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Items: 1 to 20 of 91

1.
PTPN2 Is a Critical Regulator of Ileal Paneth Cell Viability and Function in Mice
Vinicius Canale, Marianne R. Spalinger, Rocio Alvarez, Anica Sayoc-Becerra, Golshid Sanati, Salomon Manz, Pritha Chatterjee, Alina N. Santos, Hillmin Lei, Sharon Jahng, Timothy Chu, Ali Shawki, Elaine Hanson, Lars Eckmann, André J. Ouellette, Declan F. McCole
Cell Mol Gastroenterol Hepatol. 2023; 16(1): 39–62. Published online 2023 Apr 7. doi: 10.1016/j.jcmgh.2023.03.009
PMCID:
PMC10213106
AbstractArticlePDF–8.7M
2.
PTPN2 regulates bacterial clearance in a mouse model of enteropathogenic and enterohemorrhagic E. coli infection
Marianne R. Spalinger, Vinicius Canale, Anica Becerra, Ali Shawki, Meli’sa Crawford, Alina N. Santos, Pritha Chatterjee, Jiang Li, Meera G. Nair, Declan F. McCole
JCI Insight. 2023 Feb 22; 8(4): e156909. Published online 2023 Feb 22. doi: 10.1172/jci.insight.156909
PMCID:
PMC9977497
AbstractArticlePDF–6.3M
3.
Autoimmune susceptibility gene PTPN2 is required for clearance of adherent-invasive Escherichia coli by integrating bacterial uptake and lysosomal defence
Marianne Rebecca Spalinger, Ali Shawki, Pritha Chatterjee, Vinicius Canale, Alina Santos, Anica Sayoc-Becerra, Michael Scharl, Michel L Tremblay, James Borneman, Declan F McCole
Gut. 2022 Jan; 71(1): 89–99. Published online 2021 Feb 9. doi: 10.1136/gutjnl-2020-323636
PMCID:
PMC8666829
AbstractArticlePDF–7.0M
4.
Macrophages Compensate for Loss of Protein Tyrosine Phosphatase N2 in Dendritic Cells to Protect from Elevated Colitis
Larissa Hering, Egle Katkeviciute, Marlene Schwarzfischer, Anna Niechcial, Julianne B. Riggs, Marcin Wawrzyniak, Kirstin Atrott, Marnix van de Sande, Silvia Lang, Burkhard Becher, Gerhard Rogler, Michael Scharl, Marianne R. Spalinger
Int J Mol Sci. 2021 Jul; 22(13): 6820. Published online 2021 Jun 25. doi: 10.3390/ijms22136820
PMCID:
PMC8269284
AbstractArticlePDF–2.7M
5.
Programmable Unlocking Nano‐Matryoshka‐CRISPR Precisely Reverses Immunosuppression to Unleash Cascade Amplified Adaptive Immune Response
Jin Yang, Zhike Li, Meiling Shen, Yan Wang, Li Wang, Jiamiao Li, Wen Yang, Jie Li, Haijun Li, Xinxin Wang, Qinjie Wu, Changyang Gong
Adv Sci (Weinh) 2021 Jul; 8(13): 2100292. Published online 2021 May 14. doi: 10.1002/advs.202100292
PMCID:
PMC8261501
AbstractArticlePDF–5.9M
6.
Titanium Dioxide Presents a Different Profile in Dextran Sodium Sulphate-Induced Experimental Colitis in Mice Lacking the IBD Risk Gene Ptpn2 in Myeloid Cells
Javier Conde, Marlene Schwarzfischer, Egle Katkeviciute, Janine Häfliger, Anna Niechcial, Nathalie Brillant, Roberto Manzini, Katharina Bäbler, Kirstin Atrott, Silvia Lang, Michael Scharl
Int J Mol Sci. 2021 Jan; 22(2): 772. Published online 2021 Jan 14. doi: 10.3390/ijms22020772
PMCID:
PMC7828807
AbstractArticlePDF–6.5M
7.
Identification of a Novel Susceptibility Marker for SARS-CoV-2 Infection in Human Subjects and Risk Mitigation with a Clinically Approved JAK Inhibitor in Human/Mouse Cells
Marianne R. Spalinger, Rong Hai, Jiang Li, Alina N. Santos, Tara M. Nordgren, Michel L. Tremblay, Lars Eckmann, Elaine Hanson, Michael Scharl, Xiwei Wu, Brigid S. Boland, Declan F. McCole
Version 1. bioRxiv. Preprint. 2020 Dec 9. doi: 10.1101/2020.12.09.416586
PMCID:
PMC7743066
AbstractArticlePDF–3.0M
8.
The autoimmune susceptibility gene, PTPN2, restricts expansion of a novel mouse adherent-invasive E. coli
Ali Shawki, Rocio Ramirez, Marianne R. Spalinger, Paul M. Ruegger, Anica Sayoc-Becerra, Alina N. Santos, Pritha Chatterjee, Vinicius Canale, Jonathan D. Mitchell, John C. Macbeth, Casey M. Gries, Michel L. Tremblay, Ansel Hsiao, James Borneman, Declan F. McCole
Gut Microbes. 2020; 11(6): 1547–1566. Published online 2020 Jun 26. doi: 10.1080/19490976.2020.1775538
PMCID:
PMC7524159
AbstractArticlePDF–16M
9.
PTPN2 Deficiency Enhances Programmed T Cell Expansion and Survival Capacity of Activated T Cells
Markus Flosbach, Susanne G. Oberle, Stefanie Scherer, Jana Zecha, Madlaina von Hoesslin, Florian Wiede, Vijaykumar Chennupati, Jolie G. Cullen, Markus List, Josch K. Pauling, Jan Baumbach, Bernhard Kuster, Tony Tiganis, Dietmar Zehn
Cell Rep. 2020 Jul 28; 32(4): 107957. Published online 2020 Jul 28. doi: 10.1016/j.celrep.2020.107957
PMCID:
PMC7408006
AbstractArticle
10.
Tyrosine‐protein phosphatase non‐receptor type 2 inhibits alveolar bone resorption in diabetic periodontitis via dephosphorylating CSF1 receptor
Dongjiao Zhang, Yanfei Jiang, Dawei Song, Zhenkun Zhu, Cong Zhou, Li Dai, Xin Xu
J Cell Mol Med. 2019 Oct; 23(10): 6690–6699. Published online 2019 Aug 2. doi: 10.1111/jcmm.14545
PMCID:
PMC6787442
AbstractArticlePDF–1.8M
11.
PTPN2 improved renal injury and fibrosis by suppressing STAT‐induced inflammation in early diabetic nephropathy
Ya Li, Huimin Zhou, Yulin Li, Lu Han, Ming Song, Fangfang Chen, Guokai Shang, Di Wang, Zhihao Wang, Wei Zhang, Ming Zhong
J Cell Mol Med. 2019 Jun; 23(6): 4179–4195. Published online 2019 Apr 6. doi: 10.1111/jcmm.14304
PMCID:
PMC6533506
AbstractArticlePDF–4.8M
12.
Reduced expression of phosphatase PTPN2 promotes pathogenic conversion of Tregs in autoimmunity
Mattias N.D. Svensson, Karen M. Doody, Benjamin J. Schmiedel, Sourya Bhattacharyya, Bharat Panwar, Florian Wiede, Shen Yang, Eugenio Santelli, Dennis J. Wu, Cristiano Sacchetti, Ravindra Gujar, Gregory Seumois, William B. Kiosses, Isabelle Aubry, Gisen Kim, Piotr Mydel, Shimon Sakaguchi, Mitchell Kronenberg, Tony Tiganis, Michel L. Tremblay, Ferhat Ay, Pandurangan Vijayanand, Nunzio Bottini
J Clin Invest. 2019 Mar 1; 129(3): 1193–1210. Published online 2019 Feb 11. doi: 10.1172/JCI123267
PMCID:
PMC6391091
AbstractArticlePDF–14M
13.
Loss of T-cell protein tyrosine phosphatase in the intestinal epithelium promotes local inflammation by increasing colonic stem cell proliferation
Stéphanie Bussières-Marmen, Valérie Vinette, Jeremy Gungabeesoon, Isabelle Aubry, Luis Alberto Pérez-Quintero, Michel L Tremblay
Cell Mol Immunol. 2018 Apr; 15(4): 367–376. Published online 2017 Mar 13. doi: 10.1038/cmi.2016.72
PMCID:
PMC6052838
AbstractArticlePDF–3.6M
14.
Epidermal-specific deletion of TC-PTP promotes UVB-induced epidermal cell survival through the regulation of Flk-1/JNK signaling
Minwoo Baek, Mihwa Kim, Jae Sung Lim, Liza D. Morales, Joselin Hernandez, Srinivas Mummidi, Sarah Williams-Blangero, Ik-Soon Jang, Andrew T. Tsin, Dae Joon Kim
Cell Death Dis. 2018 Jul; 9(7): 730. Published online 2018 Jun 28. doi: 10.1038/s41419-018-0781-9
PMCID:
PMC6023867
AbstractArticlePDF–6.5M
15.
Targeted disruption of TC-PTP in the proliferative compartment augments STAT3 and AKT signaling and skin tumor development
Hyunseung Lee, Mihwa Kim, Minwoo Baek, Liza D. Morales, Ik-Soon Jang, Thomas J. Slaga, John DiGiovanni, Dae Joon Kim
Sci Rep. 2017; 7: 45077. Published online 2017 Mar 21. doi: 10.1038/srep45077
PMCID:
PMC5359614
AbstractArticlePDF–2.7M
16.
TCPTP-deficiency in muscle does not alter insulin signalling and glucose homeostasis
Kim Loh, Troy L. Merry, Sandra Galic, Ben J. Wu, Matthew J. Watt, Sheng Zhang, Zhong-Yin Zhang, Benjamin G. Neel, Tony Tiganis
Diabetologia. Author manuscript; available in PMC 2016 Oct 11.
Published in final edited form as: Diabetologia. 2012 Feb; 55(2): 468–478. Published online 2011 Nov 29. doi: 10.1007/s00125-011-2386-z
PMCID:
PMC5057388
AbstractArticlePDF–2.4M
17.
Pancreatic T cell protein–tyrosine phosphatase deficiency affects beta cell function in mice
Yannan Xi, Siming Liu, Ahmed Bettaieb, Kosuke Matsuo, Izumi Matsuo, Ellen Hosein, Samah Chahed, Florian Wiede, Sheng Zhang, Zhong-Yin Zhang, Rohit N. Kulkarni, Tony Tiganis, Fawaz G. Haj
Diabetologia. Author manuscript; available in PMC 2016 Jan 1.
Published in final edited form as: Diabetologia. 2015 Jan; 58(1): 122–131. Published online 2014 Oct 23. doi: 10.1007/s00125-014-3413-7
Correction in:
Diabetologia. 2023 Oct 20
PMCID:
PMC4258175
AbstractArticlePDF–1.9M
18.
Strain-Dependent Differences in Bone Development, Myeloid Hyperplasia, Morbidity and Mortality in Ptpn2-Deficient Mice
Florian Wiede, Sock Hui Chew, Catherine van Vliet, Ingrid J. Poulton, Konstantinos Kyparissoudis, Tedjo Sasmono, Kim Loh, Michel L. Tremblay, Dale I. Godfrey, Natalie A. Sims, Tony Tiganis
PLoS One. 2012; 7(5): e36703. Published online 2012 May 8. doi: 10.1371/journal.pone.0036703
PMCID:
PMC3348136
AbstractArticlePDF–5.0M
19.
Increased Susceptibility to Dextran Sulfate Sodium Induced Colitis in the T Cell Protein Tyrosine Phosphatase Heterozygous Mouse
Syed-Wajahat Hassan, Karen M. Doody, Serge Hardy, Noriko Uetani, Denis Cournoyer, Michel L. Tremblay
PLoS One. 2010; 5(1): e8868. Published online 2010 Jan 25. doi: 10.1371/journal.pone.0008868
PMCID:
PMC2810325
AbstractArticlePDF–383K
20.
Ptpn2 and KLRG1 regulate the generation and function of tissue-resident memory CD8+ T cells in skin
Katharina Hochheiser, Florian Wiede, Teagan Wagner, David Freestone, Matthias H. Enders, Moshe Olshansky, Brendan Russ, Simone Nüssing, Emma Bawden, Asolina Braun, Annabell Bachem, Elise Gressier, Robyn McConville, Simone L. Park, Claerwen M. Jones, Gayle M. Davey, David E. Gyorki, David Tscharke, Ian A. Parish, Stephen Turner, Marco J. Herold, Tony Tiganis, Sammy Bedoui, Thomas Gebhardt
J Exp Med. 2021 Jun 7; 218(6): e20200940. Published online 2021 Apr 29. doi: 10.1084/jem.20200940
PMCID:
PMC8091133
AbstractArticlePDF–5.0M

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