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Select item 106031551.

FHL1 promotes chikungunya and o’nyong-nyong virus infection and pathogenesis with implications for alphavirus vaccine design

Wern Hann Ng, Xiang Liu, Zheng L. Ling, Camilla N. O. Santos, Lucas S. Magalhães, Andrew J. Kueh, Marco J. Herold, Adam Taylor, Joseph R. Freitas, Sandra Koit, Sainan Wang, Andrew R. Lloyd, Mauro M. Teixeira, Andres Merits, Roque P. Almeida, Nicholas J. C. King, Suresh Mahalingam

Nat Commun. 2023; 14: 6605. Published online 2023 Oct 26. doi: 10.1038/s41467-023-42330-2

PMCID:: PMC10603155

Article PDF–1.8M

Select item 75941732.

Cardiomyopathy and altered integrin-actin signaling in Fhl1 mutant female mice

Akatsuki Kubota, Martí Juanola-Falgarona, Valentina Emmanuele, Maria Jose Sanchez-Quintero, Shingo Kariya, Fusako Sera, Shunichi Homma, Kurenai Tanji, Catarina M Quinzii, Michio Hirano

Hum Mol Genet. 2019 Jan 15; 28(2): 209–219. Published online 2018 Sep 26. doi: 10.1093/hmg/ddy299

PMCID:: PMC7594173

Article PDF–32M

Select item 69813273.

FHL-1 is not involved in pressure overload-induced maladaptive right ventricular remodeling and dysfunction

Christine Veith, Dariusch Neghabian, Himal Luitel, Jochen Wilhelm, Bakytbek Egemnazarov, Caja Muntanjohl, Jan-Hendrik Fischer, Bhola Kumar Dahal, Ralph Theo Schermuly, Hossein Ardeschir Ghofrani, Friedrich Grimminger, Ludger Fink, Grazyna Kwapiszewska, Norbert Weissmann, Akylbek Sydykov

Basic Res Cardiol. 2020; 115(2): 17. Published online 2020 Jan 24. doi: 10.1007/s00395-019-0767-5

PMCID:: PMC6981327

Article PDF–1.9M

Select item 47135164.

KyoT2 downregulates airway remodeling in asthma

Mei Hu, Hai-Feng Ou-Yang, Xing-Peng Han, Xin-Yu Ti, Chang-Gui Wu

Int J Clin Exp Pathol. 2015; 8(11): 14171–14179. Published online 2015 Nov 1.

PMCID:: PMC4713516

Article PDF–1.0M

Select item 43426985.

Fhl1 W122S causes loss of protein function and late-onset mild myopathy

Valentina Emmanuele, Akatsuki Kubota, Beatriz Garcia-Diaz, Caterina Garone, Hasan O. Akman, Daniel Sánchez-Gutiérrez, Luis M. Escudero, Shingo Kariya, Shunichi Homma, Kurenai Tanji, Catarina M. Quinzii, Michio Hirano

Hum Mol Genet. 2015 Feb 1; 24(3): 714–726. Published online 2014 Sep 30. doi: 10.1093/hmg/ddu490

PMCID:: PMC4342698

Article PDF–1007K

Select item 25758336.

An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice

Farah Sheikh, Anna Raskin, Pao-Hsien Chu, Stephan Lange, Andrea A. Domenighetti, Ming Zheng, Xingqun Liang, Tong Zhang, Toshitaka Yajima, Yusu Gu, Nancy D. Dalton, Sushil K. Mahata, Gerald W. Dorn, II, Joan Heller-Brown, Kirk L. Peterson, Jeffrey H. Omens, Andrew D. McCulloch, Ju Chen

J Clin Invest. 2008 Dec 1; 118(12): 3870–3880. Published online 2008 Nov 3. doi: 10.1172/JCI34472

Correction in:: J Clin Invest. 2012 Apr 2; 122(4): 1584.

PMCID:: PMC2575833

Article PDF–2.9M

Select item 77042177.

MiR-183-5p induced by saturated fatty acids regulates the myogenic differentiation by directly targeting FHL1 in C2C12 myoblasts

Mai Thi Nguyen, Kyung-Ho Min, Wan Lee

BMB Rep. 2020 Nov 30; 53(11): 605–610. Published online 2020 Nov 30. doi: 10.5483/BMBRep.2020.53.11.175

PMCID:: PMC7704217

Article PDF–4.7M

Select item 39471868.

Structure and Function of the CSL-KyoT2 Corepressor Complex – a Negative Regulator of Notch Signaling

Kelly J. Collins, Zhenyu Yuan, Rhett A. Kovall

Structure. Author manuscript; available in PMC 2015 Jan 7.

Published in final edited form as: Structure. 2014 Jan 7; 22(1): 70–81. Published online 2013 Nov 27. doi: 10.1016/j.str.2013.10.010

PMCID:: PMC3947186

Article PDF–4.5M

Select item 39341719.

5′RNA-Seq identifies Fhl1 as a genetic modifier in cardiomyopathy

Danos C. Christodoulou, Hiroko Wakimoto, Kenji Onoue, Seda Eminaga, Joshua M. Gorham, Steve R. DePalma, Daniel S. Herman, Polakit Teekakirikul, David A. Conner, David M. McKean, Andrea A. Domenighetti, Anton Aboukhalil, Stephen Chang, Gyan Srivastava, Barbara McDonough, Philip L. De Jager, Ju Chen, Martha L. Bulyk, Jochen D. Muehlschlegel, Christine E. Seidman, J.G. Seidman

J Clin Invest. 2014 Mar 3; 124(3): 1364–1370. Published online 2014 Feb 10. doi: 10.1172/JCI70108

PMCID:: PMC3934171

Article PDF–943K

Select item 391674910.

Loss of FHL1 induces an age-dependent skeletal muscle myopathy associated with myofibrillar and intermyofibrillar disorganization in mice

Andrea A. Domenighetti, Pao-Hsien Chu, Tongbin Wu, Farah Sheikh, David S. Gokhin, Ling T. Guo, Ziyou Cui, Angela K. Peter, Danos C. Christodoulou, Michael G. Parfenov, Joshua M. Gorham, Daniel Y. Li, Indroneal Banerjee, Xianyin Lai, Frank A. Witzmann, Christine E. Seidman, Jonathan G. Seidman, Aldrin V. Gomes, G. Diane Shelton, Richard L. Lieber, Ju Chen

Hum Mol Genet. 2014 Jan 1; 23(1): 209–225. Published online 2013 Aug 23. doi: 10.1093/hmg/ddt412

PMCID:: PMC3916749

Article PDF–1.7M

Select item 278603111.

SLIMMER (FHL1B/KyoT3) Interacts with the Proapoptotic Protein Siva-1 (CD27BP) and Delays Skeletal Myoblast Apoptosis

Denny L. Cottle, Meagan J. McGrath, Brendan R. Wilding, Belinda S. Cowling, Jordan M. Kane, Colleen E. D'Arcy, Melissa Holdsworth, Irene Hatzinisiriou, Mark Prescott, Susan Brown, Christina A. Mitchell

J Biol Chem. 2009 Sep 25; 284(39): 26964–26977. Published online 2009 Jul 29. doi: 10.1074/jbc.M109.036293

PMCID:: PMC2786031

Article PDF–5.9M

Select item 392792712.

Four-and-a-half LIM domains proteins are novel regulators of the protein kinase D pathway in cardiac myocytes

Konstantina Stathopoulou, Friederike Cuello, Alexandra J. Candasamy, Elizabeth M. Kemp, Elisabeth Ehler, Robert S. Haworth, Metin Avkiran

Biochem J. 2014 Feb 1; 457(Pt 3): 451–461. Prepublished online 2013 Nov 13. Published online 2014 Jan 10. doi: 10.1042/BJ20131026

PMCID:: PMC3927927

Article PDF–1.3M

Select item 12153113.

LIM Protein KyoT2 Negatively Regulates Transcription by Association with the RBP-J DNA-Binding Protein

Yoshihito Taniguchi, Takahisa Furukawa, Tin Tun, Hua Han, Tasuku Honjo

Mol Cell Biol. 1998 Jan; 18(1): 644–654. doi: 10.1128/mcb.18.1.644

PMCID:: PMC121531

Article PDF–1.0M

Select item 577205914.

Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes

Judith Krysiak, Andreas Unger, Lisa Beckendorf, Nazha Hamdani, Marion von Frieling-Salewsky, Margaret M. Redfield, Cris G. dos Remedios, Farah Sheikh, Ulrich Gergs, Peter Boknik, Wolfgang A. Linke

Nat Commun. 2018; 9: 262. Published online 2018 Jan 17. doi: 10.1038/s41467-017-02483-3

PMCID:: PMC5772059

Article PDF–5.9M

Select item 260074715.

Identification of FHL1 as a regulator of skeletal muscle mass: implications for human myopathy

Belinda S. Cowling, Meagan J. McGrath, Mai-Anh Nguyen, Denny L. Cottle, Anthony J. Kee, Susan Brown, Joachim Schessl, Yaqun Zou, Josephine Joya, Carsten G. Bönnemann, Edna C. Hardeman, Christina A. Mitchell

J Cell Biol. 2008 Dec 15; 183(6): 1033–1048. doi: 10.1083/jcb.200804077

PMCID:: PMC2600747

Article PDF–3.5M

Select item 10928516.

The T-Cell Oncogenic Protein HOX11 Activates Aldh1 Expression in NIH 3T3 Cells but Represses Its Expression in Mouse Spleen Development

Wayne K. Greene, Sabine Bahn, Norma Masson, Terence H. Rabbitts

Mol Cell Biol. 1998 Dec; 18(12): 7030–7037. doi: 10.1128/mcb.18.12.7030

PMCID:: PMC109285

Article PDF–1.9M

Select item 603393917.

Rbpj direct regulation of Atoh7 transcription in the embryonic mouse retina

Joel B. Miesfeld, Myung-soon Moon, Amy N. Riesenberg, Ashley N. Contreras, Rhett A. Kovall, Nadean L. Brown

Sci Rep. 2018; 8: 10195. Published online 2018 Jul 5. doi: 10.1038/s41598-018-28420-y

PMCID:: PMC6033939

Article PDF–3.4M

Select item 588150118.

Src-mediated phosphorylation converts FHL1 from tumor suppressor to tumor promoter

Xiang Wang, Xiaofan Wei, Yang Yuan, Qingrui Sun, Jun Zhan, Jing Zhang, Yan Tang, Feng Li, Lihua Ding, Qinong Ye, Hongquan Zhang

J Cell Biol. 2018 Apr 2; 217(4): 1335–1351. doi: 10.1083/jcb.201708064

PMCID:: PMC5881501

Article PDF–3.2M

Select item 882528619.

Multimodal profiling of the transcriptional regulatory landscape of the developing mouse cortex identifies Neurog2 as a key epigenome remodeler

Florian Noack, Silvia Vangelisti, Gerald Raffl, Madalena Carido, Jeisimhan Diwakar, Faye Chong, Boyan Bonev

Nat Neurosci. 2022; 25(2): 154–167. Published online 2022 Feb 7. doi: 10.1038/s41593-021-01002-4

PMCID:: PMC8825286

Article PDF–24M

Select item 343614920.

A Novel Mechanism Involving Four-and-a-half LIM Domain Protein-1 and Extracellular Signal-regulated Kinase-2 Regulates Titin Phosphorylation and Mechanics

Anna Raskin, Stephan Lange, Katherine Banares, Robert C. Lyon, Anke Zieseniss, Leonard K. Lee, Katrina G. Yamazaki, Henk L. Granzier, Carol C. Gregorio, Andrew D. McCulloch, Jeffrey H. Omens, Farah Sheikh

J Biol Chem. 2012 Aug 24; 287(35): 29273–29284. Published online 2012 Jul 9. doi: 10.1074/jbc.M112.372839

PMCID:: PMC3436149

Article PDF–3.1M

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