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Items: 1 to 20 of 415

1.
Genetic and antiretroviral drug resistance mutations analysis of reverse transcriptase and protease gene from Pakistani people living with HIV-1
Dilsha Siddiqui, Uzma Badar, Mahnoor Javaid, Nida Farooqui, Sharaf Ali Shah, Ayesha Iftikhar, Faisal Sultan, Fatima Mir, Sofia Furqan, Syed Faisal Mahmood, Syed Hani Abidi
PLoS One. 2023; 18(8): e0290425. Published online 2023 Aug 24. doi: 10.1371/journal.pone.0290425
PMCID:
PMC10449192
ArticlePDF–1.0M
2.
Biophysical Characterization of Novel DNA Aptamers against K103N/Y181C Double Mutant HIV-1 Reverse Transcriptase
Siriluk Ratanabunyong, Supaphorn Seetaha, Supa Hannongbua, Saeko Yanaka, Maho Yagi-Utsumi, Koichi Kato, Atchara Paemanee, Kiattawee Choowongkomon
Molecules. 2022 Jan; 27(1): 285. Published online 2022 Jan 3. doi: 10.3390/molecules27010285
PMCID:
PMC8746315
ArticlePDF–2.0M
3.
HIV-1 integrase binding to genomic RNA 5′-UTR induces local structural changes in vitro and in virio
Shuohui Liu, Pratibha C. Koneru, Wen Li, Chathuri Pathirage, Alan N. Engelman, Mamuka Kvaratskhelia, Karin Musier-Forsyth
Retrovirology. 2021; 18: 37. Published online 2021 Nov 22. doi: 10.1186/s12977-021-00582-0
PMCID:
PMC8609798
ArticlePDF–5.6M
4.
Changes in dynamic and static structures of the HIV‐1 p24 capsid protein N‐domain caused by amino‐acid substitution are associated with its viral viability
Yusuke Sato, Akimasa Matsugami, Satoru Watanabe, Fumiaki Hayashi, Munehito Arai, Takanori Kigawa, Chiaki Nishimura
Protein Sci. 2021 Nov; 30(11): 2233–2245. Published online 2021 Sep 23. doi: 10.1002/pro.4184
PMCID:
PMC8522491
ArticlePDF–3.6M
5.
High-resolution view of HIV-1 reverse transcriptase initiation complexes and inhibition by NNRTI drugs
Betty Ha, Kevin P. Larsen, Jingji Zhang, Ziao Fu, Elizabeth Montabana, Lynnette N. Jackson, Dong-Hua Chen, Elisabetta Viani Puglisi
Nat Commun. 2021; 12: 2500. Published online 2021 May 4. doi: 10.1038/s41467-021-22628-9
PMCID:
PMC8096811
ArticlePDF–1.5M
6.
Vulnerable targets in HIV-1 Pol for attenuation-based vaccine design
Doty B.A. Ojwach, Paradise Madlala, Michelle Gordon, Thumbi Ndung’u, Jaclyn K. Mann
Virology. Author manuscript; available in PMC 2022 Feb 1.
Published in final edited form as: Virology. 2021 Feb; 554: 1–8. Published online 2020 Dec 10. doi: 10.1016/j.virol.2020.12.003
PMCID:
PMC7931244
ArticlePDF–1.0M
7.
HIV-1 Gag-Pol Sequences from Ugandan Early Infections Reveal Sequence Variants Associated with Elevated Replication Capacity
Anne Kapaata, Sheila N. Balinda, Rui Xu, Maria G. Salazar, Kimberly Herard, Kelsie Brooks, Kato Laban, Jonathan Hare, Dario Dilernia, Anatoli Kamali, Eugene Ruzagira, Freddie Mukasa, Jill Gilmour, Jesus F. Salazar-Gonzalez, Ling Yue, Matthew Cotten, Eric Hunter, Pontiano Kaleebu
Viruses. 2021 Feb; 13(2): 171. Published online 2021 Jan 23. doi: 10.3390/v13020171
PMCID:
PMC7912664
ArticlePDF–1.6M
8.
Computational design of small molecular modulators of protein–protein interactions with a novel thermodynamic cycle: Allosteric inhibitors of HIV‐1 integrase
Qinfang Sun, Vijayan S. K. Ramaswamy, Ronald Levy, Nanjie Deng
Protein Sci. 2021 Feb; 30(2): 438–447. Published online 2020 Dec 5. doi: 10.1002/pro.4004
PMCID:
PMC7784772
ArticlePDF–2.1M
9.
Pre-steady-state Kinetic Studies Establish Entecavir 5′-Triphosphate as a Substrate for HIV-1 Reverse Transcriptase
Robert A. Domaoal, Moira McMahon, Chloe L. Thio, Christopher M. Bailey, Julian Tirado-Rives, Aleksander Obikhod, Mervi Detorio, Kimberly L. Rapp, Robert F. Siliciano, Raymond F. Schinazi, Karen S. Anderson
J Biol Chem. Author manuscript; available in PMC 2020 Dec 18.
Published in final edited form as: J Biol Chem. 2008 Feb 29; 283(9): 5452–5459. Published online 2007 Oct 25. doi: 10.1074/jbc.M707834200
PMCID:
PMC7748947
ArticlePDF–1.0M
10.
Close-up: HIV/SIV intasome structures shed new light on integrase inhibitor binding and viral escape mechanisms
Alan N. Engelman, Peter Cherepanov
FEBS J. Author manuscript; available in PMC 2022 Jan 1.
Published in final edited form as: FEBS J. 2021 Jan; 288(2): 427–433. Published online 2020 Jun 22. doi: 10.1111/febs.15438
PMCID:
PMC7719574
ArticlePDF–1.2M
11.
Going beyond Integration: The Emerging Role of HIV-1 Integrase in Virion Morphogenesis
Jennifer L. Elliott, Sebla B. Kutluay
Viruses. 2020 Sep; 12(9): 1005. Published online 2020 Sep 9. doi: 10.3390/v12091005
PMCID:
PMC7551943
ArticlePDF–1.9M
12.
NKNK: a New Essential Motif in the C-Terminal Domain of HIV-1 Group M Integrases
Marine Kanja, Pierre Cappy, Nicolas Levy, Oyndamola Oladosu, Sylvie Schmidt, Paola Rossolillo, Flore Winter, Romain Gasser, Christiane Moog, Marc Ruff, Matteo Negroni, Daniela Lener
J Virol. 2020 Oct; 94(20): e01035-20. Prepublished online 2020 Jul 29. Published online 2020 Sep 29. doi: 10.1128/JVI.01035-20
PMCID:
PMC7527040
ArticlePDF–2.7M
13.
Influence of the amino-terminal sequence on the structure and function of HIV integrase
Grant Eilers, Kushol Gupta, Audrey Allen, Jeffrey Zhou, Young Hwang, Michael B. Cory, Frederic D. Bushman, Gregory Van Duyne
Retrovirology. 2020; 17: 28. Published online 2020 Aug 31. doi: 10.1186/s12977-020-00537-x
PMCID:
PMC7457537
ArticlePDF–3.2M
14.
Structural investigation of 2‐naphthyl phenyl ether inhibitors bound to WT and Y181C reverse transcriptase highlights key features of the NNRTI binding site
Vincent N. Duong, Joseph A. Ippolito, Albert H. Chan, Won‐Gil Lee, Krasimir A. Spasov, William L. Jorgensen, Karen S. Anderson
Protein Sci. 2020 Sep; 29(9): 1902–1910. Published online 2020 Aug 5. doi: 10.1002/pro.3910
PMCID:
PMC7454559
ArticlePDF–1.6M
15.
HIV-1 Reverse Transcriptase Promotes Tumor Growth and Metastasis Formation via ROS-Dependent Upregulation of Twist
Ekaterina Bayurova, Juris Jansons, Dace Skrastina, Olga Smirnova, Dzeina Mezale, Anastasia Kostyusheva, Dmitry Kostyushev, Stefan Petkov, Philip Podschwadt, Vladimir Valuev-Elliston, Sviataslau Sasinovich, Sergey Korolev, Per Warholm, Anastasia Latanova, Elizaveta Starodubova, Amir Tukhvatulin, Oleg Latyshev, Renat Selimov, Pavel Metalnikov, Alexander Komarov, Olga Ivanova, Tatiana Gorodnicheva, Sergey Kochetkov, Marina Gottikh, Ilze Strumfa, Alexander Ivanov, Ilya Gordeychuk, Maria Isaguliants
Oxid Med Cell Longev. 2019; 2019: 6016278. Published online 2019 Dec 2. doi: 10.1155/2019/6016278
PMCID:
PMC6915010
ArticlePDF–3.7M
16.
A Homology Model of HIV-1 Integrase and Analysis of Mutations Designed to Test the Model
Barry C. Johnson, Mathieu Métifiot, Andrea Ferris, Yves Pommier, Stephen H. Hughes
J Mol Biol. Author manuscript; available in PMC 2019 Oct 3.
Published in final edited form as: J Mol Biol. 2013 Jun 26; 425(12): 2133–2146. Published online 2013 Mar 27. doi: 10.1016/j.jmb.2013.03.027
PMCID:
PMC6775779
ArticlePDF–2.0M
17.
Two-long terminal repeat (LTR) DNA circles are a substrate for HIV-1 integrase
Clémence Richetta, Sylvain Thierry, Eloise Thierry, Paul Lesbats, Delphine Lapaillerie, Soundasse Munir, Frédéric Subra, Hervé Leh, Eric Deprez, Vincent Parissi, Olivier Delelis
J Biol Chem. 2019 May 17; 294(20): 8286–8295. Published online 2019 Apr 10. doi: 10.1074/jbc.RA118.006755
PMCID:
PMC6527176
ArticlePDF–1.5M
18.
Structure of HIV-1 RT/dsRNA initiation complex prior to nucleotide incorporation
Kalyan Das, Sergio E. Martinez, Jeffrey J. DeStefano, Eddy Arnold
Proc Natl Acad Sci U S A. 2019 Apr 9; 116(15): 7308–7313. Published online 2019 Mar 22. doi: 10.1073/pnas.1814170116
PMCID:
PMC6462067
ArticlePDF–1.3M
19.
Selective resistance profiles emerging in patient-derived clinical isolates with cabotegravir, bictegravir, dolutegravir, and elvitegravir
Maureen Oliveira, Ruxandra-Ilinca Ibanescu, Kaitlin Anstett, Thibault Mésplède, Jean-Pierre Routy, Marjorie A. Robbins, Bluma G. Brenner, the Montreal Primary HIV (PHI) Cohort Study Group
Retrovirology. 2018; 15: 56. Published online 2018 Aug 17. doi: 10.1186/s12977-018-0440-3
PMCID:
PMC6098636
ArticlePDF–911K
20.
Architecture of an HIV-1 reverse transcriptase initiation complex
Kevin P. Larsen, Yamuna Kalyani Mathiharan, Kalli Kappel, Aaron Coey, Dong-Hua Chen, Daniel Barrero, Lauren Madigan, Joseph D. Puglisi, Georgios Skiniotis, Elisabetta Viani Puglisi
Nature. Author manuscript; available in PMC 2018 Oct 25.
Published in final edited form as: Nature. 2018 May; 557(7703): 118–122. Published online 2018 Apr 25. doi: 10.1038/s41586-018-0055-9
PMCID:
PMC5934294
ArticlePDF–3.0M

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