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Select item 102033181.

Themis suppresses the effector function of CD8⁺ T cells in acute viral infection

Jian Tang, Xian Jia, Jian Li, Junchen Dong, Jiayu Wang, Wanyun Li, Yuzhen Zhu, Yanyan Hu, Bowen Hou, Chunjie Lin, Yu Cong, Tong Ren, Changsheng Yan, Hongying Yang, Qian Lai, Haiping Zheng, Yuzhou Bao, Namrata Gautam, Hong-Rui Wang, Bing Xu, Xiao Lei Chen, Qing Li, Nicholas R. J. Gascoigne, Guo Fu

Cell Mol Immunol. 2023 May; 20(5): 512–524. Published online 2023 Mar 28. doi: 10.1038/s41423-023-00997-z

PMCID:: PMC10203318

Abstract Article PDF–5.8M

Select item 80581842.

Expansion of an Unusual Virtual Memory CD8⁺ Subpopulation Bearing Vα3.2 TCR in Themis-Deficient Mice

Mukul Prasad, Lukasz Wojciech, Joanna Brzostek, Jianfang Hu, Yen Leong Chua, Desmond Wai Hon Tung, Jiawei Yap, Vasily Rybakin, Nicholas R. J. Gascoigne

Front Immunol. 2021; 12: 644483. Published online 2021 Apr 7. doi: 10.3389/fimmu.2021.644483

PMCID:: PMC8058184

Abstract Article PDF–5.3M

Select item 55461953.

Proteomic Analysis of Regulatory T Cells Reveals the Importance of Themis1 in the Control of Their Suppressive Function

Fanny Duguet, Marie Locard-Paulet, Marlène Marcellin, Karima Chaoui, Isabelle Bernard, Olivier Andreoletti, Renaud Lesourne, Odile Burlet-Schiltz, Anne Gonzalez de Peredo, Abdelhadi Saoudi

Mol Cell Proteomics. 2017 Aug; 16(8): 1416–1432. Published online 2017 Apr 3. doi: 10.1074/mcp.M116.062745

PMCID:: PMC5546195

Abstract Article PDF–3.0M

Select item 44140234.

In vivo functional mapping of the conserved protein domains within murine Themis1

Ekaterina Zvezdova, Jan Lee, Dalal El-Khoury, Valarie Barr, Itoro Akpan, Lawrence Samelson, Paul E. Love

Immunol Cell Biol. Author manuscript; available in PMC 2015 Apr 29.

Published in final edited form as: Immunol Cell Biol. 2014 Sep; 92(8): 721–728. Published online 2014 Jun 17. doi: 10.1038/icb.2014.43

PMCID:: PMC4414023

Abstract Article PDF–1.5M

Select item 39316545.

Differential Function of Themis CABIT Domains during T Cell Development

Toshiyuki Okada, Takeshi Nitta, Kentaro Kaji, Akiko Takashima, Hiroyo Oda, Norimasa Tamehiro, Motohito Goto, Tadashi Okamura, Michael S. Patrick, Harumi Suzuki

PLoS One. 2014; 9(2): e89115. Published online 2014 Feb 21. doi: 10.1371/journal.pone.0089115

PMCID:: PMC3931654

Abstract Article PDF–1.9M

Select item 109873736.

Positive regulation of Vav1 by Themis controls CD4 T cell pathogenicity in a mouse model of central nervous system inflammation

Remi Marrocco, Isabelle Bernard, Emeline Joulia, Rebecca Barascud, Anne S. Dejean, Renaud Lesourne, Abdelhadi Saoudi

Cell Mol Life Sci. 2024 Dec; 81(1): 161. Published online 2024 Apr 2. doi: 10.1007/s00018-024-05203-5

PMCID:: PMC10987373

Abstract Article PDF–2.2M

Select item 42942547.

THEMIS Is Required for Pathogenesis of Cerebral Malaria and Protection against Pulmonary Tuberculosis

Sabrina Torre, Sebastien P. Faucher, Nassima Fodil, Silayuv E. Bongfen, Joanne Berghout, Jeremy A. Schwartzentruber, Jacek Majewski, Mark Lathrop, Andrea M. Cooper, Silvia M. Vidal, Philippe Gros

Infect Immun. 2015 Feb; 83(2): 759–768. Prepublished online 2014 Dec 1. Published online 2015 Jan 14. doi: 10.1128/IAI.02586-14

PMCID:: PMC4294254

Abstract Article PDF–2.0M

Select item 105172258.

Themis controls T cell activation, effector functions, and metabolism of peripheral CD8⁺ T cells

Namrata Gautam, Lukasz Wojciech, Jiawei Yap, Yen Leong Chua, Eyan MW Ding, Don CN Sim, Alrina SM Tan, Patricia J Ahl, Mukul Prasad, Desmond WH Tung, John E Connolly, Giulia Adriani, Joanna Brzostek, Nicholas RJ Gascoigne

Life Sci Alliance. 2023 Dec; 6(12): e202302156. Published online 2023 Sep 22. doi: 10.26508/lsa.202302156

PMCID:: PMC10517225

Abstract Article PDF–3.4M

Select item 101149209.

GRB2 promotes thymocyte positive selection by facilitating THEMIS-mediated inactivation of SHP1

Seeyoung Choi, Teri Hatzihristidis, Guillaume Gaud, Avik Dutta, Jan Lee, Awadhesh Arya, Lauren M. Clubb, Daniel B. Stamos, Adrienn Markovics, Katalin Mikecz, Paul Love

J Exp Med. 2023 Jul 3; 220(7): e20221649. Published online 2023 Apr 17. doi: 10.1084/jem.20221649

PMCID:: PMC10114920

Abstract Article PDF–4.4M

Select item 688459910.

Thymic-specific regulation of TCR signaling by Tespa1

Jun Lyu, Pengfei Wang, Ting Xu, Yichao Shen, Zejin Cui, Mingzhu Zheng, Guo Fu, Linrong Lu

Cell Mol Immunol. 2019 Dec; 16(12): 897–907. Published online 2019 Jul 17. doi: 10.1038/s41423-019-0259-4

PMCID:: PMC6884599

Abstract Article PDF–4.5M

Select item 627548011.

Themis-associated phosphatase activity controls signaling in T cell development

Monika Mehta, Joanna Brzostek, Elijah W. Chen, Desmond W. H. Tung, Shuting Chen, Shvetha Sankaran, Jiawei Yap, Vasily Rybakin, Nicholas R. J. Gascoigne

Proc Natl Acad Sci U S A. 2018 Nov 27; 115(48): E11331–E11340. Published online 2018 Nov 9. doi: 10.1073/pnas.1720209115

PMCID:: PMC6275480

Abstract Article PDF–1.2M

Select item 397700112.

Themis sets the signal threshold for positive and negative selection in T-cell development

Guo Fu, Javier Casas, Stephanie Rigaud, Vasily Rybakin, Florence Lambolez, Joanna Brzostek, John A.H. Hoerter, Wolfgang Paster, Oreste Acuto, Hilde Cheroutre, Karsten Sauer, Nicholas R.J. Gascoigne

Nature. Author manuscript; available in PMC 2014 Jun 19.

Published in final edited form as: Nature. 2013 Dec 19; 504(7480): 441–445. Published online 2013 Nov 13. doi: 10.1038/nature12718

PMCID:: PMC3977001

Article PDF–5.4M

Select item 304500813.

T Cell Receptor (TCR)-induced Tyrosine Phosphorylation Dynamics Identifies THEMIS as a New TCR Signalosome Component

Claudia Brockmeyer, Wolfgang Paster, David Pepper, Choon P. Tan, David C. Trudgian, Simon McGowan, Guo Fu, Nicholas R. J. Gascoigne, Oreste Acuto, Mogjiborahman Salek

J Biol Chem. 2011 Mar 4; 286(9): 7535–7547. Published online 2010 Dec 28. doi: 10.1074/jbc.M110.201236

PMCID:: PMC3045008

Abstract Article PDF–2.6M

Select item 273828214.

A Novel Gene Essential for the Development of Single Positive Thymocytes

Kiyokazu Kakugawa , Takuwa Yasuda, Ikuo Miura, Ayako Kobayashi, Hitomi Fukiage, Rumi Satoh, Masashi Matsuda, Haruhiko Koseki, Shigeharu Wakana, Hiroshi Kawamoto, Hisahiro Yoshida

Mol Cell Biol. 2009 Sep; 29(18): 5128–5135. Published online 2009 Jul 20. doi: 10.1128/MCB.00793-09

PMCID:: PMC2738282

Abstract Article PDF–6.6M

Select item 739756915.

THEMIS-SHP1 Recruitment by 4–1BB Tunes LCK-Mediated Priming of Chimeric Antigen Receptor-Redirected T Cells

Chuang Sun, Peishun Shou, Hongwei Du, Koichi Hirabayashi, Yuhui Chen, Laura E. Herring, Sarah Ahn, Yang Xu, Kyogo Suzuki, Guangming Li, Ourania Tsahouridis, Lishan Su, Barbara Savoldo, Gianpietro Dotti

Cancer Cell. Author manuscript; available in PMC 2021 Feb 10.

Published in final edited form as: Cancer Cell. 2020 Feb 10; 37(2): 216–225.e6. Published online 2020 Jan 30. doi: 10.1016/j.ccell.2019.12.014

PMCID:: PMC7397569

Abstract Article PDF–2.6M

Select item 732204116.

CD5 dynamically calibrates basal NF-κB signaling in T cells during thymic development and peripheral activation

Courtney A. Matson, Seeyoung Choi, Ferenc Livak, Bin Zhao, Apratim Mitra, Paul E. Love, Nevil J. Singh

Proc Natl Acad Sci U S A. 2020 Jun 23; 117(25): 14342–14353. Published online 2020 Jun 8. doi: 10.1073/pnas.1922525117

PMCID:: PMC7322041

Abstract Article PDF–1.9M

Select item 275256017.

Gasp, a Grb2-associating protein, is critical for positive selection of thymocytes

Michael S. Patrick, Hiroyo Oda, Kunihiro Hayakawa, Yoshinori Sato, Koji Eshima, Teruo Kirikae, Shun-ichiro Iemura, Mutsunori Shirai, Takaya Abe, Tohru Natsume, Takehiko Sasazuki, Harumi Suzuki

Proc Natl Acad Sci U S A. 2009 Sep 22; 106(38): 16345–16350. Published online 2009 Sep 14. doi: 10.1073/pnas.0908593106

PMCID:: PMC2752560

Abstract Article PDF–1.3M

Select item 580708018.

THEMIS enhances TCR signaling and enables positive selection by selective inhibition of SHP-1

Seeyoung Choi, Claude Warzecha, Ekaterina Zvezdova, Jan Lee, Jérémy Argenty, Renaud Lesourne, L. Aravind, Paul E. Love

Nat Immunol. Author manuscript; available in PMC 2018 Feb 9.

Published in final edited form as: Nat Immunol. 2017 Apr; 18(4): 433–441. Published online 2017 Feb 27. doi: 10.1038/ni.3692

PMCID:: PMC5807080

Abstract Article PDF–1.1M

Select item 433912419.

A THEMIS:SHP1 complex promotes T-cell survival

Wolfgang Paster, Annika M Bruger, Kristin Katsch, Claude Grégoire, Romain Roncagalli, Guo Fu, Nicholas RJ Gascoigne, Konstantina Nika, Andre Cohnen, Stephan M Feller, Philip C Simister, Kelly C Molder, Shaun-Paul Cordoba, Omer Dushek, Bernard Malissen, Oreste Acuto

EMBO J. 2015 Feb 3; 34(3): 393–409. Published online 2014 Dec 22. doi: 10.15252/embj.201387725

PMCID:: PMC4339124

Abstract Article PDF–1.3M

Select item 360740320.

GRB2-Mediated Recruitment of THEMIS to LAT Is Essential for Thymocyte Development

Wolfgang Paster, Claudia Brockmeyer, Guo Fu, Philip C. Simister, Ben de Wet, Ana Martinez-Riaño, John A. H. Hoerter, Stephan M. Feller, Christoph Wülfing, Nicholas R. J. Gascoigne, Oreste Acuto

J Immunol. 2013 Apr 1; 190(7): 3749–3756. Published online 2013 Mar 4. doi: 10.4049/jimmunol.1203389