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Select item 106799011.

Ketohexokinase-C regulates global protein acetylation to decrease carnitine palmitoyltransferase 1a-mediated fatty acid oxidation

Robert N. Helsley, Se-Hyung Park, Hemendra J. Vekaria, Patrick G. Sullivan, Lindsey R. Conroy, Ramon C. Sun, María del Mar Romero, Laura Herrero, Joanna Bons, Christina D. King, Jacob Rose, Jesse G. Meyer, Birgit Schilling, C. Ronald Kahn, Samir Softic

J Hepatol. Author manuscript; available in PMC 2023 Nov 27.

Published in final edited form as: J Hepatol. 2023 Jul; 79(1): 25–42. Published online 2023 Feb 21. doi: 10.1016/j.jhep.2023.02.010

PMCID:: PMC10679901

Article PDF–2.8M

Select item 102163602.

High Fructose Corn Syrup Accelerates Kidney Disease and Mortality in Obese Mice with Metabolic Syndrome

Ana Andres-Hernando, David J. Orlicky, Christina Cicerchi, Masanari Kuwabara, Gabriela E. Garcia, Takahiko Nakagawa, Laura Gabriela Sanchez-Lozada, Richard J. Johnson, Miguel A. Lanaspa

Biomolecules. 2023 May; 13(5): 780. Published online 2023 Apr 30. doi: 10.3390/biom13050780

PMCID:: PMC10216360

Article PDF–3.3M

Select item 89859143.

Ketohexokinase-mediated fructose metabolism is lost in hepatocellular carcinoma and can be leveraged for metabolic imaging

Sui Seng Tee, Nathaniel Kim, Quinlan Cullen, Roozbeh Eskandari, Arsen Mamakhanyan, Rami M. Srouji, Rachel Chirayil, Sangmoo Jeong, Mojdeh Shakiba, Edward R. Kastenhuber, Shuibing Chen, Carlie Sigel, Scott W. Lowe, William R. Jarnagin, Craig B. Thompson, Andrea Schietinger, Kayvan R. Keshari

Sci Adv. 2022 Apr; 8(14): eabm7985. Published online 2022 Apr 6. doi: 10.1126/sciadv.abm7985

PMCID:: PMC8985914

Article PDF–3.9M

Select item 69888574.

Fructose malabsorption induces cholecystokinin expression in the ileum and cecum by changing microbiota composition and metabolism

Xufei Zhang, Alexandra Grosfeld, Edek Williams, Daniel Vasiliauskas, Sharon Barretto, Lorraine Smith, Mahendra Mariadassou, Catherine Philippe, Fabienne Devime, Chloé Melchior, Guillaume Gourcerol, Nathalie Dourmap, Nicolas Lapaque, Pierre Larraufie, Hervé M. Blottière, Christine Herberden, Philippe Gerard, Jens F. Rehfeld, Ronaldo P. Ferraris, J. Christopher Fritton, Sandrine Ellero-Simatos, Veronique Douard

FASEB J. 2019 Jun; 33(6): 7126–7142. Published online 2019 Apr 2. doi: 10.1096/fj.201801526RR

PMCID:: PMC6988857

Article

Select item 64640655.

Correction of gene model annotations improves isoform abundance estimates: the example of ketohexokinase ( Khk)

Christophe D. Chabbert, Tanja Eberhart, Ilaria Guccini, Wilhelm Krek, Werner J. Kovacs

Version 2. F1000Res. 2018; 7: 1956. Published online 2019 Apr 3. doi: 10.12688/f1000research.17082.2

PMCID:: PMC6464065

Article PDF–4.8M

Select item 63948556.

Lacking Ketohexokinase-A Exacerbates Renal Injury in Streptozotocin-induced Diabetic Mice

Tomohito Doke, Takuji Ishimoto, Takahiro Hayasaki, Satsuki Ikeda, Masako Hasebe, Akiyoshi Hirayama, Tomoyoshi Soga, Noritoshi Kato, Tomoki Kosugi, Naotake Tsuboi, Miguel A. Lanaspa, Richard J. Johnson, Kenji Kadomatsu, Shoichi Maruyama

Metabolism. Author manuscript; available in PMC 2019 Aug 1.

Published in final edited form as: Metabolism. 2018 Aug; 85: 161–170. Published online 2018 Mar 29. doi: 10.1016/j.metabol.2018.03.020

PMCID:: PMC6394855

Article PDF–1.0M

Select item 58665457.

High salt intake causes leptin resistance and obesity in mice by stimulating endogenous fructose production and metabolism

Miguel A. Lanaspa, Masanari Kuwabara, Ana Andres-Hernando, Nanxing Li, Christina Cicerchi, Thomas Jensen, David J. Orlicky, Carlos A. Roncal-Jimenez, Takuji Ishimoto, Takahiko Nakagawa, Bernardo Rodriguez-Iturbe, Paul S. MacLean, Richard J. Johnson

Proc Natl Acad Sci U S A. 2018 Mar 20; 115(12): 3138–3143. Published online 2018 Mar 5. doi: 10.1073/pnas.1713837115

Correction in:: Proc Natl Acad Sci U S A. 2018 Oct 2; 115(40): E9509.

PMCID:: PMC5866545

Article PDF–1.3M

Select item 53168078.

Protective role of fructokinase blockade in the pathogenesis of acute kidney injury in mice

Ana Andres-Hernando, Nanxing Li, Christina Cicerchi, Shinichiro Inaba, Wei Chen, Carlos Roncal-Jimenez, Myphuong T. Le, Michael F. Wempe, Tamara Milagres, Takuji Ishimoto, Mehdi Fini, Takahiko Nakagawa, Richard J. Johnson, Miguel A. Lanaspa

Nat Commun. 2017; 8: 14181. Published online 2017 Feb 13. doi: 10.1038/ncomms14181

PMCID:: PMC5316807

Article PDF–3.2M

Select item 52884849.

Role of fructose and fructokinase in acute dehydration-induced vasopressin gene expression and secretion in mice

Zhilin Song (宋志林), Carlos A. Roncal-Jimenez, Miguel A. Lanaspa-Garcia, Sarah A. Oppelt, Masanari Kuwabara, Thomas Jensen, Tamara Milagres, Ana Andres-Hernando, Takuji Ishimoto, Gabriela E. Garcia, Ginger Johnson, Paul S. MacLean, Laura-Gabriela Sanchez-Lozada, Dean R. Tolan, Richard J. Johnson

J Neurophysiol. 2017 Feb 1; 117(2): 646–654. Published online 2016 Nov 16. doi: 10.1152/jn.00781.2016

PMCID:: PMC5288484

Article

Select item 514223210.

Aging-associated renal disease in mice is fructokinase dependent

Carlos A. Roncal-Jimenez, Takuji Ishimoto, Miguel A. Lanaspa, Tamara Milagres, Ana Andres Hernando, Thomas Jensen, Makoto Miyazaki, Tomohito Doke, Takahiro Hayasaki, Takahiko Nakagawa, Shoichi Marumaya, David A. Long, Gabriela E. Garcia, Masanari Kuwabara, Laura G. Sánchez-Lozada, Duk-Hee Kang, Richard J. Johnson

Am J Physiol Renal Physiol. 2016 Oct 1; 311(4): F722–F730. Published online 2016 Jul 27. doi: 10.1152/ajprenal.00306.2016

PMCID:: PMC5142232

Article

Select item 412067211.

Fructokinase activity mediates dehydration-induced renal injury

Carlos A Roncal Jimenez, Takuji Ishimoto, Miguel A Lanaspa, Christopher J Rivard, Takahiko Nakagawa, A. Ahsan Ejaz, Christina Cicerchi, Shinichiro Inaba, MyPhuong Le, Makoto Miyazaki, Jason Glaser, Ricardo Correa-Rotter, Marvin A González, Aurora Aragón, Catharina Wesseling, Laura G Sánchez-Lozada, Richard J Johnson

Kidney Int. 2014 Aug; 86(2): 294–302. Published online 2013 Dec 11. doi: 10.1038/ki.2013.492

PMCID:: PMC4120672

Article PDF–4.0M

Select item 389425912.

High Fat and High Sucrose (Western) Diet Induce Steatohepatitis that is Dependent on Fructokinase

Takuji Ishimoto, Miguel A. Lanaspa, Christopher J. Rivard, Carlos A. Roncal-Jimenez, David J. Orlicky, Christina Cicerchi, Rachel H. McMahan, Manal F. Abdelmalek, Hugo R. Rosen, Matthew R. Jackman, Paul S. MacLean, Christine P. Diggle, Aruna Asipu, Shinichiro Inaba, Tomoki Kosugi, Waichi Sato, Shoichi Maruyama, Laura G. Sánchez-Lozada, Yuri Y. Sautin, James O. Hill, David T. Bonthron, Richard J. Johnson

Hepatology. Author manuscript; available in PMC 2014 Nov 1.

Published in final edited form as: Hepatology. 2013 Nov; 58(5): 1632–1643. Published online 2013 Oct 8. doi: 10.1002/hep.26594

PMCID:: PMC3894259

Article PDF–1.8M

Select item 383367213.

Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome

Miguel A Lanaspa, Takuji Ishimoto, Nanxing Li, Christina Cicerchi, David J. Orlicky, Philip Ruzicky, Christopher Rivard, Shinichiro Inaba, Carlos A. Roncal-Jimenez, Elise S. Bales, Christine P. Diggle, Aruna Asipu, J. Mark Petrash, Tomoki Kosugi, Shoichi Maruyama, Laura G. Sanchez-Lozada, James L. McManaman, David T Bonthron, Yuri Y. Sautin, Richard J. Johnson

Nat Commun. Author manuscript; available in PMC 2014 Mar 11.

Published in final edited form as: Nat Commun. 2013; 4: 2434. doi: 10.1038/ncomms3434

Correction in:: Nat Commun, volume 4 on page 2929

PMCID:: PMC3833672

Article PDF–1.2M

Select item 734744414.

Deletion of fructokinase in the liver or in the intestine reveals differential effects on sugar-induced metabolic dysfunction

Ana Andres-Hernando, David J. Orlicky, Masanari Kuwabara, Takuji Ishimoto, Takahiko Nakagawa, Richard J. Johnson, Miguel A. Lanaspa

Cell Metab. Author manuscript; available in PMC 2021 Jul 7.

Published in final edited form as: Cell Metab. 2020 Jul 7; 32(1): 117–127.e3. Published online 2020 Jun 4. doi: 10.1016/j.cmet.2020.05.012

PMCID:: PMC7347444

Article PDF–2.2M

Select item 549591315.

Nutrient sensing by absorptive and secretory progenies of small intestinal stem cells

Kunihiro Kishida, Sarah C. Pearce, Shiyan Yu, Nan Gao, Ronaldo P. Ferraris

Am J Physiol Gastrointest Liver Physiol. 2017 Jun 1; 312(6): G592–G605. Published online 2017 Mar 23. doi: 10.1152/ajpgi.00416.2016

PMCID:: PMC5495913

Article

Select item 462896816.

Effect of dietary fructose on portal and systemic serum fructose levels in rats and in KHK^−/− and GLUT5^−/− mice

Chirag Patel, Keiichiro Sugimoto, Veronique Douard, Ami Shah, Hiroshi Inui, Toshikazu Yamanouchi, Ronaldo P. Ferraris

Am J Physiol Gastrointest Liver Physiol. 2015 Nov 1; 309(9): G779–G790. Published online 2015 Aug 27. doi: 10.1152/ajpgi.00188.2015

PMCID:: PMC4628968

Article

Select item 421452217.

Endogenous Fructose Production and Fructokinase Activation Mediate Renal Injury in Diabetic Nephropathy

Miguel A. Lanaspa, Takuji Ishimoto, Christina Cicerchi, Yoshifuru Tamura, Carlos A. Roncal-Jimenez, Wei Chen, Katsuyuki Tanabe, Ana Andres-Hernando, David J. Orlicky, Esteban Finol, Shinichiro Inaba, Nanxing Li, Christopher J. Rivard, Tomoki Kosugi, Laura G. Sanchez-Lozada, J. Mark Petrash, Yuri Y. Sautin, A. Ahsan Ejaz, Wataru Kitagawa, Gabriela E. Garcia, David T. Bonthron, Aruna Asipu, Christine P. Diggle, Bernardo Rodriguez-Iturbe, Takahiko Nakagawa, Richard J. Johnson

J Am Soc Nephrol. 2014 Nov; 25(11): 2526–2538. Published online 2014 May 29. doi: 10.1681/ASN.2013080901

PMCID:: PMC4214522

Article

Select item 271307618.

Ketohexokinase: Expression and Localization of the Principal Fructose-metabolizing Enzyme

Christine P. Diggle, Michael Shires, Derek Leitch, David Brooke, Ian M. Carr, Alex F. Markham, Bruce E. Hayward, Aruna Asipu, David T. Bonthron

J Histochem Cytochem. 2009 Aug; 57(8): 763–774. doi: 10.1369/jhc.2009.953190

PMCID:: PMC2713076

Article PDF–2.9M

Select item 868668519.

Dietary Fructose Improves Intestinal Cell Survival and Nutrient Absorption

Samuel R. Taylor, Shakti Ramsamooj, Roger J. Liang, Alyna Katti, Rita Pozovskiy, Neil Vasan, Seo-Kyoung Hwang, Navid Nahiyaan, Nancy J. Francoeur, Emma M. Schatoff, Jared L. Johnson, Manish A. Shah, Andrew J. Dannenberg, Robert P. Sebra, Lukas E. Dow, Lewis C. Cantley, Kyu Y. Rhee, Marcus D. Goncalves

Nature. Author manuscript; available in PMC 2022 Sep 1.

Published in final edited form as: Nature. 2021 Sep; 597(7875): 263–267. Published online 2021 Aug 18. doi: 10.1038/s41586-021-03827-2

PMCID:: PMC8686685

Article PDF–4.5M

Select item 747391120.

Sugar causes obesity and metabolic syndrome in mice independently of sweet taste

Ana Andres-Hernando, Masanari Kuwabara, David J. Orlicky, Aurelie Vandenbeuch, Christina Cicerchi, Sue C. Kinnamon, Thomas E. Finger, Richard J. Johnson, Miguel A. Lanaspa

Am J Physiol Endocrinol Metab. 2020 Aug 1; 319(2): E276–E290. Published online 2020 Jun 23. doi: 10.1152/ajpendo.00529.2019

PMCID:: PMC7473911

Article

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