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Select item 45099971.

Germline mutation rates and the long-term phenotypic effects of mutation accumulation in wild-type laboratory mice and mutator mice

Arikuni Uchimura, Mayumi Higuchi, Yohei Minakuchi, Mizuki Ohno, Atsushi Toyoda, Asao Fujiyama, Ikuo Miura, Shigeharu Wakana, Jo Nishino, Takeshi Yagi

Genome Res. 2015 Aug; 25(8): 1125–1134. doi: 10.1101/gr.186148.114

PMCID:: PMC4509997

Abstract Article PDF–718K

Select item 26152152.

DNA Polymerase δ Is Required for Early Mammalian Embryogenesis

Arikuni Uchimura, Yuko Hidaka, Takahiro Hirabayashi, Masumi Hirabayashi, Takeshi Yagi

PLoS One. 2009; 4(1): e4184. Published online 2009 Jan 15. doi: 10.1371/journal.pone.0004184

PMCID:: PMC2615215

Abstract Article PDF–1.2M

Select item 21690523.

Mutation at the Polymerase Active Site of Mouse DNA Polymerase δ Increases Genomic Instability and Accelerates Tumorigenesis

Ranga N. Venkatesan, Piper M. Treuting, Evan D. Fuller, Robert E. Goldsby, Thomas H. Norwood, Ted A. Gooley, Warren C. Ladiges, Bradley D. Preston, Lawrence A. Loeb

Mol Cell Biol. 2007 Nov; 27(21): 7669–7682. Published online 2007 Sep 4. doi: 10.1128/MCB.00002-07

PMCID:: PMC2169052

Abstract Article PDF–1.1M

Select item 35649044.

Use of somatic mutations to quantify random contributions to mouse development

Wenyu Zhou, Yunbing Tan, Donovan J Anderson, Eva M Crist, Hannele Ruohola-Baker, Stephen J Salipante, Marshall S Horwitz

BMC Genomics. 2013; 14: 39. Published online 2013 Jan 18. doi: 10.1186/1471-2164-14-39

PMCID:: PMC3564904

Abstract Article PDF–791K

Select item 1377565.

High incidence of epithelial cancers in mice deficient for DNA polymerase δ proofreading

Robert E. Goldsby, Laura E. Hays, Xin Chen, Elise A. Olmsted, William B. Slayton, Gerry J. Spangrude, Bradley D. Preston

Proc Natl Acad Sci U S A. 2002 Nov 26; 99(24): 15560–15565. Published online 2002 Nov 12. doi: 10.1073/pnas.232340999

PMCID:: PMC137756

Abstract Article PDF–408K

Select item 34361696.

Protein Arginine Methyltransferase 7 Regulates Cellular Response to DNA Damage by Methylating Promoter Histones H2A and H4 of the Polymerase δ Catalytic Subunit Gene, POLD1

Vrajesh Karkhanis, Li Wang, Sookil Tae, Yu-Jie Hu, Anthony N. Imbalzano, Saïd Sif

J Biol Chem. 2012 Aug 24; 287(35): 29801–29814. Published online 2012 Jul 2. doi: 10.1074/jbc.M112.378281

PMCID:: PMC3436169

Abstract Article PDF–1.9M

Select item 27613307.

DNA polymerase ε and δ proofreading suppress discrete mutator and cancer phenotypes in mice

Tina M. Albertson, Masanori Ogawa, James M. Bugni, Laura E. Hays, Yang Chen, Yanping Wang, Piper M. Treuting, John A. Heddle, Robert E. Goldsby, Bradley D. Preston

Proc Natl Acad Sci U S A. 2009 Oct 6; 106(40): 17101–17104. Published online 2009 Sep 24. doi: 10.1073/pnas.0907147106

PMCID:: PMC2761330

Abstract Article PDF–505K

Select item 93821178.

A hypomorphic mutation in Pold1 disrupts the coordination of embryo size expansion and morphogenesis during gastrulation

Tingxu Chen, Heather Alcorn, Sujan Devbhandari, Dirk Remus, Elizabeth Lacy, Danwei Huangfu, Kathryn V. Anderson

Biol Open. 2022 Aug 15; 11(8): bio059307. Published online 2022 Aug 8. doi: 10.1242/bio.059307

PMCID:: PMC9382117

Abstract Article PDF–10M

Select item 41512509.

Mammalian TIMELESS and Tipin are Evolutionarily Conserved Replication Fork-Associated Factors

Anthony L. Gotter, Christine Suppa, Beverly S. Emanuel

J Mol Biol. Author manuscript; available in PMC 2014 Sep 2.

Published in final edited form as: J Mol Biol. 2007 Feb 9; 366(1): 36–52. Published online 2006 Nov 3. doi: 10.1016/j.jmb.2006.10.097

PMCID:: PMC4151250

Abstract Article PDF–1.7M

Select item 597223110.

Polε Instability Drives Replication Stress, Abnormal Development, and Tumorigenesis

Roberto Bellelli, Valerie Borel, Clare Logan, Jennifer Svendsen, Danielle E. Cox, Emma Nye, Kay Metcalfe, Susan M. O’Connell, Gordon Stamp, Helen R. Flynn, Ambrosius P. Snijders, François Lassailly, Andrew Jackson, Simon J. Boulton

Mol Cell. 2018 May 17; 70(4): 707–721.e7. doi: 10.1016/j.molcel.2018.04.008

PMCID:: PMC5972231

Abstract Article PDF–5.2M

Select item 474776811.

The LMO2 oncogene regulates DNA replication in hematopoietic cells

Marie-Claude Sincennes, Magali Humbert, Benoît Grondin, Véronique Lisi, Diogo F. T. Veiga, André Haman, Christophe Cazaux, Nazar Mashtalir, EL Bachir Affar, Alain Verreault, Trang Hoang

Proc Natl Acad Sci U S A. 2016 Feb 2; 113(5): 1393–1398. Published online 2016 Jan 13. doi: 10.1073/pnas.1515071113

PMCID:: PMC4747768

Abstract Article PDF–1.0M

Select item 344801212.

Transcription factor Foxp3 and its protein partners form a complex regulatory network

Dipayan Rudra, Paul deRoos, Ashutosh Chaudhry, Rachel Niec, Aaron Arvey, Robert M. Samstein, Christina Leslie, Scott A. Shaffer, David R. Goodlett, Alexander Y. Rudensky

Nat Immunol. Author manuscript; available in PMC 2013 Apr 1.

Published in final edited form as: Nat Immunol. 2012 Oct; 13(10): 1010–1019. Published online 2012 Aug 26. doi: 10.1038/ni.2402

PMCID:: PMC3448012

Abstract Article PDF–2.6M

Select item 660230013.

New roles for the de-ubiquitylating enzyme OTUD4 in an RNA–protein network and RNA granules

Richa Das, Lukas Schwintzer, Stanislav Vinopal, Eva Aguado Roca, Marc Sylvester, Ana-Maria Oprisoreanu, Susanne Schoch, Frank Bradke, Meike Broemer

J Cell Sci. 2019 Jun 15; 132(12): jcs229252. Published online 2019 Jun 17. doi: 10.1242/jcs.229252

PMCID:: PMC6602300

Abstract Article

Select item 633346014.

ATG5 is required for B cell polarization and presentation of particulate antigens

Florent Arbogast, Johan Arnold, Philippe Hammann, Lauriane Kuhn, Johana Chicher, Diane Murera, Justine Weishaar, Sylviane Muller, Jean-Daniel Fauny, Frédéric Gros

Autophagy. 2019; 15(2): 280–294. Published online 2018 Sep 22. doi: 10.1080/15548627.2018.1516327

PMCID:: PMC6333460

Abstract Article PDF–2.7M

Select item 407349415.

The Central Role of EED in the Orchestration of Polycomb Group Complexes

Qi Cao, Xiaoju Wang, Meng Zhao, Rendong Yang, Rohit Malik, Yuanyuan Qiao, Anton Poliakov, Anastasia K. Yocum, Yong Li, Wei Chen, Xuhong Cao, Xia Jiang, Arun Dahiya, Clair Harris, Felix Y. Feng, Sundeep Kalantry, Zhaohui S. Qin, Saravana M. Dhanasekaran, Arul M. Chinnaiyan

Nat Commun. Author manuscript; available in PMC 2014 Jul 24.

Published in final edited form as: Nat Commun. 2014; 5: 3127. doi: 10.1038/ncomms4127

PMCID:: PMC4073494

Abstract Article PDF–2.1M

Select item 948193316.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 30876317.

GenePaint.org: an atlas of gene expression patterns in the mouse embryo

Axel Visel, Christina Thaller, Gregor Eichele

Nucleic Acids Res. 2004 Jan 1; 32(Database issue): D552–D556. doi: 10.1093/nar/gkh029

PMCID:: PMC308763

Abstract Article PDF–253K

Select item 1683318.

Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray

Tetsuya S. Tanaka, Saied A. Jaradat, Meng K. Lim, George J. Kargul, Xiaohong Wang, Marija J. Grahovac, Serafino Pantano, Yuri Sano, Yulan Piao, Ramaiah Nagaraja, Hirofumi Doi, William H. Wood, III, Kevin G. Becker, Minoru S. H. Ko

Proc Natl Acad Sci U S A. 2000 Aug 1; 97(16): 9127–9132. doi: 10.1073/pnas.97.16.9127

PMCID:: PMC16833

Abstract Article PDF–847K

Select item 255627019.

Large-scale gene trapping in C57BL/6N mouse embryonic stem cells

Gwenn M. Hansen, Diane C. Markesich, Michael B. Burnett, Qichao Zhu, Karen M. Dionne, Lizabeth J. Richter, Richard H. Finnell, Arthur T. Sands, Brian P. Zambrowicz, Alejandro Abuin

Genome Res. 2008 Oct; 18(10): 1670–1679. doi: 10.1101/gr.078352.108

PMCID:: PMC2556270

Abstract Article PDF–493K

Select item 357241020.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163