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Select item 92597641.

Osteochondroma formation is independent of heparanase expression as revealed in a mouse model of Hereditary Multiple Exostoses

Christina Mundy, Juliet Chung, Eiki Koyama, Stuart Bunting, Rajeev Mahimkar, Maurizio Pacifici

J Orthop Res. Author manuscript; available in PMC 2023 Oct 1.

Published in final edited form as: J Orthop Res. 2022 Jan 7 : 10.1002/jor.25260. Published online 2022 Jan 7. doi: 10.1002/jor.25260

PMCID:: PMC9259764

Abstract Article PDF–3.4M

Select item 83794622.

Heparan sulfate promotes differentiation of white adipocytes to maintain insulin sensitivity and glucose homeostasis

Takuro Matsuzawa, Masanobu Morita, Ai Shimane, Rina Otsuka, Yu Mei, Fumitoshi Irie, Yu Yamaguchi, Kazuhiko Yanai, Takeo Yoshikawa

J Biol Chem. 2021 Sep; 297(3): 101006. Published online 2021 Jul 24. doi: 10.1016/j.jbc.2021.101006

PMCID:: PMC8379462

Abstract Article PDF–1.7M

Select item 55125413.

Neuronal heparan sulfates promote amyloid pathology by modulating brain amyloid-β clearance and aggregation in Alzheimer’s disease

Chia-Chen Liu, Na Zhao, Yu Yamaguchi, John R. Cirrito, Takahisa Kanekiyo, David M. Holtzman, Guojun Bu

Sci Transl Med. Author manuscript; available in PMC 2017 Jul 17.

Published in final edited form as: Sci Transl Med. 2016 Mar 30; 8(332): 332ra44. doi: 10.1126/scitranslmed.aad3650

PMCID:: PMC5512541

Abstract Article PDF–1.0M

Select item 41074624.

Epiphyseal abnormalities, trabecular bone loss and articular chondrocyte hypertrophy develop in the long bones of postnatal Ext1-deficient mice

Federica Sgariglia, Maria Elena Candela, Julianne Huegel, Olena Jacenko, Eiki Koyama, Yu Yamaguchi, Maurizio Pacifici, Motomi Enomoto-Iwamoto

Bone. Author manuscript; available in PMC 2014 Nov 1.

Published in final edited form as: Bone. 2013 Nov; 57(1): 220–231. Published online 2013 Aug 17. doi: 10.1016/j.bone.2013.08.012

PMCID:: PMC4107462

Abstract Article PDF–1.0M

Select item 40505635.

Synthetic di-sulfated iduronic acid attenuates asthmatic response by blocking T-cell recruitment to inflammatory sites

Motohiro Nonaka, Xingfeng Bao, Fumiko Matsumura, Sebastian Götze, Jeyakumar Kandasamy, Andrew Kononov, David H. Broide, Jun Nakayama, Peter H. Seeberger, Minoru Fukuda

Proc Natl Acad Sci U S A. 2014 Jun 3; 111(22): 8173–8178. Published online 2014 May 16. doi: 10.1073/pnas.1319870111

PMCID:: PMC4050563

Abstract Article PDF–1.2M

Select item 37428576.

Heparan sulfate on intestinal epithelial cells plays a critical role in intestinal crypt homeostasis via Wnt/β-catenin signaling

Shuji Yamamoto, Hiroshi Nakase, Minoru Matsuura, Yusuke Honzawa, Kayoko Matsumura, Norimitsu Uza, Yu Yamaguchi, Emiko Mizoguchi, Tsutomu Chiba

Am J Physiol Gastrointest Liver Physiol. 2013 Aug 1; 305(3): G241–G249. Published online 2013 Jun 6. doi: 10.1152/ajpgi.00480.2012

PMCID:: PMC3742857

Abstract Article

Select item 36947557.

Role of high endothelial venule-expressed heparan sulfate in chemokine presentation and lymphocyte homing

Koichiro Tsuboi, Jotaro Hirakawa, Emiko Seki, Yasuyuki Imai, Yu Yamaguchi, Minoru Fukuda, Hiroto Kawashima

J Immunol. Author manuscript; available in PMC 2014 Jul 1.

Published in final edited form as: J Immunol. 2013 Jul 1; 191(1): 448–455. Published online 2013 Jun 3. doi: 10.4049/jimmunol.1203061

PMCID:: PMC3694755

Abstract Article PDF–3.5M

Select item 36839798.

Toward an understanding of the short bone phenotype associated with multiple osteochondromas

Kevin B. Jones, Manasi Datar, Sandhya Ravichandran, Huifeng Jin, Elizabeth Jurrus, Ross Whitaker, Mario R. Capecchi

J Orthop Res. Author manuscript; available in PMC 2014 Apr 1.

Published in final edited form as: J Orthop Res. 2013 Apr; 31(4): 651–657. Published online 2012 Nov 28. doi: 10.1002/jor.22280

PMCID:: PMC3683979

Abstract Article PDF–3.5M

Select item 34051299.

Fibroblast EXT1-Levels Influence Tumor Cell Proliferation and Migration in Composite Spheroids

Cecilia Österholm, Ning Lu, Åsa Lidén, Tine V. Karlsen, Donald Gullberg, Rolf K. Reed, Marion Kusche-Gullberg

PLoS One. 2012; 7(7): e41334. Published online 2012 Jul 25. doi: 10.1371/journal.pone.0041334

PMCID:: PMC3405129

Abstract Article PDF–4.0M

Select item 332398610.

Autism-like socio-communicative deficits and stereotypies in mice lacking heparan sulfate

Fumitoshi Irie, Hedieh Badie-Mahdavi, Yu Yamaguchi

Proc Natl Acad Sci U S A. 2012 Mar 27; 109(13): 5052–5056. Published online 2012 Mar 12. doi: 10.1073/pnas.1117881109

PMCID:: PMC3323986

Abstract Article PDF–590K

Select item 312512511.

Podocytes require the engagement of cell surface heparan sulfate proteoglycans for adhesion to extracellular matrices

Shoujun Chen, Deborah Wassenhove-McCarthy, Yu Yamaguchi, Lawrence Holzman, Toin H. van Kuppevelt, A. Wayne Orr, Steven Funk, Ann Woods, Kevin McCarthy

Kidney Int. Author manuscript; available in PMC 2011 Jun 28.

Published in final edited form as: Kidney Int. 2010 Dec; 78(11): 1088–1099. Published online 2010 May 12. doi: 10.1038/ki.2010.136

PMCID:: PMC3125125

Abstract Article PDF–1.1M

Select item 305779912.

Influencing Hematopoietic Differentiation of Mouse Embryonic Stem Cells using Soluble Heparin and Heparan Sulfate Saccharides

Rebecca J. Holley, Claire E. Pickford, Graham Rushton, Georges Lacaud, John T. Gallagher, Valerie Kouskoff, Catherine L. R. Merry

J Biol Chem. 2011 Feb 25; 286(8): 6241–6252. Published online 2010 Dec 10. doi: 10.1074/jbc.M110.178483

PMCID:: PMC3057799

Abstract Article PDF–4.6M

Select item 283670413.

EXTra hit for mouse osteochondroma

Judith V. M. G. Bovée

Proc Natl Acad Sci U S A. 2010 Feb 2; 107(5): 1813–1814. Published online 2010 Feb 2. doi: 10.1073/pnas.0914431107

PMCID:: PMC2836704

Article PDF–600K

Select item 278735614.

Mutation in the Heparan Sulfate Biosynthesis Enzyme EXT1 Influences Growth Factor Signaling and Fibroblast Interactions with the Extracellular Matrix

Cecilia Österholm, Malgorzata M. Barczyk, Marta Busse, Mona Grønning, Rolf K. Reed, Marion Kusche-Gullberg

J Biol Chem. 2009 Dec 11; 284(50): 34935–34943. Published online 2009 Oct 22. doi: 10.1074/jbc.M109.005264

PMCID:: PMC2787356

Abstract Article PDF–1.0M

Select item 968228215.

Heparin is required for the formation of granules in connective tissue mast cells

Sandra Abril Herrera-Heredia, Hsuan-Po Hsu, Cheng-Yen Kao, Yu-Huan Tsai, Yu Yamaguchi, Axel Roers, Chia-Lin Hsu, Ivan L. Dzhagalov

Front Immunol. 2022; 13: 1000405. Published online 2022 Nov 9. doi: 10.3389/fimmu.2022.1000405

PMCID:: PMC9682282

Abstract Article PDF–7.5M

Select item 809244416.

Loss of heparan sulfate glycosaminoglycan assembly in podocytes does not lead to proteinuria

Shoujun Chen, Deborah J. Wassenhove-McCarthy, Yu Yamaguchi, Lawrence B. Holzman, Toin H. van Kuppevelt, Guido J. Jenniskens, Tessa J. Wijnhoven, Ann C. Woods, Kevin J. McCarthy

Kidney Int. Author manuscript; available in PMC 2021 May 3.

Published in final edited form as: Kidney Int. 2008 Aug; 74(3): 289–299. Published online 2008 May 14. doi: 10.1038/ki.2008.159

PMCID:: PMC8092444

Abstract Article PDF–2.4M

Select item 797402817.

Heparan sulfate is essential for thymus growth

Hsuan-Po Hsu, Yun-Tzu Chen, Yu-Ying Chen, Chih-Yu Lin, Po-Yu Chen, Shio-Yi Liao, Ciara Christianne Y. Lim, Yu Yamaguchi, Chia-Lin Hsu, Ivan L. Dzhagalov

J Biol Chem. 2021 Jan-Jun; 296: 100419. Published online 2021 Feb 15. doi: 10.1016/j.jbc.2021.100419

PMCID:: PMC7974028

Abstract Article PDF–4.8M

Select item 778567818.

Heparan sulfate synthesized by Ext1 regulates receptor tyrosine kinase signaling and promotes resistance to EGFR inhibitors in GBM

Yuki Ohkawa, Anna Wade, Olle R. Lindberg, Katharine Y. Chen, Vy M. Tran, Spencer J. Brown, Anupam Kumar, Mausam Kalita, C. David James, Joanna J. Phillips

Mol Cancer Res. Author manuscript; available in PMC 2021 Jul 1.

Published in final edited form as: Mol Cancer Res. 2021 Jan; 19(1): 150–161. Published online 2020 Oct 7. doi: 10.1158/1541-7786.MCR-20-0420

PMCID:: PMC7785678

Abstract Article PDF–2.0M

Select item 760662219.

Heparan sulfate deficiency leads to hypertrophic chondrocytes by increasing bone morphogenetic protein signaling

K. Kawashima, H. Ogawa, S. Komura, T. Ishihara, Y. Yamaguchi, H. Akiyama, K. Matsumoto

Osteoarthritis Cartilage. Author manuscript; available in PMC 2021 Nov 1.

Published in final edited form as: Osteoarthritis Cartilage. 2020 Nov; 28(11): 1459–1470. Published online 2020 Aug 18. doi: 10.1016/j.joca.2020.08.003

PMCID:: PMC7606622

Abstract Article PDF–1.1M

Select item 666879320.

Abnormal sodium and water homeostasis in mice with defective heparan sulfate polymerization

Rik H. G. Olde Engberink, Judith de Vos, Angela van Weert, Yahua Zhang, Naomi van Vlies, Bert-Jan H. van den Born, Jens M. Titze, Ed van Bavel, Liffert Vogt

PLoS One. 2019; 14(7): e0220333. Published online 2019 Jul 31. doi: 10.1371/journal.pone.0220333

PMCID:: PMC6668793

Abstract Article PDF–1.4M

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PMC Links for Gene (Select 14042) (77)
PMC
Homo sapiens isolate CHM13 chromosome 19, alternate assembly T2T-CHM13v2.0
Homo sapiens isolate CHM13 chromosome 19, alternate assembly T2T-CHM13v2.0
gi|2194972797|gnl|ASM:GCF_009914825 ef|NC_060943.1||gpp|GPC_000012758.1||gnl|NCBI_GENOMES|119579

Nucleotide
PREDICTED: Homo sapiens ubiquinol-cytochrome c reductase complex assembly factor...
PREDICTED: Homo sapiens ubiquinol-cytochrome c reductase complex assembly factor 1 (UQCC1), transcript variant X6, mRNA
gi|2462580711|ref|XM_054323612.1|

Nucleotide
Chromosome neighbors for GEO Profiles (Select 6759845) (20)
GEO Profiles
Nocardiaceae bacterium KVD-1700-21 16S ribosomal RNA gene, partial sequence
Nocardiaceae bacterium KVD-1700-21 16S ribosomal RNA gene, partial sequence
gi|94995736|gb|DQ490430.1|

Nucleotide

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