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Items: 1 to 20 of 292

1.
BRCA1 heterozygosity promotes DNA damage-induced senescence in a sex-specific manner following repeated mild traumatic brain injury
Emily Leung, Daria Taskina, Nicole Schwab, Lili-Naz Hazrati
Front Neurosci. 2023; 17: 1225226. Published online 2023 Aug 10. doi: 10.3389/fnins.2023.1225226
PMCID:
PMC10450634
ArticlePDF–15M
2.
Sustained, local delivery of the PARP inhibitor talazoparib prevents the development of mammary gland hyperplasia in Brca1-deficient mice
Di Zhang, Bijay Singh, Jessica Moerland, Owen Mitchell, Lizbeth Lockwood, Sarah Carapellucci, Srinivas Sridhar, Karen T. Liby
Sci Rep. 2021; 11: 1234. Published online 2021 Jan 13. doi: 10.1038/s41598-020-79663-7
PMCID:
PMC7806744
ArticlePDF–1.5M
3.
Loss of BRCA1 Spontaneously Induces the Tumorigenesis in Lacrimal Gland
Sun Eui Kim, Hye Jung Baek, Eun Jung Park, Sung Chul Lim, Sang Soo Kim
Anal Cell Pathol (Amst) 2018; 2018: 8120579. Published online 2018 Dec 17. doi: 10.1155/2018/8120579
PMCID:
PMC6311772
ArticlePDF–11M
4.
Inhibition of Estrogen Signaling Reduces the Incidence of BRCA1-associated Mammary Tumor Formation
Hye Jung Baek, Sun Eui Kim, Eun Kyung Choi, Jong Kwang Kim, Dong Hoon Shin, Eun Jung Park, Tae Hyun Kim, Joo-Young Kim, Kwang Gi Kim, Chu-Xia Deng, Sang Soo Kim
Int J Biol Sci. 2018; 14(12): 1755–1768. Published online 2018 Oct 3. doi: 10.7150/ijbs.28142
PMCID:
PMC6216038
ArticlePDF–2.8M
5.
Breast cancer susceptibility protein 1 (BRCA1) rescues neurons from cerebral ischemia/reperfusion injury through NRF2-mediated antioxidant pathway
Pengfei Xu, Qian Liu, Yi Xie, Xiaolei Shi, Yunzi Li, Mengna Peng, Hongquan Guo, Rui Sun, Juanji Li, Ye Hong, Xinfeng Liu, Gelin Xu
Redox Biol. 2018 Sep; 18: 158–172. Published online 2018 Jul 7. doi: 10.1016/j.redox.2018.06.012
Correction in:
Redox Biol. 2020 Jan; 28: 008.
PMCID:
PMC6068089
ArticlePDF–7.1M
6.
The CST Complex Mediates End Protection at Double-Strand Breaks and Promotes PARP Inhibitor Sensitivity in BRCA1-Deficient Cells
Marco Barazas, Stefano Annunziato, Stephen J. Pettitt, Inge de Krijger, Hind Ghezraoui, Stefan J. Roobol, Catrin Lutz, Jessica Frankum, Fei Fei Song, Rachel Brough, Bastiaan Evers, Ewa Gogola, Jinhyuk Bhin, Marieke van de Ven, Dik C. van Gent, Jacqueline J.L. Jacobs, Ross Chapman, Christopher J. Lord, Jos Jonkers, Sven Rottenberg
Cell Rep. 2018 May 15; 23(7): 2107–2118. Published online 2018 May 15. doi: 10.1016/j.celrep.2018.04.046
PMCID:
PMC5972230
Article
7.
Mechanism of tandem duplication formation in BRCA1 mutant cells
Nicholas A. Willis, Richard L. Frock, Francesca Menghi, Erin E. Duffey, Arvind Panday, Virginia Camacho, E. Paul Hasty, Edison T. Liu, Frederick W. Alt, Ralph Scully
Nature. Author manuscript; available in PMC 2018 May 22.
Published in final edited form as: Nature. 2017 Nov 30; 551(7682): 590–595. Published online 2017 Nov 22. doi: 10.1038/nature24477
PMCID:
PMC5728692
ArticlePDF–5.3M
8.
Distinct Brca1 mutations differentially reduce hematopoietic stem cell function
Victoria E. Mgbemena, Robert A.J. Signer, Ranjula Wijayatunge, Travis Laxson, Sean J. Morrison, Theodora S. Ross
Cell Rep. Author manuscript; available in PMC 2017 Jan 26.
Published in final edited form as: Cell Rep. 2017 Jan 24; 18(4): 947–960. doi: 10.1016/j.celrep.2016.12.075
PMCID:
PMC5267932
ArticlePDF–1.8M
9.
Increased sensitivity of BRCA defective triple negative breast tumors to plumbagin through induction of DNA Double Strand Breaks (DSB)
Rakesh Sathish Nair, Jerald Mahesh Kumar, Jedy Jose, Veena Somasundaram, Sreelatha K. Hemalatha, Satheesh Kumar Sengodan, Revathy Nadhan, Thapasimuthu V. Anilkumar, Priya Srinivas
Sci Rep. 2016; 6: 26631. Published online 2016 May 25. doi: 10.1038/srep26631
PMCID:
PMC4879579
ArticlePDF–1.8M
10.
Brca1 deficiency causes bone marrow failure and spontaneous hematologic malignancies in mice
Aparna Vasanthakumar, Stephen Arnovitz, Rafael Marquez, Janet Lepore, George Rafidi, Anase Asom, Madison Weatherly, Elizabeth M. Davis, Barbara Neistadt, Robert Duszynski, James W. Vardiman, Michelle M. Le Beau, Lucy A. Godley, Jane E. Churpek
Blood. 2016 Jan 21; 127(3): 310–313. Prepublished online 2015 Dec 7. doi: 10.1182/blood-2015-03-635599
PMCID:
PMC4722284
Article
11.
POTENTIAL CONSEQUENCES OF THE BRCA1 MUTATION CARRIER STATE ON ESTROGEN RESPONSIVE ORGANS
Hai-Yun Yen, Yankel Gabet, Ying Liu, Anthony Martin, Nancy L Wu, Malcolm C Pike, Baruch Frenkel, Robert Maxson, Louis Dubeau
Lab Invest. Author manuscript; available in PMC 2015 Aug 10.
Published in final edited form as: Lab Invest. 2012 Jun; 92(6): 802–811. Published online 2012 Apr 9. doi: 10.1038/labinvest.2012.58
PMCID:
PMC4530993
ArticlePDF–1.1M
12.
BRCA1 controls homologous recombination at Tus/Ter-stalled mammalian replication forks
Nicholas A. Willis, Gurushankar Chandramouly, Bin Huang, Amy Kwok, Cindy Follonier, Chuxia Deng, Ralph Scully
Nature. Author manuscript; available in PMC 2014 Dec 26.
Published in final edited form as: Nature. 2014 Jun 26; 510(7506): 556–559. Published online 2014 Apr 28. doi: 10.1038/nature13295
PMCID:
PMC4118467
ArticlePDF–1.2M
13.
CDDO-Methyl ester delays breast cancer development in BRCA1-mutated mice
Eun-Hee Kim, Chuxia Deng, Michael B. Sporn, Darlene B. Royce, Renee Risingsong, Charlotte R. Williams, Karen T. Liby
Cancer Prev Res (Phila) Author manuscript; available in PMC 2013 Jan 1.
Published in final edited form as: Cancer Prev Res (Phila). 2012 Jan; 5(1): 89–97. Published online 2011 Sep 20. doi: 10.1158/1940-6207.CAPR-11-0359
PMCID:
PMC3252488
ArticlePDF–2.4M
14.
Detoxification: A Novel Function of BRCA1 in Tumor Suppression?
Hyo Jin Kang, Young Bin Hong, Hee Jeong Kim, Olga C. Rodriguez, Raghu G. Nath, Elena M. Tilli, Christopher Albanese, Fung-Lung Chung, Sang Hoon Kwon, Insoo Bae
Toxicol Sci. 2011 Jul; 122(1): 26–37. Published online 2011 Apr 19. doi: 10.1093/toxsci/kfr089
PMCID:
PMC3143468
ArticlePDF–1.0M
15.
CHANGES IN THE MOUSE ESTRUS CYCLE IN RESPONSE TO Brca1 INACTIVATION SUGGEST A POTENTIAL LINK BETWEEN RISK FACTORS FOR FAMILIAL AND SPORADIC OVARIAN CANCER
Hao Hong, Hai-Yun Yen, Amy Brockmeyer, Ying Liu, Rajas Chodankar, Malcolm C Pike, Frank Z Stanczyk, Robert Maxson, Louis Dubeau
Cancer Res. Author manuscript; available in PMC 2011 Jan 1.
Published in final edited form as: Cancer Res. 2010 Jan 1; 70(1): 221–228. Published online 2009 Dec 22. doi: 10.1158/0008-5472.CAN-09-3232
PMCID:
PMC2805040
ArticlePDF–730K
16.
Expression of human BRCA1 variants in mouse ES cells allows functional analysis of BRCA1 mutations
Suhwan Chang, Kajal Biswas, Betty K. Martin, Stacey Stauffer, Shyam K. Sharan
J Clin Invest. 2009 Oct 1; 119(10): 3160–3171. Published online 2009 Sep 21. doi: 10.1172/JCI39836
PMCID:
PMC2752086
ArticlePDF–5.2M
17.
Identification and characterization of cancer initiating cells from BRCA1 related mammary tumors using markers for normal mammary stem cells
Athanassios Vassilopoulos, Rui-Hong Wang, Constantinos Petrovas, David Ambrozak, Richard Koup, Chu-Xia Deng
Int J Biol Sci. 2008; 4(3): 133–142. Published online 2008 May 4. doi: 10.7150/ijbs.4.133
PMCID:
PMC2367429
ArticlePDF–1.2M
18.
Closing in on a breast cancer gene on chromosome 17q.
J M Hall, L Friedman, C Guenther, M K Lee, J L Weber, D M Black, M C King
Am J Hum Genet. 1992 Jun; 50(6): 1235–1242.
PMCID:
PMC1682570
SummaryPage BrowsePDF–902K
19.
Hyperplasia and Spontaneous Tumor Development in the Gynecologic System in Mice Lacking the BRCA1-Δ11 Isoform
Sang Soo Kim, Liu Cao, Sung-Chul Lim, Cuiling Li, Rui-Hong Wang, Xiaoling Xu, Richard Bachelier, Chu-Xia Deng
Mol Cell Biol. 2006 Sep; 26(18): 6983–6992. doi: 10.1128/MCB.00796-06
PMCID:
PMC1592852
ArticlePDF–1.4M
20.
BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution
Chu-Xia Deng
Nucleic Acids Res. 2006; 34(5): 1416–1426. Published online 2006 Mar 6. doi: 10.1093/nar/gkl010
PMCID:
PMC1390683
ArticlePDF–335K

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