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Select item 84109101.

Converting fibroblastic fates leads to wound healing without scar

Dongsheng Jiang, Yuval Rinkevich

Signal Transduct Target Ther. 2021; 6: 332. Published online 2021 Sep 1. doi: 10.1038/s41392-021-00738-6

PMCID:: PMC8410910

Article PDF–824K

Select item 66982222.

EN1 is a transcriptional dependency in triple-negative breast cancer associated with brain metastasis

Guillermo Peluffo, Ashim Subedee, Nicholas W. Harper, Natalie Kingston, Bojana Jovanović, Felipe Flores, Laura E. Stevens, Francisco Beca, Anne Trinh, Chandra Sekhar Reddy Chilamakuri, Evangelia K. Papachristou, Katherine Murphy, Ying Su, Andriy Marusyk, Clive S. D’Santos, Oscar M. Rueda, Andrew H. Beck, Carlos Caldas, Jason S. Carroll, Kornelia Polyak

Cancer Res. Author manuscript; available in PMC 2020 Feb 15.

Published in final edited form as: Cancer Res. 2019 Aug 15; 79(16): 4173–4183. Published online 2019 Jun 25. doi: 10.1158/0008-5472.CAN-18-3264

PMCID:: PMC6698222

Article PDF–1.7M

Select item 59022373.

Engrailed 1 overexpression as a potential prognostic marker in quintuple-negative breast cancer

Yu Jin Kim, Minjung Sung, Ensel Oh, Michael Van Vrancken, Ji-Young Song, Kyungsoo Jung, Yoon-La Choi

Cancer Biol Ther. 2018; 19(4): 335–345. Published online 2018 Feb 13. doi: 10.1080/15384047.2018.1423913

PMCID:: PMC5902237

Article PDF–1.1M

Select item 54826844.

Association between EN1 rs4144782 and susceptibility of knee osteoarthritis: A case-control study

Haohuan Li, Xiaolong Zhang, Yiping Cao, Song Hu, Fei Peng, Jianlin Zhou, Jianping Li

Oncotarget. 2017 May 30; 8(22): 36650–36657. Published online 2017 Apr 5. doi: 10.18632/oncotarget.16842

PMCID:: PMC5482684

Article PDF–1.5M

Select item 41842175.

Novel role of Engrailed 1 as a prosurvival transcription factor in basal-like breast cancer and engineering of interference peptides block its oncogenic function

A S Beltran, L M Graves, P Blancafort

Oncogene. 2014 Sep 25; 33(39): 4767–4777. Published online 2013 Oct 21. doi: 10.1038/onc.2013.422

PMCID:: PMC4184217

Article PDF–2.3M

Select item 32080846.

Developmental transcription factor EN1- novel biomarker in human salivary gland adenoid cystic carcinoma

Diana Bell, Achim Bell, Dianna Roberts, Randal S. Weber, Adel K. El-Naggar

Cancer. Author manuscript; available in PMC 2013 Mar 1.

Published in final edited form as: Cancer. 2012 Mar 1; 118(5): 1288–1292. Published online 2011 Jul 28. doi: 10.1002/cncr.26412

PMCID:: PMC3208084

Article PDF–1.4M

Select item 26967497.

Long-range epigenetic silencing at 2q14.2 affects most human colorectal cancers and may have application as a non-invasive biomarker of disease

R Mayor, L Casadomé, D Azuara, V Moreno, S J Clark, G Capellà, M A Peinado

Br J Cancer. 2009 May 19; 100(10): 1534–1539. Published online 2009 Apr 21. doi: 10.1038/sj.bjc.6605045

PMCID:: PMC2696749

Article PDF–199K

Select item 88349038.

EN1 Regulates Cell Growth and Proliferation in Human Glioma Cells via Hedgehog Signaling

Jinchun Chang, Chenjia Guo, Jianyu Li, Zhangqian Liang, Yankai Wang, Anliang Yu, Runze Liu, Yuting Guo, Jian Chen, Song Huang

Int J Mol Sci. 2022 Feb; 23(3): 1123. Published online 2022 Jan 20. doi: 10.3390/ijms23031123

PMCID:: PMC8834903

Article PDF–2.6M

Select item 80723679.

Repeated mutation of a developmental enhancer contributed to human thermoregulatory evolution

Daniel Aldea, Yuji Atsuta, Blerina Kokalari, Stephen F. Schaffner, Rexxi D. Prasasya, Adam Aharoni, Heather L. Dingwall, Bailey Warder, Yana G. Kamberov

Proc Natl Acad Sci U S A. 2021 Apr 20; 118(16): e2021722118. Published online 2021 Apr 13. doi: 10.1073/pnas.2021722118

PMCID:: PMC8072367

Article PDF–1.4M

Select item 475571410.

Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture

Hou-Feng Zheng, Vincenzo Forgetta, Yi-Hsiang Hsu, Karol Estrada, Alberto Rosello-Diez, Paul J Leo, Chitra L Dahia, Kyung Hyun Park-Min, Jonathan H Tobias, Charles Kooperberg, Aaron Kleinman, Unnur Styrkarsdottir, Ching-Ti Liu, Charlotta Uggla, Daniel S Evans, Carrie M Nielson, Klaudia Walter, Ulrika Pettersson-Kymmer, Shane McCarthy, Joel Eriksson, Tony Kwan, Mila Jhamai, Katerina Trajanoska, Yasin Memari, Josine Min, Jie Huang, Petr Danecek, Beth Wilmot, Rui Li, Wen-Chi Chou, Lauren E Mokry, Alireza Moayyeri, Melina Claussnitzer, Chia-Ho Cheng, Warren Cheung, Carolina Medina-Gómez, Bing Ge, Shu-Huang Chen, Kwangbom Choi, Ling Oei, James Fraser, Robert Kraaij, Matthew A Hibbs, Celia L Gregson, Denis Paquette, Albert Hofman, Carl Wibom, Gregory J Tranah, Mhairi Marshall, Brooke B Gardiner, Katie Cremin, Paul Auer, Li Hsu, Sue Ring, Joyce Y Tung, Gudmar Thorleifsson, Anke W Enneman, Natasja M van Schoor, Lisette C.P.G.M. de Groot, Nathalie van der Velde, Beatrice Melin, John P Kemp, Claus Christiansen, Adrian Sayers, Yanhua Zhou, Sophie Calderari, Jeroen van Rooij, Chris Carlson, Ulrike Peters, Soizik Berlivet, Josée Dostie, Andre G Uitterlinden, Stephen R. Williams, Charles Farber, Daniel Grinberg, Andrea Z LaCroix, Jeff Haessler, Daniel I Chasman, Franco Giulianini, Lynda M Rose, Paul M Ridker, John A Eisman, Tuan V Nguyen, Jacqueline R Center, Xavier Nogues, Natalia Garcia-Giralt, Lenore L Launer, Vilmunder Gudnason, Dan Mellström, Liesbeth Vandenput, Magnus K Karlsson, Östen Ljunggren, Olle Svensson, Göran Hallmans, François Rousseau, Sylvie Giroux, Johanne Bussière, Pascal P Arp, Fjorda Koromani, Richard L Prince, Joshua R Lewis, Bente L Langdahl, A Pernille Hermann, Jens-Erik B Jensen, Stephen Kaptoge, Kay-Tee Khaw, Jonathan Reeve, Melissa M Formosa, Angela Xuereb-Anastasi, Kristina Åkesson, Fiona E McGuigan, Gaurav Garg, Jose M Olmos, Maria T Zarrabeitia, Jose A Riancho, Stuart H Ralston, Nerea Alonso, Xi Jiang, David Goltzman, Tomi Pastinen, Elin Grundberg, Dominique Gauguier, Eric S Orwoll, David Karasik, George Davey-Smith, AOGC Consortium, Albert V Smith, Kristin Siggeirsdottir, Tamara B Harris, M Carola Zillikens, Joyce BJ van Meurs, Unnur Thorsteinsdottir, Matthew T Maurano, Nicholas J Timpson, Nicole Soranzo, Richard Durbin, Scott G Wilson, Evangelia E Ntzani, Matthew A Brown, Kari Stefansson, David A Hinds, Tim Spector, L Adrienne Cupples, Claes Ohlsson, Celia MT Greenwood, Rebecca D Jackson, David W Rowe, Cynthia A Loomis, David M Evans, Cheryl L Ackert-Bicknell, Alexandra L Joyner, Emma L Duncan, Douglas P Kiel, Fernando Rivadeneira, J Brent Richards

Nature. Author manuscript; available in PMC 2016 Apr 1.

Published in final edited form as: Nature. 2015 Oct 1; 526(7571): 112–117. Published online 2015 Sep 14. doi: 10.1038/nature14878

PMCID:: PMC4755714

Article PDF–4.7M

Select item 399873711.

The lifelong maintenance of mesencephalic dopaminergic neurons by Nurr1 and engrailed

Kambiz N Alavian, Sharmin Jeddi, Sahar I Naghipour, Pegah Nabili, Pawel Licznerski, Travis S Tierney

J Biomed Sci. 2014; 21(1): 27. Published online 2014 Apr 1. doi: 10.1186/1423-0127-21-27

PMCID:: PMC3998737

Article PDF–1.4M

Select item 4176612.

Deregulated expression of PAX5 in medulloblastoma.

Z Kozmik, U Sure, D Rüedi, M Busslinger, A Aguzzi

Proc Natl Acad Sci U S A. 1995 Jun 6; 92(12): 5709–5713. doi: 10.1073/pnas.92.12.5709

PMCID:: PMC41766

Summary Page Browse PDF–1.8M

Select item 828850313.

Engrailed 1 coordinates cytoskeletal reorganization to induce myofibroblast differentiation

Andrea-Hermina Györfi, Alexandru-Emil Matei, Maximilian Fuchs, Chunguang Liang, Aleix Rius Rigau, Xuezhi Hong, Honglin Zhu, Markus Luber, Christina Bergmann, Clara Dees, Ingo Ludolph, Raymund E. Horch, Oliver Distler, Jiucun Wang, Bertram Bengsch, Georg Schett, Meik Kunz, Jörg H.W. Distler

J Exp Med. 2021 Sep 6; 218(9): e20201916. Published online 2021 Jul 14. doi: 10.1084/jem.20201916

PMCID:: PMC8288503

Article PDF–9.3M

Select item 277959114.

Cofactor-Activated Phosphorylation Is Required for Inhibition of Cortical Neuron Differentiation by Groucho/TLE1

Manuel Buscarlet, Robert Hermann, Rita Lo, Yeman Tang, Kerline Joachim, Stefano Stifani

PLoS One. 2009; 4(12): e8107. Published online 2009 Dec 1. doi: 10.1371/journal.pone.0008107

PMCID:: PMC2779591

Article PDF–3.4M

Select item 147479515.

Engrailed-1 Negatively Regulates β-Catenin Transcriptional Activity by Destabilizing β-Catenin via a Glycogen Synthase Kinase-3β–independent Pathway

Liora Bachar-Dahan, Janna Goltzmann, Abraham Yaniv, Arnona Gazit

Mol Biol Cell. 2006 Jun; 17(6): 2572–2580. doi: 10.1091/mbc.E06-01-0052

PMCID:: PMC1474795

Article PDF–771K

Select item 325981216.

Inhibition of Cortical Neuron Differentiation by Groucho/TLE1 Requires Interaction with WRPW, but Not Eh1, Repressor Peptides

Manuel Buscarlet, Alessandro Perin, Adam Laing, Joshua Mark Brickman, Stefano Stifani

J Biol Chem. 2008 Sep 5; 283(36): 24881–24888. doi: 10.1074/jbc.M800722200

PMCID:: PMC3259812

Article PDF–532K

Select item 396951517.

Differentiation of Human Epidermal Neural Crest Stem Cells (hEPI-NCSC) into Virtually Homogenous Populations of Dopaminergic Neurons

Alla Narytnyk, Bernard Verdon, Andrew Loughney, Michele Sweeney, Oliver Clewes, Michael J. Taggart, Maya Sieber-Blum

Stem Cell Rev. 2014; 10(2): 316–326. Published online 2014 Jan 8. doi: 10.1007/s12015-013-9493-9

PMCID:: PMC3969515

Article PDF–1.9M

Select item 108720818.

Differentiation of Insulin-Producing Cells from Human Neural Progenitor Cells

Yuichi Hori, Xueying Gu, Xiaodong Xie, Seung K Kim

PLoS Med. 2005 Apr; 2(4): e103. Published online 2005 Apr 26. doi: 10.1371/journal.pmed.0020103

PMCID:: PMC1087208

Article PDF–416K

Select item 433481419.

Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis

Sergio E. Baranzini, Joanne Wang, Rachel A. Gibson, Nicholas Galwey, Yvonne Naegelin, Frederik Barkhof, Ernst-Wilhelm Radue, Raija L.P. Lindberg, Bernard M.G. Uitdehaag, Michael R. Johnson, Aspasia Angelakopoulou, Leslie Hall, Jill C. Richardson, Rab K. Prinjha, Achim Gass, Jeroen J.G. Geurts, Jolijn Kragt, Madeleine Sombekke, Hugo Vrenken, Pamela Qualley, Robin R. Lincoln, Refujia Gomez, Stacy J. Caillier, Michaela F. George, Hourieh Mousavi, Rosa Guerrero, Darin T. Okuda, Bruce A. C. Cree, Ari J. Green, Emmanuelle Waubant, Douglas S. Goodin, Daniel Pelletier, Paul M. Matthews, Stephen L. Hauser, Ludwig Kappos, Chris H. Polman, Jorge R. Oksenberg

Hum Mol Genet. 2009 Feb 15; 18(4): 767–778. Published online 2008 Nov 14. doi: 10.1093/hmg/ddn388

PMCID:: PMC4334814

Article PDF–274K

Select item 279151820.

High-Density Association Study of 383 Candidate Genes for Volumetric BMD at the Femoral Neck and Lumbar Spine Among Older Men

Laura M. Yerges, Lambertus Klei, Jane A. Cauley, Kathryn Roeder, Candace M. Kammerer, Susan P. Moffett, Kristine E. Ensrud, Cara S. Nestlerode, Lynn M. Marshall, Andrew R. Hoffman, Cora Lewis, Thomas F. Lang, Elizabeth Barrett-Connor, Robert E. Ferrell, Eric S. Orwoll, Joseph M. Zmuda

J Bone Miner Res. 2009 Dec; 24(12): 2039–2049. Published online 2009 May 18. doi: 10.1359/JBMR.090524

PMCID:: PMC2791518

Article PDF–759K

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