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Select item 105314601.

HCN2 Channels in the Ventral Hippocampal CA1 Regulate Nociceptive Hypersensitivity in Mice

Yawen Zheng, Shan Shao, Yu Zhang, Shulu Yuan, Yuanwei Xing, Jiaxin Wang, Xuetao Qi, Kun Cui, Jifu Tong, Fengyu Liu, Shuang Cui, You Wan, Ming Yi

Int J Mol Sci. 2023 Sep; 24(18): 13823. Published online 2023 Sep 7. doi: 10.3390/ijms241813823

PMCID:: PMC10531460

Abstract Article PDF–4.4M

Select item 101699822.

Thalamocortical Circuit Controls Neuropathic Pain via Up-regulation of HCN2 in the Ventral Posterolateral Thalamus

Yi Yan, Mengye Zhu, Xuezhong Cao, Gang Xu, Wei Shen, Fan Li, Jinjin Zhang, Lingyun Luo, Xuexue Zhang, Daying Zhang, Tao Liu

Neurosci Bull. 2023 May; 39(5): 774–792. Published online 2022 Dec 20. doi: 10.1007/s12264-022-00989-5

PMCID:: PMC10169982

Abstract Article PDF–12M

Select item 91960473.

Hippocampal cAMP regulates HCN channel function on two time scales with differential effects on animal behavior

Kyle A. Lyman, Ye Han, Chengwen Zhou, Isabelle Renteria, Gai-Linn Besing, Jonathan E. Kurz, Dane M. Chetkovich

Sci Transl Med. Author manuscript; available in PMC 2022 Jun 14.

Published in final edited form as: Sci Transl Med. 2021 Nov 24; 13(621): eabl4580. Published online 2021 Nov 24. doi: 10.1126/scitranslmed.abl4580

PMCID:: PMC9196047

Abstract Article PDF–2.2M

Select item 87067034.

The Role of Prostaglandin E1 as a Pain Mediator through Facilitation of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 2 via the EP2 Receptor in Trigeminal Ganglion Neurons of Mice

Jean Kwon, Young In Choi, Hang Joon Jo, Sang Hoon Lee, Han Kyu Lee, Heesoo Kim, Jee Youn Moon, Sung Jun Jung

Int J Mol Sci. 2021 Dec; 22(24): 13534. Published online 2021 Dec 16. doi: 10.3390/ijms222413534

PMCID:: PMC8706703

Abstract Article PDF–1.9M

Select item 82694125.

Loss of HCN2 in Dorsal Hippocampus of Young Adult Mice Induces Specific Apoptosis of the CA1 Pyramidal Neuron Layer

Matthias Deutsch, Carina Stegmayr, Sabine Balfanz, Arnd Baumann

Int J Mol Sci. 2021 Jul; 22(13): 6699. Published online 2021 Jun 22. doi: 10.3390/ijms22136699

PMCID:: PMC8269412

Abstract Article PDF–5.5M

Select item 72940806.

The HCN domain is required for HCN channel cell-surface expression and couples voltage- and cAMP-dependent gating mechanisms

Ze-Jun Wang, Ismary Blanco, Sebastien Hayoz, Tinatin I. Brelidze

J Biol Chem. 2020 Jun 12; 295(24): 8164–8173. Published online 2020 Apr 27. doi: 10.1074/jbc.RA120.013281

PMCID:: PMC7294080

Abstract Article PDF–6.8M

Select item 68793467.

N⁶-modified cAMP derivatives that activate protein kinase A also act as full agonists of murine HCN2 channels

Tim Leypold, Michele Bonus, Felix Spiegelhalter, Frank Schwede, Tina Schwabe, Holger Gohlke, Jana Kusch

J Biol Chem. 2019 Nov 22; 294(47): 17978–17987. Published online 2019 Oct 15. doi: 10.1074/jbc.RA119.010246

PMCID:: PMC6879346

Abstract Article PDF–2.2M

Select item 67335768.

HCN channel-mediated neuromodulation can control action potential velocity and fidelity in central axons

Niklas Byczkowicz, Abdelmoneim Eshra, Jacqueline Montanaro, Andrea Trevisiol, Johannes Hirrlinger, Maarten HP Kole, Ryuichi Shigemoto, Stefan Hallermann

eLife. 2019; 8: e42766. Published online 2019 Sep 9. doi: 10.7554/eLife.42766

PMCID:: PMC6733576

Abstract Article PDF–3.8M

Select item 65836979.

Overexpression of the HCN2 channel increases the arrhythmogenicity induced by hypokalemia

Kensuke Oshita, Yuko Kozasa, Yasuaki Nakagawa, Yoshihiro Kuwabara, Koichiro Kuwahara, Taku Nakagawa, Noriyuki Nakashima, Teruyuki Hiraki, Makoto Takano

J Physiol Sci. 2019 Jul; 69(4): 653–660. Published online 2019 May 13. doi: 10.1007/s12576-019-00684-7

PMCID:: PMC6583697

Abstract Article PDF–1.6M

Select item 653832510.

Abolishing cAMP sensitivity in HCN2 pacemaker channels induces generalized seizures

Verena Hammelmann, Marc Sebastian Stieglitz, Henrik Hülle, Karim Le Meur, Jennifer Kass, Manuela Brümmer, Christian Gruner, René Dominik Rötzer, Stefanie Fenske, Jana Hartmann, Benedikt Zott, Anita Lüthi, Saskia Spahn, Markus Moser, Dirk Isbrandt, Andreas Ludwig, Arthur Konnerth, Christian Wahl-Schott, Martin Biel

JCI Insight. 2019 May 2; 4(9): e126418. Published online 2019 May 2. doi: 10.1172/jci.insight.126418

PMCID:: PMC6538325

Abstract Article PDF–6.1M

Select item 582137111.

Loss of HCN2 leads to delayed gastrointestinal motility and reduced energy intake in mice

Daniel W. Fisher, Phillip Luu, Neha Agarwal, Jonathan E. Kurz, Dane M. Chetkovich

PLoS One. 2018; 13(2): e0193012. Published online 2018 Feb 21. doi: 10.1371/journal.pone.0193012

PMCID:: PMC5821371

Abstract Article PDF–3.7M

Select item 572034212.

Hyperpolarization-activated cyclic nucleotide–gated 2 (HCN2) ion channels drive pain in mouse models of diabetic neuropathy

Christoforos Tsantoulas, Sergio Laínez, Sara Wong, Ishita Mehta, Bruno Vilar, Peter A. McNaughton

Sci Transl Med. Author manuscript; available in PMC 2018 Mar 27.

Published in final edited form as: Sci Transl Med. 2017 Sep 27; 9(409): eaam6072. doi: 10.1126/scitranslmed.aam6072

PMCID:: PMC5720342

Abstract Article PDF–2.5M

Select item 485386813.

Relevance of HCN2-expressing human mesenchymal stem cells for the generation of biological pacemakers

Ieva Bruzauskaite, Daiva Bironaite, Edvardas Bagdonas, Vytenis Arvydas Skeberdis, Jaroslav Denkovskij, Tomas Tamulevicius, Valentinas Uvarovas, Eiva Bernotiene

Stem Cell Res Ther. 2016; 7: 67. Published online 2016 Apr 30. doi: 10.1186/s13287-016-0326-z

PMCID:: PMC4853868

Abstract Article PDF–3.7M

Select item 469717214.

Structure and Energetics of Allosteric Regulation of HCN2 Ion Channels by Cyclic Nucleotides

Hannah A. DeBerg, Peter S. Brzovic, Galen E. Flynn, William N. Zagotta, Stefan Stoll

J Biol Chem. 2016 Jan 1; 291(1): 371–381. Published online 2015 Nov 11. doi: 10.1074/jbc.M115.696450

PMCID:: PMC4697172

Abstract Article PDF–1.9M

Select item 439403915.

Structural mechanism for the regulation of HCN ion channels by the accessory protein TRIP8b

Hannah A. DeBerg, John R. Bankston, Joel C. Rosenbaum, Peter S. Brzovic, William N. Zagotta, Stefan Stoll

Structure. Author manuscript; available in PMC 2016 Apr 7.

Published in final edited form as: Structure. 2015 Apr 7; 23(4): 734–744. Published online 2015 Mar 19. doi: 10.1016/j.str.2015.02.007

PMCID:: PMC4394039

Abstract Article PDF–1.2M

Select item 410337116.

Double electron–electron resonance reveals cAMP-induced conformational change in HCN channels

Michael C. Puljung, Hannah A. DeBerg, William N. Zagotta, Stefan Stoll

Proc Natl Acad Sci U S A. 2014 Jul 8; 111(27): 9816–9821. Published online 2014 Jun 23. doi: 10.1073/pnas.1405371111

PMCID:: PMC4103371

Abstract Article PDF–1.1M

Select item 383126417.

Flavonoid Regulation of HCN2 Channels

Anne E. Carlson, Joel C. Rosenbaum, Tinatin I. Brelidze, Rachel E. Klevit, William N. Zagotta

J Biol Chem. 2013 Nov 15; 288(46): 33136–33145. Published online 2013 Oct 1. doi: 10.1074/jbc.M113.501759

PMCID:: PMC3831264

Abstract Article PDF–1.4M

Select item 304320918.

State-Dependent cAMP Binding to Functioning HCN Channels Studied by Patch-Clamp Fluorometry

Shengjun Wu, Zhanna V. Vysotskaya, Xinping Xu, Changan Xie, Qinglian Liu, Lei Zhou

Biophys J. 2011 Mar 2; 100(5): 1226–1232. doi: 10.1016/j.bpj.2011.01.034

PMCID:: PMC3043209

Abstract Article PDF–1.1M

Select item 270886219.

Alanine Scanning of the S6 Segment Reveals a Unique and cAMP-sensitive Association between the Pore and Voltage-dependent Opening in HCN Channels

Vincenzo Macri, Hamed Nazzari, Evan McDonald, Eric A. Accili

J Biol Chem. 2009 Jun 5; 284(23): 15659–15667. Published online 2009 Mar 6. doi: 10.1074/jbc.M809164200

PMCID:: PMC2708862

Abstract Article PDF–4.3M

Select item 264333320.

Absence epilepsy in apathetic, a spontaneous mutant mouse lacking the h channel subunit, HCN2

Wendy K. Chung, Minyoung Shin, Thomas C. Jaramillo, Rudolph L. Leibel, Charles A. LeDuc, Stuart G. Fischer, Efthia Tzilianos, Ayman A. Gheith, Alan S. Lewis, Dane M. Chetkovich

Neurobiol Dis. Author manuscript; available in PMC 2010 Mar 1.

Published in final edited form as: Neurobiol Dis. 2009 Mar; 33(3): 499–508. Published online 2008 Dec 25. doi: 10.1016/j.nbd.2008.12.004