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Select item 108009281.

Metabolic remodeling in cardiac hypertrophy and heart failure with reduced ejection fraction occurs independent of transcription factor EB in mice

Niklas Dörmann, Elke Hammer, Karlotta Struckmann, Julia Rüdebusch, Kirsten Bartels, Kristin Wenzel, Julia Schulz, Stefan Gross, Stefan Schwanz, Elisa Martin, Britta Fielitz, Cristina Pablo Tortola, Alexander Hahn, Alexander Benkner, Uwe Völker, Stephan B. Felix, Jens Fielitz

Front Cardiovasc Med. 2023; 10: 1323760. Published online 2024 Jan 8. doi: 10.3389/fcvm.2023.1323760

PMCID:: PMC10800928

Article PDF–18M

Select item 107765642.

TFEB drives mTORC1 hyperactivation and kidney disease in Tuberous Sclerosis Complex

Nicola Alesi, Damir Khabibullin, Dean M. Rosenthal, Elie W. Akl, Pieter M. Cory, Michel Alchoueiry, Samer Salem, Melissa Daou, William F. Gibbons, Jennifer A. Chen, Long Zhang, Harilaos Filippakis, Laura Graciotti, Caterina Miceli, Jlenia Monfregola, Claudia Vilardo, Manrico Morroni, Chiara Di Malta, Gennaro Napolitano, Andrea Ballabio, Elizabeth P. Henske

Nat Commun. 2024; 15: 406. Published online 2024 Jan 9. doi: 10.1038/s41467-023-44229-4

PMCID:: PMC10776564

Article PDF–5.7M

Select item 105881683.

Intermittent hypoxia therapy ameliorates beta-amyloid pathology via TFEB-mediated autophagy in murine Alzheimer's disease

Xueting Wang, Yuqi Xie, Guijuan Chen, Yapeng Lu, Dan Wang, Li Zhu

J Neuroinflammation. 2023; 20: 240. Published online 2023 Oct 20. doi: 10.1186/s12974-023-02931-6

PMCID:: PMC10588168

Article PDF–14M

Select item 96941364.

TFEB acetylation promotes lysosome biogenesis and ameliorates Alzheimer’s disease–relevant phenotypes in mice

Tianyou Li, Limin Yin, Xinyi Kang, Wenlong Xue, Ning Wang, Jie Zhang, Ping Yuan, Lingxi Lin, Yang Li

J Biol Chem. 2022 Dec; 298(12): 102649. Published online 2022 Oct 27. doi: 10.1016/j.jbc.2022.102649

PMCID:: PMC9694136

Article PDF–9.0M

Select item 95197405.

TFEB regulates sulfur amino acid and coenzyme A metabolism to support hepatic metabolic adaptation and redox homeostasis

David Matye, Sumedha Gunewardena, Jianglei Chen, Huaiwen Wang, Yifeng Wang, Mohammad Nazmul Hasan, Lijie Gu, Yung Dai Clayton, Yanhong Du, Cheng Chen, Jacob E. Friedman, Shelly C. Lu, Wen-Xing Ding, Tiangang Li

Nat Commun. 2022; 13: 5696. Published online 2022 Sep 28. doi: 10.1038/s41467-022-33465-9

PMCID:: PMC9519740

Article PDF–7.5M

Select item 93812686.

Melatonin Ameliorates the Progression of Alzheimer's Disease by Inducing TFEB Nuclear Translocation, Promoting Mitophagy, and Regulating NLRP3 Inflammasome Activity

Li Fan, Xie Zhaohong, Wang Xiangxue, Xu Yingying, Zhang Xiao, Zhou Xiaoyan, Yan Jieke, Lai Chao

Biomed Res Int. 2022; 2022: 8099459. Published online 2022 Aug 9. doi: 10.1155/2022/8099459

PMCID:: PMC9381268

Article PDF–2.1M

Select item 89212237.

Lysosomal Ca²⁺-mediated TFEB activation modulates mitophagy and functional adaptation of pancreatic β-cells to metabolic stress

Kihyoun Park, Hyejin Lim, Jinyoung Kim, Yeseong Hwang, Yu Seol Lee, Soo Han Bae, Hyeongseok Kim, Hail Kim, Shin-Wook Kang, Joo Young Kim, Myung-Shik Lee

Nat Commun. 2022; 13: 1300. Published online 2022 Mar 14. doi: 10.1038/s41467-022-28874-9

PMCID:: PMC8921223

Article PDF–10M

Select item 89209218.

The Ragulator complex serves as a substrate-specific mTORC1 scaffold in regulating the nuclear translocation of transcription factor EB

Tetsuya Kimura, Yoshitomo Hayama, Daisuke Okuzaki, Shigeyuki Nada, Masato Okada

J Biol Chem. 2022 Mar; 298(3): 101744. Published online 2022 Feb 18. doi: 10.1016/j.jbc.2022.101744

PMCID:: PMC8920921

Article PDF–1.0M

Select item 87736719.

Tfeb-Mediated Transcriptional Regulation of Autophagy Induces Autosis during Ischemia/Reperfusion in the Heart

Jihoon Nah, Eun-Ah Sung, Peiyong Zhai, Daniela Zablocki, Junichi Sadoshima

Cells. 2022 Jan; 11(2): 258. Published online 2022 Jan 13. doi: 10.3390/cells11020258

PMCID:: PMC8773671

Article PDF–2.9M

Select item 863229810.

Electroacupuncture ameliorates beta-amyloid pathology and cognitive impairment in Alzheimer disease via a novel mechanism involving activation of TFEB (transcription factor EB)

Xiaoyan Zheng, Wenjia Lin, Yimin Jiang, Kejia Lu, Wenjing Wei, Qingwei Huo, Shaoyang Cui, Xifei Yang, Min Li, Nenggui Xu, Chunzhi Tang, Ju-Xian Song

Autophagy. 2021; 17(11): 3833–3847. Published online 2021 Feb 23. doi: 10.1080/15548627.2021.1886720

PMCID:: PMC8632298

Article PDF–4.8M

Select item 863229211.

Trehalose causes low-grade lysosomal stress to activate TFEB and the autophagy-lysosome biogenesis response

Se-Jin Jeong, Jeremiah Stitham, Trent D. Evans, Xiangyu Zhang, Astrid Rodriguez-Velez, Yu-Sheng Yeh, Joan Tao, Koki Takabatake, Slava Epelman, Irfan J. Lodhi, Joel D. Schilling, Brian J. DeBosch, Abhinav Diwan, Babak Razani

Autophagy. 2021; 17(11): 3740–3752. Published online 2021 Mar 11. doi: 10.1080/15548627.2021.1896906

PMCID:: PMC8632292

Article PDF–3.4M

Select item 801686712.

TFEB regulates pluripotency transcriptional network in mouse embryonic stem cells independent of autophagy–lysosomal biogenesis

Anderson Tan, Renuka Prasad, Eek-hoon Jho

Cell Death Dis. 2021 Apr; 12(4): 343. Published online 2021 Apr 1. doi: 10.1038/s41419-021-03632-9

PMCID:: PMC8016867

Article PDF–5.8M

Select item 790301413.

TFEB deficiency attenuates mitochondrial degradation upon brown adipose tissue whitening at thermoneutrality

Frederike Sass, Christian Schlein, Michelle Y. Jaeckstein, Paul Pertzborn, Michaela Schweizer, Thorsten Schinke, Andrea Ballabio, Ludger Scheja, Joerg Heeren, Alexander W. Fischer

Mol Metab. 2021 May; 47: 101173. Published online 2021 Jan 29. doi: 10.1016/j.molmet.2021.101173

PMCID:: PMC7903014

Article PDF–4.5M

Select item 760957014.

TFEB regulates lysosomal exocytosis of tau and its loss of function exacerbates tau pathology and spreading

Yin Xu, Shuqi Du, Jacob A. Marsh, Kanta Horie, Chihiro Sato, Andrea Ballabio, Celeste M. Karch, David M. Holtzman, Hui Zheng

Mol Psychiatry. Author manuscript; available in PMC 2021 Nov 4.

Published in final edited form as: Mol Psychiatry. 2021 Oct; 26(10): 5925–5939. Published online 2020 May 4. doi: 10.1038/s41380-020-0738-0

PMCID:: PMC7609570

Article PDF–1.9M

Select item 746960915.

Dysregulation of TFEB contributes to manganese-induced autophagic failure and mitochondrial dysfunction in astrocytes

Ziyan Zhang, Jingqi Yan, Aaron B. Bowman, Miles R. Bryan, Rajat Singh, Michael Aschner

Autophagy. 2020; 16(8): 1506–1523. Published online 2019 Nov 24. doi: 10.1080/15548627.2019.1688488

PMCID:: PMC7469609

Article PDF–6.9M

Select item 733739616.

Potentiation of rifampin activity in a mouse model of tuberculosis by activation of host transcription factor EB

Ruslana Bryk, Shashirekha Mundhra, Xiuju Jiang, Madeleine Wood, Daniel Pfau, Elaina Weber, Suna Park, Li Zhang, Colin Wilson, Renier Van der Westhuyzen, Leslie Street, Kelly Chibale, Matthew Zimmerman, Véronique Dartois, Nunzia Pastore, Andrea Ballabio, Natalie Hawryluk, Stacie Canan, Vikram Khetani, Joseph Camardo, Carl Nathan

PLoS Pathog. 2020 Jun; 16(6): e1008567. Published online 2020 Jun 23. doi: 10.1371/journal.ppat.1008567