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Select item 99538751.

Role of Cholesterol 25-Hydroxylase (Ch25h) in Mediating Innate Immune Responses to Streptococcus pneumoniae Infection

Soo Jung Cho, Alexander Pronko, Jianjun Yang, Kassandra Pagan, Heather Stout-Delgado

Cells. 2023 Feb; 12(4): 570. Published online 2023 Feb 10. doi: 10.3390/cells12040570

PMCID:: PMC9953875

Article PDF–2.1M

Select item 97807392.

Cholesterol 25-hydroxylase is a metabolic switch to constrain T cell-mediated inflammation in the skin

Hayato Takahashi, Hisashi Nomura, Hisato Iriki, Akiko Kubo, Koichi Isami, Yohei Mikami, Miho Mukai, Takashi Sasaki, Jun Yamagami, Jun Kudoh, Hiromi Ito, Aki Kamata, Yutaka Kurebayashi, Hiroki Yoshida, Akihiko Yoshimura, Hong-Wei Sun, Makoto Suematsu, Jonh J. O’Shea, Yuka Kanno, Masayuki Amagai

Sci Immunol. Author manuscript; available in PMC 2022 Dec 23.

Published in final edited form as: Sci Immunol. 2021 Oct 15; 6(64): eabb6444. Published online 2021 Oct 8. doi: 10.1126/sciimmunol.abb6444

PMCID:: PMC9780739

Article PDF–2.3M

Select item 86600513.

A Proinflammatory Stimulus Disrupts Hippocampal Plasticity and Learning via Microglial Activation and 25-Hydroxycholesterol

Yukitoshi Izumi, Anil G. Cashikar, Kathiresan Krishnan, Steven M. Paul, Douglas F. Covey, Steven J. Mennerick, Charles F. Zorumski

J Neurosci. 2021 Dec 8; 41(49): 10054–10064. doi: 10.1523/JNEUROSCI.1502-21.2021

PMCID:: PMC8660051

Article PDF–1.9M

Select item 84574774.

Tumor Necrosis Factor-alpha utilizes MAPK/NFκB pathways to induce cholesterol-25 hydroxylase for amplifying pro-inflammatory response via 25-hydroxycholesterol-integrin-FAK pathway

Swechha M. Pokharel, Kim Chiok, Niraj K. Shil, Indira Mohanty, Santanu Bose

PLoS One. 2021; 16(9): e0257576. Published online 2021 Sep 22. doi: 10.1371/journal.pone.0257576

PMCID:: PMC8457477

Article PDF–1.5M

Select item 81215295.

Regulation of intercellular biomolecule transfer–driven tumor angiogenesis and responses to anticancer therapies

Zhen Lu, Angelica Ortiz, Ioannis I. Verginadis, Amy R. Peck, Farima Zahedi, Christina Cho, Pengfei Yu, Rachel M. DeRita, Hongru Zhang, Ryan Kubanoff, Yunguang Sun, Andrew T. Yaspan, Elise Krespan, Daniel P. Beiting, Enrico Radaelli, Sandra W. Ryeom, J. Alan Diehl, Hallgeir Rui, Constantinos Koumenis, Serge Y. Fuchs

J Clin Invest. 2021 May 17; 131(10): e144225. Published online 2021 May 17. doi: 10.1172/JCI144225

PMCID:: PMC8121529

Article PDF–9.0M

Select item 74557286.

Cholesterol 25-hydroxylase protects against experimental colitis in mice by modulating epithelial gut barrier function

Na Sheng, Zhongnan Ma, Yi Zhou, Juan Xu, Yan Gao, Xin-Yuan Fu

Sci Rep. 2020; 10: 14246. Published online 2020 Aug 28. doi: 10.1038/s41598-020-71198-1

PMCID:: PMC7455728

Article PDF–6.8M

Select item 73080637.

Cholesterol 25-hydroxylase promotes efferocytosis and resolution of lung inflammation

Jennifer H. Madenspacher, Eric D. Morrell, Kymberly M. Gowdy, Jeffrey G. McDonald, Bonne M. Thompson, Ginger Muse, Jennifer Martinez, Seddon Thomas, Carmen Mikacenic, Jerry A. Nick, Edward Abraham, Stavros Garantziotis, Renee D. Stapleton, Julie M. Meacham, Mary Jane Thomassen, William J. Janssen, Donald N. Cook, Mark M. Wurfel, Michael B. Fessler

JCI Insight. 2020 Jun 4; 5(11): e137189. Published online 2020 Jun 4. doi: 10.1172/jci.insight.137189

PMCID:: PMC7308063

Article PDF–5.7M

Select item 53373528.

Hepatic Cholesterol-25-Hydroxylase Overexpression Improves Systemic Insulin Sensitivity in Mice

Britta Noebauer, Alexander Jais, Jelena Todoric, Klaus Gossens, Hedwig Sutterlüty-Fall, Elisa Einwallner

J Diabetes Res. 2017; 2017: 4108768. Published online 2017 Feb 19. doi: 10.1155/2017/4108768

PMCID:: PMC5337352

Article PDF–1008K

Select item 42896379.

25-hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon

Andrea Reboldi, Eric V. Dang, Jeffrey G. McDonald, Guosheng Liang, David W. Russell, Jason G. Cyster

Science. Author manuscript; available in PMC 2015 Feb 8.

Published in final edited form as: Science. 2014 Aug 8; 345(6197): 679–684. doi: 10.1126/science.1254790

PMCID:: PMC4289637

Article PDF–942K

Select item 369897510.

Interferon-Inducible Cholesterol-25-Hydroxylase Broadly Inhibits Viral Entry by Production of 25-Hydroxycholesterol

Su-Yang Liu, Roghiyh Aliyari, Kelechi Chikere, Guangming Li, Matthew D. Marsden, Jennifer K. Smith, Olivier Pernet, Haitao Guo, Rebecca Nusbaum, Jerome A. Zack, Alexander N. Freiberg, Lishan Su, Benhur Lee, Genhong Cheng

Immunity. Author manuscript; available in PMC 2013 Jul 2.

Published in final edited form as: Immunity. 2013 Jan 24; 38(1): 92–105. Published online 2012 Dec 27. doi: 10.1016/j.immuni.2012.11.005

PMCID:: PMC3698975

Article PDF–5.2M

Select item 306755511.

Listeria monocytogenes Infection Induces Prosurvival Metabolic Signaling in Macrophages

Tie Zou, Oleg Garifulin, Robert Berland, Victor L. Boyartchuk

Infect Immun. 2011 Apr; 79(4): 1526–1535. Published online 2011 Jan 24. doi: 10.1128/IAI.01195-10

PMCID:: PMC3067555

Article PDF–1.6M

Select item 1070411512.

Endogenous and Therapeutic 25-Hydroxycholesterols May Worsen Early SARS-CoV-2 Pathogenesis in Mice

Michael B. Fessler, Jennifer H. Madenspacher, Paul J. Baker, Kerry L. Hilligan, Andrea C. Bohrer, Ehydel Castro, Julie Meacham, Shih-Heng Chen, Reed F. Johnson, Jeffrey G. McDonald, Negin P. Martin, Charles J. Tucker, Debabrata Mahapatra, Mark Cesta, Katrin D. Mayer-Barber

Am J Respir Cell Mol Biol. 2023 Dec 1; 69(6): 638–648. Published online 2023 Aug 14. doi: 10.1165/rcmb.2023-0007OC

PMCID:: PMC10704115

Article PDF–1.6M

Select item 963620213.

Tumor factors stimulate lysosomal degradation of tumor antigens and undermine their cross-presentation in lung cancer

Zhen Lu, Jinyun Chen, Pengfei Yu, Matthew J. Atherton, Jun Gui, Vivek S. Tomar, Justin D. Middleton, Neil T. Sullivan, Sunil Singhal, Subin S. George, Ashley G. Woolfork, Aalim M. Weljie, Tsonwin Hai, Evgeniy B. Eruslanov, Serge Y. Fuchs

Nat Commun. 2022; 13: 6623. Published online 2022 Nov 4. doi: 10.1038/s41467-022-34428-w

PMCID:: PMC9636202

Article PDF–6.2M

Select item 726773514.

Cholesterol 25-hydroxylase (CH25H) as a promoter of adipose tissue inflammation in obesity and diabetes

Lucia Russo, Lindsey Muir, Lynn Geletka, Jennifer Delproposto, Nicki Baker, Carmen Flesher, Robert O'Rourke, Carey N. Lumeng

Mol Metab. 2020 Sep; 39: 100983. Published online 2020 Mar 27. doi: 10.1016/j.molmet.2020.100983

PMCID:: PMC7267735

Article PDF–3.6M

Select item 660213015.

Elevated oxysterol levels in human and mouse livers reflect nonalcoholic steatohepatitis

Tina Raselli, Tom Hearn, Annika Wyss, Kirstin Atrott, Alain Peter, Isabelle Frey-Wagner, Marianne R. Spalinger, Ewerton M. Maggio, Andreas W. Sailer, Johannes Schmitt, Philipp Schreiner, Anja Moncsek, Joachim Mertens, Michael Scharl, William J. Griffiths, Marco Bueter, Andreas Geier, Gerhard Rogler, Yuqin Wang, Benjamin Misselwitz

J Lipid Res. 2019 Jul; 60(7): 1270–1283. Published online 2019 May 21. doi: 10.1194/jlr.M093229

PMCID:: PMC6602130

Article PDF–1.9M

Select item 275983116.

Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide

Ulf Diczfalusy, Katarina E. Olofsson, Ann-Margreth Carlsson, Mei Gong, Douglas T. Golenbock, Olav Rooyackers, Urban Fläring, Harry Björkbacka

J Lipid Res. 2009 Nov; 50(11): 2258–2264. doi: 10.1194/jlr.M900107-JLR200

PMCID:: PMC2759831

Article PDF–740K

Select item 275782117.

25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production

David R. Bauman, Andrew D. Bitmansour, Jeffrey G. McDonald, Bonne M. Thompson, Guosheng Liang, David W. Russell

Proc Natl Acad Sci U S A. 2009 Sep 29; 106(39): 16764–16769. Published online 2009 Sep 15. doi: 10.1073/pnas.0909142106

PMCID:: PMC2757821

Article PDF–455K

Select item 1049646118.

ATF3 and CH25H regulate effector trogocytosis and anti-tumor activities of endogenous and immunotherapeutic cytotoxic T lymphocytes

Zhen Lu, Noreen McBrearty, Jinyun Chen, Vivek S. Tomar, Hongru Zhang, Gianluca De Rosa, Aiwen Tan, Aalim M. Weljie, Daniel P. Beiting, Zhen Miao, Subin S. George, Allison Berger, Gurpanna Saggu, J. Alan Diehl, Constantinos Koumenis, Serge Y. Fuchs

Cell Metab. Author manuscript; available in PMC 2023 Sep 12.

Published in final edited form as: Cell Metab. 2022 Sep 6; 34(9): 1342–1358.e7. doi: 10.1016/j.cmet.2022.08.007

Correction in:: Cell Metab. 2024 Apr 10

PMCID:: PMC10496461

Article PDF–3.6M

Select item 644380919.

Integrin activation by the lipid molecule 25-hydroxycholesterol induces a proinflammatory response

Swechha M. Pokharel, Niraj K. Shil, Jeevan B. GC, Zachary T. Colburn, Su-Yu Tsai, Jesus A. Segovia, Te-Hung Chang, Smarajit Bandyopadhyay, Senthil Natesan, Jonathan C. R. Jones, Santanu Bose

Nat Commun. 2019; 10: 1482. Published online 2019 Apr 1. doi: 10.1038/s41467-019-09453-x

PMCID:: PMC6443809

Article PDF–2.5M

Select item 593861520.

Cholesterol metabolism promotes B‐cell positioning during immune pathogenesis of chronic obstructive pulmonary disease

Jie Jia, Thomas M Conlon, Rim SJ Sarker, Demet Taşdemir, Natalia F Smirnova, Barkha Srivastava, Stijn E Verleden, Gizem Güneş, Xiao Wu, Cornelia Prehn, Jiaqi Gao, Katharina Heinzelmann, Jutta Lintelmann, Martin Irmler, Stefan Pfeiffer, Michael Schloter, Ralf Zimmermann, Martin Hrabé de Angelis, Johannes Beckers, Jerzy Adamski, Hasan Bayram, Oliver Eickelberg, Ali Önder Yildirim

EMBO Mol Med. 2018 May; 10(5): e8349. Published online 2018 Apr 19. doi: 10.15252/emmm.201708349

PMCID:: PMC5938615

Article PDF–2.2M

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