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Select item 69341891.

BubR1 allelic effects drive phenotypic heterogeneity in mosaic-variegated aneuploidy progeria syndrome

Cynthia J. Sieben, Karthik B. Jeganathan, Grace G. Nelson, Ines Sturmlechner, Cheng Zhang, Willemijn H. van Deursen, Bjorn Bakker, Floris Foijer, Hu Li, Darren J. Baker, Jan M. van Deursen

J Clin Invest. 2020 Jan 2; 130(1): 171–188. Published online 2019 Nov 18. doi: 10.1172/JCI126863

Correction in:: J Clin Invest. 2020 Nov 2; 130(11): 6188.

PMCID:: PMC6934189

Article PDF–12M

Select item 64959702.

BubR1 deficiency results in enhanced activation of MEK and ERKs upon microtubule stresses

Y. L. Yang, Q. Duan, T. B. Guo, X. X. Wang, Q. Ruan, G. T. Xu, J. W. Zhang, Z. Y. Lu, M. Xu, L. Lu, W. Dai

Cell Prolif. 2007 Jun; 40(3): 397–410. Published online 2007 May 22. doi: 10.1111/j.1365-2184.2007.00443.x

PMCID:: PMC6495970

Article PDF–259K

Select item 64137503.

sFRP3 inhibition improves age‐related cellular changes in BubR1 progeroid mice

Chang Hoon Cho, Ki Hyun Yoo, Alfredo Oliveros, Summer Paulson, Syed Mohammed Qasim Hussaini, Jan M. van Deursen, Mi‐Hyeon Jang

Aging Cell. 2019 Apr; 18(2): e12899. Published online 2019 Jan 4. doi: 10.1111/acel.12899

PMCID:: PMC6413750

Article PDF–1000K

Select item 54182054.

Zhongxi Yang, Heechul Jun, Chan‐II Choi, Ki Hyun Yoo, Chang Hoon Cho, Syed Mohammed Qasim Hussaini, Ambrosia J. Simmons, Seonhee Kim, Jan M. van Deursen, Darren J. Baker, Mi‐Hyeon Jang

Aging Cell. 2017 Jun; 16(3): 598–601. Published online 2017 Apr 6. doi: 10.1111/acel.12594

PMCID:: PMC5418205

Article PDF–1.9M

Select item 51918625.

The progeroid gene BubR1 regulates axon myelination and motor function

Chan-Il Choi, Ki Hyun Yoo, Syed Mohammed Qasim Hussaini, Byeong Tak Jeon, John Welby, Haiyun Gan, Isobel A. Scarisbrick, Zhiguo Zhang, Darren J. Baker, Jan M. van Deursen, Moses Rodriguez, Mi-Hyeon Jang

Aging (Albany NY) 2016 Nov; 8(11): 2667–2684. Published online 2016 Sep 12. doi: 10.18632/aging.101032

PMCID:: PMC5191862

Article PDF–4.4M

Select item 48451016.

Naturally occurring p16^Ink4a-positive cells shorten healthy lifespan

Darren J. Baker, Bennett G. Childs, Matej Durik, Melinde E. Wijers, Cynthia J. Sieben, Jian Zhong, Rachel Saltness, Karthik B. Jeganathan, Grace C. Versoza, Abdul-Mohammad Pezeshki, Khashayarsha Khazaie, Jordan D. Miller, Jan M. van Deursen

Nature. Author manuscript; available in PMC 2016 Aug 3.

Published in final edited form as: Nature. 2016 Feb 11; 530(7589): 184–189. Published online 2016 Feb 3. doi: 10.1038/nature16932

PMCID:: PMC4845101

Article PDF–4.6M

Select item 41699157.

Single cell sequencing reveals low levels of aneuploidy across mammalian tissues

Kristin A. Knouse, Jie Wu, Charles A. Whittaker, Angelika Amon

Proc Natl Acad Sci U S A. 2014 Sep 16; 111(37): 13409–13414. Published online 2014 Sep 2. doi: 10.1073/pnas.1415287111

PMCID:: PMC4169915

Article PDF–1.7M

Select item 37189758.

Loss of BubR1 acetylation causes defects in spindle assembly checkpoint signaling and promotes tumor formation

Inai Park, Hae-ock Lee, Eunhee Choi, Yoo-Kyung Lee, Mi-Sun Kwon, Jaewon Min, Pil-Gu Park, Seonju Lee, Young-Yun Kong, Gyungyub Gong, Hyunsook Lee

J Cell Biol. 2013 Jul 22; 202(2): 295–309. doi: 10.1083/jcb.201210099

PMCID:: PMC3718975

Article PDF–3.2M

Select item 35314869.

Reduced Life- and Healthspan in Mice Carrying a Mono-Allelic BubR1 MVA Mutation

Tobias Wijshake, Liviu A. Malureanu, Darren J. Baker, Karthik B. Jeganathan, Bart van de Sluis, Jan M. van Deursen

PLoS Genet. 2012 Dec; 8(12): e1003138. Published online 2012 Dec 27. doi: 10.1371/journal.pgen.1003138

PMCID:: PMC3531486

Article PDF–2.3M

Select item 342883410.

BubR1 is required for prophase I arrest and prometaphase progression during female meiosis I

Hayden Homer, Liming Gui, John Carroll

Science. Author manuscript; available in PMC 2012 Aug 28.

Published in final edited form as: Science. 2009 Nov 13; 326(5955): 991–994. doi: 10.1126/science.1175326

PMCID:: PMC3428834

Article PDF–1.2M

Select item 714183411.

The cohesin release factor Wapl interacts with Bub3 to govern SAC activity in female meiosis I

Changyin Zhou, Yilong Miao, Zhaokang Cui, Xiayan ShiYang, Yu Zhang, Bo Xiong

Sci Adv. 2020 Apr; 6(15): eaax3969. Published online 2020 Apr 8. doi: 10.1126/sciadv.aax3969

PMCID:: PMC7141834

Article PDF–6.0M

Select item 577088312.

Sirt2‐BubR1 acetylation pathway mediates the effects of advanced maternal age on oocyte quality

Danhong Qiu, Xiaojing Hou, Longsen Han, Xiaoyan Li, Juan Ge, Qiang Wang

Aging Cell. 2018 Feb; 17(1): e12698. Published online 2017 Oct 25. doi: 10.1111/acel.12698

PMCID:: PMC5770883

Article PDF–1.4M

Select item 502748113.

EZH2 is required for mouse oocyte meiotic maturation by interacting with and stabilizing spindle assembly checkpoint protein BubRI

Yi Qu, Danyu Lu, Hao Jiang, Xiaochun Chi, Hongquan Zhang

Nucleic Acids Res. 2016 Sep 19; 44(16): 7659–7672. Published online 2016 May 25. doi: 10.1093/nar/gkw463

PMCID:: PMC5027481

Article PDF–18M

Select item 499995114.

BubR1 Insufficiency Impairs Liver Regeneration in Aged Mice after Hepatectomy through Intercalated Disc Abnormality

Ayae Ikawa-Yoshida, Takuya Matsumoto, Shinji Okano, Yukihiko Aoyagi, Yutaka Matsubara, Tadashi Furuyama, Yoshimichi Nakatsu, Teruhisa Tsuzuki, Mitsuho Onimaru, Tomoko Ohkusa, Masatoshi Nomura, Yoshihiko Maehara

Sci Rep. 2016; 6: 32399. Published online 2016 Aug 26. doi: 10.1038/srep32399

PMCID:: PMC4999951

Article PDF–2.2M

Select item 474340915.

Haplo-insufficiency of both BubR1 and SGO1 accelerates cellular senescence

Sung-Hyun Park, Steve Xie, Chinthalapally V. Rao, Wei Dai

J Hematol Oncol. 2016; 9: 7. Published online 2016 Feb 4. doi: 10.1186/s13045-016-0238-5

PMCID:: PMC4743409

Article PDF–2.1M

Select item 443992716.

Mouse oocytes depend on BubR1 for proper chromosome segregation but not for prophase I arrest

Sandra A. Touati, Eulalie Buffin, Damien Cladière, Khaled Hached, Christophe Rachez, Jan M. van Deursen, Katja Wassmann

Nat Commun. Author manuscript; available in PMC 2015 May 21.

Published in final edited form as: Nat Commun. 2015; 6: 6946. Published online 2015 Apr 21. doi: 10.1038/ncomms7946

PMCID:: PMC4439927

Article PDF–1.4M

Select item 375011017.

Diaphragm Muscle Sarcopenia in Aging Mice

Sarah M. Greising, Carlos B. Mantilla, Britney A. Gorman, Leonid G. Ermilov, Gary C. Sieck

Exp Gerontol. Author manuscript; available in PMC 2014 Sep 1.

Published in final edited form as: Exp Gerontol. 2013 Sep; 48(9): 881–887. Published online 2013 Jun 19. doi: 10.1016/j.exger.2013.06.001

PMCID:: PMC3750110

Article PDF–1.0M

Select item 346832318.

Clearance of p16^Ink4a-positive senescent cells delays ageing-associated disorders

Darren J. Baker, Tobias Wijshake, Tamar Tchkonia, Nathan K. LeBrasseur, Bennett G. Childs, Bart van de Sluis, James L. Kirkland, Jan M. van Deursen

Nature. Author manuscript; available in PMC 2012 Oct 10.

Published in final edited form as: Nature. 2011 Nov 2; 479(7372): 232–236. Published online 2011 Nov 2. doi: 10.1038/nature10600

PMCID:: PMC3468323

Article PDF–2.4M

Select item 259401419.

Opposing roles for p16^Ink4a and p19^Arf in senescence and ageing caused by BubR1 insufficiency

Darren J. Baker, Carmen Perez-Terzic, Fang Jin, Kevin Pitel, Nicolas J. Niederländer, Karthik Jeganathan, Satsuki Yamada, Santiago Reyes, Lois Rowe, H. Jay Hiddinga, Norman L. Eberhardt, Andre Terzic, Jan M. van Deursen

Nat Cell Biol. Author manuscript; available in PMC 2008 Dec 4.

Published in final edited form as: Nat Cell Biol. 2008 Jul; 10(7): 825–836. Published online 2008 May 30. doi: 10.1038/ncb1744