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Select item 88918151.

Role of prostaglandin D₂ receptors in the pathogenesis of abdominal aortic aneurysm formation

Neal L. Weintraub, Andra L. Blomkalns, Mourad Ogbi, Tetsuo Horimatsu, Tyler W. Benson, Yuqing Huo, David J. Fulton, Gautam Agarwal, Richard Lee, Michael A. Winkler, Lufei Young, Ken Fujise, Avirup Guha, Tohru Fukai, Masuko Ushio-Fukai, Xiaochun Long, Brian H. Annex, Ha Won Kim

Clin Sci (Lond) 2022 Mar; 136(5): 309–321. Published online 2022 Mar 2. doi: 10.1042/CS20220031

PMCID:: PMC8891815

Article PDF–3.3M

Select item 82949492.

PGD₂ and CRTH2 counteract Type 2 cytokine–elicited intestinal epithelial responses during helminth infection

Oyebola O. Oyesola, Michael T. Shanahan, Matt Kanke, Bridget M. Mooney, Lauren M. Webb, Shuchi Smita, Macy K. Matheson, Pamela Campioli, Duc Pham, Simon P. Früh, John W. McGinty, Madeline J. Churchill, Jordan L. Cahoon, Pavithra Sundaravaradan, Becca A. Flitter, Karthik Mouli, Marija S. Nadjsombati, Elena Kamynina, Seth A. Peng, Rebecca L. Cubitt, Karsten Gronert, James D. Lord, Isabella Rauch, Jakob von Moltke, Praveen Sethupathy, Elia D. Tait Wojno

J Exp Med. 2021 Sep 6; 218(9): e20202178. Published online 2021 Jul 20. doi: 10.1084/jem.20202178

PMCID:: PMC8294949

Article PDF–6.6M

Select item 69888533.

Crth2 receptor signaling down-regulates lipopolysaccharide-induced NF-κB activation in murine macrophages via changes in intracellular calcium

Bastihalli T. Diwakar, Ryan Yoast, Shaneice Nettleford, Fenghua Qian, Tai-Jung Lee, Svanjita Berry, Ian Huffnagle, Randall M. Rossi, Mohamed Trebak, Robert F. Paulson, K. Sandeep Prabhu

FASEB J. 2019 Nov; 33(11): 12838–12852. Published online 2019 Nov. doi: 10.1096/fj.201802608R

PMCID:: PMC6988853

Article

Select item 68027504.

Central CRTH2, a Second Prostaglandin D₂ Receptor, Mediates Emotional Impairment in the Lipopolysaccharide and Tumor-Induced Sickness Behavior Model

Ryota Haba, Norihito Shintani, Yusuke Onaka, Takuya Kanoh, Hyper Wang, Risa Takenaga, Atsuko Hayata, Hiroyuki Hirai, Kin-ya Nagata, Masataka Nakamura, Atsushi Kasai, Ryota Hashimoto, Kazuki Nagayasu, Takanobu Nakazawa, Hitoshi Hashimoto, Akemichi Baba

J Neurosci. 2014 Feb 12; 34(7): 2514–2523. doi: 10.1523/JNEUROSCI.1407-13.2014

PMCID:: PMC6802750

Article PDF–2.2M

Select item 58405495.

CRTH2 promotes endoplasmic reticulum stress‐induced cardiomyocyte apoptosis through m‐calpain

Shengkai Zuo, Deping Kong, Chenyao Wang, Jiao Liu, Yuanyang Wang, Qiangyou Wan, Shuai Yan, Jian Zhang, Juan Tang, Qianqian Zhang, Luheng Lyu, Xin Li, Zhixin Shan, Li Qian, Yujun Shen, Ying Yu

EMBO Mol Med. 2018 Mar; 10(3): e8237. Published online 2018 Jan 15. doi: 10.15252/emmm.201708237

PMCID:: PMC5840549

Article PDF–3.9M

Select item 34989536.

CRTH2 Is A Critical Regulator of Neutrophil Migration and Resistance to Polymicrobial Sepsis

Makoto Ishii, Koichiro Asano, Ho Namkoong, Sadatomo Tasaka, Kosuke Mizoguchi, Takahiro Asami, Hirofumi Kamata, Yoshifumi Kimizuka, Hiroshi Fujiwara, Yohei Funatsu, Shizuko Kagawa, Jun Miyata, Ken Ishii, Masataka Nakamura, Hiroyuki Hirai, Kinya Nagata, Steven L. Kunkel, Naoki Hasegawa, Tomoko Betsuyaku

J Immunol. Author manuscript; available in PMC 2013 Jun 1.

Published in final edited form as: J Immunol. 2012 Jun 1; 188(11): 5655–5664. Published online 2012 Apr 27. doi: 10.4049/jimmunol.1102330

PMCID:: PMC3498953

Article PDF–1.2M

Select item 34827317.

PGD₂-CRTH2 Pathway Promotes Tubulointerstitial Fibrosis

Hideyuki Ito, Xiaoxiang Yan, Nanae Nagata, Kosuke Aritake, Yoshinori Katsumata, Tomohiro Matsuhashi, Masataka Nakamura, Hiroyuki Hirai, Yoshihiro Urade, Koichiro Asano, Masato Kubo, Yasunori Utsunomiya, Tatsuo Hosoya, Keiichi Fukuda, Motoaki Sano

J Am Soc Nephrol. 2012 Nov; 23(11): 1797–1809. doi: 10.1681/ASN.2012020126

PMCID:: PMC3482731

Article

Select item 29502318.

The prostaglandin D2 receptor CRTH2 is important for allergic skin inflammation following epicutaneous antigen challenge

Rui He, Michiko K. Oyoshi, James YT. Wang, Martin R. Hodge, Haoli Jin, Raif S. Geha

J Allergy Clin Immunol. Author manuscript; available in PMC 2011 Oct 1.

Published in final edited form as: J Allergy Clin Immunol. 2010 Oct; 126(4): 784–790. Published online 2010 Aug 14. doi: 10.1016/j.jaci.2010.07.006

PMCID:: PMC2950231

Article PDF–1.5M

Select item 26388419.

A small molecule CRTH2 antagonist inhibits FITC-induced allergic cutaneous inflammation

Stefen A. Boehme, Karin Franz-Bacon, Edward P. Chen, Roman Šášik, L. James Sprague, Tai Wei Ly, Gary Hardiman, Kevin B. Bacon

Int Immunol. 2009 Jan; 21(1): 81–93. Published online 2008 Dec 9. doi: 10.1093/intimm/dxn127

PMCID:: PMC2638841

Article PDF–1.2M

Select item 263883910.

Antagonism of CRTH2 ameliorates chronic epicutaneous sensitization-induced inflammation by multiple mechanisms

Stefen A. Boehme, Edward P. Chen, Karin Franz-Bacon, Roman Šášik, L. James Sprague, Tai Wei Ly, Gary Hardiman, Kevin B. Bacon

Int Immunol. 2009 Jan; 21(1): 1–17. Published online 2008 Dec 9. doi: 10.1093/intimm/dxn118

PMCID:: PMC2638839

Article PDF–1.8M

Select item 1042807611.

Activation of GPR44 decreases severity of myeloid leukemia via specific targeting of leukemia initiating stem cells

Fenghua Qian, Shaneice K. Nettleford, Jiayan Zhou, Brooke E. Arner, Molly A. Hall, Arati Sharma, Charyguly Annageldiyev, Randy M. Rossi, Diwakar B. Tukaramrao, Deborpita Sarkar, Shailaja Hegde, Ujjawal H. Gandhi, Emily R. Finch, Laura Goodfield, Michael D. Quickel, David F. Claxton, Robert F. Paulson, K. Sandeep Prabhu

Cell Rep. Author manuscript; available in PMC 2023 Aug 16.

Published in final edited form as: Cell Rep. 2023 Jul 25; 42(7): 112794. Published online 2023 Jul 18. doi: 10.1016/j.celrep.2023.112794

PMCID:: PMC10428076

Article PDF–4.0M

Select item 836526612.

ER‐anchored CRTH2 antagonizes collagen biosynthesis and organ fibrosis via binding LARP6

Shengkai Zuo, Bei Wang, Jiao Liu, Deping Kong, Hui Cui, Yaonan Jia, Chenyao Wang, Xin Xu, Guilin Chen, Yuanyang Wang, Linlin Yang, Kai Zhang, Ding Ai, Jie Du, Yujun Shen, Ying Yu

EMBO J. 2021 Aug 16; 40(16): e107403. Published online 2021 Jul 5. doi: 10.15252/embj.2020107403

PMCID:: PMC8365266

Article PDF–5.6M

Select item 699484213.

The Prostaglandin D₂ Receptor CRTH2 Promotes IL-33–Induced ILC2 Accumulation in the Lung

Oyebola O. Oyesola, Carolina Duque, Linda C. Huang, Elisabeth M. Larson, Simon P. Früh, Lauren M. Webb, Seth A. Peng, Elia D. Tait Wojno

J Immunol. 2020 Feb 15; 204(4): 1001–1011. Published online 2020 Jan 3. doi: 10.4049/jimmunol.1900745

PMCID:: PMC6994842

Article PDF–3.2M

Select item 608090114.

Inhibition of CRTH2-mediated Th2 activation attenuates pulmonary hypertension in mice

Guilin Chen, Shengkai Zuo, Juan Tang, Caojian Zuo, Daile Jia, Qian Liu, Guizhu Liu, Qian Zhu, Yuanyang Wang, Jian Zhang, Yujun Shen, Dongrui Chen, Ping Yuan, Zhiqiang Qin, Chengchao Ruan, Jue Ye, Xiao-Jian Wang, Yuping Zhou, Pingjin Gao, Peng Zhang, Jinming Liu, Zhi-Cheng Jing, Ankang Lu, Ying Yu

J Exp Med. 2018 Aug 6; 215(8): 2175–2195. doi: 10.1084/jem.20171767

PMCID:: PMC6080901

Article PDF–4.5M

Select item 495460615.

Activated prostaglandin D₂ receptors on macrophages enhance neutrophil recruitment into the lung

Katharina Jandl, Elvira Stacher, Zoltán Bálint, Eva Maria Sturm, Jovana Maric, Miriam Peinhaupt, Petra Luschnig, Ida Aringer, Alexander Fauland, Viktoria Konya, Sven-Erik Dahlen, Craig E. Wheelock, Dagmar Kratky, Andrea Olschewski, Gunther Marsche, Rufina Schuligoi, Akos Heinemann

J Allergy Clin Immunol. Author manuscript; available in PMC 2016 Jul 20.

Published in final edited form as: J Allergy Clin Immunol. 2016 Mar; 137(3): 833–843. Published online 2016 Jan 12. doi: 10.1016/j.jaci.2015.11.012

PMCID:: PMC4954606

Article PDF–2.4M

Select item 489235416.

Eosinophils contribute to intestinal inflammation via chemoattractant receptor-homologous molecule expressed on Th2 cells, CRTH2, in experimental Crohn’s disease

Balázs Radnai, Eva M Sturm, Angela Stančić, Katharina Jandl, Sandra Labocha, Nerea Ferreirós, Magdalena Grill, Carina Hasenoehrl, Gregor Gorkiewicz, Gunther Marsche, Ákos Heinemann, Christoph Högenauer, Rudolf Schicho

J Crohns Colitis. Author manuscript; available in PMC 2017 Sep 1.

Published in final edited form as: J Crohns Colitis. 2016 Sep; 10(9): 1087–1095. Published online 2016 Feb 29. doi: 10.1093/ecco-jcc/jjw061

PMCID:: PMC4892354

Article PDF–1.7M

Select item 459824617.

The prostaglandin D₂ receptor CRTH2 regulates accumulation of group 2 innate lymphoid cells in the inflamed lung

ED Tait Wojno, LA Monticelli, SV Tran, T Alenghat, LC Osborne, JJ Thome, C Willis, A Budelsky, DL Farber, D Artis

Mucosal Immunol. Author manuscript; available in PMC 2016 May 1.

Published in final edited form as: Mucosal Immunol. 2015 Nov; 8(6): 1313–1323. Published online 2015 Apr 8. doi: 10.1038/mi.2015.21

PMCID:: PMC4598246

Article PDF–2.0M

Select item 370118218.

The CRTH2 agonist Pyl A prevents lipopolysaccharide-induced fetal death but induces preterm labour

Lynne Sykes, Bronwen R Herbert, David A MacIntyre, Emma Hunte, Sathana Ponnampalam, Mark R Johnson, Tiong G Teoh, Phillip R Bennett

Immunology. 2013 Jul; 139(3): 352–365. Published online 2013 Jun 13. doi: 10.1111/imm.12085

PMCID:: PMC3701182

Article PDF–664K

Select item 304331719.

Lipopolysaccharide induces proinflammatory cytokines and chemokines in experimental otitis media through the prostaglandin D₂ receptor (DP)-dependent pathway

M Eguchi, S Kariya, M Okano, T Higaki, S Makihara, T Fujiwara, K Nagata, H Hirai, S Narumiya, M Nakamura, K Nishizaki

Clin Exp Immunol. 2011 Feb; 163(2): 260–269. doi: 10.1111/j.1365-2249.2010.04292.x

PMCID:: PMC3043317

Article PDF–6.7M

Select item 259674520.

Role of prostaglandin D₂ receptor DP as a suppressor of tumor hyperpermeability and angiogenesis in vivo

Takahisa Murata, Michelle I. Lin, Kosuke Aritake, Shigeko Matsumoto, Shu Narumiya, Hiroshi Ozaki, Yoshihiro Urade, Masatoshi Hori, William C. Sessa

Proc Natl Acad Sci U S A. 2008 Dec 16; 105(50): 20009–20014. Published online 2008 Dec 5. doi: 10.1073/pnas.0805171105

PMCID:: PMC2596745

Article PDF–1.0M

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