 6. doi: 10.1111/gbb.12119

PMCID:: PMC4436591

Article PDF–3.3M

Select item 36189685.

Noddy, a Mouse Harboring a Missense Mutation in Protocadherin-15, Reveals the Impact of Disrupting a Critical Interaction Site between Tip-Link Cadherins in Inner Ear Hair Cells

Ruishuang Geng, Marcos Sotomayor, Kimberly J. Kinder, Suhasini R. Gopal, John Gerka-Stuyt, Daniel H.-C. Chen, Rachel E. Hardisty-Hughes, Greg Ball, Andy Parker, Rachelle Gaudet, David Furness, Steve D. Brown, David P. Corey, Kumar N. Alagramam

J Neurosci. 2013 Mar 6; 33(10): 4395–4404. doi: 10.1523/JNEUROSCI.4514-12.2013

PMCID:: PMC3618968

Article PDF–2.7M

Select item 25383306.

Characterization of Vestibular Dysfunction in the Mouse Model for Usher Syndrome 1F

Kumar N. Alagramam, John S. Stahl, Sherri M. Jones, Karen S. Pawlowski, Charles G. Wright

J Assoc Res Otolaryngol. 2005 Jun; 6(2): 106–118. Published online 2005 Jun 10. doi: 10.1007/s10162-004-5032-3

PMCID:: PMC2538330

Article PDF–748K

Select item 25045817.

Progression of Inner Ear Pathology in Ames Waltzer Mice and the Role of Protocadherin 15 in Hair Cell Development

Karen S. Pawlowski, Yayoi S. Kikkawa, Charles G. Wright, Kumar N. Alagramam

J Assoc Res Otolaryngol. 2006 Jun; 7(2): 83–94. Published online 2006 Jan 12. doi: 10.1007/s10162-005-0024-5

PMCID:: PMC2504581

Article PDF–894K

Select item 63020408.

A Mechanically Weak Extracellular Membrane-Adjacent Domain Induces Dimerization of Protocadherin-15

Pedro De-la-Torre, Deepanshu Choudhary, Raul Araya-Secchi, Yoshie Narui, Marcos Sotomayor

Biophys J. 2018 Dec 18; 115(12): 2368–2385. Published online 2018 Nov 16. doi: 10.1016/j.bpj.2018.11.010

PMCID:: PMC6302040

Article PDF–4.4M

Select item 61682019.

Mechanotransduction by Pcdh15 relies on a novel cis-dimeric architecture

Gilman Dionne, Xufeng Qiu, Micah Rapp, Xiaoping Liang, Bo Zhao, Guihong Peng, Phinikoula S. Katsamba, Goran Ahlsen, Rotem Rubinstein, Clinton S. Potter, Bridget Carragher, Barry Honig, Ulrich Müller, Lawrence Shapiro

Neuron. Author manuscript; available in PMC 2018 Oct 2.

Published in final edited form as: Neuron. 2018 Aug 8; 99(3): 480–492.e5. Published online 2018 Jul 26. doi: 10.1016/j.neuron.2018.07.006

PMCID:: PMC6168201

Article PDF–1.5M

Select item 609212110.

Structure of mouse protocadherin 15 of the stereocilia tip link in complex with LHFPL5

Jingpeng Ge, Johannes Elferich, April Goehring, Huaying Zhao, Peter Schuck, Eric Gouaux

eLife. 2018; 7: e38770. Published online 2018 Aug 2. doi: 10.7554/eLife.38770

PMCID:: PMC6092121

Article PDF–5.4M

Select item 573622011.

Using thermal scanning assays to test protein-protein interactions of inner-ear cadherins

Deepanshu Choudhary, Anusha Kumar, Thomas J. Magliery, Marcos Sotomayor

PLoS One. 2017; 12(12): e0189546. Published online 2017 Dec 19. doi: 10.1371/journal.pone.0189546

PMCID:: PMC5736220

Article PDF–7.0M

Select item 565630212.

Spatiotemporal changes in the distribution of LHFPL5 in mice cochlear hair bundles during development and in the absence of PCDH15

Shanthini Mahendrasingam, Robert Fettiplace, Kumar N. Alagramam, Ellen Cross, David N. Furness

PLoS One. 2017; 12(10): e0185285. Published online 2017 Oct 25. doi: 10.1371/journal.pone.0185285

PMCID:: PMC5656302

Article PDF–39M

Select item 351876013.

Structure of a Force-Conveying Cadherin Bond Essential for Inner-Ear Mechanotransduction

Marcos Sotomayor, Wilhelm A. Weihofen, Rachelle Gaudet, David P. Corey

Nature. Author manuscript; available in PMC 2013 Jun 6.

Published in final edited form as: Nature. 2012 Dec 6; 492(7427): 128–132. Published online 2012 Nov 7. doi: 10.1038/nature11590

PMCID:: PMC3518760

Article PDF–1.6M

Select item 308091714.

Mutations in Protocadherin 15 and Cadherin 23 Affect Tip Links and Mechanotransduction in Mammalian Sensory Hair Cells

Kumar N. Alagramam, Richard J. Goodyear, Ruishuang Geng, David N. Furness, Alexander F. J. van Aken, Walter Marcotti, Corné J. Kros, Guy P. Richardson

PLoS One. 2011; 6(4): e19183. Published online 2011 Apr 21. doi: 10.1371/journal.pone.0019183

PMCID:: PMC3080917

Article PDF–1.4M

Select item 306242815.

Regulation of PCDH15 function in mechanosensory hair cells by alternative splicing of the cytoplasmic domain

Stuart W. Webb, Nicolas Grillet, Leonardo R. Andrade, Wei Xiong, Lani Swarthout, Charley C. Della Santina, Bechara Kachar, Ulrich Müller

Development. 2011 Apr 15; 138(8): 1607–1617. doi: 10.1242/dev.060061

PMCID:: PMC3062428

Article

Select item 294908516.

Development and Regeneration of Sensory Transduction in Auditory Hair Cells Requires Functional Interaction Between Cadherin-23 and Protocadherin-15

Andrea Lelli, Piotr Kazmierczak, Yoshiyuki Kawashima, Ulrich Müller, Jeffrey R. Holt

J Neurosci. 2010 Aug 25; 30(34): 11259–11269. doi: 10.1523/JNEUROSCI.1949-10.2010

PMCID:: PMC2949085

Article PDF–2.6M

Select item 284616117.

Proteomics, bioinformatics and targeted gene expression analysis reveals up-regulation of cochlin and identifies other potential biomarkers in the mouse model for deafness in usher syndrome type 1F

Mark R. Chance, Jinsook Chang, Shuqing Liu, Giridharan Gokulrangan, Daniel H.-C. Chen, Aaron Lindsay, Ruishuang Geng, Qing Y. Zheng, Kumar Alagramam

Hum Mol Genet. 2010 Apr 15; 19(8): 1515–1527. Published online 2010 Jan 22. doi: 10.1093/hmg/ddq025

PMCID:: PMC2846161

Article PDF–428K

Select item 279337618.

A nonsynonymous SNP within PCDH15 is associated with lipid traits in familial combined hyperlipidemia

Adriana Huertas-Vazquez, Christopher L. Plaisier, Ruishuang Geng, Blake E. Haas, Jenny Lee, Marleen M. Greevenbroek, Carla van der Kallen, Tjerk W. A. de Bruin, Marja-Riitta Taskinen, Kumar N. Alagramam, Päivi Pajukanta

Hum Genet. 2010; 127(1): 83–89. Published online 2009 Oct 9. doi: 10.1007/s00439-009-0749-z

PMCID:: PMC2793376

Article PDF–381K

Select item 266406519.

A mouse model for nonsyndromic deafness (DFNB12) links hearing loss to defects in tip links of mechanosensory hair cells

Martin Schwander, Wei Xiong, Joshua Tokita, Andrea Lelli, Heather M. Elledge, Piotr Kazmierczak, Anna Sczaniecka, Anand Kolatkar, Tim Wiltshire, Peter Kuhn, Jeffrey R. Holt, Bechara Kachar, Lisa Tarantino, Ulrich Müller

Proc Natl Acad Sci U S A. 2009 Mar 31; 106(13): 5252–5257. Published online 2009 Mar 6. doi: 10.1073/pnas.0900691106

PMCID:: PMC2664065

Article PDF–1.6M

Select item 259375120.

Double homozygous waltzer and Ames waltzer mice provide no evidence of retinal degeneration

Zubair M. Ahmed, Sten Kjellstrom, Ricky J. L. Haywood-Watson, II, Ronald A. Bush, Lori L. Hampton, James F. Battey, Saima Riazuddin, Gregory Frolenkov, Paul A. Sieving, Thomas B. Friedman

Mol Vis. 2008; 14: 2227–2236. Published online 2008 Dec 8.