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Select item 52229821.

SAG/Rbx2-Dependent Neddylation Regulates T-Cell Responses

Nathan D. Mathewson, Hideaki Fujiwara, Shin-Rong Wu, Tomomi Toubai, Katherine Oravecz-Wilson, Yaping Sun, Corinne Rossi, Cynthia Zajac, Yi Sun, Pavan Reddy

Am J Pathol. 2016 Oct; 186(10): 2679–2691. doi: 10.1016/j.ajpath.2016.06.014

PMCID:: PMC5222982

Article PDF–2.7M

Select item 66390382.

Comparative Analysis of cul5 and rbx2 Expression in the Developing and Adult Murine Brain and Their Essentiality During Mouse Embryogenesis

Keiko Hino, Sergi Simó, Jonathan A. Cooper

Dev Dyn. Author manuscript; available in PMC 2019 Nov 7.

Published in final edited form as: Dev Dyn. 2018 Nov; 247(11): 1227–1236. Published online 2018 Nov 7. doi: 10.1002/dvdy.24675

PMCID:: PMC6639038

Article PDF–3.0M

Select item 62917373.

SAG/RBX2 E3 Ubiquitin Ligase Differentially Regulates Inflammatory Responses of Myeloid Cell Subsets

Xiufang Xiong, Nathan D. Mathewson, Hua Li, Mingjia Tan, Hideaki Fujiwara, Haomin Li, Pavan Reddy, Yi Sun

Front Immunol. 2018; 9: 2882. Published online 2018 Dec 6. doi: 10.3389/fimmu.2018.02882

PMCID:: PMC6291737

Article PDF–1.5M

Select item 43096844.

Inactivation of Sag/Rbx2/Roc2 E3 Ubiquitin Ligase Triggers Senescence and Inhibits Kras-Induced Immortalization

Mingjia Tan, Hua Li, Yi Sun

Neoplasia. 2015 Jan; 17(1): 114–123. Published online 2015 Jan 23. doi: 10.1016/j.neo.2014.11.008

PMCID:: PMC4309684

Article PDF–1.8M

Select item 39046155.

Inactivation of SAG/RBX2 E3 ubiquitin ligase suppresses Kras^G12D-driven lung tumorigenesis

Hua Li, Mingjia Tan, Lijun Jia, Dongping Wei, Yongchao Zhao, Guoan Chen, Jie Xu, Lili Zhao, Dafydd Thomas, David G. Beer, Yi Sun

J Clin Invest. 2014 Feb 3; 124(2): 835–846. Published online 2014 Jan 16. doi: 10.1172/JCI70297

PMCID:: PMC3904615

Article PDF–4.9M

Select item 40169966.

Endothelial deletion of Sag/Rbx2/Roc2 E3 ubiquitin ligase causes embryonic lethality and blocks tumor angiogenesis

Mingjia Tan, Hua Li, Yi Sun

Oncogene. Author manuscript; available in PMC 2015 Apr 30.

Published in final edited form as: Oncogene. 2014 Oct 30; 33(44): 5211–5220. Published online 2013 Nov 11. doi: 10.1038/onc.2013.473

PMCID:: PMC4016996

Article PDF–1.2M

Select item 841087.

SAG, a Novel Zinc RING Finger Protein That Protects Cells from Apoptosis Induced by Redox Agents

Hangjun Duan, Yuli Wang, Micheal Aviram, Manju Swaroop, Joseph A. Loo, Junhui Bian, Ye Tian, Tom Mueller, Charles L. Bisgaier, Yi Sun

Mol Cell Biol. 1999 Apr; 19(4): 3145–3155. doi: 10.1128/mcb.19.4.3145

PMCID:: PMC84108

Article PDF–3.4M

Select item 44601468.

Erbin is a novel substrate of the Sag-βTrCP E3 ligase that regulates Kras^G12D-induced skin tumorigenesis

Chuan-Ming Xie, Dongping Wei, Lili Zhao, Sylvie Marchetto, Lin Mei, Jean-Paul Borg, Yi Sun

J Cell Biol. 2015 Jun 8; 209(5): 721–738. doi: 10.1083/jcb.201411104

PMCID:: PMC4460146

Article PDF–3.6M

Select item 32418509.

SAG/RBX2/ROC2 E3 ubiquitin ligase is essential for vascular and neural development by targeting NF1 for degradation

Mingjia Tan, Yongchao Zhao, Sun-Jung Kim, Margaret Liu, Lijun Jia, Thomas L. Saunders, Yuan Zhu, Yi Sun

Dev Cell. Author manuscript; available in PMC 2012 Dec 13.

Published in final edited form as: Dev Cell. 2011 Dec 13; 21(6): 1062–1076. Published online 2011 Nov 23. doi: 10.1016/j.devcel.2011.09.014

PMCID:: PMC3241850

Article PDF–3.7M

Select item 795013210.

The Mechanism of NEDD8 Activation of CUL5 Ubiquitin E3 Ligases

Ryan J. Lumpkin, Alla S. Ahmad, Rachel Blake, Christopher J. Condon, Elizabeth A. Komives

Mol Cell Proteomics. 2021; 20: 100019. Published online 2021 Jan 6. doi: 10.1074/mcp.RA120.002414

PMCID:: PMC7950132

Article PDF–3.1M

Select item 292145611.

Disruption of Sag/Rbx2/Roc2 induces radiosensitization by increasing ROS levels and blocking NF-κB activation in mouse embryonic stem cells

Mingjia Tan, Yueming Zhu, Jordan Kovacev, Yongchao Zhao, Zhen-Qiang Pan, Douglas R. Spitz, Yi Sun

Free Radic Biol Med. Author manuscript; available in PMC 2011 Sep 15.

Published in final edited form as: Free Radic Biol Med. 2010 Sep 15; 49(6): 976–983. Published online 2010 Jun 8. doi: 10.1016/j.freeradbiomed.2010.05.030

PMCID:: PMC2921456

Article PDF–2.6M

Select item 750271712.

CRL5-dependent regulation of the small GTPases ARL4C and ARF6 controls hippocampal morphogenesis

Jisoo S. Han, Keiko Hino, Wenzhe Li, Raenier V. Reyes, Cesar P. Canales, Adam M. Miltner, Yasmin Haddadi, Junqing Sun, Chao-Yin Chen, Anna La Torre, Sergi Simó

Proc Natl Acad Sci U S A. 2020 Sep 15; 117(37): 23073–23084. Published online 2020 Sep 1. doi: 10.1073/pnas.2002749117

PMCID:: PMC7502717

Article PDF–3.3M

Select item 374913613.

Suppressor of Cytokine Signaling (SOCS) 5 Utilises Distinct Domains for Regulation of JAK1 and Interaction with the Adaptor Protein Shc-1

Edmond M. Linossi, Indu R. Chandrashekaran, Tatiana B. Kolesnik, James M. Murphy, Andrew I. Webb, Tracy A. Willson, Lukasz Kedzierski, Alex N. Bullock, Jeffrey J. Babon, Raymond S. Norton, Nicos A. Nicola, Sandra E. Nicholson

PLoS One. 2013; 8(8): e70536. Published online 2013 Aug 21. doi: 10.1371/journal.pone.0070536

PMCID:: PMC3749136

Article PDF–3.3M

Select item 260974314.

Mammalian Elongin A complex mediates DNA-damage-induced ubiquitylation and degradation of Rpb1

Takashi Yasukawa, Takumi Kamura, Shigetaka Kitajima, Ronald C Conaway, Joan W Conaway, Teijiro Aso

EMBO J. 2008 Dec 17; 27(24): 3256–3266. Published online 2008 Nov 27. doi: 10.1038/emboj.2008.249

PMCID:: PMC2609743

Article PDF–529K

Select item 581799915.

RBX2 maintains final retinal cell position in a DAB1-dependent and -independent fashion

Corinne L. Fairchild, Keiko Hino, Jisoo S. Han, Adam M. Miltner, Gabriel Peinado Allina, Caileigh E. Brown, Marie E. Burns, Anna La Torre, Sergi Simó

Development. 2018 Feb 1; 145(3): dev155283. doi: 10.1242/dev.155283

PMCID:: PMC5817999

Article

Select item 53591616.

VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases

Takumi Kamura, Katsumi Maenaka, Shuhei Kotoshiba, Masaki Matsumoto, Daisuke Kohda, Ronald C. Conaway, Joan Weliky Conaway, Keiichi I. Nakayama

Genes Dev. 2004 Dec 15; 18(24): 3055–3065. doi: 10.1101/gad.1252404

PMCID:: PMC535916

Article PDF–465K

Select item 399878817.

Fine-mapping quantitative trait loci affecting murine external ear tissue regeneration in the LG/J by SM/J advanced intercross line

J M Cheverud, H A Lawson, K Bouckaert, A V Kossenkov, L C Showe, L Cort, E P Blankenhorn, K Bedelbaeva, D Gourevitch, Y Zhang, E Heber-Katz

Heredity (Edinb) 2014 May; 112(5): 508–518. Published online 2014 Feb 26. doi: 10.1038/hdy.2013.133

PMCID:: PMC3998788

Article PDF–1.8M

Select item 333610418.

The Glomuvenous Malformation Protein Glomulin Binds Rbx1 and Regulates Cullin RING Ligase-Mediated Turnover of Fbw7

Adriana E. Tron, Takehiro Arai, David M. Duda, Hiroshi Kuwabara, Jennifer L. Olszewski, Yuko Fujiwara, Brittany N. Bahamon, Sabina Signoretti, Brenda A. Schulman, James A. DeCaprio

Mol Cell. Author manuscript; available in PMC 2012 Oct 13.

Published in final edited form as: Mol Cell. 2012 Apr 13; 46(1): 67–78. Published online 2012 Mar 8. doi: 10.1016/j.molcel.2012.02.005

PMCID:: PMC3336104

Article PDF–3.4M

Select item 385151919.

Rbx2 regulates neuronal migration through different Cullin5-RING ligase adaptors

Sergi Simó, Jonathan A. Cooper

Dev Cell. Author manuscript; available in PMC 2014 Nov 25.

Published in final edited form as: Dev Cell. 2013 Nov 25; 27(4): 10.1016/j.devcel.2013.09.022. Published online 2013 Nov 7. doi: 10.1016/j.devcel.2013.09.022

PMCID:: PMC3851519

Article PDF–6.4M

Select item 504520020.

Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury

Yong Wu, Fan-Yan Wei, Layla Kawarada, Takeo Suzuki, Kimi Araki, Yoshihiro Komohara, Atsushi Fujimura, Taku Kaitsuka, Motohiro Takeya, Yuichi Oike, Tsutomu Suzuki, Kazuhito Tomizawa

PLoS Genet. 2016 Sep; 12(9): e1006355. Published online 2016 Sep 30. doi: 10.1371/journal.pgen.1006355