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Items: 1 to 20 of 175

1.
DYRK1A: a down syndrome-related dual protein kinase with a versatile role in tumorigenesis
Amina Jamal Laham, Maha Saber-Ayad, Raafat El-Awady
Cell Mol Life Sci. 2021 Jan; 78(2): 603–619. Published online 2020 Sep 1. doi: 10.1007/s00018-020-03626-4
PMCID:
PMC11071757
AbstractArticlePDF–1.6M
2.
DYRK1A is a multifunctional host factor that regulates coronavirus replication in a kinase-independent manner
Zhen Fu, Yixin Xiang, Yanan Fu, Zhelin Su, Yubei Tan, Mengfang Yang, Yuanyuan Yan, Hakimeh Baghaei Daemi, Yuejun Shi, Shengsong Xie, Limeng Sun, Guiqing Peng
J Virol. 2024 Jan; 98(1): e01239-23. Published online 2023 Dec 15. doi: 10.1128/jvi.01239-23
PMCID:
PMC10805018
AbstractArticlePDF–5.0M
3.
Dose imbalance of DYRK1A kinase causes systemic progeroid status in Down syndrome by increasing the un-repaired DNA damage and reducing LaminB1 levels
Aoife Murray, Gillian Gough, Ana Cindrić, Frano Vučković, David Koschut, Vincenzo Borelli, Dražen J. Petrović, Ana Bekavac, Ante Plećaš, Valentina Hribljan, Reinhard Brunmeir, Julija Jurić, Maja Pučić-Baković, Anita Slana, Helena Deriš, Azra Frkatović, Jűrgen Groet, Niamh L. O’Brien, Hong Yu Chen, Yee Jie Yeap, Frederic Delom, Steven Havlicek, Luke Gammon, Sarah Hamburg, Carla Startin, Hana D’Souza, Dinko Mitrečić, Mijana Kero, Ljubica Odak, Božo Krušlin, Željka Krsnik, Ivica Kostović, Jia Nee Foo, Yuin-Han Loh, Norris Ray Dunn, Susana de la Luna, Tim Spector, Ingeborg Barišić, Michael S.C. Thomas, Andre Strydom, Claudio Franceschi, Gordan Lauc, Jasminka Krištić, Ivan Alić, Dean Nižetić
eBioMedicine. 2023 Aug; 94: 104692. Published online 2023 Jul 12. doi: 10.1016/j.ebiom.2023.104692
PMCID:
PMC10435767
AbstractArticlePDF–4.3M
4.
The Conserved Transcriptional Activation Activity Identified in Dual-Specificity Tyrosine-(Y)-Phosphorylation-Regulated Kinase 1
Xiuke Ouyang, Zhuqing Wang, Bingtong Wu, Xiuxia Yang, Bo Dong
Biomolecules. 2023 Feb; 13(2): 283. Published online 2023 Feb 2. doi: 10.3390/biom13020283
PMCID:
PMC9953678
AbstractArticlePDF–3.5M
5.
The Omnipresence of DYRK1A in Human Diseases
Estelle Deboever, Alessandra Fistrovich, Christopher Hulme, Travis Dunckley
Int J Mol Sci. 2022 Aug; 23(16): 9355. Published online 2022 Aug 19. doi: 10.3390/ijms23169355
PMCID:
PMC9408930
AbstractArticlePDF–1.4M
6.
The chromosome 21 kinase DYRK1A: emerging roles in cancer biology and potential as a therapeutic target
Malini Rammohan, Ethan Harris, Rahul S. Bhansali, Emily Zhao, Loretta S. Li, John D. Crispino
Oncogene. Author manuscript; available in PMC 2022 Aug 26.
Published in final edited form as: Oncogene. 2022 Apr; 41(14): 2003–2011. Published online 2022 Feb 26. doi: 10.1038/s41388-022-02245-6
PMCID:
PMC8977259
AbstractArticlePDF–668K
7.
Novel and Potential Small Molecule Scaffolds as DYRK1A Inhibitors by Integrated Molecular Docking-Based Virtual Screening and Dynamics Simulation Study
Mir Mohammad Shahroz, Hemant Kumar Sharma, Abdulmalik S. A. Altamimi, Mubarak A. Alamri, Abuzer Ali, Amena Ali, Safar Alqahtani, Ali Altharawi, Alhumaidi B. Alabbas, Manal A. Alossaimi, Yassine Riadi, Ahmad Firoz, Obaid Afzal
Molecules. 2022 Feb; 27(4): 1159. Published online 2022 Feb 9. doi: 10.3390/molecules27041159
PMCID:
PMC8875901
AbstractArticlePDF–10M
8.
Global kinome profiling reveals DYRK1A as critical activator of the human mitochondrial import machinery
Corvin Walter, Adinarayana Marada, Tamara Suhm, Ralf Ernsberger, Vera Muders, Cansu Kücükköse, Pablo Sánchez-Martín, Zehan Hu, Abhishek Aich, Stefan Loroch, Fiorella Andrea Solari, Daniel Poveda-Huertes, Alexandra Schwierzok, Henrike Pommerening, Stanka Matic, Jan Brix, Albert Sickmann, Claudine Kraft, Jörn Dengjel, Sven Dennerlein, Tilman Brummer, F.-Nora Vögtle, Chris Meisinger
Nat Commun. 2021; 12: 4284. Published online 2021 Jul 13. doi: 10.1038/s41467-021-24426-9
PMCID:
PMC8277783
AbstractArticlePDF–2.5M
9.
Whole genome sequencing of 45 Japanese patients with intellectual disability
Chihiro Abe‐Hatano, Aritoshi Iida, Shunichi Kosugi, Yukihide Momozawa, Chikashi Terao, Keiko Ishikawa, Mariko Okubo, Yasuo Hachiya, Hiroya Nishida, Kazuyuki Nakamura, Rie Miyata, Chie Murakami, Kan Takahashi, Kyoko Hoshino, Haruko Sakamoto, Sayaka Ohta, Masaya Kubota, Eri Takeshita, Akihiko Ishiyama, Eiji Nakagawa, Masayuki Sasaki, Mitsuhiro Kato, Naomichi Matsumoto, Yoichiro Kamatani, Michiaki Kubo, Yoshiyuki Takahashi, Jun Natsume, Ken Inoue, Yu‐Ichi Goto
Am J Med Genet A. 2021 May; 185(5): 1468–1480. Published online 2021 Feb 24. doi: 10.1002/ajmg.a.62138
PMCID:
PMC8247954
AbstractArticlePDF–4.3M
10.
Ocular Phenotype Associated with DYRK1A Variants
Cécile Méjécase, Christopher M. Way, Nicholas Owen, Mariya Moosajee
Genes (Basel) 2021 Feb; 12(2): 234. Published online 2021 Feb 5. doi: 10.3390/genes12020234
PMCID:
PMC7915179
AbstractArticlePDF–795K
11.
DYRK1A pathogenic variants in two patients with syndromic intellectual disability and a review of the literature
Laura E. Meissner, Ellen F. Macnamara, Precilla D'Souza, John Yang, Gilbert Vezina, Undiagnosed Diseases Network, Carlos R. Ferreira, Wadih M. Zein, Cynthia J. Tifft, David R. Adams
Mol Genet Genomic Med. 2020 Dec; 8(12): e1544. Published online 2020 Nov 7. doi: 10.1002/mgg3.1544
PMCID:
PMC7767569
AbstractArticlePDF–495K
12.
Pharmacologic and genetic approaches define human pancreatic β cell mitogenic targets of DYRK1A inhibitors
Courtney Ackeifi, Ethan Swartz, Kunal Kumar, Hongtao Liu, Suebsuwong Chalada, Esra Karakose, Donald K. Scott, Adolfo Garcia-Ocaña, Roberto Sanchez, Robert J. DeVita, Andrew F. Stewart, Peng Wang
JCI Insight. 2020 Jan 16; 5(1): e132594. Published online 2020 Jan 16. doi: 10.1172/jci.insight.132594
PMCID:
PMC7030849
AbstractArticlePDF–9.4M
13.
Abnormalities of DYRK1A-Cytoskeleton Complexes in the Blood Cells as Potential Biomarkers of Alzheimer’s Disease
Karol Dowjat, Tatyana Adayev, Urszula Wojda, Katarzyna Brzozowska, Anna Barczak, Tomasz Gabryelewicz, Yu-Wen Hwang
J Alzheimers Dis. 2019; 72(4): 1059–1075. Prepublished online 2019 Oct 29. Published online 2019 Dec 12. doi: 10.3233/JAD-190475
PMCID:
PMC6971831
AbstractArticlePDF–1.0M
14.
Inhibition of DYRK1A proteolysis modifies its kinase specificity and rescues Alzheimer phenotype in APP/PS1 mice
Benoît Souchet, Mickael Audrain, Jean Marie Billard, Julien Dairou, Romain Fol, Nicola Salvatore Orefice, Satoru Tada, Yuchen Gu, Gaelle Dufayet-Chaffaud, Emmanuelle Limanton, François Carreaux, Jean-Pierre Bazureau, Sandro Alves, Laurent Meijer, Nathalie Janel, Jérôme Braudeau, Nathalie Cartier
Acta Neuropathol Commun. 2019; 7: 46. Published online 2019 Mar 18. doi: 10.1186/s40478-019-0678-6
PMCID:
PMC6421685
AbstractArticlePDF–2.5M
15.
Autism-associated Dyrk1a truncation mutants impair neuronal dendritic and spine growth and interfere with postnatal cortical development
T Dang, W Y Duan, B Yu, D L Tong, C Cheng, Y F Zhang, W Wu, K Ye, W X Zhang, M Wu, B B Wu, Y An, Z L Qiu, B L Wu
Mol Psychiatry. 2018; 23(3): 747–758. Published online 2017 Feb 7. doi: 10.1038/mp.2016.253
PMCID:
PMC5822466
AbstractArticlePDF–675K
16.
Inhibition of DYRK1A disrupts neural lineage specificationin human pluripotent stem cells
Stephanie F Bellmaine, Dmitry A Ovchinnikov, David T Manallack, Claire E Cuddy, Andrew G Elefanty, Edouard G Stanley, Ernst J Wolvetang, Spencer J Williams, Martin Pera
eLife. 2017; 6: e24502. Published online 2017 Sep 8. doi: 10.7554/eLife.24502
PMCID:
PMC5656431
AbstractArticlePDF–5.6M
17.
Clinical phenotype of ASD-associated DYRK1A haploinsufficiency
Rachel K. Earl, Tychele N. Turner, Heather C. Mefford, Caitlin M. Hudac, Jennifer Gerdts, Evan E. Eichler, Raphael A. Bernier
Mol Autism. 2017; 8: 54. Published online 2017 Oct 5. doi: 10.1186/s13229-017-0173-5
PMCID:
PMC5629761
AbstractArticlePDF–2.2M
18.
Combined assessment of DYRK1A, BDNF and homocysteine levels as diagnostic marker for Alzheimer’s disease
N Janel, P Alexopoulos, A Badel, F Lamari, A C Camproux, J Lagarde, S Simon, C Feraudet-Tarisse, P Lamourette, M Arbones, J L Paul, B Dubois, M C Potier, M Sarazin, J M Delabar
Transl Psychiatry. 2017 Jun; 7(6): e1154. Published online 2017 Jun 20. doi: 10.1038/tp.2017.123
PMCID:
PMC5537644
AbstractArticlePDF–1.3M
19.
Structural analysis of pathogenic mutations in the DYRK1A gene in patients with developmental disorders
Jochem M.G. Evers, Roman A. Laskowski, Marta Bertolli, Jill Clayton-Smith, Charu Deshpande, Jacqueline Eason, Frances Elmslie, Frances Flinter, Carol Gardiner, Jane A. Hurst, Helen Kingston, Usha Kini, Anne K. Lampe, Derek Lim, Alison Male, Swati Naik, Michael J. Parker, Sue Price, Leema Robert, Ajoy Sarkar, Volker Straub, Geoff Woods, Janet M. Thornton, the DDD Study, Caroline F. Wright
Hum Mol Genet. 2017 Feb 1; 26(3): 519–526. Published online 2017 Jan 4. doi: 10.1093/hmg/ddw409
PMCID:
PMC5409128
AbstractArticlePDF–584K
20.
A dual specificity kinase, DYRK1A, as a potential therapeutic target for head and neck squamous cell carcinoma
Aneesha Radhakrishnan, Vishalakshi Nanjappa, Remya Raja, Gajanan Sathe, Vinuth N. Puttamallesh, Ankit P. Jain, Sneha M. Pinto, Sai A. Balaji, Sandip Chavan, Nandini A. Sahasrabuddhe, Premendu P. Mathur, Mahesh M. Kumar, T. S. Keshava Prasad, Vani Santosh, Geethanjali Sukumar, Joseph A. Califano, Annapoorni Rangarajan, David Sidransky, Akhilesh Pandey, Harsha Gowda, Aditi Chatterjee
Sci Rep. 2016; 6: 36132. Published online 2016 Oct 31. doi: 10.1038/srep36132
Correction in:
Sci Rep. 2017; 7: 46864.
PMCID:
PMC5086852
AbstractArticlePDF–2.5M

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