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Select item 98342981.

Prolyl-tRNA synthetase as a novel therapeutic target in multiple myeloma

Keiji Kurata, Anna James-Bott, Mark A. Tye, Leona Yamamoto, Mehmet K. Samur, Yu-Tzu Tai, James Dunford, Catrine Johansson, Filiz Senbabaoglu, Martin Philpott, Charlotte Palmer, Karthik Ramasamy, Sarah Gooding, Mihaela Smilova, Giorgia Gaeta, Manman Guo, John C. Christianson, N. Connor Payne, Kritika Singh, Kubra Karagoz, Matthew E. Stokes, Maria Ortiz, Patrick Hagner, Anjan Thakurta, Adam Cribbs, Ralph Mazitschek, Teru Hideshima, Kenneth C. Anderson, Udo Oppermann

Blood Cancer J. 2023 Dec; 13(1): 12. Published online 2023 Jan 12. doi: 10.1038/s41408-023-00787-w

Correction in:: Blood Cancer J. 2023 Dec; 13(1): 24.

PMCID:: PMC9834298

Abstract Article PDF–4.5M

Select item 85119522.

Disease-associated mutations in a bifunctional aminoacyl-tRNA synthetase gene elicit the integrated stress response

Danni Jin, Sheree A. Wek, Nathan T. Kudlapur, William A. Cantara, Marina Bakhtina, Ronald C. Wek, Karin Musier-Forsyth

J Biol Chem. 2021 Oct; 297(4): 101203. Published online 2021 Sep 17. doi: 10.1016/j.jbc.2021.101203

PMCID:: PMC8511952

Abstract Article PDF–2.5M

Select item 59955263.

Structural control of caspase-generated glutamyl-tRNA synthetase by appended noncatalytic WHEP domains

Dalia Halawani, Valentin Gogonea, Joseph A. DiDonato, Vitaliy Pipich, Peng Yao, Arnab China, Celalettin Topbas, Kommireddy Vasu, Abul Arif, Stanley L. Hazen, Paul L. Fox

J Biol Chem. 2018 Jun 8; 293(23): 8843–8860. Published online 2018 Apr 11. doi: 10.1074/jbc.M117.807503

PMCID:: PMC5995526

Abstract Article PDF–5.0M

Select item 59852834.

Bi-allelic Mutations in EPRS, Encoding the Glutamyl-Prolyl-Aminoacyl-tRNA Synthetase, Cause a Hypomyelinating Leukodystrophy

Marisa I. Mendes, Mariana Gutierrez Salazar, Kether Guerrero, Isabelle Thiffault, Gajja S. Salomons, Laurence Gauquelin, Luan T. Tran, Diane Forget, Marie-Soleil Gauthier, Quinten Waisfisz, Desiree E.C. Smith, Cas Simons, Marjo S. van der Knaap, Iris Marquardt, Aida Lemes, Hanna Mierzewska, Bernhard Weschke, Wolfgang Koehler, Benoit Coulombe, Nicole I. Wolf, Geneviève Bernard

Am J Hum Genet. 2018 Apr 5; 102(4): 676–684. Published online 2018 Mar 22. doi: 10.1016/j.ajhg.2018.02.011

PMCID:: PMC5985283

Abstract Article PDF–1.4M

Select item 28193955.

WHEP Domains Direct Noncanonical Function of Glutamyl-Prolyl tRNA Synthetase in Translational Control of Gene Expression

Jie Jia, Abul Arif, Partho S. Ray, Paul L. Fox

Mol Cell. Author manuscript; available in PMC 2010 Feb 10.

Published in final edited form as: Mol Cell. 2008 Mar 28; 29(6): 679–690. doi: 10.1016/j.molcel.2008.01.010

PMCID:: PMC2819395

Abstract Article PDF–2.4M

Select item 27522896.

Two-site Phosphorylation of EPRS Coordinates Multimodal Regulation of Noncanonical Translational Control Activity

Abul Arif, Jie Jia, Rupak Mukhopadhyay, Belinda Willard, Michael Kinter, Paul L. Fox

Mol Cell. Author manuscript; available in PMC 2010 Jul 31.

Published in final edited form as: Mol Cell. 2009 Jul 31; 35(2): 164–180. doi: 10.1016/j.molcel.2009.05.028

PMCID:: PMC2752289

Abstract Article PDF–1.2M

Select item 3367747.

The core region of human glutaminyl-tRNA synthetase homologies with the Escherichia coli and yeast enzymes.

P Thömmes, R Fett, B Schray, N Kunze, R Knippers

Nucleic Acids Res. 1988 Jun 24; 16(12): 5391–5406. doi: 10.1093/nar/16.12.5391

PMCID:: PMC336774

Summary Page Browse PDF–1.3M

Select item 53425008.

EPRS is a critical regulator of cell proliferation and estrogen signaling in ER⁺ breast cancer

Igor Katsyv, Minghui Wang, Won Min Song, Xianxiao Zhou, Yongzhong Zhao, Sun Park, Jun Zhu, Bin Zhang, Hanna Y. Irie

Oncotarget. 2016 Oct 25; 7(43): 69592–69605. Published online 2016 Sep 6. doi: 10.18632/oncotarget.11870

PMCID:: PMC5342500

Abstract Article PDF–6.5M

Select item 4531799.

A component of the multisynthetase complex is a multifunctional aminoacyl-tRNA synthetase.

C Cerini, P Kerjan, M Astier, D Gratecos, M Mirande, M Sémériva

EMBO J. 1991 Dec; 10(13): 4267–4277. doi: 10.1002/j.1460-2075.1991.tb05005.x

PMCID:: PMC453179

Summary Page Browse PDF–2.9M

Select item 748427110.

Glutamyl-Prolyl-tRNA Synthetase Regulates Proline-Rich Pro-Fibrotic Protein Synthesis During Cardiac Fibrosis

Jiangbin Wu, Kadiam C Venkata Subbaiah, Li Huitong Xie, Feng Jiang, Eng-Soon Khor, Deanne Mickelsen, Jason R Myers, Wai Hong Wilson Tang, Peng Yao

Circ Res. Author manuscript; available in PMC 2021 Aug 28.

Published in final edited form as: Circ Res. 2020 Aug 28; 127(6): 827–846. Published online 2020 Jul 1. doi: 10.1161/CIRCRESAHA.119.315999

PMCID:: PMC7484271

Abstract Article PDF–4.0M

Select item 361545611.

Dynamic Modeling of GAIT System Reveals Transcriptome Expansion and Translational Trickle Control Device

Peng Yao, Alka A. Potdar, Abul Arif, Partho Sarothi Ray, Rupak Mukhopadhyay, Belinda Willard, Yichi Xu, Jun Yan, Gerald M. Saidel, Paul L. Fox

Cell. Author manuscript; available in PMC 2013 Apr 3.

Published in final edited form as: Cell. 2012 Mar 30; 149(1): 88–100. doi: 10.1016/j.cell.2012.02.018

PMCID:: PMC3615456

Abstract Article PDF–5.9M

Select item 356906812.

ATP-Directed Capture of Bioactive Herbal-Based Medicine on Human tRNA Synthetase

Huihao Zhou, Litao Sun, Xiang-Lei Yang, Paul Schimmel

Nature. Author manuscript; available in PMC 2013 Aug 7.

Published in final edited form as: Nature. 2013 Feb 7; 494(7435): 121–124. Published online 2012 Dec 23. doi: 10.1038/nature11774

PMCID:: PMC3569068

Article PDF–675K

Select item 470593713.

Assembly of Multi-tRNA Synthetase Complex via Heterotetrameric Glutathione Transferase-homology Domains

Ha Yeon Cho, Seo Jin Maeng, Hyo Je Cho, Yoon Seo Choi, Jeong Min Chung, Sangmin Lee, Hoi Kyoung Kim, Jong Hyun Kim, Chi-Yong Eom, Yeon-Gil Kim, Min Guo, Hyun Suk Jung, Beom Sik Kang, Sunghoon Kim

J Biol Chem. 2015 Dec 4; 290(49): 29313–29328. Published online 2015 Oct 15. doi: 10.1074/jbc.M115.690867

PMCID:: PMC4705937

Abstract Article PDF–5.3M

Select item 137005614.

The bI4 group I intron binds directly to both its protein splicing partners, a tRNA synthetase and maturase, to facilitate RNA splicing activity.

S B Rho, S A Martinis

RNA. 2000 Dec; 6(12): 1882–1894. doi: 10.1017/s1355838200001254

PMCID:: PMC1370056

Summary PDF–958K

Select item 565632915.

Condensin II and GAIT complexes cooperate to restrict LINE-1 retrotransposition in epithelial cells

Jacqueline R. Ward, Kommireddy Vasu, Emily Deutschman, Dalia Halawani, Peter A. Larson, Dongmei Zhang, Belinda Willard, Paul L. Fox, John V. Moran, Michelle S. Longworth

PLoS Genet. 2017 Oct; 13(10): e1007051. Published online 2017 Oct 13. doi: 10.1371/journal.pgen.1007051

PMCID:: PMC5656329

Abstract Article PDF–10M

Select item 384688216.

Reinvestigation of Aminoacyl-TRNA Synthetase Core Complex by Affinity Purification-Mass Spectrometry Reveals TARSL2 as a Potential Member of the Complex

Kyutae Kim, Seong-Jun Park, Seungjin Na, Jun Seok Kim, Hyungwon Choi, Yoon Ki Kim, Eunok Paek, Cheolju Lee

PLoS One. 2013; 8(12): e81734. Published online 2013 Dec 2. doi: 10.1371/journal.pone.0081734

PMCID:: PMC3846882

Abstract Article PDF–2.7M

Select item 302969517.

Phosphorylation of glutamyl-prolyl tRNA synthetase by cyclin-dependent kinase 5 dictates transcript-selective translational control

Abul Arif, Jie Jia, Robyn A. Moodt, Paul E. DiCorleto, Paul L. Fox

Proc Natl Acad Sci U S A. 2011 Jan 25; 108(4): 1415–1420. Published online 2011 Jan 10. doi: 10.1073/pnas.1011275108

PMCID:: PMC3029695

Abstract Article PDF–1.0M

Select item 548061018.

EPRS is a critical mTORC1-S6K1 effector that influences adiposity in mice

Abul Arif, Fulvia Terenzi, Alka A. Potdar, Jie Jia, Jessica Sacks, Arnab China, Dalia Halawani, Kommireddy Vasu, Xiaoxia Li, J. Mark Brown, Jie Chen, Sara C. Kozma, George Thomas, Paul L. Fox

Nature. Author manuscript; available in PMC 2017 Aug 8.

Published in final edited form as: Nature. 2017 Feb 16; 542(7641): 357–361. Published online 2017 Feb 8. doi: 10.1038/nature21380

PMCID:: PMC5480610

Abstract Article PDF–2.8M

Select item 964351419.

Regulation of BRCA1 stability through the tandem UBX domains of isoleucyl-tRNA synthetase 1

Scisung Chung, Mi-Sun Kang, Dauren S. Alimbetov, Gil-Im Mun, Na-Oh Yunn, Yunjin Kim, Byung-Gyu Kim, Minwoo Wie, Eun A. Lee, Jae Sun Ra, Jung-Min Oh, Donghyun Lee, Keondo Lee, Jihan Kim, Seung Hyun Han, Kyong-Tai Kim, Wan Kyun Chung, Ki Hyun Nam, Jaehyun Park, ByungHoon Lee, Sunghoon Kim, Weixing Zhao, Sung Ho Ryu, Yun-Sil Lee, Kyungjae Myung, Yunje Cho

Nat Commun. 2022; 13: 6732. Published online 2022 Nov 8. doi: 10.1038/s41467-022-34612-y

PMCID:: PMC9643514

Abstract Article PDF–2.1M

Select item 4466820.

Evolution of the Glx-tRNA synthetase family: the glutaminyl enzyme as a case of horizontal gene transfer.

V Lamour, S Quevillon, S Diriong, V C N'Guyen, M Lipinski, M Mirande

Proc Natl Acad Sci U S A. 1994 Aug 30; 91(18): 8670–8674. doi: 10.1073/pnas.91.18.8670

PMCID:: PMC44668

Summary Page Browse PDF–1.5M

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