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Select item 107649921.

Partial Deletion of Perk Improved High-Fat Diet-Induced Glucose Intolerance in Mice

Jooyeop Lee, Min Joo Kim, Seoil Moon, Ji Yoon Lim, Kyong Soo Park, Hye Seung Jung

Endocrinol Metab (Seoul) 2023 Dec; 38(6): 782–787. Published online 2023 Nov 13. doi: 10.3803/EnM.2023.1738

PMCID:: PMC10764992

Article PDF–821K

Select item 104248022.

PERK Inhibition Suppresses Neovascularization and Protects Neurons During Ischemia-Induced Retinopathy

Shuizhen Shi, Chun Ding, Shuang Zhu, Fan Xia, Seth E. Buscho, Shengguo Li, Massoud Motamedi, Hua Liu, Wenbo Zhang

Invest Ophthalmol Vis Sci. 2023 Aug; 64(11): 17. Published online 2023 Aug 11. doi: 10.1167/iovs.64.11.17

PMCID:: PMC10424802

Article PDF–6.1M

Select item 93114633.

Preventing Cholesterol-Induced Perk (Protein Kinase RNA-Like Endoplasmic Reticulum Kinase) Signaling in Smooth Muscle Cells Blocks Atherosclerotic Plaque Formation

Abhijnan Chattopadhyay, Pujun Guan (关蒲骏), Suravi Majumder, Kaveeta Kaw, Zhen Zhou (周桢), Chen Zhang, Siddharth K. Prakash, Anita Kaw, L. Maximillian Buja, Callie S. Kwartler, Dianna M. Milewicz

Arterioscler Thromb Vasc Biol. 2022 Aug; 42(8): 1005–1022. Published online 2022 Jun 16. doi: 10.1161/ATVBAHA.121.317451

PMCID:: PMC9311463

Article PDF–1.6M

Select item 90091244.

Inhibition of unfolded protein response prevents post‐anesthesia neuronal hyperactivity and synapse loss in aged mice

Kai Chen, Qiuping Hu, Riya Gupta, Jessie Stephens, Zhongcong Xie, Guang Yang

Aging Cell. 2022 Apr; 21(4): e13592. Published online 2022 Mar 17. doi: 10.1111/acel.13592

PMCID:: PMC9009124

Article PDF–2.2M

Select item 89654995.

Endothelial PERK-ATF4-JAG1 axis activated by T-ALL remodels bone marrow vascular niche

Cui Liu, Qiuyun Chen, Yinghui Shang, Lechuang Chen, Jay Myers, Amad Awadallah, Jinger Sun, Shuiliang Yu, Katharine Umphred-Wilson, Danian Che, Yingtong Dou, Luoyi Li, Pamela Wearsch, Diana Ramírez-Bergeron, Rose Beck, Wei Xin, Ge Jin, Stanley Adoro, Lan Zhou

Theranostics. 2022; 12(6): 2894–2907. Published online 2022 Mar 21. doi: 10.7150/thno.67710

PMCID:: PMC8965499

Article PDF–2.6M

Select item 85634446.

Integrated Stress Response Couples Mitochondrial Protein Translation with Oxidative Stress Control

Guangyu Zhang, Xiaoding Wang, Chao Li, Qinfeng Li, Yu A. An, Xiang Luo, Yingfeng Deng, Thomas G. Gillette, Philipp E. Scherer, Zhao V. Wang

Circulation. Author manuscript; available in PMC 2022 Nov 2.

Published in final edited form as: Circulation. 2021 Nov 2; 144(18): 1500–1515. Published online 2021 Sep 29. doi: 10.1161/CIRCULATIONAHA.120.053125

PMCID:: PMC8563444

Article PDF–2.8M

Select item 76744627.

PERK participates in cardiac valve development via fatty acid oxidation and endocardial-mesenchymal transformation

Takashi Shimizu, Kazuaki Maruyama, Takeshi Kawamura, Yoshihiro Urade, Youichiro Wada

Sci Rep. 2020; 10: 20094. Published online 2020 Nov 18. doi: 10.1038/s41598-020-77199-4

Correction in:: Sci Rep. 2021; 11: 5167.

PMCID:: PMC7674462

Article PDF–1.7M

Select item 73784648.

PERK-Mediated Suppression of microRNAs by Sildenafil Improves Mitochondrial Dysfunction in Heart Failure

Takashi Shimizu, Akashi Taguchi, Yoshiki Higashijima, Naoko Takubo, Yasuharu Kanki, Yoshihiro Urade, Youichiro Wada

iScience. 2020 Aug 21; 23(8): 101410. Published online 2020 Jul 24. doi: 10.1016/j.isci.2020.101410

PMCID:: PMC7378464

Article PDF–3.8M

Select item 72636159.

Enhanced phosphorylation of PERK in primary cultured neurons as an autonomous neuronal response to prion infection

Misaki Tanaka, Takeshi Yamasaki, Rie Hasebe, Akio Suzuki, Motohiro Horiuchi

PLoS One. 2020; 15(6): e0234147. Published online 2020 Jun 1. doi: 10.1371/journal.pone.0234147

PMCID:: PMC7263615

Article PDF–3.4M

Select item 718856610.

PERK (Protein Kinase RNA-Like ER Kinase) Branch of the Unfolded Protein Response Confers Neuroprotection in Ischemic Stroke by Suppressing Protein Synthesis

Ya-chao Wang, Xuan Li, Yuntian Shen, Jingjun Lyu, Huaxin Sheng, Wulf Paschen, Wei Yang

Stroke. Author manuscript; available in PMC 2021 May 1.

Published in final edited form as: Stroke. 2020 May; 51(5): 1570–1577. Published online 2020 Mar 26. doi: 10.1161/STROKEAHA.120.029071

PMCID:: PMC7188566

Article PDF–1.4M

Select item 701002111.

ER-resident sensor PERK is essential for mitochondrial thermogenesis in brown adipose tissue

Hironori Kato, Kohki Okabe, Masato Miyake, Kazuki Hattori, Tomohiro Fukaya, Kousuke Tanimoto, Shi Beini, Mariko Mizuguchi, Satoru Torii, Satoko Arakawa, Masaya Ono, Yusuke Saito, Takashi Sugiyama, Takashi Funatsu, Katsuaki Sato, Shigeomi Shimizu, Seiichi Oyadomari, Hidenori Ichijo, Hisae Kadowaki, Hideki Nishitoh

Life Sci Alliance. 2020 Mar; 3(3): e201900576. Published online 2020 Feb 6. doi: 10.26508/lsa.201900576

PMCID:: PMC7010021

Article PDF–3.3M

Select item 679784112.

Janus Kinase 1 Is Required for Transcriptional Reprograming of Murine Astrocytes in Response to Endoplasmic Reticulum Stress

Savannah G. Sims, Gordon P. Meares

Front Cell Neurosci. 2019; 13: 446. Published online 2019 Oct 11. doi: 10.3389/fncel.2019.00446

PMCID:: PMC6797841

Article PDF–5.3M

Select item 659619313.

Local Inhibition of PERK Enhances Memory and Reverses Age-Related Deterioration of Cognitive and Neuronal Properties

Vijendra Sharma, Hadile Ounallah-Saad, Darpan Chakraborty, Mohammad Hleihil, Rapita Sood, Iliana Barrera, Efrat Edry, Sailendrakumar Kolatt Chandran, Shlomo Ben Tabou de Leon, Hanoch Kaphzan, Kobi Rosenblum

J Neurosci. 2018 Jan 17; 38(3): 648–658. doi: 10.1523/JNEUROSCI.0628-17.2017

PMCID:: PMC6596193

Article PDF–2.2M

Select item 633863314.

PERK regulates skeletal muscle mass and contractile function in adult mice

Yann S. Gallot, Kyle R. Bohnert, Alex R. Straughn, Guangyan Xiong, Sajedah M. Hindi, Ashok Kumar

FASEB J. 2019 Feb; 33(2): 1946–1962. Published online 2018 Sep 11. doi: 10.1096/fj.201800683RR

PMCID:: PMC6338633

Article

Select item 608196215.

Leishmania donovani induced Unfolded Protein Response delays host cell apoptosis in PERK dependent manner

Kumar Abhishek, Sushmita Das, Ashish Kumar, Ajay Kumar, Vinod Kumar, Savita Saini, Abhishek Mandal, Sudha Verma, Manjay Kumar, Pradeep Das

PLoS Negl Trop Dis. 2018 Jul; 12(7): e0006646. Published online 2018 Jul 23. doi: 10.1371/journal.pntd.0006646

PMCID:: PMC6081962

Article PDF–8.3M

Select item 522530516.

HIV Protease Inhibitors Alter Amyloid Precursor Protein Processing via β-Site Amyloid Precursor Protein Cleaving Enzyme-1 Translational Up-Regulation

Patrick J. Gannon, Cagla Akay-Espinoza, Alan C. Yee, Lisa A. Briand, Michelle A. Erickson, Benjamin B. Gelman, Yan Gao, Norman J. Haughey, M. Christine Zink, Janice E. Clements, Nicholas S. Kim, Gabriel Van De Walle, Brigid K. Jensen, Robert Vassar, R. Christopher Pierce, Alexander J. Gill, Dennis L. Kolson, J. Alan Diehl, Joseph L. Mankowski, Kelly L. Jordan-Sciutto

Am J Pathol. 2017 Jan; 187(1): 91–109. doi: 10.1016/j.ajpath.2016.09.006

PMCID:: PMC5225305

Article PDF–2.8M

Select item 502310117.

PERK Regulates Working Memory and Protein Synthesis-Dependent Memory Flexibility

Siying Zhu, Keely Henninger, Barbara C. McGrath, Douglas R. Cavener

PLoS One. 2016; 11(9): e0162766. Published online 2016 Sep 14. doi: 10.1371/journal.pone.0162766

PMCID:: PMC5023101

Article PDF–1.9M

Select item 498352518.

Calcineurin ß protects brain after injury by activating the unfolded protein response

Yanan Chen, Deborah M. Holstein, Sofia Aime, Mariana Bollo, James D. Lechleiter

Neurobiol Dis. Author manuscript; available in PMC 2017 Oct 1.

Published in final edited form as: Neurobiol Dis. 2016 Oct; 94: 139–156. Published online 2016 Jun 19. doi: 10.1016/j.nbd.2016.06.011

PMCID:: PMC4983525

Article PDF–4.0M

Select item 495706419.

Attenuation of PKR-like ER Kinase (PERK) Signaling Selectively Controls Endoplasmic Reticulum Stress-induced Inflammation Without Compromising Immunological Responses

Lauren N. Guthrie, Kavitha Abiraman, Emily S. Plyler, Neil T. Sprenkle, Sara A. Gibson, Braden C. McFarland, Rajani Rajbhandari, Amber L. Rowse, Etty N. Benveniste, Gordon P. Meares

J Biol Chem. 2016 Jul 22; 291(30): 15830–15840. Published online 2016 May 23. doi: 10.1074/jbc.M116.738021

PMCID:: PMC4957064

Article PDF–2.9M

Select item 484493220.

Perk Ablation Ameliorates Myelination in S63del-Charcot–Marie–Tooth 1B Neuropathy

Nicolò Musner, Mariapaola Sidoli, Desireè Zambroni, Ubaldo Del Carro, Daniela Ungaro, Maurizio D’Antonio, Maria L. Feltri, Lawrence Wrabetz

ASN Neuro. 2016 Mar-Apr; 8(2): 1759091416642351. Published online 2016 Apr 14. doi: 10.1177/1759091416642351

PMCID:: PMC4844932

Article PDF–1.9M

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