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Select item 103230871.

The histone demethylase Utx controls CD8⁺ T‐cell‐dependent antitumor immunity via epigenetic regulation of the effector function

Haruna Noda, Junpei Suzuki, Yuko Matsuoka, Akira Matsumoto, Makoto Kuwahara, Yoshiaki Kamei, Yasutsugu Takada, Masakatsu Yamashita

Cancer Sci. 2023 Jul; 114(7): 2787–2797. Published online 2023 Apr 17. doi: 10.1111/cas.15814

PMCID:: PMC10323087

Article PDF–6.8M

Select item 102355012.

Integrative bioinformatics and validation studies reveal KDM6B and its associated molecules as crucial modulators in Idiopathic Pulmonary Fibrosis

Anning Chen, Zhun Sun, Donglin Sun, Meiying Huang, Hongwei Fang, Jinyuan Zhang, Guojun Qian

Front Immunol. 2023; 14: 1183871. Published online 2023 May 19. doi: 10.3389/fimmu.2023.1183871

PMCID:: PMC10235501

Article PDF–7.4M

Select item 97723983.

JMJD3 Is Required for Acute Pancreatitis and Pancreatitis-Associated Lung Injury

Li Chen, Xiangxian Zhang, Yu Liu, Li Liu, Xiao Liang, Shengqun Yang, Qing Xia, Tao Jin, Yun Ma, Yonghua Chen, Xia Yuan, Yan Tie, Yangzhuo Gu, Chunju Fang, Siyuan Chen, Fei Mo, Ting Yu, Yuzhu Hu, Zhiyong Qian, Yong Peng, Jia Geng, Zongguang Zhou, Min Wu, Jiansheng Ding, Daoke Yang, Xiawei Wei

J Immunol. 2023 Jan 15; 210(2): 180–190. Published online 2023 Jan 15. doi: 10.4049/jimmunol.2200484

PMCID:: PMC9772398

Article PDF–3.0M

Select item 92873234.

The histone demethylase Kdm6b regulates the maturation and cytotoxicity of TCRαβ⁺CD8αα⁺ intestinal intraepithelial lymphocytes

Haohao Zhang, Yiming Hu, Dandan Liu, Zhi Liu, Ningxia Xie, Sanhong Liu, Jie Zhang, Yuhang Jiang, Cuifeng Li, Qi Wang, Xi Chen, Deji Ye, Donglin Sun, Yujia Zhai, Xinhui Yan, Yongzhong Liu, Charlie Degui Chen, Xingxu Huang, Y. Eugene Chin, Yufang Shi, Baojin Wu, Xiaoren Zhang

Cell Death Differ. 2022 Jul; 29(7): 1349–1363. Published online 2022 Jan 9. doi: 10.1038/s41418-021-00921-w

PMCID:: PMC9287323

Article PDF–7.4M

Select item 90521615.

Downregulation of the endothelial histone demethylase JMJD3 is associated with neointimal hyperplasia of arteriovenous fistulas in kidney failure

Shaozhen Feng, Eric K. Peden, Qunying Guo, Tae Hoon Lee, Qingtian Li, Yuhui Yuan, Changyi Chen, Fengzhang Huang, Jizhong Cheng

J Biol Chem. 2022 May; 298(5): 101816. Published online 2022 Mar 10. doi: 10.1016/j.jbc.2022.101816

PMCID:: PMC9052161

Article PDF–4.7M

Select item 84923206.

Mitochondrial dysfunction–induced H3K27 hyperacetylation perturbs enhancers in Parkinson’s disease

Minhong Huang, Dan Lou, Adhithiya Charli, Dehui Kong, Huajun Jin, Gary Zenitsky, Vellareddy Anantharam, Arthi Kanthasamy, Zhibin Wang, Anumantha G. Kanthasamy

JCI Insight. 2021 Sep 8; 6(17): e138088. Published online 2021 Sep 8. doi: 10.1172/jci.insight.138088

PMCID:: PMC8492320

Article PDF–14M

Select item 80083657.

Inhibition of macrophage histone demethylase JMJD3 protects against abdominal aortic aneurysms

Frank M. Davis, Lam C. Tsoi, William J. Melvin, Aaron denDekker, Rachael Wasikowski, Amrita D. Joshi, Sonya Wolf, Andrea T. Obi, Allison C. Billi, Xianying Xing, Christopher Audu, Bethany B. Moore, Steven L. Kunkel, Alan Daugherty, Hong S. Lu, Johann E. Gudjonsson, Katherine A. Gallagher

J Exp Med. 2021 Jun 7; 218(6): e20201839. Published online 2021 Mar 29. doi: 10.1084/jem.20201839

PMCID:: PMC8008365

Article PDF–6.1M

Select item 74938938.

Critical role of histone H3 lysine 27 demethylase Kdm6b in the homeostasis and function of medullary thymic epithelial cells

Zhi Liu, Haohao Zhang, Yiming Hu, Dandan Liu, Lingling Li, Cuifeng Li, Qi Wang, Junhaohui Huo, Hanshao Liu, Ningxia Xie, Xingxu Huang, Yongzhong Liu, Charlie Degui Chen, Yufang Shi, Xiaoren Zhang

Cell Death Differ. 2020 Oct; 27(10): 2843–2855. Published online 2020 Apr 28. doi: 10.1038/s41418-020-0546-8

PMCID:: PMC7493893

Article PDF–3.7M

Select item 63491619.

Leonurine suppresses neuroinflammation through promoting oligodendrocyte maturation

Min Jin, Qian Li, Yuting Gu, Bing Wan, Jiefang Huang, Xuanbai Xu, Rui Huang, Yanyun Zhang

J Cell Mol Med. 2019 Feb; 23(2): 1470–1485. Published online 2018 Dec 16. doi: 10.1111/jcmm.14053

PMCID:: PMC6349161

Article PDF–2.0M

Select item 610567910.

JMJD3 facilitates C/EBPβ-centered transcriptional program to exert oncorepressor activity in AML

Shan-He Yu, Kang-Yong Zhu, Juan Chen, Xiang-Zhen Liu, Peng-Fei Xu, Wu Zhang, Li Yan, He-Zhou Guo, Jiang Zhu

Nat Commun. 2018; 9: 3369. Published online 2018 Aug 22. doi: 10.1038/s41467-018-05548-z

PMCID:: PMC6105679

Article PDF–2.6M

Select item 498865011.

MUSASHI-Mediated Expression of JMJD3, a H3K27me3 Demethylase, Is Involved in Foamy Macrophage Generation during Mycobacterial Infection

Sahana Holla, Praveen Prakhar, Vikas Singh, Anupama Karnam, Tanushree Mukherjee, Kasturi Mahadik, Pankti Parikh, Amit Singh, R. S. Rajmani, Subbaraya G. Ramachandra, Kithiganahalli Narayanaswamy Balaji

PLoS Pathog. 2016 Aug; 12(8): e1005814. Published online 2016 Aug 17. doi: 10.1371/journal.ppat.1005814

PMCID:: PMC4988650

Article PDF–11M

Select item 454823212.

Histone demethylase JMJD3 is required for osteoblast differentiation in mice

Feng Zhang, Longyong Xu, Longxia Xu, Qing Xu, Gerard Karsenty, Charlie Degui Chen

Sci Rep. 2015; 5: 13418. Published online 2015 Aug 25. doi: 10.1038/srep13418

PMCID:: PMC4548232

Article PDF–1.5M

Select item 427475013.

Critical role of histone demethylase Jmjd3 in the regulation of CD4⁺ T cell differentiation

Qingtian Li, Jia Zou, Mingjun Wang, Xilai Ding, Iouri Chepelev, Xikun Zhou, Wei Zhao, Gang Wei, Jun Cui, Keji Zhao, Helen Y. Wang, Rong-Fu Wang

Nat Commun. Author manuscript; available in PMC 2015 Jun 22.

Published in final edited form as: Nat Commun. 2014; 5: 5780. Published online 2014 Dec 22. doi: 10.1038/ncomms6780

PMCID:: PMC4274750

Article PDF–2.0M

Select item 413854614.

The histone lysine demethylase Kdm6b is required for activity-dependent preconditioning of hippocampal neuronal survival

Ranjula Wijayatunge, Liang-Fu Chen, Young May Cha, Anthony S. Zannas, Christopher L. Frank, Anne E. West

Mol Cell Neurosci. Author manuscript; available in PMC 2015 Jul 1.

Published in final edited form as: Mol Cell Neurosci. 2014 Jul; 61: 187–200. Published online 2014 Jun 28. doi: 10.1016/j.mcn.2014.06.008

PMCID:: PMC4138546

Article PDF–1019K

Select item 410413915.

Jmjd3-mediated epigenetic regulation of inflammatory cytokine gene expression in serum amyloid A-stimulated macrophages

Qian Yan, Lei Sun, Ziyan Zhu, Lili Wang, Shuqin Li, Richard D. Ye

Cell Signal. Author manuscript; available in PMC 2015 Sep 1.

Published in final edited form as: Cell Signal. 2014 Sep; 26(9): 1783–1791. Published online 2014 Apr 1. doi: 10.1016/j.cellsig.2014.03.025

PMCID:: PMC4104139

Article PDF–612K

Select item 374446016.

H3K27 Demethylase, JMJD3, Regulates Fragmentation of Spermatogonial Cysts

Naoki Iwamori, Tokuko Iwamori, Martin M. Matzuk

PLoS One. 2013; 8(8): e72689. Published online 2013 Aug 15. doi: 10.1371/journal.pone.0072689

PMCID:: PMC3744460

Article PDF–4.0M

Select item 356454217.

RNA polymerase II progression through H3K27me3-enriched gene bodies requires JMJD3 histone demethylase

Conchi Estarás, Raquel Fueyo, Naiara Akizu, Sergi Beltrán, Marian A. Martínez-Balbás

Mol Biol Cell. 2013 Feb 1; 24(3): 351–360. doi: 10.1091/mbc.E12-07-0561

PMCID:: PMC3564542

Article PDF–2.3M

Select item 275202518.

Jmjd3 contributes to the control of gene expression in LPS-activated macrophages

Francesca De Santa, Vipin Narang, Zhei Hwee Yap, Betsabeh Khoramian Tusi, Thomas Burgold, Liv Austenaa, Gabriele Bucci, Marieta Caganova, Samuele Notarbartolo, Stefano Casola, Giuseppe Testa, Wing-Kin Sung, Chia-Lin Wei, Gioacchino Natoli

EMBO J. 2009 Nov 4; 28(21): 3341–3352. Published online 2009 Sep 24. doi: 10.1038/emboj.2009.271

PMCID:: PMC2752025

Article PDF–2.0M

Select item 268553319.

Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS

Marta Barradas, Emma Anderton, Juan Carlos Acosta, SiDe Li, Ana Banito, Marc Rodriguez-Niedenführ, Goedele Maertens, Michaela Banck, Ming-Ming Zhou, Martin J. Walsh, Gordon Peters, Jesús Gil

Genes Dev. 2009 May 15; 23(10): 1177–1182. doi: 10.1101/gad.511109

PMCID:: PMC2685533

Article PDF–513K

Select item 1068656520.

KDM6B drives epigenetic reprogramming associated with lymphoid stromal cell early commitment and immune properties

Marvin Sylvestre, Nicolas Barbier, Vonick Sibut, Saba Nayar, Céline Monvoisin, Simon Leonard, Julien Saint-Vanne, Ansie Martin, Marion Guirriec, Maëlle Latour, Florence Jouan, Sylvain Baulande, Mylène Bohec, Léa Verdière, Fatima Mechta-Grigoriou, Frédéric Mourcin, Nicolas Bertheuil, Francesca Barone, Karin Tarte, David Roulois

Sci Adv. 2023 Dec 1; 9(48): eadh2708. Published online 2023 Nov 29. doi: 10.1126/sciadv.adh2708