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Select item 85529711.

Conditional Knockout of Pdha1 in Mouse Hippocampus Impairs Cognitive Function: The Possible Involvement of Lactate

Wanxin Chen, Xiaoxia Sun, Libin Zhan, Wen Zhou, Tingting Bi

Front Neurosci. 2021; 15: 767560. Published online 2021 Oct 14. doi: 10.3389/fnins.2021.767560

PMCID:: PMC8552971

Abstract Article PDF–5.5M

Select item 77850542.

Reprogramming of aerobic glycolysis in non‐transformed mouse liver with pyruvate dehydrogenase complex deficiency

Mulchand S. Patel, Saleh Mahmood, Jiwon Jung, Todd C. Rideout

Physiol Rep. 2021 Jan; 9(1): e14684. Published online 2021 Jan 5. doi: 10.14814/phy2.14684

Correction in:: Physiol Rep. 2021 Mar; 9(5): e14793.

PMCID:: PMC7785054

Abstract Article PDF–1.2M

Select item 70577763.

Conditional knockout of pyruvate dehydrogenase in mouse pancreatic β-cells causes morphological and functional changes

Xiao Wang, Shuchang Lai, Yanshi Ye, Yuanyuan Hu, Daoyan Pan, Xiaochun Bai, Jie Shen

Mol Med Rep. 2020 Apr; 21(4): 1717–1726. Published online 2020 Feb 20. doi: 10.3892/mmr.2020.10993

PMCID:: PMC7057776

Abstract Article PDF–1.3M

Select item 62931704.

Defining the contribution of skeletal muscle pyruvate dehydrogenase α1 to exercise performance and insulin action

Kristoffer Svensson, Jessica R. Dent, Shahriar Tahvilian, Vitor F. Martins, Abha Sathe, Julien Ochala, Mulchand S. Patel, Simon Schenk

Am J Physiol Endocrinol Metab. 2018 Nov 1; 315(5): E1034–E1045. Published online 2018 Aug 28. doi: 10.1152/ajpendo.00241.2018

PMCID:: PMC6293170

Abstract Article

Select item 56681455.

Genetic dissociation of glycolysis and the TCA cycle affects neither normal nor neoplastic proliferation

Laura E. Jackson, Sucheta Kulkarni, Huabo Wang, Jie Lu, James M. Dolezal, Sivakama S. Bharathi, Sarangarajan Ranganathan, Mulchand S. Patel, Rahul Deshpande, Frances Alencastro, Stacy G. Wendell, Eric S. Goetzman, Andrew W. Duncan, Edward V. Prochownik

Cancer Res. Author manuscript; available in PMC 2018 Nov 1.

Published in final edited form as: Cancer Res. 2017 Nov 1; 77(21): 5795–5807. Published online 2017 Sep 7. doi: 10.1158/0008-5472.CAN-17-1325

Correction in:: Cancer Res. 2022 Mar 1; 82(5): 944.

PMCID:: PMC5668145

Abstract Article PDF–823K

Select item 36940236.

Cerebral Developmental Abnormalities in a Mouse with Systemic Pyruvate Dehydrogenase Deficiency

Lioudmila Pliss, Kathryn A. Hausknecht, Michal K. Stachowiak, Cynthia A. Dlugos, Jerry B. Richards, Mulchand S. Patel

PLoS One. 2013; 8(6): e67473. Published online 2013 Jun 26. doi: 10.1371/journal.pone.0067473

PMCID:: PMC3694023

Abstract Article PDF–4.0M

Select item 30062567.

β-Cell-specific pyruvate dehydrogenase deficiency impairs glucose-stimulated insulin secretion

Malathi Srinivasan, Cheol S. Choi, Pushpankur Ghoshal, Lioudmila Pliss, Jignesh D. Pandya, David Hill, Gary Cline, Mulchand S. Patel

Am J Physiol Endocrinol Metab. 2010 Dec; 299(6): E910–E917. Published online 2010 Sep 14. doi: 10.1152/ajpendo.00339.2010

PMCID:: PMC3006256

Abstract Article

Select item 2315298.

Expression of E1A in terminally differentiated muscle cells reactivates the cell cycle and suppresses tissue-specific genes by separable mechanisms.

M Tiainen, D Spitkovsky, P Jansen-Dürr, A Sacchi, M Crescenzi

Mol Cell Biol. 1996 Oct; 16(10): 5302–5312. doi: 10.1128/mcb.16.10.5302

PMCID:: PMC231529

Summary PDF–640K

Select item 58456469.

Cardiac-Specific Deletion of Pyruvate Dehydrogenase Impairs Glucose Oxidation Rates and Induces Diastolic Dysfunction

Keshav Gopal, Malak Almutairi, Rami Al Batran, Farah Eaton, Manoj Gandhi, John Reyes Ussher

Front Cardiovasc Med. 2018; 5: 17. Published online 2018 Mar 6. doi: 10.3389/fcvm.2018.00017

PMCID:: PMC5845646

Abstract Article PDF–1.6M

Select item 577347210.

Characterization of the impact of glutaredoxin-2 (GRX2) deficiency on superoxide/hydrogen peroxide release from cardiac and liver mitochondria

Julia Chalker, Danielle Gardiner, Nidhi Kuksal, Ryan J. Mailloux

Redox Biol. 2018 May; 15: 216–227. Published online 2017 Dec 14. doi: 10.1016/j.redox.2017.12.006

PMCID:: PMC5773472

Abstract Article PDF–1.3M

Select item 556151911.

Acetyl-CoA production from pyruvate is not necessary for preservation of myelin

Gustavo Della-Flora Nunes, Lauren Mueller, Nicholas Silvestri, Mulchand S Patel, Lawrence Wrabetz, M Laura Feltri, Yannick Poitelon

Glia. Author manuscript; available in PMC 2018 Oct 1.

Published in final edited form as: Glia. 2017 Oct; 65(10): 1626–1639. Published online 2017 Jun 28. doi: 10.1002/glia.23184

PMCID:: PMC5561519

Abstract Article PDF–1.2M

Select item 496714312.

Lack of mitochondria-generated acetyl-CoA by pyruvate dehydrogenase complex downregulates gene expression in the hepatic de novo lipogenic pathway

Saleh Mahmood, Barbara Birkaya, Todd C. Rideout, Mulchand S. Patel

Am J Physiol Endocrinol Metab. 2016 Jul 1; 311(1): E117–E127. Published online 2016 May 10. doi: 10.1152/ajpendo.00064.2016

PMCID:: PMC4967143

Abstract Article

Select item 491571213.

Lack of Skeletal Muscle IL-6 Affects Pyruvate Dehydrogenase Activity at Rest and during Prolonged Exercise

Anders Gudiksen, Camilla Lindgren Schwartz, Lærke Bertholdt, Ella Joensen, Jakob G. Knudsen, Henriette Pilegaard

PLoS One. 2016; 11(6): e0156460. Published online 2016 Jun 21. doi: 10.1371/journal.pone.0156460

PMCID:: PMC4915712

Abstract Article PDF–873K

Select item 491480514.

Cardiac-Specific Deletion of the Pdha1 Gene Sensitizes Heart to Toxicological Actions of Ischemic Stress

Wanqing Sun, Nanhu Quan, Lin Wang, Hui Yang, Dongyang Chu, Quan Liu, Xuezhong Zhao, Jiyan Leng, Ji Li

Toxicol Sci. 2016 May; 151(1): 193–203. Published online 2016 Feb 15. doi: 10.1093/toxsci/kfw035

Correction in:: Toxicol Sci. 2016 Oct; 153(2): 411.

PMCID:: PMC4914805

Abstract Article PDF–895K

Select item 409223915.

Effects of IL-6 on pyruvate dehydrogenase regulation in mouse skeletal muscle

Rasmus S. Biensø, Jakob G. Knudsen, Nina Brandt, Per A. Pedersen, Henriette Pilegaard

Pflugers Arch. 2014; 466(8): 1647–1657. Published online 2013 Nov 14. doi: 10.1007/s00424-013-1399-5

PMCID:: PMC4092239

Abstract Article PDF–608K

Select item 254448716.

Tissue-specific pyruvate dehydrogenase complex deficiency causes cardiac hypertrophy and sudden death of weaned male mice

Sukhdeep Sidhu, Ashish Gangasani, Lioubov G. Korotchkina, Gen Suzuki, James A. Fallavollita, John M. Canty, Jr., Mulchand S. Patel

Am J Physiol Heart Circ Physiol. 2008 Sep; 295(3): H946–H952. Published online 2008 Jun 27. doi: 10.1152/ajpheart.00363.2008

PMCID:: PMC2544487

Abstract Article

Select item 669233517.

Sirtuin 3-mediated pyruvate dehydrogenase activity determines brown adipocytes phenotype under high-salt conditions

Tong Wei, Gaojian Huang, Penghao Liu, Jing Gao, Chenglin Huang, Mengwei Sun, Weili Shen

Cell Death Dis. 2019 Aug; 10(8): 614. Published online 2019 Aug 14. doi: 10.1038/s41419-019-1834-4

PMCID:: PMC6692335

Abstract Article PDF–3.3M

Select item 581091218.

Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer

Jingjing Chen, Ilaria Guccini, Diletta Di Mitri, Daniela Brina, Ajinkya Revandkar, Manuela Sarti, Emiliano Pasquini, Abdullah Alajati, Sandra Pinton, Marco Losa, Gianluca Civenni, Carlo V. Catapano, Jacopo Sgrignani, Andrea Cavalli, Rocco D'Antuono, John M. Asara, Andrea Morandi, Paola Chiarugi, Sara Crotti, Marco Agostini, Monica Montopoli, Ionica Masgras, Andrea Rasola, Ramon Garcia-Escudero, Nicolas Delaleu, Andrea Rinaldi, Francesco Bertoni, Johann de Bono, Arkaitz Carracedo, Andrea Alimonti

Nat Genet. Author manuscript; available in PMC 2018 Jul 15.

Published in final edited form as: Nat Genet. 2018 Feb; 50(2): 219–228. Published online 2018 Jan 15. doi: 10.1038/s41588-017-0026-3

PMCID:: PMC5810912

Abstract Article PDF–1.9M

Select item 753473519.

Phosphorylation of PDHA by AMPK Drives TCA Cycle to Promote Cancer Metastasis

Zhen Cai, Chien-Feng Li, Fei Han, Chunfang Liu, Anmei Zhang, Che-Chia Hsu, Danni Peng, Xian Zhang, Guoxiang Jin, Abdol-Hossein Rezaeian, Guihua Wang, Weina Zhang, Bo-Syong Pan, Chi-Yun Wang, Yu-Hui Wang, Shih-Ying Wu, Shun-Chin Yang, Fang-Chi Hsu, Ralph B. D’Agostino, Jr., Christina M. Furdui, Gregory L. Kucera, John S. Parks, Floyd H. Chilton, Chih-Yang Huang, Fuu-Jen Tsai, Boris Pasche, Kounosuke Watabe, Hui-Kuan Lin

Mol Cell. 2020 Oct 15; 80(2): 263–278.e7. Published online 2020 Oct 5. doi: 10.1016/j.molcel.2020.09.018

PMCID:: PMC7534735

Abstract Article PDF–7.1M

Select item 1079224720.

Atrial natriuretic peptide signaling co-regulates lipid metabolism and ventricular conduction system gene expression in the embryonic heart

Abhishek Mishra, Mahtab Tavasoli, Stanislav Sokolenko, Christopher R. McMaster, Kishore B.S. Pasumarthi

iScience. 2024 Jan 19; 27(1): 108748. Published online 2023 Dec 14. doi: 10.1016/j.isci.2023.108748

PMCID:: PMC10792247

Abstract Article PDF–9.2M

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