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Select item 88671191.

Loss of phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (Pip5k1c) in mesenchymal stem cells leads to osteopenia by impairing bone remodeling

Qinnan Yan, Huanqing Gao, Qing Yao, Kun Ling, Guozhi Xiao

J Biol Chem. 2022 Mar; 298(3): 101639. Published online 2022 Jan 25. doi: 10.1016/j.jbc.2022.101639

PMCID:: PMC8867119

Article PDF–3.9M

Select item 87424332.

Adipocyte-specific deletion of PIP5K1c reduces diet-induced obesity and insulin resistance by increasing energy expenditure

Guan Huang, Cuishan Yang, Sheng Guo, Miaoling Huang, Liping Deng, Ying Huang, Puxin Chen, Feng Chen, Xiaohong Huang

Lipids Health Dis. 2022; 21: 6. Published online 2022 Jan 7. doi: 10.1186/s12944-021-01616-4

PMCID:: PMC8742433

Article PDF–4.3M

Select item 70185473.

Control of Rab7a activity and localization through endosomal type Igamma PIP 5-kinase is required for endosome maturation and lysosome function

Ming Sun, Gary Luong, Faiz Plastikwala, Yue Sun

FASEB J. Author manuscript; available in PMC 2021 Feb 1.

Published in final edited form as: FASEB J. 2020 Feb; 34(2): 2730–2748. Published online 2019 Dec 19. doi: 10.1096/fj.201901830R

PMCID:: PMC7018547

Article PDF–3.7M

Select item 56561094.

Conditional deletion of Pip5k1c in sensory ganglia and effects on nociception and inflammatory sensitization

Lipin Loo, Mark J Zylka

Mol Pain. 2017; 13: 1744806917737907. Published online 2017 Oct 11. doi: 10.1177/1744806917737907

PMCID:: PMC5656109

Article PDF–730K

Select item 44599445.

Targeting Type I? Phosphatidylinositol Phosphate Kinase Inhibits Breast Cancer Metastasis

Chunhua Chen, Xiangling Wang, Xunhao Xiong, Qingbo Liu, Yan Huang, Qingwen Xu, Jinghua Hu, Gaoxiang Ge, Kun Ling

Oncogene. Author manuscript; available in PMC 2016 Feb 27.

Published in final edited form as: Oncogene. 2015 Aug 27; 34(35): 4635–4646. Published online 2014 Dec 8. doi: 10.1038/onc.2014.393

PMCID:: PMC4459944

Article PDF–3.8M

Select item 37574966.

Determinants of phosphatidylinositol-4-phosphate 5-kinase type Iγ90 uropod location in T-lymphocytes and its role in uropod formation

Lucia Mathis, Sarah Wernimont, Sarah Affentranger, Anna Huttenlocher, Verena Niggli

PeerJ. 2013; 1: e131. Published online 2013 Aug 29. doi: 10.7717/peerj.131

PMCID:: PMC3757496

Article PDF–4.9M

Select item 32435967.

Integrin adhesion and force coupling are independently regulated by localized PtdIns(4,5)₂ synthesis

Kyle R Legate, Seiichiro Takahashi, Navid Bonakdar, Ben Fabry, David Boettiger, Roy Zent, Reinhard Fässler

EMBO J. 2011 Nov 16; 30(22): 4539–4553. Published online 2011 Sep 16. doi: 10.1038/emboj.2011.332

PMCID:: PMC3243596

Article PDF–1.6M

Select item 30146058.

PIPKIγ90 negatively regulates LFA-1 mediated adhesion and activation in antigen-induced CD4+ T cells

Sarah A Wernimont, Kyle R Legate, William TN Simonson, Reinhard Fassler, Anna Huttenlocher

J Immunol. Author manuscript; available in PMC 2011 Oct 15.

Published in final edited form as: J Immunol. 2010 Oct 15; 185(8): 4714–4723. Published online 2010 Sep 20. doi: 10.4049/jimmunol.1001445

PMCID:: PMC3014605

Article PDF–2.7M

Select item 29477979.

Integrin-Induced PIP5K1C Kinase Polarization Regulates Neutrophil Polarization, Directionality, and in vivo Infiltration

Wenwen Xu, Ping Wang, Björn Petri, Yong Zhang, Wenwen Tang, Le Sun, Holger Kress, Tom Mann, Yan Shi, Paul Kubes, Dianqing Wu

Immunity. Author manuscript; available in PMC 2011 Sep 24.

Published in final edited form as: Immunity. 2010 Sep 24; 33(3): 340–350. doi: 10.1016/j.immuni.2010.08.015

PMCID:: PMC2947797

Article PDF–2.3M

Select item 267949210.

Clathrin Regulates the Association of PIPKIγ661 with the AP-2 Adaptor β2 Appendage

James R. Thieman, Sanjay K. Mishra, Kun Ling, Balraj Doray, Richard A. Anderson, Linton M. Traub

J Biol Chem. 2009 May 15; 284(20): 13924–13939. doi: 10.1074/jbc.M901017200

PMCID:: PMC2679492

Article PDF–1.2M

Select item 55560411.

Phosphatidylinositol phosphate kinase type Iγ regulates dynamics of large dense-core vesicle fusion

Liang-Wei Gong, Gilbert Di Paolo, Ester Diaz, Gianluca Cestra, Maria-Elena Diaz, Manfred Lindau, Pietro De Camilli, Derek Toomre

Proc Natl Acad Sci U S A. 2005 Apr 5; 102(14): 5204–5209. Published online 2005 Mar 25. doi: 10.1073/pnas.0501412102

PMCID:: PMC555604

Article PDF–488K

Select item 450686212.

Crosstalk between Shp1 and PIPKIγ controls leukocyte recruitment.

Anika Stadtmann, Helena Block, Stephanie Volmering, Clare Abram, Charlotte Sohlbach, Mark Boras, Clifford A. Lowell, Alexander Zarbock

J Immunol. Author manuscript; available in PMC 2016 Aug 1.

Published in final edited form as: J Immunol. 2015 Aug 1; 195(3): 1152–1161. Published online 2015 Jun 22. doi: 10.4049/jimmunol.1500606

PMCID:: PMC4506862

Article PDF–2.2M

Select item 358136913.

Type I Phosphotidylinosotol 4-Phosphate 5-Kinase γ Regulates Osteoclasts in a Bifunctional Manner

Tingting Zhu, Jean C. Chappel, Fong-Fu Hsu, John Turk, Rajeev Aurora, Krzysztof Hyrc, Pietro De Camilli, Thomas J. Broekelmann, Robert P. Mecham, Steven L. Teitelbaum, Wei Zou

J Biol Chem. 2013 Feb 22; 288(8): 5268–5277. Published online 2013 Jan 8. doi: 10.1074/jbc.M112.446054

PMCID:: PMC3581369

Article PDF–2.5M

Select item 343516614.

Reduced phosphatidylinositol 4,5-bisphosphate synthesis impairs inner ear Ca²⁺ signaling and high-frequency hearing acquisition

Laura Rodriguez, Elena Simeonato, Pietro Scimemi, Fabio Anselmi, Bianca Calì, Giulia Crispino, Catalin D. Ciubotaru, Mario Bortolozzi, Fabian Galindo Ramirez, Paromita Majumder, Edoardo Arslan, Pietro De Camilli, Tullio Pozzan, Fabio Mammano

Proc Natl Acad Sci U S A. 2012 Aug 28; 109(35): 14013–14018. Published online 2012 Aug 13. doi: 10.1073/pnas.1211869109

PMCID:: PMC3435166

Article PDF–860K

Select item 265430015.

Essential and unique roles of PIP5K-γ and -α in Fcγ receptor-mediated phagocytosis

Yuntao S. Mao, Masaki Yamaga, Xiaohui Zhu, Yongjie Wei, Hui-Qiao Sun, Jing Wang, Mia Yun, Yanfeng Wang, Gilbert Di Paolo, Michael Bennett, Ira Mellman, Charles S. Abrams, Pietro De Camilli, Christopher Y. Lu, Helen L. Yin

J Cell Biol. 2009 Jan 26; 184(2): 281–296. doi: 10.1083/jcb.200806121

PMCID:: PMC2654300

Article PDF–3.6M

Select item 122409016.

A novel neuronal-specific splice variant of Type I phosphatidylinositol 4-phosphate 5-kinase isoform gamma.

Maria-Luisa Giudici, Piers C Emson, Robin F Irvine

Biochem J. 2004 Apr 15; 379(Pt 2): 489–496. doi: 10.1042/BJ20031394

PMCID:: PMC1224090

Summary PDF–336K

Select item 594031017.

PI(4,5)P₂ controls plasma membrane PI4P and PS levels via ORP5/8 recruitment to ER–PM contact sites

Mira Sohn, Marek Korzeniowski, James P. Zewe, Rachel C. Wills, Gerald R.V. Hammond, Jana Humpolickova, Lukas Vrzal, Dominika Chalupska, Vaclav Veverka, Gregory D. Fairn, Evzen Boura, Tamas Balla

J Cell Biol. 2018 May 7; 217(5): 1797–1813. doi: 10.1083/jcb.201710095

PMCID:: PMC5940310

Article PDF–2.8M

Select item 361763618.

Platelets lacking PIP5KIγ have normal integrin activation but impaired cytoskeletal-membrane integrity and adhesion

Yanfeng Wang, Liang Zhao, Aae Suzuki, Lurong Lian, Sang H. Min, Ziqian Wang, Rustem I. Litvinov, Timothy J. Stalker, Tadayuki Yago, Arkadiusz G. Klopocki, David W. Schmidtke, Helen Yin, John K. Choi, Rodger P. McEver, John W. Weisel, John H. Hartwig, Charles S. Abrams

Blood. 2013 Apr 4; 121(14): 2743–2752. Prepublished online 2013 Jan 31. doi: 10.1182/blood-2012-07-445205

PMCID:: PMC3617636

Article

Select item 354706919.

PIP5KIβ Selectively Modulates Apical Endocytosis in Polarized Renal Epithelial Cells

Christina M. Szalinski, Christopher J. Guerriero, Wily G. Ruiz, Brianne E. Docter, Youssef Rbaibi, Núria M. Pastor-Soler, Gerard Apodaca, Manojkumar A. Puthenveedu, Ora A. Weisz

PLoS One. 2013; 8(1): e53790. Published online 2013 Jan 16. doi: 10.1371/journal.pone.0053790