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Select item 107434761.

Loss of Cdc42 in Exocrine Acini Decreases Saliva Secretion but Increases Tear Secretion—A Potential Model of Exocrine Gland Senescence

Haruna Nagase, Akiko Shitara, Yuta Ohno, Keitaro Satoh, Masanori Kashimata

Int J Mol Sci. 2023 Dec; 24(24): 17220. Published online 2023 Dec 7. doi: 10.3390/ijms242417220

PMCID:: PMC10743476

Article PDF–12M

Select item 93998542.

Cdc42 upregulation under high glucose induces podocyte apoptosis and impairs β-cell insulin secretion

Shan Jiang, Chun-mei Xu, Shuai Yao, Rui Zhang, Xian-zhi Li, Ru-zhen Zhang, Tian-yue Xie, Yi-qian Xing, Qian Zhang, Xiao-jun Zhou, Lin Liao, Jian-jun Dong

Front Endocrinol (Lausanne) 2022; 13: 905703. Published online 2022 Aug 10. doi: 10.3389/fendo.2022.905703

PMCID:: PMC9399854

Article PDF–4.2M

Select item 91900173.

Palmitoylation of the small GTPase Cdc42 by DHHC5 modulates spine formation and gene transcription

Alexander Wirth, Josephine Labus, Dalia Abdel Galil, Yvonne Schill, Silke Schmidt, Tania Bunke, Nataliya Gorinski, Norihiko Yokoi, Masaki Fukata, Evgeni Ponimaskin

J Biol Chem. 2022 Jun; 298(6): 102048. Published online 2022 May 18. doi: 10.1016/j.jbc.2022.102048

PMCID:: PMC9190017

Article PDF–1.6M

Select item 80444264.

Suppression of elevated Cdc42 activity promotes the regenerative potential of aged intestinal stem cells

Kodandaramireddy Nalapareddy, Aishlin Hassan, Leesa L. Sampson, Yi Zheng, Hartmut Geiger

iScience. 2021 Apr 23; 24(4): 102362. Published online 2021 Mar 26. doi: 10.1016/j.isci.2021.102362

PMCID:: PMC8044426

Article PDF–4.6M

Select item 78546025.

Photoactivatable CaMKII induces synaptic plasticity in single synapses

Akihiro C. E. Shibata, Hiromi H. Ueda, Kei Eto, Maki Onda, Aiko Sato, Tatsuko Ohba, Junichi Nabekura, Hideji Murakoshi

Nat Commun. 2021; 12: 751. Published online 2021 Feb 2. doi: 10.1038/s41467-021-21025-6

PMCID:: PMC7854602

Article PDF–2.7M

Select item 74551426.

Elevating EGFR-MAPK program by a nonconventional Cdc42 enhances intestinal epithelial survival and regeneration

Xiao Zhang, Sheila Bandyopadhyay, Leandro Pires Araujo, Kevin Tong, Juan Flores, Daniel Laubitz, Yanlin Zhao, George Yap, Jingren Wang, Qingze Zou, Ronaldo Ferraris, Lanjing Zhang, Wenwei Hu, Edward M. Bonder, Pawel R. Kiela, Robert Coffey, Michael P. Verzi, Ivaylo I. Ivanov, Nan Gao

JCI Insight. 2020 Aug 20; 5(16): e135923. Published online 2020 Aug 20. doi: 10.1172/jci.insight.135923

PMCID:: PMC7455142

Article PDF–17M

Select item 67082807.

Endocytosis of commensal antigens by intestinal epithelial cells regulates mucosal T cell homeostasis

Mark S. Ladinsky, Leandro P. Araujo, Xiao Zhang, John Veltri, Marta Galan-Diez, Salima Soualhi, Carolyn Lee, Koichiro Irie, Elisha Y. Pinker, Seiko Narushima, Sheila Bandyopadhyay, Manabu Nagayama, Wael Elhenawy, Brian K. Coombes, Ronaldo P. Ferraris, Kenya Honda, Iliyan D. Iliev, Nan Gao, Pamela J. Bjorkman, Ivaylo I. Ivanov

Science. Author manuscript; available in PMC 2020 Mar 8.

Published in final edited form as: Science. 2019 Mar 8; 363(6431): eaat4042. doi: 10.1126/science.aat4042

PMCID:: PMC6708280

Article PDF–4.5M

Select item 65895728.

Cdc42 negatively regulates endocytosis during apical membrane maintenance in live animals

Akiko Shitara, Lenka Malec, Seham Ebrahim, Desu Chen, Christopher Bleck, Matthew P. Hoffman, Roberto Weigert

Mol Biol Cell. 2019 Feb 1; 30(3): 324–332. doi: 10.1091/mbc.E18-10-0615

PMCID:: PMC6589572

Article PDF–1.6M

Select item 64140739.

Rational identification of a Cdc42 inhibitor presents a new regimen for long-term hematopoietic stem cell mobilization

Wei Liu, Wei Du, Xun Shang, Lei Wang, Chris Evelyn, Maria Carolina Florian, Marnie A. Ryan, Ahmad Rayes, Xueheng Zhao, Kenneth Setchell, Jarek Meller, Fukun Guo, Nicolas Nassar, Hartmut Geiger, Qishen Pang, Yi Zheng

Leukemia. Author manuscript; available in PMC 2020 Mar 1.

Published in final edited form as: Leukemia. 2019 Mar; 33(3): 749–761. Published online 2018 Sep 25. doi: 10.1038/s41375-018-0251-5

PMCID:: PMC6414073

Article PDF–965K

Select item 641184110.

Alternative 3′ UTRs direct localization of functionally diverse protein isoforms in neuronal compartments

Camilla Ciolli Mattioli, Aviv Rom, Vedran Franke, Koshi Imami, Gerard Arrey, Mandy Terne, Andrew Woehler, Altuna Akalin, Igor Ulitsky, Marina Chekulaeva

Nucleic Acids Res. 2019 Mar 18; 47(5): 2560–2573. Published online 2018 Dec 22. doi: 10.1093/nar/gky1270

PMCID:: PMC6411841

Article PDF–2.6M

Select item 631065411.

Rational targeting Cdc42 restrains Th2 cell differentiation and prevents allergic airway inflammation

Jun-Qi Yang, Khalid W. Kalim, Yuan Li, Xin Duan, Phuong Nguyen, Gurjit K. Khurana Hershey, John Kroner, Brandy Ruff, Li Zhang, Nathan Salomonis, Mark Rochman, Ting Wen, Yi Zheng, Fukun Guo

Clin Exp Allergy. Author manuscript; available in PMC 2020 Jan 1.

Published in final edited form as: Clin Exp Allergy. 2019 Jan; 49(1): 92–107. Published online 2018 Nov 13. doi: 10.1111/cea.13293

PMCID:: PMC6310654

Article PDF–2.9M

Select item 613365312.

Cdc42-dependent modulation of rigidity sensing and cell spreading in tumor repopulating cells

Farhan Chowdhury, Sultan Doğanay, Benjamin J. Leslie, Rishi Singh, Kshitij Amar, Bhavana Talluri, Seongjin Park, Ning Wang, Taekjip Ha

Biochem Biophys Res Commun. Author manuscript; available in PMC 2018 Dec 7.

Published in final edited form as: Biochem Biophys Res Commun. 2018 Jun 7; 500(3): 557–563. Published online 2018 Apr 23. doi: 10.1016/j.bbrc.2018.04.085

PMCID:: PMC6133653

Article PDF–1.5M

Select item 603329213.

CDC42 controls the activation of primordial follicles by regulating PI3K signaling in mouse oocytes

Hao Yan, Jiawei Zhang, Jia Wen, Yibo Wang, Wanbao Niu, Zhen Teng, Tongtong Zhao, Yanli Dai, Yan Zhang, Chao Wang, Yingying Qin, Guoliang Xia, Hua Zhang

BMC Biol. 2018; 16: 73. Published online 2018 Jul 5. doi: 10.1186/s12915-018-0541-4

PMCID:: PMC6033292

Article PDF–16M

Select item 580647114.

Endothelial Cdc42 deficiency impairs endothelial regeneration and vascular repair after inflammatory vascular injury

Jiawen Lv, Junchao Zeng, Fukun Guo, Yiran Li, Mengying Xu, Yuanxiong Cheng, Lin Zhang, Shaoxi Cai, Yinghua Chen, Yi Zheng, Guodong Hu

Respir Res. 2018; 19: 27. Published online 2018 Feb 8. doi: 10.1186/s12931-018-0729-8

PMCID:: PMC5806471

Article PDF–4.3M

Select item 575023015.

Non-canonical Wnt signaling regulates neural stem cell quiescence during homeostasis and after demyelination

Manideep Chavali, Michael Klingener, Alexandros G. Kokkosis, Yury Garkun, Sylwia Felong, Arianna Maffei, Adan Aguirre

Nat Commun. 2018; 9: 36. Published online 2018 Jan 2. doi: 10.1038/s41467-017-02440-0

PMCID:: PMC5750230

Article PDF–4.6M

Select item 486145816.

An Essential Role for Cdc42 in the Functioning of the Adult Mammary Gland

Joseph E. Druso, Makoto Endo, Miao-chong Joy Lin, Xu Peng, Marc A. Antonyak, Stephanie Meller, Richard A. Cerione

J Biol Chem. 2016 Apr 22; 291(17): 8886–8895. Published online 2016 Feb 24. doi: 10.1074/jbc.M115.694349

PMCID:: PMC4861458

Article PDF–2.4M

Select item 463987317.

Cdc42-dependent actin dynamics controls maturation and secretory activity of dendritic cells

Anna M. Schulz, Susanne Stutte, Sebastian Hogl, Nancy Luckashenak, Diana Dudziak, Céline Leroy, Ignasi Forné, Axel Imhof, Stephan A. Müller, Cord H. Brakebusch, Stefan F. Lichtenthaler, Thomas Brocker

J Cell Biol. 2015 Nov 9; 211(3): 553–567. doi: 10.1083/jcb.201503128

PMCID:: PMC4639873

Article PDF–6.3M

Select item 446474818.

Pharmacological inhibition of EGFR signaling enhances G-CSF–induced hematopoietic stem cell mobilization

Marnie A Ryan, Kalpana J Nattamai, Ellen Xing, David Schleimer, Deidre Daria, Amitava Sengupta, Anja Köhler, Wei Liu, Matthias Gunzer, Michael Jansen, Nancy Ratner, Timothy D Le Cras, Amanda Waterstrat, Gary Van Zant, Jose A Cancelas, Yi Zheng, Hartmut Geiger

Nat Med. Author manuscript; available in PMC 2015 Jun 13.

Published in final edited form as: Nat Med. 2010 Oct; 16(10): 1141–1146. Published online 2010 Sep 26. doi: 10.1038/nm.2217

PMCID:: PMC4464748

Article PDF–1.3M

Select item 441673719.

The Rho GTPase Cdc42 Is Essential for the Activation and Function of Mature B Cells

Natalija Gerasimcik, Carin I. M. Dahlberg, Marisa A. P. Baptista, Michel J. Massaad, Raif S. Geha, Lisa S. Westerberg, Eva Severinson

J Immunol. 2015 May 15; 194(10): 4750–4758. Published online 2015 Apr 13. doi: 10.4049/jimmunol.1401634

PMCID:: PMC4416737

Article PDF–1.8M

Select item 429152320.

Cdc42 is a key regulator of B cell differentiation and is required for antiviral humoral immunity

Marianne Burbage, Selina J. Keppler, Francesca Gasparrini, Nuria Martínez-Martín, Mauro Gaya, Christoph Feest, Marie-Charlotte Domart, Cord Brakebusch, Lucy Collinson, Andreas Bruckbauer, Facundo D. Batista

J Exp Med. 2015 Jan 12; 212(1): 53–72. doi: 10.1084/jem.20141143

PMCID:: PMC4291523

Article PDF–4.2M

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