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Select item 76421101.

CRISPR/Cas9-Mediated Point Mutation in Nkx3.1 Prolongs Protein Half-Life and Reverses Effects Nkx3.1 Allelic Loss

Cai Bowen, Maho Shibata, Hailan Zhang, Sarah K. Bergren, Michael M. Shen, Edward P. Gelmann

Cancer Res. Author manuscript; available in PMC 2021 May 1.

Published in final edited form as: Cancer Res. 2020 Nov 1; 80(21): 4805–4814. Published online 2020 Sep 17. doi: 10.1158/0008-5472.CAN-20-1742

PMCID:: PMC7642110

Article PDF–3.8M

Select item 76116242.

NKX3.1 localization to mitochondria suppresses prostate cancer initiation

Alexandros Papachristodoulou, Antonio Rodriguez-Calero, Sukanya Panja, Elizabeth Margolskee, Renu K. Virk, Teresa A. Milner, Luis Pina Martina, Jaime Y. Kim, Matteo Di Bernardo, Alanna B. Williams, Elvis A. Maliza, Joseph M. Caputo, Christopher Haas, Vinson Wang, Guarionex Joel De Castro, Sven Wenske, Hanina Hibshoosh, James M. McKiernan, Michael M. Shen, Mark A. Rubin, Antonina Mitrofanova, Aditya Dutta, Cory Abate-Shen

Cancer Discov. Author manuscript; available in PMC 2022 Mar 1.

Published in final edited form as: Cancer Discov. 2021 Sep; 11(9): 2316–2333. Published online 2021 Apr 23. doi: 10.1158/2159-8290.CD-20-1765

PMCID:: PMC7611624

Article PDF–3.3M

Select item 60438303.

Intronic DNA Elements Regulate Androgen-Dependent Expression of the Murine Nkx3.1 Gene

Chinatsu Kojima, Yan Zhang, Warren E. Zimmer

Gene Expr. 2011; 15(2): 89–102. Published online 2018 Jul 13. doi: 10.3727/105221611x12973615737622

PMCID:: PMC6043830

Article PDF–595K

Select item 47384284.

Nkx3.1 controls the DNA repair response in the mouse prostate

Hailan Zhang, Tian Zheng, Chee Wai Chua, Michael Shen, Edward P. Gelmann

Prostate. 2016 Mar; 76(4): 402–408. Published online 2015 Dec 10. doi: 10.1002/pros.23131

PMCID:: PMC4738428

Article PDF–2.4M

Select item 37880825.

Canonical Wnt signaling regulates Nkx3.1 expression and luminal epithelial differentiation during prostate organogenesis

Marianna Kruithof-de Julio, Maho Shibata, Nishita Desai, Melissa Reynon, M. Vivienne Halili, Ya-Ping Hu, Sandy M. Price, Cory Abate-Shen, Michael M. Shen

Dev Dyn. Author manuscript; available in PMC 2014 Oct 1.

Published in final edited form as: Dev Dyn. 2013 Oct; 242(10): 1160–1171. Published online 2013 Jul 29. doi: 10.1002/dvdy.24008

PMCID:: PMC3788082

Article PDF–6.0M

Select item 34719146.

Antioxidant Treatment Promotes Prostate Epithelial Proliferation in Nkx3.1 Mutant Mice

Erin E. Martinez, Philip D. Anderson, Monica Logan, Sarki A. Abdulkadir

PLoS One. 2012; 7(10): e46792. Published online 2012 Oct 15. doi: 10.1371/journal.pone.0046792

PMCID:: PMC3471914

Article PDF–927K

Select item 28193897.

Distinct Regulatory Elements Mediate the Dynamic Expression Pattern of Nkx3.1

Hui Chen, Laura N. Mutton, Gail S. Prins, Charles J. Bieberich

Dev Dyn. Author manuscript; available in PMC 2010 Feb 10.

Published in final edited form as: Dev Dyn. 2005 Dec; 234(4): 961. doi: 10.1002/dvdy.20596

PMCID:: PMC2819389

Article PDF–2.3M

Select item 97418658.

Loss of IGF2 gene imprinting in murine prostate promotes widespread neoplastic growth

Nathan A. Damaschke, Bing Yang, Sachin Bhusari, Mele Avilla, Weixiong Zhong, Michael L. Blute, Jr., Wei Huang, David F. Jarrard

Cancer Res. Author manuscript; available in PMC 2022 Dec 11.

Published in final edited form as: Cancer Res. 2017 Oct 1; 77(19): 5236–5247. Published online 2017 Aug 3. doi: 10.1158/0008-5472.CAN-16-3089

PMCID:: PMC9741865

Article PDF–2.1M

Select item 56433049.

Analysis of Nkx3.1:Cre-driven Erk5 deletion reveals a profound spinal deformity which is linked to increased osteoclast activity

Carolyn J. Loveridge, Rob J. van ’t Hof, Gemma Charlesworth, Ayala King, Ee Hong Tan, Lorraine Rose, Anna Daroszewska, Amanda Prior, Imran Ahmad, Michelle Welsh, Ernest J. Mui, Catriona Ford, Mark Salji, Owen Sansom, Karen Blyth, Hing Y. Leung

Sci Rep. 2017; 7: 13241. Published online 2017 Oct 16. doi: 10.1038/s41598-017-13346-8

PMCID:: PMC5643304

Article PDF–7.4M

Select item 560082310.

Co-clinical Analysis of a Genetically Engineered Mouse Model and Human Prostate Cancer Reveals Significance of NKX3.1 Expression for Response to 5α-reductase Inhibition

Aditya Dutta, Sukanya Panja, Renu K. Virk, Jaime Yeji Kim, Roseann Zott, Serge Cremers, David M. Golombos, Deli Liu, Juan Miguel Mosquera, Elahe A. Mostaghel, Christopher E. Barbieri, Antonina Mitrofanova, Cory Abate-Shen

Eur Urol. Author manuscript; available in PMC 2018 Oct 1.

Published in final edited form as: Eur Urol. 2017 Oct; 72(4): 499–506. Published online 2017 Apr 4. doi: 10.1016/j.eururo.2017.03.031

PMCID:: PMC5600823

Article PDF–1.6M

Select item 556651211.

Transcriptional regulation of the Nkx3.1 gene in prostate luminal stem cell specification and cancer initiation via its 3′ genomic region

Qing Xie, Zhu A. Wang

J Biol Chem. 2017 Aug 18; 292(33): 13521–13530. Published online 2017 Jul 5. doi: 10.1074/jbc.M117.788315

PMCID:: PMC5566512

Article PDF–3.7M

Select item 397863112.

Lack of an Additive Effect between the Deletions of Klf5 and Nkx3-1 in Mouse Prostatic Tumorigenesis

Changsheng Xing, Xiaoying Fu, Xiaodong Sun, Jin-Tang Dong

J Genet Genomics. Author manuscript; available in PMC 2014 Apr 8.

Published in final edited form as: J Genet Genomics. 2013 Jun 20; 40(6): 315–318. Published online 2013 May 2. doi: 10.1016/j.jgg.2013.04.005

PMCID:: PMC3978631

Article PDF–1.8M

Select item 348487213.

Initiation of prostate cancer in mice by Tp53^R270H: evidence for an alternative molecular progression

Ruth L. Vinall, Jane Q. Chen, Neil E. Hubbard, Shola S. Sulaimon, Michael M. Shen, Ralph W. DeVere White, Alexander D. Borowsky

Dis Model Mech. 2012 Nov; 5(6): 914–920. Published online 2012 Apr 12. doi: 10.1242/dmm.008995

PMCID:: PMC3484872

Article

Select item 343267614.

Dual targeting of the Akt/mTOR signaling pathway inhibits castration-resistant prostate cancer in a genetically engineered mouse model

Nicolas Floc'h, Carolyn Waugh Kinkade, Takashi Kobayashi, Alvaro Aytes, Celine Lefebvre, Antonina Mitrofanova, Robert D. Cardiff, Andrea Califano, Michael M. Shen, Cory Abate-Shen

Cancer Res. Author manuscript; available in PMC 2013 Sep 1.

Published in final edited form as: Cancer Res. 2012 Sep 1; 72(17): 4483–4493. Published online 2012 Jul 19. doi: 10.1158/0008-5472.CAN-12-0283

Correction in:: Cancer Res. 2023 Apr 4; 83(7): 1160.

PMCID:: PMC3432676

Article PDF–2.8M

Select item 340713715.

Transcriptional Activation of Prostate Specific Homeobox Gene NKX3-1 in Subsets of T-Cell Lymphoblastic Leukemia (T-ALL)

Stefan Nagel, Stefan Ehrentraut, Jürgen Tomasch, Stefan Lienenklaus, Björn Schneider, Robert Geffers, Corinna Meyer, Maren Kaufmann, Hans G. Drexler, Roderick A. F. MacLeod

PLoS One. 2012; 7(7): e40747. Published online 2012 Jul 27. doi: 10.1371/journal.pone.0040747

PMCID:: PMC3407137

Article PDF–2.7M

Select item 314095016.

Autophagy promotes necrosis in apoptosis-deficient cells in response to ER stress

E Ullman, Y Fan, M Stawowczyk, H-M Chen, Z Yue, W-X Zong

Cell Death Differ. Author manuscript; available in PMC 2011 Jul 21.

Published in final edited form as: Cell Death Differ. 2008 Feb; 15(2): 422–425. Published online 2007 Oct 5. doi: 10.1038/sj.cdd.4402234

PMCID:: PMC3140950

Article PDF–860K

Select item 286109117.

Loss of Nkx3.1 Expression in Bacterial Prostatitis : A Potential Link Between Inflammation and Neoplasia

May Khalili, Laura N. Mutton, Bora Gurel, Jessica L. Hicks, Angelo M. De Marzo, Charles J. Bieberich

Am J Pathol. 2010 May; 176(5): 2259–2268. doi: 10.2353/ajpath.2010.080747

PMCID:: PMC2861091

Article PDF–1.4M

Select item 281153718.

Stromal TGF-ß signaling mediates prostatic response to androgen ablation by paracrine Wnt activity

Veronica R. Placencio, Ali-Reza Sharif-Afshar, Xiaohong Li, Hongxia Huang, Consolate Uwamariya, Eric G. Neilson, Michael M. Shen, Robert J. Matusik, Simon W. Hayward, Neil A. Bhowmick

Cancer Res. Author manuscript; available in PMC 2010 Jan 26.

Published in final edited form as: Cancer Res. 2008 Jun 15; 68(12): 4709–4718. doi: 10.1158/0008-5472.CAN-07-6289

PMCID:: PMC2811537

Article PDF–4.2M

Select item 253888619.

A causal role for ERG in neoplastic transformation of prostate epithelium

Olga Klezovitch, Michael Risk, Ilsa Coleman, Jared M. Lucas, Manda Null, Lawrence D. True, Peter S. Nelson, Valeri Vasioukhin

Proc Natl Acad Sci U S A. 2008 Feb 12; 105(6): 2105–2110. Published online 2008 Feb 1. doi: 10.1073/pnas.0711711105

PMCID:: PMC2538886

Article PDF–1.3M

Select item 251807420.

Targeting AKT/mTOR and ERK MAPK signaling inhibits hormone-refractory prostate cancer in a preclinical mouse model

Carolyn Waugh Kinkade, Mireia Castillo-Martin, Anna Puzio-Kuter, Jun Yan, Thomas H. Foster, Hui Gao, Yvonne Sun, Xuesong Ouyang, William L. Gerald, Carlos Cordon-Cardo, Cory Abate-Shen

J Clin Invest. 2008 Sep 2; 118(9): 3051–3064. Published online 2008 Aug 21. doi: 10.1172/JCI34764

PMCID:: PMC2518074

Article PDF–2.2M

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