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Select item 109315771.

Identification of IGF-1 Effects on White Adipose Tissue and Hippocampus in Alzheimer’s Disease Mice via Transcriptomic and Cellular Analysis

Young-Kook Kim, Danbi Jo, Archana Arjunan, Yeongseo Ryu, Yeong-Hwan Lim, Seo Yoon Choi, Hee Kyung Kim, Juhyun Song

Int J Mol Sci. 2024 Mar; 25(5): 2567. Published online 2024 Feb 22. doi: 10.3390/ijms25052567

PMCID:: PMC10931577

Article PDF–6.1M

Select item 108798702.

Mrc1⁺ macrophage-derived IGF1 mitigates crystal nephropathy by promoting renal tubule cell proliferation via the AKT/Rb signaling pathway

Linxi Huang, Wei Chen, Zhuojing Tan, Yunxiao Huang, Xinji Gu, Lantian Liu, Hongxia Zhang, Yihan Shi, Jiarong Ding, Chengjian Zheng, Zhiyong Guo, Bing Yu

Theranostics. 2024; 14(4): 1764–1780. Published online 2024 Feb 17. doi: 10.7150/thno.89174

PMCID:: PMC10879870

Article PDF–17M

Select item 108138443.

Microglia-Derived Insulin-like Growth Factor 1 Is Critical for Neurodevelopment

Dominika Rusin, Lejla Vahl Becirovic, Gabriela Lyszczarz, Martin Krueger, Anouk Benmamar-Badel, Cecilie Vad Mathiesen, Eydís Sigurðardóttir Schiöth, Kate Lykke Lambertsen, Agnieszka Wlodarczyk

Cells. 2024 Jan; 13(2): 184. Published online 2024 Jan 18. doi: 10.3390/cells13020184

PMCID:: PMC10813844

Article PDF–2.9M

Select item 108033904.

Combination of blockade of endothelin signalling and compensation of IGF1 expression protects the retina from degeneration

Naoya Shigesada, Naoya Shikada, Manabu Shirai, Michinori Toriyama, Fumiaki Higashijima, Kazuhiro Kimura, Toru Kondo, Yasumasa Bessho, Takuma Shinozuka, Noriaki Sasai

Cell Mol Life Sci. 2024; 81(1): 51. Published online 2024 Jan 22. doi: 10.1007/s00018-023-05087-x

PMCID:: PMC10803390

Article PDF–3.2M

Select item 107231105.

Role of IGF-I Signaling in Regulating Osteoclastogenesis

Yongmei Wang, Shigeki Nishida, Hashem Z Elalieh, Roger K Long, Bernard P Halloran, Daniel D Bikle

J Bone Miner Res. Author manuscript; available in PMC 2023 Dec 15.

Published in final edited form as: J Bone Miner Res. 2006 Sep; 21(9): 1350–1358. doi: 10.1359/jbmr.060610

PMCID:: PMC10723110

Article PDF–2.0M

Select item 103552886.

Brain IGF-I regulates LTP, spatial memory, and sexual dimorphic behavior

Raquel Herrero-Labrador, Joaquín Fernández-Irigoyen, Rebeca Vecino, Candela González-Arias, Karina Ausín, Inmaculada Crespo, Francisco J Fernández Acosta, Vanesa Nieto-Estévez, M José Román, Gertrudis Perea, Ignacio Torres-Alemán, Enrique Santamaría, Carlos Vicario

Life Sci Alliance. 2023 Oct; 6(10): e202201691. Published online 2023 Jul 18. doi: 10.26508/lsa.202201691

PMCID:: PMC10355288

Article PDF–4.9M

Select item 93716717.

Unexpected role for IGF-1 in starvation: Maintenance of blood glucose

Fei Fang, Joseph L. Goldstein, Xuanming Shi, Guosheng Liang, Michael S. Brown

Proc Natl Acad Sci U S A. 2022 Aug 9; 119(32): e2208855119. Published online 2022 Aug 1. doi: 10.1073/pnas.2208855119

PMCID:: PMC9371671

Article PDF–1.0M

Select item 91016278.

Insulin-like Growth Factor I Couples Metabolism with Circadian Activity through Hypothalamic Orexin Neurons

Jaime Pignatelli, M. Estrella Fernandez de Sevilla, Jacob Sperber, Daniel Horrillo, Gema Medina-Gomez, Ignacio Torres Aleman

Int J Mol Sci. 2022 May; 23(9): 4679. Published online 2022 Apr 23. doi: 10.3390/ijms23094679

PMCID:: PMC9101627

Article PDF–2.4M

Select item 90206189.

Recent developments in the structural characterisation of the IR and IGF1R: implications for the design of IR–IGF1R hybrid receptor modulators

Samuel J. Turvey, Martin J. McPhillie, Mark T. Kearney, Stephen P. Muench, Katie J. Simmons, Colin W. G. Fishwick

RSC Med Chem. 2022 Apr 20; 13(4): 360–374. Published online 2022 Feb 21. doi: 10.1039/d1md00300c

PMCID:: PMC9020618

Article PDF–8.1M

Select item 895992410.

Increased Susceptibility to Cerebral Microhemorrhages Is Associated With Imaging Signs of Microvascular Degeneration in the Retina in an Insulin-Like Growth Factor 1 Deficient Mouse Model of Accelerated Aging

Lauren R. Miller, Stefano Tarantini, Ádám Nyúl-Tóth, Morgan P. Johnston, Teryn Martin, Elizabeth C. Bullen, Marisa A. Bickel, William E. Sonntag, Andriy Yabluchanskiy, Anna Csiszar, Zoltan I. Ungvari, Michael H. Elliott, Shannon M. Conley

Front Aging Neurosci. 2022; 14: 788296. Published online 2022 Mar 9. doi: 10.3389/fnagi.2022.788296

PMCID:: PMC8959924

Article PDF–10M

Select item 878496411.

Liver is a Primary Source of Insulin-like Growth Factor-1 in Skin Wound Healing

Rita E. Roberts, Jacqueline Cavalcante-Silva, Rhonda D. Kineman, Timothy J. Koh

J Endocrinol. Author manuscript; available in PMC 2022 Nov 24.

Published in final edited form as: J Endocrinol. 2021 Nov 24; 252(1): 59–70. Published online 2021 Nov 24. doi: 10.1530/JOE-21-0298

PMCID:: PMC8784964

Article PDF–1.1M

Select item 846180512.

Deletion of muscle Igf1 exacerbates disuse atrophy weakness in mice

Ray A. Spradlin, Georgios Vassilakos, Michael K. Matheny, Nathan C. Jones, Jessica L. Goldman, Hanqin Lei, Elisabeth R. Barton

J Appl Physiol (1985) 2021 Sep 1; 131(3): 881–894. Published online 2021 Jul 22. doi: 10.1152/japplphysiol.00090.2021

PMCID:: PMC8461805

Article

Select item 834815813.

Transcriptomic and Metabolic Network Analysis of Metabolic Reprogramming and IGF-1 Modulation in SCA3 Transgenic Mice

Yu-Te Lin, Yong-Shiou Lin, Wen-Ling Cheng, Jui-Chih Chang, Yi-Chun Chao, Chin-San Liu, An-Chi Wei

Int J Mol Sci. 2021 Aug; 22(15): 7974. Published online 2021 Jul 26. doi: 10.3390/ijms22157974

PMCID:: PMC8348158

Article PDF–7.0M

Select item 800967314.

Selenium supplementation inhibits IGF-1 signaling and confers methionine restriction-like healthspan benefits to mice

Jason D Plummer, Spike DL Postnikoff, Jessica K Tyler, Jay E Johnson

eLife. 2021; 10: e62483. Published online 2021 Mar 30. doi: 10.7554/eLife.62483

PMCID:: PMC8009673

Article PDF–1.9M

Select item 779501115.

Impairment of IGF-1 Signaling and Antioxidant Response Are Associated with Radiation Sensitivity and Mortality

Saeed Y. Aghdam, Doreswamy Kenchegowda, Gregory P. Holmes-Hampton, Maria Moroni, Sanchita P. Ghosh

Int J Mol Sci. 2021 Jan; 22(1): 451. Published online 2021 Jan 5. doi: 10.3390/ijms22010451

PMCID:: PMC7795011

Article PDF–1.7M

Select item 750257716.

Insulin-like Growth Factor-1 and mTORC1 Signaling Promote the Intestinal Regenerative Response After Irradiation Injury

Natacha Bohin, Kevin P. McGowan, Theresa M. Keeley, Elizabeth A. Carlson, Kelley S. Yan, Linda C. Samuelson

Cell Mol Gastroenterol Hepatol. 2020; 10(4): 797–810. Published online 2020 Jun 2. doi: 10.1016/j.jcmgh.2020.05.013

PMCID:: PMC7502577

Article PDF–4.8M

Select item 734892817.

Overlap of Peak Growth Activity and Peak IGF-1 to IGFBP Ratio: Delayed Increase of IGFBPs Versus IGF-1 in Serum as a Mechanism to Speed up and down Postnatal Weight Gain in Mice

Michael Walz, Luong Chau, Christina Walz, Mandy Sawitzky, Daniela Ohde, Julia Brenmoehl, Armin Tuchscherer, Martina Langhammer, Friedrich Metzger, Christine Höflich, Andreas Hoeflich

Cells. 2020 Jun; 9(6): 1516. Published online 2020 Jun 22. doi: 10.3390/cells9061516

PMCID:: PMC7348928

Article PDF–2.6M

Select item 714707018.

Insulin-like growth factor-1 overexpression increases long-term survival of posttrauma-born hippocampal neurons while inhibiting ectopic migration following traumatic brain injury

Erica L. Littlejohn, Danielle Scott, Kathryn E. Saatman

Acta Neuropathol Commun. 2020; 8: 46. Published online 2020 Apr 10. doi: 10.1186/s40478-020-00925-6

PMCID:: PMC7147070

Article PDF–2.9M

Select item 706096819.

Disparate Central and Peripheral Effects of Circulating IGF-1 Deficiency on Tissue Mitochondrial Function

Gavin Pharaoh, Daniel Owen, Alexander Yeganeh, Pavithra Premkumar, Julie Farley, Shylesh Bhaskaran, Nicole Ashpole, Michael Kinter, Holly Van Remmen, Sreemathi Logan

Mol Neurobiol. 2020; 57(3): 1317–1331. Published online 2019 Nov 15. doi: 10.1007/s12035-019-01821-4