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Select item 88256011.

Endothelial PPARδ facilitates the post-ischemic vascular repair through interaction with HIF1α

Yalan Wu, Xiaolong Tang, Sharen Lee, Huiling Hong, Xiaoyun Cao, Chi Wai Lau, Baohua Liu, Ajay Chawla, Ronald Ching Wan Ma, Yu Huang, Kathy O Lui, Xiao Yu Tian

Theranostics. 2022; 12(4): 1855–1869. Published online 2022 Jan 24. doi: 10.7150/thno.69017

PMCID:: PMC8825601

Abstract Article PDF–3.5M

Select item 75090742.

Procyanidin B2 mitigates endothelial endoplasmic reticulum stress through a PPARδ-Dependent mechanism

Xin Nie, Weiqi Tang, Zihui Zhang, Chunmiao Yang, Lei Qian, Xinya Xie, Erjiao Qiang, Jingyang Zhao, Wenfei Zhao, Lei Xiao, Nanping Wang

Redox Biol. 2020 Oct; 37: 101728. Published online 2020 Sep 15. doi: 10.1016/j.redox.2020.101728

PMCID:: PMC7509074

Abstract Article PDF–8.8M

Select item 74298693.

Deficiency in fibroblast PPARβ/δ reduces nonmelanoma skin cancers in mice

Mark Wei Yi Tan, Ming Keat Sng, Hong Sheng Cheng, Zun Siong Low, Benjamin Jia Juin Leong, Damien Chua, Eddie Han Pin Tan, Jeremy Soon Kiat Chan, Yun Sheng Yip, Yin Hao Lee, Mintu Pal, Xiaomeng Wang, Walter Wahli, Nguan Soon Tan

Cell Death Differ. 2020 Sep; 27(9): 2668–2680. Published online 2020 Apr 20. doi: 10.1038/s41418-020-0535-y

PMCID:: PMC7429869

Abstract Article PDF–7.9M

Select item 73530584.

Investigating the Role of PPARβ/δ in Retinal Vascular Remodeling Using Pparβ/δ-Deficient Mice

Sze Yuan Ho, Yuet Ping Kwan, Beiying Qiu, Alison Tan, Hannah Louise Murray, Veluchamy Amutha Barathi, Nguan Soon Tan, Chui Ming Gemmy Cheung, Tien Yin Wong, Walter Wahli, Xiaomeng Wang

Int J Mol Sci. 2020 Jun; 21(12): 4403. Published online 2020 Jun 20. doi: 10.3390/ijms21124403

PMCID:: PMC7353058

Abstract Article PDF–2.7M

Select item 73517545.

PPARβ/δ-dependent MSC metabolism determines their immunoregulatory properties

R. A. Contreras-Lopez, R. Elizondo-Vega, M. J. Torres, A. M. Vega-Letter, N. Luque-Campos, M. J. Paredes-Martinez, C. Pradenas, G. Tejedor, K. Oyarce, M. Salgado, C. Jorgensen, M. Khoury, G. Kronke, M. A. Garcia-Robles, C. Altamirano, P. Luz-Crawford, F. Djouad

Sci Rep. 2020; 10: 11423. Published online 2020 Jul 10. doi: 10.1038/s41598-020-68347-x

PMCID:: PMC7351754

Abstract Article PDF–1.1M

Select item 72424796.

PPARδ-mediated mitochondrial rewiring of osteoblasts determines bone mass

Dorothea I. H. Müller, Cornelia Stoll, Katrin Palumbo-Zerr, Christina Böhm, Brenda Krishnacoumar, Natacha Ipseiz, Jule Taubmann, Max Zimmermann, Martin Böttcher, Dimitrios Mougiakakos, Jan Tuckermann, Farida Djouad, Georg Schett, Carina Scholtysek, Gerhard Krönke

Sci Rep. 2020; 10: 8428. Published online 2020 May 21. doi: 10.1038/s41598-020-65305-5

PMCID:: PMC7242479

Abstract Article PDF–2.9M

Select item 62136497.

The Role of PPARβ/δ in Melanoma Metastasis

Jonathan Chee Woei Lim, Yuet Ping Kwan, Michelle Siying Tan, Melissa Hui Yen Teo, Shunsuke Chiba, Walter Wahli, Xiaomeng Wang

Int J Mol Sci. 2018 Oct; 19(10): 2860. Published online 2018 Sep 20. doi: 10.3390/ijms19102860

PMCID:: PMC6213649

Abstract Article PDF–3.0M

Select item 54929778.

PPARδ Promotes Running Endurance by Preserving Glucose

Weiwei Fan, Wanda Waizenegger, Chun Shi Lin, Vincenzo Sorrentino, Ming-Xiao He, Christopher E. Wall, Hao Li, Christopher Liddle, Ruth T. Yu, Annette R. Atkins, Johan Auwerx, Michael Downes, Ronald M. Evans

Cell Metab. Author manuscript; available in PMC 2018 May 2.

Published in final edited form as: Cell Metab. 2017 May 2; 25(5): 1186–1193.e4. doi: 10.1016/j.cmet.2017.04.006

PMCID:: PMC5492977

Abstract Article PDF–2.0M

Select item 54298059.

Intestinal PPARδ protects against diet-induced obesity, insulin resistance and dyslipidemia

Marcela Doktorova, Irene Zwarts, Tim van Zutphen, Theo H. van Dijk, Vincent W. Bloks, Liesbeth Harkema, Alain de Bruin, Michael Downes, Ronald M. Evans, Henkjan J. Verkade, Johan W. Jonker

Sci Rep. 2017; 7: 846. Published online 2017 Apr 12. doi: 10.1038/s41598-017-00889-z

PMCID:: PMC5429805

Abstract Article PDF–2.7M

Select item 534336010.

Peroxisome proliferator‐activated receptor‐β/δ modulates mast cell phenotype

Pei‐Li Yao, Jose L. Morales, Frank J. Gonzalez, Jeffrey M. Peters

Immunology. 2017 Apr; 150(4): 456–467. Published online 2017 Jan 24. doi: 10.1111/imm.12699

PMCID:: PMC5343360

Abstract Article PDF–1.1M

Select item 515710611.

Genetic Deletion of Neuronal PPARγ Enhances the Emotional Response to Acute Stress and Exacerbates Anxiety: An Effect Reversed by Rescue of Amygdala PPARγ Function

Esi Domi, Stefanie Uhrig, Laura Soverchia, Rainer Spanagel, Anita C. Hansson, Estelle Barbier, Markus Heilig, Roberto Ciccocioppo, Massimo Ubaldi

J Neurosci. 2016 Dec 14; 36(50): 12611–12623. doi: 10.1523/JNEUROSCI.4127-15.2016

PMCID:: PMC5157106

Abstract Article PDF–3.0M

Select item 477227112.

Hippocampal PPARδ Overexpression or Activation Represses Stress-Induced Depressive Behaviors and Enhances Neurogenesis

Miao-Jin Ji, Xu-Ben Yu, Zhen-Lin Mei, Yun-Qi An, Su-Su Tang, Mei Hu, Yan Long, Ming-Xing Miao, Qing-Hua Hu, Hong-Bin Sun, Ling-Yi Kong, Hao Hong

Int J Neuropsychopharmacol. 2016 Jan; 19(1): pyv083. Published online 2015 Sep 10. doi: 10.1093/ijnp/pyv083

Correction in:: Int J Neuropsychopharmacol. 2016 Oct; 19(10): pyw031.

PMCID:: PMC4772271

Abstract Article PDF–1.9M

Select item 471555213.

Regulation of the orexigenic neuropeptide, enkephalin, by PPARδ and fatty acids in neurons of the hypothalamus and forebrain

Kinning Poon, Mohammad Alam, Olga Karatayev, Jessica R. Barson, Sarah F. Leibowitz

J Neurochem. Author manuscript; available in PMC 2016 Dec 1.

Published in final edited form as: J Neurochem. 2015 Dec; 135(5): 918–931. Published online 2015 Sep 29. doi: 10.1111/jnc.13298

PMCID:: PMC4715552

Abstract Article PDF–2.1M

Select item 467103414.

Peroxisome proliferator-activated receptor-delta agonist ameliorated inflammasome activation in nonalcoholic fatty liver disease

Hyun Jung Lee, Jong Eun Yeon, Eun Jung Ko, Eileen L Yoon, Sang Jun Suh, Keunhee Kang, Hae Rim Kim, Seoung Hee Kang, Yang Jae Yoo, Jihye Je, Beom Jae Lee, Ji Hoon Kim, Yeon Seok Seo, Hyung Joon Yim, Kwan Soo Byun

World J Gastroenterol. 2015 Dec 7; 21(45): 12787–12799. Published online 2015 Dec 7. doi: 10.3748/wjg.v21.i45.12787

PMCID:: PMC4671034

Abstract Article PDF–1.3M

Select item 465715415.

The coactivator PGC-1α regulates mouse skeletal muscle oxidative metabolism independently of the nuclear receptor PPARβ/δ in sedentary mice fed a regular chow diet

Joaquín Pérez-Schindler, Kristoffer Svensson, Elyzabeth Vargas-Fernández, Gesa Santos, Walter Wahli, Christoph Handschin

Diabetologia. Author manuscript; available in PMC 2015 Nov 24.

Published in final edited form as: Diabetologia. 2014 Nov; 57(11): 2405–2412. Published online 2014 Aug 13. doi: 10.1007/s00125-014-3352-3

PMCID:: PMC4657154

Abstract Article PDF–1.5M

Select item 464561416.

Peroxisome Proliferator-activated Receptor-D (PPARD) Coordinates Mouse Spermatogenesis by Modulating Extracellular Signal-regulated Kinase (ERK)-dependent Signaling

Pei-Li Yao, LiPing Chen, Rex A. Hess, Rolf Müller, Frank J. Gonzalez, Jeffrey M. Peters

J Biol Chem. 2015 Sep 18; 290(38): 23416–23431. Published online 2015 Aug 4. doi: 10.1074/jbc.M115.664508

PMCID:: PMC4645614

Abstract Article PDF–9.1M

Select item 442179917.

A metabolomic study of the PPARδ agonist GW501516 for enhancing running endurance in Kunming mice

Wei Chen, Rong Gao, Xinni Xie, Zhibing Zheng, Haijing Li, Song Li, Fangting Dong, Lili Wang

Sci Rep. 2015; 5: 9884. Published online 2015 May 6. doi: 10.1038/srep09884

PMCID:: PMC4421799

Abstract Article PDF–2.0M

Select item 423942618.

Impaired Musculoskeletal Response to Age and Exercise in PPARβ^−/− Diabetic Mice

He Fu, Beatrice Desvergne, Serge Ferrari, Nicolas Bonnet

Endocrinology. 2014 Dec; 155(12): 4686–4696. Published online 2014 Oct 3. doi: 10.1210/en.2014-1585

PMCID:: PMC4239426

Abstract Article

Select item 404318019.

Pharmacological activation of PPARβ promotes rapid and calcineurin-dependent fiber remodeling and angiogenesis in mouse skeletal muscle

Céline Gaudel, Chantal Schwartz, Christian Giordano, Nada A. Abumrad, Paul A. Grimaldi

Am J Physiol Endocrinol Metab. 2008 Aug; 295(2): E297–E304. doi: 10.1152/ajpendo.00581.2007

PMCID:: PMC4043180

Abstract Article

Select item 393649120.

Src is activated by the nuclear receptor peroxisome proliferator-activated receptor β/δ in ultraviolet radiation-induced skin cancer

Alexandra Montagner, Maria B Delgado, Corinne Tallichet-Blanc, Jeremy S K Chan, Ming K Sng, Hélène Mottaz, Gwendoline Degueurce, Yannick Lippi, Catherine Moret, Michael Baruchet, Maria Antsiferova, Sabine Werner, Daniel Hohl, Talal Al Saati, Pierre J Farmer, Nguan S Tan, Liliane Michalik, Walter Wahli

EMBO Mol Med. 2014 Jan; 6(1): 80–98. Published online 2013 Nov 6. doi: 10.1002/emmm.201302666