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Select item 100575111.

A Conserved Acidic Residue in the C-Terminal Flexible Loop of HIV-1 Nef Contributes to the Activity of SERINC5 and CD4 Downregulation

Claudia Firrito, Cinzia Bertelli, Annachiara Rosa, Ajit Chande, Swetha Ananth, Hannah van Dijk, Oliver T. Fackler, Charlotte Stoneham, Rajendra Singh, John Guatelli, Massimo Pizzato

Viruses. 2023 Mar; 15(3): 652. Published online 2023 Feb 28. doi: 10.3390/v15030652

PMCID:: PMC10057511

Article PDF–2.7M

Select item 100310672.

Novel role of HIV-1 Nef in regulating the ubiquitination of cellular proteins

Maria Ghaly, Jessica Proulx, Kathleen Borgmann, In-Woo Park

Front Cell Infect Microbiol. 2023; 13: 1106591. Published online 2023 Mar 8. doi: 10.3389/fcimb.2023.1106591

PMCID:: PMC10031067

Article PDF–4.8M

Select item 87807793.

HIV-1 Nef Protein Affects Cytokine and Extracellular Vesicles Production in the GEN2.2 Plasmacytoid Dendritic Cell Line

Alessandra Aiello, Flavia Giannessi, Zulema Antonia Percario, Katia Fecchi, Claudia Arenaccio, Stefano Leone, Maria Carollo, Elisabetta D’Aversa, Laurence Chaperot, Roberto Gambari, Massimo Sargiacomo, Elisabetta Affabris

Viruses. 2022 Jan; 14(1): 74. Published online 2021 Dec 31. doi: 10.3390/v14010074

PMCID:: PMC8780779

Article PDF–5.4M

Select item 83128664.

An Amino Acid Polymorphism within the HIV-1 Nef Dileucine Motif Functionally Uncouples Cell Surface CD4 and SERINC5 Downregulation

Mitchell J. Mumby, Aaron L. Johnson, Steven M. Trothen, Cassandra R. Edgar, Richard Gibson, Peter B. Stathopulos, Eric J. Arts, Jimmy D. Dikeakos

J Virol. 2021 Aug; 95(16): e00588-21. Prepublished online 2021 May 26. Published online 2021 Jul 26. doi: 10.1128/JVI.00588-21

PMCID:: PMC8312866

Article PDF–7.7M

Select item 81041045.

HIV-1 Nef-Induced Secretion of the Proinflammatory Protease TACE into Extracellular Vesicles Is Mediated by Raf-1 and Can Be Suppressed by Clinical Protein Kinase Inhibitors

Zhe Zhao, Riku Fagerlund, Andreas S. Baur, Kalle Saksela

J Virol. 2021 May; 95(9): e00180-21. Prepublished online 2021 Feb 17. Published online 2021 Apr 12. doi: 10.1128/JVI.00180-21

PMCID:: PMC8104104

Article PDF–851K

Select item 71323206.

Loss of Nef-mediated CD3 down-regulation in the HIV-1 lineage increases viral infectivity and spread

Dejan Mesner, Dominik Hotter, Frank Kirchhoff, Clare Jolly

Proc Natl Acad Sci U S A. 2020 Mar 31; 117(13): 7382–7391. Published online 2020 Mar 16. doi: 10.1073/pnas.1921135117

PMCID:: PMC7132320

Article PDF–1.8M

Select item 70447727.

A Novel HIV-1 Nef Mutation in a Primary Pediatric Isolate Impairs MHC-Class I Downregulation and Cytopathicity

Ayub Ali, Robert L. Furler, Livia Pedroza-Martins, Arnaud D. Colantonio, Deborah Anisman-Posner, Yvonne Bryson, Otto O. Yang, Christel H. Uittenbogaart

AIDS Res Hum Retroviruses. February 2020; 36(2): 122–130. Published online 2020 Feb 5. doi: 10.1089/aid.2019.0160

PMCID:: PMC7044772

Article PDF–603K

Select item 69532808.

Longitudinal within-host evolution of HIV Nef-mediated CD4, HLA and SERINC5 downregulation activity: a case study

Hanwei Sudderuddin, Natalie N. Kinloch, Steven W. Jin, Rachel L. Miller, Bradley R. Jones, Chanson J. Brumme, Jeffrey B. Joy, Mark A. Brockman, Zabrina L. Brumme

Retrovirology. 2020; 17: 3. Published online 2020 Jan 9. doi: 10.1186/s12977-019-0510-1

PMCID:: PMC6953280

Article PDF–1.7M

Select item 69255899.

Natural HIV-1 Nef Polymorphisms Impair SERINC5 Downregulation Activity

Steven W. Jin, Nirmin Alsahafi, Xiaomei T. Kuang, Shayda A. Swann, Mako Toyoda, Heinrich Göttlinger, Bruce D. Walker, Takamasa Ueno, Andrés Finzi, Zabrina L. Brumme, Mark A. Brockman

Cell Rep. Author manuscript; available in PMC 2019 Dec 21.

Published in final edited form as: Cell Rep. 2019 Nov 5; 29(6): 1449–1457.e5. doi: 10.1016/j.celrep.2019.10.007

PMCID:: PMC6925589

Article PDF–1.1M

Select item 691212210.

Multifunctional Roles of the N-Terminal Region of HIV-1_SF2Nef Are Mediated by Three Independent Protein Interaction Sites

Swetha Ananth, Katharina Morath, Birthe Trautz, Nadine Tibroni, Iart Luca Shytaj, Benedikt Obermaier, Bettina Stolp, Marina Lusic, Oliver T. Fackler

J Virol. 2020 Jan; 94(1): e01398-19. Prepublished online 2019 Oct 9. Published online 2019 Dec 12. doi: 10.1128/JVI.01398-19

PMCID:: PMC6912122

Article PDF–1.6M

Select item 664009011.

Nef-Induced Differential Gene Expression in Primary CD4+ T Cells Following Infection with HIV-1 Isolates.

Robert L. Furler, Ayub Ali, Otto O. Yang, Douglas F. Nixon

Virus Genes. Author manuscript; available in PMC 2020 Aug 1.

Published in final edited form as: Virus Genes. 2019 Aug; 55(4): 541–544. Published online 2019 May 15. doi: 10.1007/s11262-019-01670-2

PMCID:: PMC6640090

Article PDF–236K

Select item 652628212.

Nef-mediated inhibition of NFAT following TCR stimulation differs between HIV-1 subtypes

Lisa Naidoo, Zinhle Mzobe, Steven W. Jin, Erasha Rajkoomar, Tarylee Reddy, Mark A. Brockman, Zabrina L. Brumme, Thumbi Ndung’u, Jaclyn K. Mann

Virology. Author manuscript; available in PMC 2020 May 1.

Published in final edited form as: Virology. 2019 May; 531: 192–202. Published online 2019 Feb 21. doi: 10.1016/j.virol.2019.02.011

PMCID:: PMC6526282

Article PDF–1.1M

Select item 614173313.

Killing of Latently HIV-Infected CD4 T Cells by Autologous CD8 T Cells Is Modulated by Nef

Ziv Sevilya, Ehud Chorin, Orit Gal-Garber, Einat Zelinger, Dan Turner, Boaz Avidor, Gideon Berke, David Hassin

Front Immunol. 2018; 9: 2068. Published online 2018 Sep 11. doi: 10.3389/fimmu.2018.02068

PMCID:: PMC6141733

Article PDF–2.8M

Select item 580109814.

Remodeling of HIV-1 Nef Structure by Src-Family Kinase Binding

Jamie A. Moroco, John Jeff Alvarado, Ryan P. Staudt, Haibin Shi, Thomas E. Wales, Thomas E. Smithgall, John R. Engen

J Mol Biol. Author manuscript; available in PMC 2019 Feb 2.

Published in final edited form as: J Mol Biol. 2018 Feb 2; 430(3): 310–321. Published online 2017 Dec 16. doi: 10.1016/j.jmb.2017.12.008

PMCID:: PMC5801098

Article PDF–1.1M

Select item 579231815.

Brain-specific HIV Nef identified in multiple patients with neurological disease

Susanna L. Lamers, Gary B. Fogel, Enoch S. Liu, Andrew E. Barbier, Christopher W. Rodriguez, Elyse J. Singer, David J. Nolan, Rebecca Rose, Michael S. McGrath

J Neurovirol. Author manuscript; available in PMC 2019 Feb 1.

Published in final edited form as: J Neurovirol. 2018 Feb; 24(1): 1–15. Published online 2017 Oct 23. doi: 10.1007/s13365-017-0586-0

PMCID:: PMC5792318

Article PDF–1009K

Select item 556117116.

HIV-1 Nef-induced cardiotoxicity through dysregulation of autophagy

Manish K. Gupta, Rafal Kaminski, Brian Mullen, Jennifer Gordon, Tricia H. Burdo, Joseph Y. Cheung, Arthur M. Feldman, Muniswamy Madesh, Kamel Khalili

Sci Rep. 2017; 7: 8572. Published online 2017 Aug 17. doi: 10.1038/s41598-017-08736-x

PMCID:: PMC5561171

Article PDF–10M

Select item 538637417.

HIV-1 Nef is released in extracellular vesicles derived from astrocytes: evidence for Nef-mediated neurotoxicity

A Sami Saribas, Stephanie Cicalese, Taha Mohseni Ahooyi, Kamel Khalili, Shohreh Amini, Ilker Kudret Sariyer

Cell Death Dis. 2017 Jan; 8(1): e2542. Published online 2017 Jan 12. doi: 10.1038/cddis.2016.467

PMCID:: PMC5386374

Article PDF–2.8M

Select item 524000018.

Short Communication: Accumulation of Neutral Lipids in Liver and Aorta of Nef-Transgenic Mice

Tatiana Pushkarsky, Evgeny Shilov, Natalya Kruglova, Ronald Naumann, Beda Brichacek, Lucas Jennelle, Dmitri Sviridov, Andrei Kruglov, Sergei A. Nedospasov, Michael Bukrinsky

AIDS Res Hum Retroviruses. 2017 Jan 1; 33(1): 57–60. Published online 2017 Jan 1. doi: 10.1089/aid.2016.0128