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Select item 85287071.

PRKAR2A deficiency protects mice from experimental colitis by increasing IFN-stimulated gene expression and modulating the intestinal microbiota

Lumin Wei, Rongjing Zhang, Jinzhao Zhang, Juanjuan Li, Deping Kong, Qi Wang, Jing Fang, Lifu Wang

Mucosal Immunol. 2021; 14(6): 1282–1294. Published online 2021 Aug 4. doi: 10.1038/s41385-021-00426-2

PMCID:: PMC8528707

Abstract Article PDF–14M

Select item 77144112.

Loss of habenular Prkar2a reduces hedonic eating and increases exercise motivation

Edra London, Jason C. Wester, Michelle Bloyd, Shelby Bettencourt, Chris J. McBain, Constantine A. Stratakis

JCI Insight. 2020 Dec 3; 5(23): e141670. Published online 2020 Dec 3. doi: 10.1172/jci.insight.141670

PMCID:: PMC7714411

Abstract Article PDF–40M

Select item 41385733.

Differentially Regulated Protein Kinase A (PKA) Activity in Adipose Tissue and Liver Is Associated With Resistance to Diet-Induced Obesity and Glucose Intolerance in Mice That Lack PKA Regulatory Subunit Type IIα

Edra London, Maria Nesterova, Ninet Sinaii, Eva Szarek, Tatyana Chanturiya, Spyridon A. Mastroyannis, Oksana Gavrilova, Constantine A. Stratakis

Endocrinology. 2014 Sep; 155(9): 3397–3408. Published online 2014 Jun 10. doi: 10.1210/en.2014-1122

PMCID:: PMC4138573

Abstract Article

Select item 40366974.

PKA Type IIα Holoenzyme Reveals a Combinatorial Strategy for Isoform Diversity

Jian Wu, Simon H. J. Brown, Sventja von Daake, Susan S. Taylor

Science. Author manuscript; available in PMC 2014 May 28.

Published in final edited form as: Science. 2007 Oct 12; 318(5848): 274–279. doi: 10.1126/science.1146447

PMCID:: PMC4036697

Abstract Article PDF–1.9M

Select item 59877175.

PKA-RII subunit phosphorylation precedes activation by cAMP and regulates activity termination

Jörg Isensee, Melanie Kaufholz, Matthias J. Knape, Jan Hasenauer, Hanna Hammerich, Humberto Gonczarowska-Jorge, René P. Zahedi, Frank Schwede, Friedrich W. Herberg, Tim Hucho

J Cell Biol. 2018 Jun 4; 217(6): 2167–2184. doi: 10.1083/jcb.201708053

PMCID:: PMC5987717

Abstract Article PDF–3.3M

Select item 2988206.

The molecular cloning of a type II regulatory subunit of the cAMP-dependent protein kinase from rat skeletal muscle and mouse brain.

J D Scott, M B Glaccum, M J Zoller, M D Uhler, D M Helfman, G S McKnight, E G Krebs

Proc Natl Acad Sci U S A. 1987 Aug; 84(15): 5192–5196. doi: 10.1073/pnas.84.15.5192

PMCID:: PMC298820

Summary Page Browse PDF–967K

Select item 236037.

Type II regulatory subunits are not required for the anchoring-dependent modulation of Ca²⁺ channel activity by cAMP-dependent protein kinase

Kimberly A. Burton, Barry D. Johnson, Zachary E. Hausken, Ruth E. Westenbroek, Rejean L. Idzerda, Todd Scheuer, John D. Scott, William A. Catterall, G. Stanley McKnight

Proc Natl Acad Sci U S A. 1997 Sep 30; 94(20): 11067–11072. doi: 10.1073/pnas.94.20.11067

PMCID:: PMC23603

Abstract Article PDF–388K

Select item 50308068.

PKA regulatory IIα subunit is essential for PGD₂-mediated resolution of inflammation

Deping Kong, Yujun Shen, Guizhu Liu, Shengkai Zuo, Yong Ji, Ankang Lu, Masataka Nakamura, Michael Lazarus, Constantine A. Stratakis, Richard M. Breyer, Ying Yu

J Exp Med. 2016 Sep 19; 213(10): 2209–2226. doi: 10.1084/jem.20160459

PMCID:: PMC5030806

Abstract Article PDF–4.1M

Select item 45996689.

Haploinsufficiency for either one of the type-II regulatory subunits of protein kinase A improves the bone phenotype of Prkar1a^+/− mice

Sisi Liu, Emmanouil Saloustros, Edward L. Mertz, Kitman Tsang, Matthew F. Starost, Paraskevi Salpea, Fabio R. Faucz, Eva Szarek, Maria Nesterova, Sergey Leikin, Constantine A. Stratakis

Hum Mol Genet. 2015 Nov 1; 24(21): 6080–6092. Published online 2015 Aug 5. doi: 10.1093/hmg/ddv320

PMCID:: PMC4599668

Abstract Article PDF–1.7M

Select item 347492210.

Anchored phosphatases modulate glucose homeostasis

Simon A Hinke, Manuel F Navedo, Allison Ulman, Jennifer L Whiting, Patrick J Nygren, Geng Tian, Antonio J Jimenez-Caliani, Lorene K Langeberg, Vincenzo Cirulli, Anders Tengholm, Mark L Dell’Acqua, L Fernando Santana, John D Scott

EMBO J. 2012 Oct 17; 31(20): 3991–4004. Published online 2012 Aug 31. doi: 10.1038/emboj.2012.244

Correction in:: EMBO J. 2012 Nov 28; 31(23): 4481.

PMCID:: PMC3474922

Abstract Article PDF–1.4M

Select item 123653311.

Antioxidants modulate mitochondrial PKA and increase CREB binding to D-loop DNA of the mitochondrial genome in neurons

Hoon Ryu, Junghee Lee, Soren Impey, Rajiv R. Ratan, Robert J. Ferrante

Proc Natl Acad Sci U S A. 2005 Sep 27; 102(39): 13915–13920. Published online 2005 Sep 16. doi: 10.1073/pnas.0502878102

PMCID:: PMC1236533

Abstract Article PDF–685K

Select item 466063912.

Hematopoietic neoplasms in Prkar2a-deficient mice

Emmanouil Saloustros, Paraskevi Salpea, Chen-Feng Qi, Lina A. Gugliotti, Kitman Tsang, Sisi Liu, Matthew F. Starost, Herbert C. Morse, III, Constantine A. Stratakis

J Exp Clin Cancer Res. 2015; 34: 143. Published online 2015 Nov 25. doi: 10.1186/s13046-015-0257-z

PMCID:: PMC4660639

Abstract Article PDF–1.8M

Select item 293463113.

Disruption of Protein Kinase A Localization Using a Trans-activator of Transcription (TAT)-conjugated A-kinase-anchoring Peptide Reduces Cardiac Function

Hemal H. Patel, Lora L. Hamuro, Byeong Jo Chun, Yoshitaka Kawaraguchi, Alexander Quick, Brian Rebolledo, Juniper Pennypacker, Jackie Thurston, Natalia Rodriguez-Pinto, Christopher Self, Gary Olson, Paul A. Insel, Wayne R. Giles, Susan S. Taylor, David M. Roth

J Biol Chem. 2010 Sep 3; 285(36): 27632–27640. Published online 2010 Jun 26. doi: 10.1074/jbc.M110.146589

PMCID:: PMC2934631

Abstract Article PDF–2.8M

Select item 379524114.

Cypher/ZASP Is a Novel A-kinase Anchoring Protein

Changsong Lin, Xiaogang Guo, Stephan Lange, Jie Liu, Kunfu Ouyang, Xiang Yin, Liujun Jiang, Yibo Cai, Yongxin Mu, Farah Sheikh, Sheng Ye, Ju Chen, Yuehai Ke, Hongqiang Cheng

J Biol Chem. 2013 Oct 11; 288(41): 29403–29413. Published online 2013 Aug 31. doi: 10.1074/jbc.M113.470708