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Select item 78844711.

P2RX1-Involved Glycolytic Metabolism Supports Neutrophil Activation in Acute Pancreatitis

Xu Wang, Dadong Liu, Weiting Qin, Yishu Liu, Xiao Yuan, Xiaoxin Zhang, Chunhua Dai, Danyi Zhang

Front Immunol. 2020; 11: 549179. Published online 2021 Feb 2. doi: 10.3389/fimmu.2020.549179

PMCID:: PMC7884471

Abstract Article PDF–2.9M

Select item 77944392.

Identification of a subset of immunosuppressive P2RX1-negative neutrophils in pancreatic cancer liver metastasis

Xu Wang, Li-Peng Hu, Wei-Ting Qin, Qin Yang, De-Yu Chen, Qing Li, Kai-Xia Zhou, Pei-Qi Huang, Chun-Jie Xu, Jun Li, Lin-Li Yao, Ya-Hui Wang, Guang-Ang Tian, Jian-Yu Yang, Min-Wei Yang, De-Jun Liu, Yong-Wei Sun, Shu-Heng Jiang, Xue-Li Zhang, Zhi-Gang Zhang

Nat Commun. 2021; 12: 174. Published online 2021 Jan 8. doi: 10.1038/s41467-020-20447-y

PMCID:: PMC7794439

Abstract Article PDF–6.5M

Select item 64357403.

The ATP-gated P2X₁ ion channel contributes to the severity of antibody-mediated Transfusion-Related Acute Lung Injury in mice

Marie-Belle El Mdawar, Blandine Maître, Stéphanie Magnenat, Christian Gachet, Béatrice Hechler, Henri de la Salle

Sci Rep. 2019; 9: 5159. Published online 2019 Mar 26. doi: 10.1038/s41598-019-41742-9

PMCID:: PMC6435740

Abstract Article PDF–1.9M

Select item 41999604.

P2X1 expressed on polymorphonuclear neutrophils and platelets is required for thrombosis in mice

Roxane Darbousset, Céline Delierneux, Soraya Mezouar, Alexandre Hego, Christelle Lecut, Isabelle Guillaumat, Markus A. Riederer, Richard J. Evans, Françoise Dignat-George, Laurence Panicot-Dubois, Cécile Oury, Christophe Dubois

Blood. 2014 Oct 16; 124(16): 2575–2585. Prepublished online 2014 Aug 22. doi: 10.1182/blood-2014-04-571679

PMCID:: PMC4199960

Abstract Article

Select item 27902645.

Nerve-evoked purinergic signalling suppresses action potentials, Ca²⁺ flashes and contractility evoked by muscarinic receptor activation in mouse urinary bladder smooth muscle

Thomas J Heppner, Matthias E Werner, Bernhard Nausch, Catherine Vial, Richard J Evans, Mark T Nelson

J Physiol. 2009 Nov 1; 587(Pt 21): 5275–5288. Published online 2009 Sep 7. doi: 10.1113/jphysiol.2009.178806

PMCID:: PMC2790264

Abstract Article PDF–819K

Select item 21510086.

Electrical and optical study of nerve impulse-evoked ATP-induced, P2X-receptor-mediated sympathetic neurotransmission at single smooth muscle cells in mouse isolated vas deferens

J.S. Young, K.L. Brain, T.C. Cunnane

Neuroscience. 2007 Aug 10; 148(1): 82–91. doi: 10.1016/j.neuroscience.2007.05.044

PMCID:: PMC2151008

Abstract Article

Select item 98980317.

P2X1 enhances leukemogenesis through PBX3-BCAT1 pathways

Xiaoxiao He, Yilu Xu, Dan Huang, Zhuo Yu, Jing Yu, Li Xie, Ligen Liu, Ye Yu, Chiqi Chen, Jiangbo Wan, Yaping Zhang, Junke Zheng

Leukemia. 2023; 37(2): 265–275. Published online 2022 Nov 23. doi: 10.1038/s41375-022-01759-y

PMCID:: PMC9898031

Abstract Article PDF–3.9M

Select item 45789908.

Mechanisms underlying uridine adenosine tetraphosphate-induced vascular contraction in mouse aorta: role of thromboxane and purinergic receptors

Zhichao Zhou, Changyan Sun, Stephen L. Tilley, Jamal Mustafa

Vascul Pharmacol. Author manuscript; available in PMC 2016 Oct 1.

Published in final edited form as: Vascul Pharmacol. 2015 Oct; 73: 78–85. Published online 2015 Apr 25. doi: 10.1016/j.vph.2015.04.009

PMCID:: PMC4578990

Abstract Article PDF–2.3M

Select item 41925129.

Nucleoside Triphosphate Diphosphohydrolase-1 Ectonucleotidase Is Required for Normal Vas Deferens Contraction and Male Fertility through Maintaining P2X1 Receptor Function

Gilles Kauffenstein, Julie Pelletier, Elise G. Lavoie, Filip Kukulski, Mireia Martín-Satué, Sébastien S. Dufresne, Jérôme Frenette, Cristina Ribas Fürstenau, Michal J. Sereda, Bertrand Toutain, Daniel Henrion, Robert Sullivan, Catherine Vial, Jean Sévigny

J Biol Chem. 2014 Oct 10; 289(41): 28629–28639. Published online 2014 Aug 25. doi: 10.1074/jbc.M114.604082

PMCID:: PMC4192512

Abstract Article PDF–2.1M

Select item 387070710.

Male contraception via simultaneous knockout of α_1A-adrenoceptors and P2X1-purinoceptors in mice

Carl W. White, Yan-Ting Choong, Jennifer L. Short, Betty Exintaris, Daniel T. Malone, Andrew M. Allen, Richard J. Evans, Sabatino Ventura

Proc Natl Acad Sci U S A. 2013 Dec 17; 110(51): 20825–20830. Published online 2013 Dec 2. doi: 10.1073/pnas.1318624110

PMCID:: PMC3870707

Abstract Article PDF–1.0M

Select item 288681511.

P2X₁ receptor blockade inhibits whole kidney autoregulation of renal blood flow in vivo

David A. Osmond, Edward W. Inscho

Am J Physiol Renal Physiol. 2010 Jun; 298(6): F1360–F1368. Published online 2010 Mar 24. doi: 10.1152/ajprenal.00016.2010

PMCID:: PMC2886815

Abstract Article

Select item 257308412.

Ectodomain Lysines and Suramin Block of P2X₁ Receptors

Joan A. Sim, Helen E. Broomhead, R. Alan North

J Biol Chem. 2008 Oct 31; 283(44): 29841–29846. doi: 10.1074/jbc.M802523200

PMCID:: PMC2573084

Abstract Article PDF–459K

Select item 219416613.

A Role of the Fast ATP-gated P2X₁ Cation Channel in Thrombosis of Small Arteries In Vivo

Béatrice Hechler, Nadège Lenain, Patrizia Marchese, Catherine Vial, Véronique Heim, Monique Freund, Jean-Pierre Cazenave, Marco Cattaneo, Zaverio M. Ruggeri, Richard Evans, Christian Gachet

J Exp Med. 2003 Aug 18; 198(4): 661–667. doi: 10.1084/jem.20030144

PMCID:: PMC2194166

Abstract Article PDF–246K

Select item 203450814.

P2X₁ and P2X₄ receptor currents in mouse macrophages

J A Sim, C-K Park, S B Oh, R J Evans, R A North

Br J Pharmacol. 2007 Dec; 152(8): 1283–1290. Published online 2007 Oct 15. doi: 10.1038/sj.bjp.0707504

PMCID:: PMC2034508

Abstract Article PDF–259K

Select item 157314915.

A study of P2X₁ receptor function in murine megakaryocytes and human platelets reveals synergy with P2Y receptors

Catherine Vial, Michael G Rolf, Martyn P Mahaut-Smith, Richard J Evans

Br J Pharmacol. 2002 Jan; 135(2): 363–372. doi: 10.1038/sj.bjp.0704486

PMCID:: PMC1573149

Abstract Article PDF–428K

Select item 29699316.

Physiological role for P2X₁ receptors in renal microvascular autoregulatory behavior

Edward W. Inscho, Anthony K. Cook, John D. Imig, Catherine Vial, Richard J. Evans

J Clin Invest. 2003 Dec 15; 112(12): 1895–1905. doi: 10.1172/JCI18499

PMCID:: PMC296993

Abstract Article PDF–560K

Select item 1069353617.

P2rx1 deficiency alleviates acetaminophen-induced acute liver failure by regulating the STING signaling pathway

Yeping Yu, Ling Chang, Qingluan Hu, Jianjun Zhu, Jianjun Zhang, Qiang Xia, Jie Zhao

Cell Biol Toxicol. 2023; 39(6): 2761–2774. Published online 2023 Apr 13. doi: 10.1007/s10565-023-09800-1

PMCID:: PMC10693536

Abstract Article PDF–11M

Select item 121989818.

P2 receptor subtypes in the cardiovascular system.

S P Kunapuli, J L Daniel

Biochem J. 1998 Dec 15; 336(Pt 3): 513–523. doi: 10.1042/bj3360513

PMCID:: PMC1219898

Summary PDF–190K

Select item 538221219.

P2X₁, P2X₄, and P2X₇ Receptor Knock Out Mice Expose Differential Outcome of Sepsis Induced by α-Haemolysin Producing Escherichia coli

Anne-Sofie Greve, Marianne Skals, Steen K. Fagerberg, Wulf Tonnus, Svend Ellermann-Eriksen, Richard J. Evans, Andreas Linkermann, Helle A. Praetorius

Front Cell Infect Microbiol. 2017; 7: 113. Published online 2017 Apr 6. doi: 10.3389/fcimb.2017.00113

PMCID:: PMC5382212

Abstract Article PDF–3.1M

Select item 819979220.

Update of P2X receptor properties and their pharmacology: IUPHAR Review 30

Peter Illes, Christa E. Müller, Kenneth A. Jacobson, Thomas Grutter, Annette Nicke, Samuel J. Fountain, Charles Kennedy, Günther Schmalzing, Michael F. Jarvis, Stanko S. Stojilkovic, Brian F. King, Francesco Di Virgilio

Br J Pharmacol. Author manuscript; available in PMC 2022 Feb 1.

Published in final edited form as: Br J Pharmacol. 2021 Feb; 178(3): 489–514. Published online 2020 Dec 21. doi: 10.1111/bph.15299