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Select item 97043781.

CTPS1 inhibition suppresses proliferation and migration in colorectal cancer cells

Fahong Wu, Yudong Mao, Tao Ma, Xiaoli Wang, Hangzhi Wei, Tianwei Wang, Jia Wang, Youcheng Zhang

Cell Cycle. 2022; 21(24): 2563–2574. Published online 2022 Aug 1. doi: 10.1080/15384101.2022.2105084

PMCID:: PMC9704378

Article PDF–2.7M

Select item 71413952.

Impaired lymphocyte function and differentiation in CTPS1-deficient patients result from a hypomorphic homozygous mutation

Emmanuel Martin, Norbert Minet, Anne-Claire Boschat, Sylvia Sanquer, Steicy Sobrino, Christelle Lenoir, Jean Pierre de Villartay, Maria Leite-de-Moraes, Capucine Picard, Claire Soudais, Tim Bourne, Sophie Hambleton, Stephen M. Hughes, Robert F. Wynn, Tracy A. Briggs, Genomics England Research Consortium, Smita Patel, Monica G. Lawrence, Alain Fischer, Peter D. Arkwright, Sylvain Latour

JCI Insight. 2020 Mar 12; 5(5): e133880. Published online 2020 Mar 12. doi: 10.1172/jci.insight.133880

PMCID:: PMC7141395

Article PDF–1.9M

Select item 54722203.

Human CTP synthase filament structure reveals the active enzyme conformation

Eric M. Lynch, Derrick R. Hicks, Matthew Shepherd, James A. Endrizzi, Allison Maker, Jesse M. Hansen, Rachael M. Barry, Zemer Gitai, Enoch P. Baldwin, Justin M. Kollman

Nat Struct Mol Biol. Author manuscript; available in PMC 2017 Nov 1.

Published in final edited form as: Nat Struct Mol Biol. 2017 Jun; 24(6): 507–514. Published online 2017 May 1. doi: 10.1038/nsmb.3407

PMCID:: PMC5472220

Article PDF–909K

Select item 32484244.

Induction of Cytoplasmic Rods and Rings Structures by Inhibition of the CTP and GTP Synthetic Pathway in Mammalian Cells

Wendy C. Carcamo, Minoru Satoh, Hideko Kasahara, Naohiro Terada, Takashi Hamazaki, Jason Y. F. Chan, Bing Yao, Stephanie Tamayo, Giovanni Covini, Carlos A. von Mühlen, Edward K. L. Chan

PLoS One. 2011; 6(12): e29690. Published online 2011 Dec 29. doi: 10.1371/journal.pone.0029690

PMCID:: PMC3248424

Article PDF–7.3M

Select item 5519285.

Molecular cloning of the human CTP synthetase gene by functional complementation with purified human metaphase chromosomes.

M Yamauchi, N Yamauchi, M Meuth

EMBO J. 1990 Jul; 9(7): 2095–2099. doi: 10.1002/j.1460-2075.1990.tb07377.x

PMCID:: PMC551928

Summary Page Browse PDF–1.2M

Select item 87342406.

CTPS1 promotes malignant progression of triple-negative breast cancer with transcriptional activation by YBX1

Yuxiang Lin, Jie Zhang, Yan Li, Wenhui Guo, Lili Chen, Minyan Chen, Xiaobin Chen, Wenzhe Zhang, Xuan Jin, Meichen Jiang, Han Xiao, Chuan Wang, Chuangui Song, Fangmeng Fu

J Transl Med. 2022; 20: 17. Published online 2022 Jan 6. doi: 10.1186/s12967-021-03206-5

PMCID:: PMC8734240

Article PDF–4.4M

Select item 64854707.

CTP synthase 1 deficiency in humans reveals its central role in lymphocyte proliferation

Emmanuel Martin, Noé Palmic, Sylvia Sanquer, Christelle Lenoir, Fabian Hauck, Cédric Mongellaz, Sylvie Fabrega, Patrick Nitschké, Mauro Degli Esposti, Jeremy Schwartzentruber, Naomi Taylor, Jacek Majewski, Nada Jabado, Robert Wynn, Capucine Picard, Alain Fischer, Peter Arkwright, Sylvain Latour

Nature. Author manuscript; available in PMC 2019 Apr 26.

Published in final edited form as: Nature. 2014 Jun 12; 510(7504): 288–292. Published online 2014 May 28. doi: 10.1038/nature13386

PMCID:: PMC6485470

Article PDF–1.3M

Select item 38526778.

CTP synthase 1, a smooth muscle-sensitive therapeutic target for effective vascular repair

Rui Tang, Xiao-Bing Cui, Jia-Ning Wang, Shi-You Chen

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2014 Oct 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2013 Oct; 33(10): 10.1161/ATVBAHA.113.301561. Published online 2013 Sep 5. doi: 10.1161/ATVBAHA.113.301561

PMCID:: PMC3852677

Article PDF–5.6M

Select item 29624719.

Regulation of Human Cytidine Triphosphate Synthetase 2 by Phosphorylation

Karen M. Kassel, Da Ryung Au, Matthew J. Higgins, Maria Hines, Lee M. Graves

J Biol Chem. 2010 Oct 29; 285(44): 33727–33736. Published online 2010 Aug 25. doi: 10.1074/jbc.M110.178566

PMCID:: PMC2962471

Article PDF–1003K

Select item 208115910.

Phosphorylation of Human CTP Synthetase 1 by Protein Kinase C IDENTIFICATION OF Ser⁴⁶² AND Thr⁴⁵⁵ AS MAJOR SITES OF PHOSPHORYLATION

Yu-Fang Chang, Shelley S. Martin, Enoch P. Baldwin, George M. Carman

J Biol Chem. Author manuscript; available in PMC 2007 Nov 19.

Published in final edited form as: J Biol Chem. 2007 Jun 15; 282(24): 17613–17622. Published online 2007 Apr 26. doi: 10.1074/jbc.M702799200

PMCID:: PMC2081159

Article PDF–596K

Select item 201473811.

Phosphorylation of Human CTP Synthetase 1 by Protein Kinase A: IDENTIFICATION OF Thr⁴⁵⁵ AS A MAJOR SITE OF PHOSPHORYLATION

Mal-Gi Choi, George M. Carman

J Biol Chem. Author manuscript; available in PMC 2007 Oct 10.

Published in final edited form as: J Biol Chem. 2007 Feb 23; 282(8): 5367–5377. Published online 2006 Dec 22. doi: 10.1074/jbc.M610993200

PMCID:: PMC2014738

Article PDF–1.4M

Select item 343629412.

Introduction of a Fluorine Atom at C3 of 3-Deazauridine Shifts Its Antimetabolic Activity from Inhibition of CTP Synthetase to Inhibition of Orotidylate Decarboxylase, an Early Event in the de Novo Pyrimidine Nucleotide Biosynthesis Pathway

Jan Balzarini, Federico Gago, Wim Kulik, André B. P. van Kuilenburg, Anna Karlsson, Matt A. Peterson, Morris J. Robins

J Biol Chem. 2012 Aug 31; 287(36): 30444–30454. Published online 2012 Jun 24. doi: 10.1074/jbc.M112.378091

PMCID:: PMC3436294

Article PDF–1.6M

Select item 425349213.

Ack kinase regulates CTP synthase filaments during Drosophila oogenesis

Todd I Strochlic, Kevin P Stavrides, Sam V Thomas, Emmanuelle Nicolas, Alana M O’Reilly, Jeffrey R Peterson

EMBO Rep. 2014 Nov; 15(11): 1184–1191. Published online 2014 Sep 15. doi: 10.15252/embr.201438688

PMCID:: PMC4253492

Article PDF–1.1M

Select item 140055214.

Expression of Human CTP Synthetase in Saccharomyces cerevisiae Reveals Phosphorylation by Protein Kinase A

Gil-Soo Han, Avula Sreenivas, Mal-Gi Choi, Yu-Fang Chang, Shelley S. Martin, Enoch P. Baldwin, George M. Carman

J Biol Chem. Author manuscript; available in PMC 2006 Mar 13.

Published in final edited form as: J Biol Chem. 2005 Nov 18; 280(46): 38328–38336. Published online 2005 Sep 22. doi: 10.1074/jbc.M509622200

PMCID:: PMC1400552

Article PDF–1.2M

Select item 745748415.

UBR-box containing protein, UBR5, is over-expressed in human lung adenocarcinoma and is a potential therapeutic target

Kumar Saurabh, Parag P. Shah, Mark A. Doll, Leah J. Siskind, Levi J. Beverly

BMC Cancer. 2020; 20: 824. Published online 2020 Aug 31. doi: 10.1186/s12885-020-07322-1

PMCID:: PMC7457484

Article PDF–3.1M

Select item 267689916.

A Targeted Proteomic Analysis of the Ubiquitin-Like Modifier Nedd8 and Associated Proteins

Jeffrey Jones, Kenneth Wu, Yingying Yang, Cortnie Guerrero, Nadinath Nillegoda, Zhen-Qiang Pan, Lan Huang

J Proteome Res. Author manuscript; available in PMC 2009 May 4.

Published in final edited form as: J Proteome Res. 2008 Mar; 7(3): 1274–1287. Published online 2008 Feb 5. doi: 10.1021/pr700749v

PMCID:: PMC2676899

Article PDF–2.6M

Select item 835040917.

The N-terminal domain of the Schaaf–Yang syndrome protein MAGEL2 likely has a role in RNA metabolism

Matthea R. Sanderson, Richard P. Fahlman, Rachel Wevrick

J Biol Chem. 2021 Aug; 297(2): 100959. Published online 2021 Jul 12. doi: 10.1016/j.jbc.2021.100959

PMCID:: PMC8350409

Article PDF–2.2M

Select item 936342718.

The SWI/SNF chromatin remodeling factor DPF3 regulates metastasis of ccRCC by modulating TGF-β signaling

Huanhuan Cui, Hongyang Yi, Hongyu Bao, Ying Tan, Chi Tian, Xinyao Shi, Diwen Gan, Bin Zhang, Weizheng Liang, Rui Chen, Qionghua Zhu, Liang Fang, Xin Gao, Hongda Huang, Ruijun Tian, Silke R. Sperling, Yuhui Hu, Wei Chen

Nat Commun. 2022; 13: 4680. Published online 2022 Aug 9. doi: 10.1038/s41467-022-32472-0

PMCID:: PMC9363427

Article PDF–3.6M

Select item 581617619.

K63 ubiquitylation triggers proteasomal degradation by seeding branched ubiquitin chains

Fumiaki Ohtake, Hikaru Tsuchiya, Yasushi Saeki, Keiji Tanaka

Proc Natl Acad Sci U S A. 2018 Feb 13; 115(7): E1401–E1408. Published online 2018 Jan 29. doi: 10.1073/pnas.1716673115

PMCID:: PMC5816176

Article PDF–1.1M

Select item 349950720.

Nucleolar Protein Trafficking in Response to HIV-1 Tat: Rewiring the Nucleolus

Mohamed Ali Jarboui, Carlo Bidoia, Elena Woods, Barbara Roe, Kieran Wynne, Giuliano Elia, William W. Hall, Virginie W. Gautier

PLoS One. 2012; 7(11): e48702. Published online 2012 Nov 15. doi: 10.1371/journal.pone.0048702

PMCID:: PMC3499507

Article PDF–1.5M

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