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Select item 96845571.

Manipulating PP2Acα-ASK-JNK signaling to favor apoptotic over necroptotic hepatocyte fate reduces the extent of necrosis and fibrosis upon acute liver injury

Ke Lu, Si-Yu Shen, Ou-Yang Luo, Yue Lu, Tian-Shu Shi, Jing Wu, Qi Cheng, Hua-Jian Teng, Di Chen, Xiang Lu, Chao-Jun Li, Qing Jiang, Lei Fang, Bin Xue

Cell Death Dis. 2022 Nov; 13(11): 985. Published online 2022 Nov 22. doi: 10.1038/s41419-022-05353-z

PMCID:: PMC9684557

Abstract Article PDF–8.0M

Select item 91010922.

Protein Phosphatase 2A Improves Cardiac Functional Response to Ischemia and Sepsis

Ulrich Gergs, Tina Jahn, Nico Schulz, Claudia Großmann, Uwe Rueckschloss, Uta Demus, Igor B. Buchwalow, Joachim Neumann

Int J Mol Sci. 2022 May; 23(9): 4688. Published online 2022 Apr 23. doi: 10.3390/ijms23094688

PMCID:: PMC9101092

Abstract Article PDF–4.3M

Select item 81778053.

Tumor‐associated macrophages promote the metastasis and growth of non‐small‐cell lung cancer cells through NF‐κB/PP2Ac‐positive feedback loop

Zhan‐Wen Liang, Xin‐Xin Ge, Meng‐Dan Xu, Hualong Qin, Meng‐Yao Wu, Meng Shen, Yan Zhang, Xiao‐Meng Liu, Kai Chen, Wei Li, Weiming Duan, Songbing Qin

Cancer Sci. 2021 Jun; 112(6): 2140–2157. Published online 2021 May 1. doi: 10.1111/cas.14863

PMCID:: PMC8177805

Abstract Article PDF–3.7M

Select item 74670594.

Inhibition of Protein Phosphatase-2A with LB-100 Enhances Antitumor Immunity Against Glioblastoma

Dominic Maggio, Winson S. Ho, Rebecca Breese, Stuart Walbridge, Herui Wang, Jing Cui, John D. Heiss, Mark R. Gilbert, John S. Kovach, Rongze O. Lu, Zhengping Zhuang

J Neurooncol. Author manuscript; available in PMC 2020 Sep 2.

Published in final edited form as: J Neurooncol. 2020 Jun; 148(2): 231–244. Published online 2020 Apr 27. doi: 10.1007/s11060-020-03517-5

PMCID:: PMC7467059

Abstract Article PDF–1.8M

Select item 65896835.

Protein phosphatase 2A has an essential role in promoting thymocyte survival during selection

Mingzhu Zheng, Dan Li, Zhishan Zhao, Dmytro Shytikov, Qin Xu, Xuexiao Jin, Jingjing Liang, Jun Lou, Songquan Wu, Lie Wang, Hu Hu, Yiting Zhou, Xiang Gao, Linrong Lu

Proc Natl Acad Sci U S A. 2019 Jun 18; 116(25): 12422–12427. Published online 2019 May 31. doi: 10.1073/pnas.1821116116

PMCID:: PMC6589683

Abstract Article PDF–1.5M

Select item 63388616.

Phosphatase PP2A is essential for T_H17 differentiation

Qin Xu, Xuexiao Jin, Mingzhu Zheng, Deepak Rohila, Guotong Fu, Zhuoyu Wen, Jun Lou, Songquan Wu, Richard Sloan, Lie Wang, Hu Hu, Xiang Gao, Linrong Lu

Proc Natl Acad Sci U S A. 2019 Jan 15; 116(3): 982–987. Published online 2018 Dec 28. doi: 10.1073/pnas.1807484116

PMCID:: PMC6338861

Abstract Article PDF–1.3M

Select item 51305327.

Protein phosphatase 2A activation attenuates inflammation in murine models of acute lung injury

Walker M. McHugh, William W. Russell, Andrew J. Fleszar, Paul E. Rodenhouse, Skyler P. Rietberg, Lei Sun, Thomas P. Shanley, Timothy T. Cornell

Am J Physiol Lung Cell Mol Physiol. 2016 Nov 1; 311(5): L903–L912. Published online 2016 Sep 16. doi: 10.1152/ajplung.00007.2016

PMCID:: PMC5130532

Abstract Article

Select item 48815778.

Conditional Knockout in Mice Reveals the Critical Roles of Ppp2ca in Epidermis Development

Chao Fang, Lei Li, Jianmin Li

Int J Mol Sci. 2016 May; 17(5): 756. Published online 2016 May 18. doi: 10.3390/ijms17050756

PMCID:: PMC4881577

Abstract Article PDF–14M

Select item 48127279.

PP2A methylation controls sensitivity and resistance to β-amyloid–induced cognitive and electrophysiological impairments

Russell E. Nicholls, Jean-Marie Sontag, Hong Zhang, Agnieszka Staniszewski, Shijun Yan, Carla Y. Kim, Michael Yim, Caitlin M. Woodruff, Erland Arning, Brandi Wasek, Deqi Yin, Teodoro Bottiglieri, Estelle Sontag, Eric R. Kandel, Ottavio Arancio

Proc Natl Acad Sci U S A. 2016 Mar 22; 113(12): 3347–3352. Published online 2016 Mar 7. doi: 10.1073/pnas.1521018113

PMCID:: PMC4812727

Abstract Article PDF–1.1M

Select item 472618910.

Blocking protein phosphatase 2A signaling prevents endothelial-to-mesenchymal transition and renal fibrosis: a peptide-based drug therapy

Yuanjun Deng, Yanyan Guo, Ping Liu, Rui Zeng, Yong Ning, Guangchang Pei, Yueqiang Li, Meixue Chen, Shuiming Guo, Xiaoqing Li, Min Han, Gang Xu

Sci Rep. 2016; 6: 19821. Published online 2016 Jan 25. doi: 10.1038/srep19821

PMCID:: PMC4726189

Abstract Article PDF–2.8M

Select item 461997711.

Protein Phosphatase 2A Mediates Oxidative Stress Induced Apoptosis in Osteoblasts

Chong-xin Huang, Bo Lv, Yue Wang

Mediators Inflamm. 2015; 2015: 804260. Published online 2015 Oct 11. doi: 10.1155/2015/804260

PMCID:: PMC4619977

Abstract Article PDF–2.2M

Select item 442908712.

Liver-specific deletion of Ppp2cα enhances glucose metabolism and insulin sensitivity

Li Xian, Siyuan Hou, Zan Huang, An Tang, Peiliang Shi, Qinghua Wang, Anying Song, Shujun Jiang, Zhaoyu Lin, Shiying Guo, Xiang Gao

Aging (Albany NY) 2015 Apr; 7(4): 223–232. Published online 2015 Feb 21. doi: 10.18632/aging.100725

PMCID:: PMC4429087

Abstract Article PDF–2.7M

Select item 406024713.

Protein Phosphatase 2A Catalytic Subunit α (PP2Ac) Plays a MyD88-dependent, Central Role in the Gene-Specific Regulation of Endotoxin Tolerance (ET)

Ling Xie, Cui Liu, Li Wang, Harsha P. Gunawardena, Yanbao Yu, Ruyun Du, Debra J. Taxman, Penggao Dai, Zhen Yan, Jing Yu, Stephen P. Holly, Leslie V. Parise, Yisong Wan, Jenny P. Ting, Xian Chen

Cell Rep. Author manuscript; available in PMC 2014 Jun 17.

Published in final edited form as: Cell Rep. 2013 Mar 28; 3(3): 678–688. Published online 2013 Feb 21. doi: 10.1016/j.celrep.2013.01.029

PMCID:: PMC4060247

Abstract Article PDF–1.6M

Select item 377222314.

Protein Phosphatase 2A Enables Expression of Interleukin 17 (IL-17) through Chromatin Remodeling

Sokratis A. Apostolidis, Thomas Rauen, Christian M. Hedrich, George C. Tsokos, José C. Crispín

J Biol Chem. 2013 Sep 13; 288(37): 26775–26784. Published online 2013 Aug 5. doi: 10.1074/jbc.M113.483743

PMCID:: PMC3772223

Abstract Article PDF–2.3M

Select item 332467215.

Protein phosphatase 2A confers susceptibility to autoimmune disease through an IL-17-dependent mechanism

José C. Crispín, Sokratis A. Apostolidis, Florencia Rosetti, Marton Keszei, Ninghai Wang, Cox Terhorst, Tanya N. Mayadas, George C. Tsokos

J Immunol. Author manuscript; available in PMC 2013 Apr 15.

Published in final edited form as: J Immunol. 2012 Apr 15; 188(8): 3567–3571. Published online 2012 Mar 14. doi: 10.4049/jimmunol.1200143

PMCID:: PMC3324672

Abstract Article PDF–1.5M

Select item 289133116.

Declining phosphatases underlie aging-related hyperphosphorylation of neurofilaments

Veeranna, Dun-Sheng Yang, Ju-Hyun Lee, K. Yaragudri Vinod, Philip Stavrides, Niranjana D. Amin, Harish C. Pant, Ralph A. Nixon

Neurobiol Aging. Author manuscript; available in PMC 2012 Nov 1.

Published in final edited form as: Neurobiol Aging. 2011 Nov; 32(11): 2016–2029. Published online 2009 Dec 23. doi: 10.1016/j.neurobiolaging.2009.12.001

PMCID:: PMC2891331

Abstract Article PDF–3.1M

Select item 1032757717.

Protein phosphatase 2A propels follicular T helper cell development in lupus

Yu Jiang, Xuexiao Jin, Zhexu Chi, Yadan Bai, Kalpana Manthiram, Pamela Mudd, Kaixiang Zhu, Lie Wang, Pamela L. Schwartzberg, Yongmei Han, Xiang Gao, Linrong Lu, Qin Xu

J Autoimmun. Author manuscript; available in PMC 2024 Apr 1.

Published in final edited form as: J Autoimmun. 2023 Apr; 136: 103028. Published online 2023 Mar 29. doi: 10.1016/j.jaut.2023.103028

PMCID:: PMC10327577

Abstract Article PDF–2.6M

Select item 970060018.

ATM phosphorylates PP2A subunit A resulting in nuclear export and spatiotemporal regulation of the DNA damage response

Amrita Sule, Sarah E. Golding, Syed F. Ahmad, James Watson, Mostafa H. Ahmed, Glen E. Kellogg, Tytus Bernas, Sean Koebley, Jason C. Reed, Lawrence F. Povirk, Kristoffer Valerie

Cell Mol Life Sci. 2022; 79(12): 603. Published online 2022 Nov 24. doi: 10.1007/s00018-022-04550-5

PMCID:: PMC9700600

Abstract Article PDF–3.6M

Select item 942158419.

Liver PP2A-Cα Protects From Parenteral Nutrition-associated Hepatic Steatosis

Gulisudumu Maitiabula, Feng Tian, Peng Wang, Li Zhang, Xuejin Gao, Songlin Wan, Haifeng Sun, Jianbo Yang, Yupeng Zhang, Tingting Gao, Bin Xue, Chaojun Li, Jieshou Li, Xinying Wang

Cell Mol Gastroenterol Hepatol. 2022; 14(3): 669–692. Published online 2022 May 26. doi: 10.1016/j.jcmgh.2022.05.008