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Select item 102354211.

Heterogeneity of voltage gated sodium current density between neurons decorrelates spiking and suppresses network synchronization in Scn1b null mouse models

Jacob M. Hull, Nicholas Denomme, Yukun Yuan, Victoria Booth, Lori L. Isom

Sci Rep. 2023; 13: 8887. Published online 2023 Jun 1. doi: 10.1038/s41598-023-36036-0

PMCID:: PMC10235421

Article PDF–10M

Select item 90764212.

Scn1b expression in the adult mouse heart modulates Na⁺ influx in myocytes and reveals a mechanistic link between Na⁺ entry and diastolic function

Daniel O. Cervantes, Emanuele Pizzo, Harshada Ketkar, Sreema P. Parambath, Samantha Tang, Eleonora Cianflone, Antonio Cannata, Govindaiah Vinukonda, Sudhir Jain, Jason T. Jacobson, Marcello Rota

Am J Physiol Heart Circ Physiol. 2022 Jun 1; 322(6): H975–H993. Published online 2022 Apr 8. doi: 10.1152/ajpheart.00465.2021

PMCID:: PMC9076421

Article

Select item 79348433.

Sodium channel β1 subunits participate in regulated intramembrane proteolysis-excitation coupling

Alexandra A. Bouza, Nnamdi Edokobi, Samantha L. Hodges, Alexa M. Pinsky, James Offord, Lin Piao, Yan-Ting Zhao, Anatoli N. Lopatin, Luis F. Lopez-Santiago, Lori L. Isom

JCI Insight. 2021 Feb 8; 6(3): e141776. Published online 2021 Feb 8. doi: 10.1172/jci.insight.141776

PMCID:: PMC7934843

Article PDF–2.1M

Select item 76642744.

Excitatory and inhibitory neuron defects in a mouse model of Scn1b‐linked EIEE52

Jacob M. Hull, Heather A. O’Malley, Chunling Chen, Yukun Yuan, Nicholas Denomme, Alexandra A. Bouza, Charles Anumonwo, Luis F. Lopez‐Santiago, Lori L. Isom

Ann Clin Transl Neurol. 2020 Nov; 7(11): 2137–2149. Published online 2020 Sep 26. doi: 10.1002/acn3.51205

PMCID:: PMC7664274

Article PDF–3.3M

Select item 53773275.

SCN1B gene variants in Brugada Syndrome: a study of 145 SCN5A-negative patients

Maria Teresa Ricci, Silvia Menegon, Simona Vatrano, Giorgia Mandrile, Natascia Cerrato, Paula Carvalho, Mario De Marchi, Fiorenzo Gaita, Carla Giustetto, Daniela Francesca Giachino

Sci Rep. 2014; 4: 6470. Published online 2014 Sep 25. doi: 10.1038/srep06470

PMCID:: PMC5377327

Article PDF–566K

Select item 48995246.

β1-C121W Is Down But Not Out: Epilepsy-Associated Scn1b-C121W Results in a Deleterious Gain-of-Function

Larisa C. Kruger, Heather A. O'Malley, Jacob M. Hull, Amanda Kleeman, Gustavo A. Patino, Lori L. Isom

J Neurosci. 2016 Jun 8; 36(23): 6213–6224. doi: 10.1523/JNEUROSCI.0405-16.2016

PMCID:: PMC4899524

Article PDF–3.4M

Select item 47443617.

SCN1A and SCN1B gene polymorphisms and their association with plasma concentrations of carbamazepine and carbamazepine 10, 11 epoxide in Iranian epileptic patients

Soha Namazi, Negar Azarpira, Katayoon Javidnia, Mehrdad Emami, Rahimeh Rahjoo, Razieh Berahmand, Afshin Borhani-Haghighi

Iran J Basic Med Sci. 2015 Dec; 18(12): 1215–1220.

PMCID:: PMC4744361

Article

Select item 46381358.

Late Na⁺ current and protracted electrical recovery are critical determinants of the aging myopathy

Sergio Signore, Andrea Sorrentino, Giulia Borghetti, Antonio Cannata, Marianna Meo, Yu Zhou, Ramaswamy Kannappan, Francesco Pasqualini, Heather O'Malley, Mark Sundman, Nikolaos Tsigkas, Eric Zhang, Christian Arranto, Chiara Mangiaracina, Kazuya Isobe, Brena F. Sena, Junghyun Kim, Polina Goichberg, Matthias Nahrendorf, Lori L. Isom, Annarosa Leri, Piero Anversa, Marcello Rota

Nat Commun. 2015; 6: 8803. Published online 2015 Nov 6. doi: 10.1038/ncomms9803

PMCID:: PMC4638135

Article PDF–3.5M

Select item 43764209.

Scn1b deletion leads to increased tetrodotoxin-sensitive sodium current, altered intracellular calcium homeostasis and arrhythmias in murine hearts

Xianming Lin, Heather O'Malley, Chunling Chen, David Auerbach, Monique Foster, Akshay Shekhar, Mingliang Zhang, William Coetzee, José Jalife, Glenn I Fishman, Lori Isom, Mario Delmar

J Physiol. 2015 Mar 15; 593(Pt 6): 1389–1407. Published online 2014 Sep 17. doi: 10.1113/jphysiol.2014.277699

PMCID:: PMC4376420

Article PDF–1.6M

Select item 354909210.

Abnormal neuronal patterning occurs during early postnatal brain development of Scn1b-null mice and precedes hyperexcitability

William J. Brackenbury, Yukun Yuan, Heather A. O’Malley, Jack M. Parent, Lori L. Isom

Proc Natl Acad Sci U S A. 2013 Jan 15; 110(3): 1089–1094. Published online 2012 Dec 31. doi: 10.1073/pnas.1208767110

PMCID:: PMC3549092

Article PDF–1.7M

Select item 349488511.

Modulation of voltage-gated K⁺ channels by the sodium channel β1 subunit

Hai M. Nguyen, Haruko Miyazaki, Naoto Hoshi, Brian J. Smith, Nobuyuki Nukina, Alan L. Goldin, K. George Chandy

Proc Natl Acad Sci U S A. 2012 Nov 6; 109(45): 18577–18582. Published online 2012 Oct 5. doi: 10.1073/pnas.1209142109

PMCID:: PMC3494885

Article PDF–1.0M

Select item 318143112.

Na⁺ Channel β Subunits: Overachievers of the Ion Channel Family

William J. Brackenbury, Lori L. Isom

Front Pharmacol. 2011; 2: 53. Prepublished online 2011 Aug 16. Published online 2011 Sep 28. doi: 10.3389/fphar.2011.00053

PMCID:: PMC3181431

Article PDF–920K

Select item 312305913.

Na⁺ Channel Scn1b Gene Regulates Dorsal Root Ganglion Nociceptor Excitability in Vivo

Luis F. Lopez-Santiago, William J. Brackenbury, Chunling Chen, Lori L. Isom

J Biol Chem. 2011 Jul 1; 286(26): 22913–22923. Published online 2011 May 9. doi: 10.1074/jbc.M111.242370

PMCID:: PMC3123059

Article PDF–2.5M

Select item 291219314.

Axon initial segment dysfunction in a mouse model of genetic epilepsy with febrile seizures plus

Verena C. Wimmer, Christopher A. Reid, Suzanne Mitchell, Kay L. Richards, Byron B. Scaf, Bryan T. Leaw, Elisa L. Hill, Michel Royeck, Marie-Therese Horstmann, Brett A. Cromer, Philip J. Davies, Ruwei Xu, Holger Lerche, Samuel F. Berkovic, Heinz Beck, Steven Petrou

J Clin Invest. 2010 Aug 2; 120(8): 2661–2671. Published online 2010 Jul 12. doi: 10.1172/JCI42219

PMCID:: PMC2912193

Article PDF–4.5M

Select item 265475415.

Sodium Channel β1 Regulatory Subunit Deficiency Reduces Pancreatic Islet Glucose-Stimulated Insulin and Glucagon Secretion

Sara J. Ernst, Lydia Aguilar-Bryan, Jeffrey L. Noebels

Endocrinology. 2009 Mar; 150(3): 1132–1139. Published online 2008 Nov 6. doi: 10.1210/en.2008-0991

PMCID:: PMC2654754

Article

Select item 957914516.

Tmem65 is critical for the structure and function of the intercalated discs in mouse hearts

Allen C. T. Teng, Liyang Gu, Michelle Di Paola, Robert Lakin, Zachary J. Williams, Aaron Au, Wenliang Chen, Neal I. Callaghan, Farigol Hakem Zadeh, Yu-Qing Zhou, Meena Fatah, Diptendu Chatterjee, L. Jane Jourdan, Jack Liu, Craig A. Simmons, Thomas Kislinger, Christopher M. Yip, Peter H. Backx, Robert G. Gourdie, Robert M. Hamilton, Anthony O. Gramolini

Nat Commun. 2022; 13: 6166. Published online 2022 Oct 18. doi: 10.1038/s41467-022-33303-y

PMCID:: PMC9579145

Article PDF–11M

Select item 922082317.

Neonatal Scn1b-null mice have sinoatrial node dysfunction, altered atrial structure, and atrial fibrillation

Roberto Ramos-Mondragon, Nnamdi Edokobi, Samantha L. Hodges, Shuyun Wang, Alexandra A. Bouza, Chandrika Canugovi, Caroline Scheuing, Lena Juratli, William R. Abel, Sami F. Noujaim, Nageswara R. Madamanchi, Marschall S. Runge, Luis F. Lopez-Santiago, Lori L. Isom

JCI Insight. 2022 May 23; 7(10): e152050. Published online 2022 May 23. doi: 10.1172/jci.insight.152050

PMCID:: PMC9220823

Article PDF–2.1M

Select item 738338218.

Sodium channel β1 subunits are post-translationally modified by tyrosine phosphorylation, S-palmitoylation, and regulated intramembrane proteolysis

Alexandra A. Bouza, Julie M. Philippe, Nnamdi Edokobi, Alexa M. Pinsky, James Offord, Jeffrey D. Calhoun, Mariana Lopez-Florán, Luis F. Lopez-Santiago, Paul M. Jenkins, Lori L. Isom

J Biol Chem. 2020 Jul 24; 295(30): 10380–10393. Published online 2020 Jun 5. doi: 10.1074/jbc.RA120.013978