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Select item 104054991.

Viral protein R (Vpr)-induced neuroinflammation and its potential contribution to neuronal dysfunction: a scoping review

Monray Edward Williams, Aurelia A. Williams, Petrus J.W. Naudé

BMC Infect Dis. 2023; 23: 512. Published online 2023 Aug 6. doi: 10.1186/s12879-023-08495-3

PMCID:: PMC10405499

Article PDF–1.7M

Select item 99749162.

Tubular-specific expression of HIV protein Vpr leads to severe tubulointerstitial damage accompanied by progressive fibrosis and cystic development

Yuqiang Chen, Ya Chen, Jia Fu, Zeguo Sun, Huilin Li, Wenzhen Xiao, Jing E, Benjamin Y. Lo, Niansong Wang, Weijia Zhang, Mary Klotman, Paul Klotman, Jeffrey B. Kopp, Vivette D. D’Agati, John Cijiang He, Kyung Lee

Kidney Int. Author manuscript; available in PMC 2024 Mar 1.

Published in final edited form as: Kidney Int. 2023 Mar; 103(3): 529–543. Published online 2022 Dec 22. doi: 10.1016/j.kint.2022.12.012

PMCID:: PMC9974916

Article PDF–3.5M

Select item 82630073.

HIV-1 Vpr Induces Widespread Transcriptomic Changes in CD4⁺ T Cells Early Postinfection

Hélène Bauby, Christopher C. Ward, Rupert Hugh-White, Chad M. Swanson, Reiner Schulz, Caroline Goujon, Michael H. Malim

mBio. 2021 May-Jun; 12(3): e01369-21. Published online 2021 Jun 22. doi: 10.1128/mBio.01369-21

PMCID:: PMC8263007

Article PDF–4.4M

Select item 77593854.

HIV-1 Vpr antagonizes innate immune activation by targeting karyopherin-mediated NF-κB/IRF3 nuclear transport

Hataf Khan, Rebecca P Sumner, Jane Rasaiyaah, Choon Ping Tan, Maria Teresa Rodriguez-Plata, Chris Van Tulleken, Douglas Fink, Lorena Zuliani-Alvarez, Lucy Thorne, David Stirling, Richard SB Milne, Greg J Towers

eLife. 2020; 9: e60821. Published online 2020 Dec 10. doi: 10.7554/eLife.60821

PMCID:: PMC7759385

Article PDF–5.0M

Select item 55461975.

Quantitative Temporal Viromics of an Inducible HIV-1 Model Yields Insight to Global Host Targets and Phospho-Dynamics Associated with Protein Vpr

John D. Lapek, Jr., Mary K. Lewinski, Jacob M. Wozniak, John Guatelli, David J. Gonzalez

Mol Cell Proteomics. 2017 Aug; 16(8): 1447–1461. Published online 2017 Jun 12. doi: 10.1074/mcp.M116.066019

PMCID:: PMC5546197

Article PDF–3.6M

Select item 53972986.

HIV-1 Vpr disrupts mitochondria axonal transport and accelerates neuronal aging

Ying Wang, Maryline Santerre, Italo Tempera, Kayla Martin, Ruma Mukerjee, Bassel E Sawaya

Neuropharmacology. Author manuscript; available in PMC 2018 May 1.

Published in final edited form as: Neuropharmacology. 2017 May 1; 117: 364–375. Published online 2017 Feb 14. doi: 10.1016/j.neuropharm.2017.02.008

PMCID:: PMC5397298

Article PDF–1.0M

Select item 51445767.

Defining the roles for Vpr in HIV-1-associated neuropathogenesis

Tony James, Michael R. Nonnemacher, Brian Wigdahl, Fred C. Krebs

J Neurovirol. Author manuscript; available in PMC 2017 Aug 1.

Published in final edited form as: J Neurovirol. 2016 Aug; 22(4): 403–415. Published online 2016 Apr 7. doi: 10.1007/s13365-016-0436-5

PMCID:: PMC5144576

Article PDF–580K

Select item 50563868.

HIV-1 Vpr N-terminal tagging affects alternative splicing of the viral genome

Ann Baeyens, Evelien Naessens, Anouk Van Nuffel, Karin E. Weening, Anne-Marie Reilly, Eva Claeys, Wim Trypsteen, Linos Vandekerckhove, Sven Eyckerman, Kris Gevaert, Bruno Verhasselt

Sci Rep. 2016; 6: 34573. Published online 2016 Oct 10. doi: 10.1038/srep34573

PMCID:: PMC5056386

Article PDF–1.5M

Select item 50046759.

Glutamate metabolism in HIV-1 infected macrophages: Role of HIV-1 Vpr

Prasun K. Datta, Satish Deshmane, Kamel Khalili, Salim Merali, John C. Gordon, Chiara Fecchio, Carlos A. Barrero

Cell Cycle. 2016; 15(17): 2288–2298. Published online 2016 May 31. doi: 10.1080/15384101.2016.1190054

PMCID:: PMC5004675

Article PDF–1.1M

Select item 403956010.

HIV-1 vpr inhibits cytokinesis in human proximal tubule cells

Paul Rosenstiel, Tina Gruosso, Audrey Letourneau, Justin Chan, Amanda LeBlanc, Mohammad Husain, Vesna Najfeld, Vicente Planelles, Vivette D’Agati, Mary Klotman, Paul E. Klotman

Kidney Int. Author manuscript; available in PMC 2014 May 30.

Published in final edited form as: Kidney Int. 2008 Oct; 74(8): 1049–1058. Published online 2008 Jul 9. doi: 10.1038/ki.2008.303

PMCID:: PMC4039560

Article PDF–757K

Select item 392917511.

Human immunodeficiency virus type 1 Vpr polymorphisms associated with progressor and nonprogressor individuals alter Vpr-associated functions

Kevin Hadi, Leah A. Walker, Debjani Guha, Ramachandran Murali, Simon C. Watkins, Patrick Tarwater, Alagarsamy Srinivasan, Velpandi Ayyavoo

J Gen Virol. 2014 Mar; 95(Pt 3): 700–711. doi: 10.1099/vir.0.059576-0

PMCID:: PMC3929175

Article PDF–1.3M

Select item 289401812.

Human immunodeficiency virus type 1 Vpr: oligomerization is an essential feature for its incorporation into virus particles

Narasimhan J Venkatachari, Leah A Walker, Oznur Tastan, Thien Le, Timothy M Dempsey, Yaming Li, Naveena Yanamala, Alagarsamy Srinivasan, Judith Klein-Seetharaman, Ronald C Montelaro, Velpandi Ayyavoo

Virol J. 2010; 7: 119. Published online 2010 Jun 7. doi: 10.1186/1743-422X-7-119

PMCID:: PMC2894018

Article PDF–1.7M

Select item 195143913.

Vpr Cytopathicity Independent of G₂/M Cell Cycle Arrest in Human Immunodeficiency Virus Type 1-Infected CD4⁺ T Cells

Diane L. Bolton, Michael J. Lenardo

J Virol. 2007 Sep; 81(17): 8878–8890. Published online 2007 Jun 6. doi: 10.1128/JVI.00122-07

PMCID:: PMC1951439

Article PDF–740K

Select item 195140214.

Proline 35 of Human Immunodeficiency Virus Type 1 (HIV-1) Vpr Regulates the Integrity of the N-Terminal Helix and the Incorporation of Vpr into Virus Particles and Supports the Replication of R5-Tropic HIV-1 in Human Lymphoid Tissue Ex Vivo

Jörg Votteler, Nicole Studtrucker, Stefan Sörgel, Jan Münch, Elke Rücker, Frank Kirchhoff, Bernhard Schick, Peter Henklein, Torgils Fossen, Karsten Bruns, Alok Sharma, Victor Wray, Ulrich Schubert

J Virol. 2007 Sep; 81(17): 9572–9576. Published online 2007 Jun 6. doi: 10.1128/JVI.02803-06

PMCID:: PMC1951402

Article PDF–439K

Select item 861707615.

Structure of HIV-1 Vpr in complex with the human nucleotide excision repair protein hHR23A

In-Ja L. Byeon, Guillermo Calero, Ying Wu, Chang H. Byeon, Jinwon Jung, Maria DeLucia, Xiaohong Zhou, Simon Weiss, Jinwoo Ahn, Caili Hao, Jacek Skowronski, Angela M. Gronenborn

Nat Commun. 2021; 12: 6864. Published online 2021 Nov 25. doi: 10.1038/s41467-021-27009-w

PMCID:: PMC8617076

Article PDF–2.3M

Select item 845276416.

HIV reprograms host m⁶Am RNA methylome by viral Vpr protein-mediated degradation of PCIF1

Qiong Zhang, Yuqi Kang, Shaobo Wang, Gwendolyn Michelle Gonzalez, Wanyu Li, Hui Hui, Yinsheng Wang, Tariq M. Rana

Nat Commun. 2021; 12: 5543. Published online 2021 Sep 20. doi: 10.1038/s41467-021-25683-4

PMCID:: PMC8452764

Article PDF–2.7M

Select item 821170917.

Vpr counteracts the restriction of LAPTM5 to promote HIV-1 infection in macrophages

Li Zhao, Shumei Wang, Meng Xu, Yang He, Xiaowei Zhang, Ying Xiong, Hong Sun, Haibo Ding, Wenqing Geng, Hong Shang, Guoxin Liang

Nat Commun. 2021; 12: 3691. Published online 2021 Jun 17. doi: 10.1038/s41467-021-24087-8

PMCID:: PMC8211709

Article PDF–3.9M

Select item 741844018.

Impact of HIV-1 Vpr manipulation of the DNA repair enzyme UNG2 on B lymphocyte class switch recombination

Patrick Eldin, Sophie Péron, Anastasia Galashevskaya, Nicolas Denis-Lagache, Michel Cogné, Geir Slupphaug, Laurence Briant

J Transl Med. 2020; 18: 310. Published online 2020 Aug 10. doi: 10.1186/s12967-020-02478-7

PMCID:: PMC7418440

Article PDF–1.6M

Select item 740708219.

HIV Vpr Modulates the Host DNA Damage Response at Two Independent Steps to Damage DNA and Repress Double-Strand DNA Break Repair

Donna Li, Andrew Lopez, Carina Sandoval, Randilea Nichols Doyle, Oliver I. Fregoso

mBio. 2020 Jul-Aug; 11(4): e00940-20. Published online 2020 Aug 4. doi: 10.1128/mBio.00940-20

PMCID:: PMC7407082

Article PDF–2.9M

Select item 699776020.

HIV-1 Accessory Protein Vpr Interacts with REAF/RPRD2 To Mitigate Its Antiviral Activity

Joseph M. Gibbons, Kelly M. Marno, Rebecca Pike, Wing-yiu Jason Lee, Christopher E. Jones, Babatunji W. Ogunkolade, Claire Pardieu, Alexander Bryan, Rebecca Menhua Fu, Gary Warnes, Paul A. Rowley, Richard D. Sloan, Áine McKnight

J Virol. 2020 Feb; 94(4): e01591-19. Prepublished online 2019 Nov 27. Published online 2020 Jan 31. doi: 10.1128/JVI.01591-19