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Select item 109735251.

A novel proteomic signature of osteoclast differentiation unveils the deubiquitinase UCHL1 as a necessary osteoclastogenic driver

Maria Materozzi, Massimo Resnati, Cecilia Facchi, Matteo Trudu, Ugo Orfanelli, Tommaso Perini, Luigi Gennari, Enrico Milan, Simone Cenci

Sci Rep. 2024; 14: 7290. Published online 2024 Mar 27. doi: 10.1038/s41598-024-57898-y

PMCID:: PMC10973525

Abstract Article PDF–8.3M

Select item 109377942.

Deubiquitinase UCHL1 promotes angiogenesis and blood–spinal cord barrier function recovery after spinal cord injury by stabilizing Sox17

Jiaxing Wang, Chengyue Ji, Wu Ye, Yuluo Rong, Xuhui Ge, Zhuanghui Wang, Pengyu Tang, Zheng Zhou, Yongjun Luo, Weihua Cai

Cell Mol Life Sci. 2024 Dec; 81(1): 137. Published online 2024 Mar 13. doi: 10.1007/s00018-024-05186-3

PMCID:: PMC10937794

Abstract Article PDF–5.3M

Select item 101978893.

The deubiquitinase UCHL1 negatively controls osteoclastogenesis by regulating TAZ/NFATC1 signalling

Zhenhua Feng, Siyue Tao, Zhaobo Huang, Bingjie Zheng, Xiangxi Kong, Yufeng Xiang, Qibin Zhang, Haixin Song, Zhikun Xu, Xiaoan Wei, Fengdong Zhao, Jian Chen

Int J Biol Sci. 2023; 19(8): 2319–2332. Published online 2023 Apr 24. doi: 10.7150/ijbs.82152

PMCID:: PMC10197889

Abstract Article PDF–7.7M

Select item 101020224.

Non-functional ubiquitin C-terminal hydrolase L1 drives podocyte injury through impairing proteasomes in autoimmune glomerulonephritis

Julia Reichelt, Wiebke Sachs, Sarah Frömbling, Julia Fehlert, Maja Studencka-Turski, Anna Betz, Desiree Loreth, Lukas Blume, Susanne Witt, Sandra Pohl, Johannes Brand, Maire Czesla, Jan Knop, Bogdan I. Florea, Stephanie Zielinski, Marlies Sachs, Elion Hoxha, Irm Hermans-Borgmeyer, Gunther Zahner, Thorsten Wiech, Elke Krüger, Catherine Meyer-Schwesinger

Nat Commun. 2023; 14: 2114. Published online 2023 Apr 13. doi: 10.1038/s41467-023-37836-8

Correction in:: Nat Commun. 2023; 14: 2453.

PMCID:: PMC10102022

Abstract Article PDF–9.7M

Select item 93823725.

The requirement of ubiquitin C-terminal hydrolase L1 in mouse ovarian development and fertility

Morgan F Woodman, Meghan C H Ozcan, Megan A Gura, Payton De La Cruz, Alexis K Gadson, Kathryn J Grive

Biol Reprod. 2022 Aug; 107(2): 500–513. Published online 2022 May 3. doi: 10.1093/biolre/ioac086

PMCID:: PMC9382372

Abstract Article PDF–1.7M

Select item 90214186.

Ubiquitin Carboxyl-Terminal Hydrolase L1 of Cardiomyocytes Promotes Macroautophagy and Proteostasis and Protects Against Post-myocardial Infarction Cardiac Remodeling and Heart Failure

Penglong Wu, Yifan Li, Mingqi Cai, Bo Ye, Bingchuan Geng, Faqian Li, Hua Zhu, Jinbao Liu, Xuejun Wang

Front Cardiovasc Med. 2022; 9: 866901. Published online 2022 Apr 7. doi: 10.3389/fcvm.2022.866901

PMCID:: PMC9021418

Abstract Article PDF–7.1M

Select item 85309567.

Mutation of a ubiquitin carboxy terminal hydrolase L1 lipid binding site alleviates cell death, axonal injury, and behavioral deficits after traumatic brain injury in mice

Zhiping Mi, Hao Liu, Marie E. Rose, Jie Ma, Daniel P. Reay, Xiecheng Ma, Jeremy J. Henchir, C. Edward Dixon, Steven H. Graham

Neuroscience. Author manuscript; available in PMC 2022 Nov 1.

Published in final edited form as: Neuroscience. 2021 Nov 1; 475: 127–136. Published online 2021 Sep 8. doi: 10.1016/j.neuroscience.2021.09.001

PMCID:: PMC8530956

Abstract Article PDF–1.3M

Select item 84656108.

Loss of Ubiquitin Carboxy-Terminal Hydrolase L1 Impairs Long-Term Differentiation Competence and Metabolic Regulation in Murine Spermatogonial Stem Cells

Whitney F. Alpaugh, Anna L. Voigt, Rkia Dardari, Lin Su, Iman Al Khatib, Wisoo Shin, Taylor M. Goldsmith, Krysta M. Coyle, Lin A. Tang, Timothy E. Shutt, Claudia Klein, Jeff Biernaskie, Ina Dobrinski

Cells. 2021 Sep; 10(9): 2265. Published online 2021 Aug 31. doi: 10.3390/cells10092265

PMCID:: PMC8465610

Abstract Article PDF–4.6M

Select item 82381599.

UCHL1, a deubiquitinating enzyme, regulates lung endothelial cell permeability in vitro and in vivo

Sumegha Mitra, Yulia Epshtein, Saad Sammani, Hector Quijada, Weiguo Chen, Mounica Bandela, Ankit A. Desai, Joe G.N. Garcia, Jeffrey R. Jacobson

Am J Physiol Lung Cell Mol Physiol. 2021 Apr 1; 320(4): L497–L507. Published online 2021 Jan 13. doi: 10.1152/ajplung.00492.2020

PMCID:: PMC8238159

Abstract Article

Select item 785581810.

Abolishing UCHL1’s hydrolase activity exacerbates TBI-induced axonal injury and neuronal death in mice

Zhiping Mi, Hao Liu, Marie E. Rose, Xiecheng Ma, Daniel P. Reay, Jie Ma, Jeremy Henchir, C. Edward Dixon, Steven H. Graham

Exp Neurol. Author manuscript; available in PMC 2022 Feb 1.

Published in final edited form as: Exp Neurol. 2021 Feb; 336: 113524. Published online 2020 Nov 4. doi: 10.1016/j.expneurol.2020.113524

PMCID:: PMC7855818

Abstract Article PDF–2.5M

Select item 760135911.

UCH-L1 inhibitor LDN-57444 hampers mouse oocyte maturation by regulating oxidative stress and mitochondrial function and reducing ERK1/2 expression

Pan Yuan, Li Zhou, Xiaona Zhang, Lan Yao, Jun Ning, Xiao Han, Caifeng Ming, Yunhe Zhao, Liqun Zhang

Biosci Rep. 2020 Oct 30; 40(10): BSR20201308. Published online 2020 Oct 30. doi: 10.1042/BSR20201308

PMCID:: PMC7601359

Abstract Article PDF–1.0M

Select item 686876012.

UCH-L1 is a Poor Serum Biomarker of Murine Traumatic Brain Injury After Polytrauma

Mackenzie C. Morris, Aron Bercz, Grace M. Niziolek, Farzaan Kassam, Rose Veile, Lou Ann Friend, Timothy A. Pritts, Amy T. Makley, Michael D. Goodman

J Surg Res. Author manuscript; available in PMC 2019 Dec 1.

Published in final edited form as: J Surg Res. 2019 Dec; 244: 63–68. Published online 2019 Jul 3. doi: 10.1016/j.jss.2019.06.023

PMCID:: PMC6868760

Abstract Article PDF–753K

Select item 641086013.

Role of UCHL1 in axonal injury and functional recovery after cerebral ischemia

Hao Liu, Nadya Povysheva, Marie E. Rose, Zhiping Mi, Joseph S. Banton, Wenjin Li, Fenghua Chen, Daniel P. Reay, Germán Barrionuevo, Feng Zhang, Steven H. Graham

Proc Natl Acad Sci U S A. 2019 Mar 5; 116(10): 4643–4650. Published online 2019 Feb 13. doi: 10.1073/pnas.1821282116

PMCID:: PMC6410860

Abstract Article PDF–1.4M

Select item 612639614.

Proteomic Analysis of Hippocampus in a Mouse Model of Depression Reveals Neuroprotective Function of Ubiquitin C-terminal Hydrolase L1 (UCH-L1) via Stress-induced Cysteine Oxidative Modifications

Jung-Eun Choi, Jae-Jin Lee, Wonmo Kang, Hyun Jung Kim, Jin-Hwan Cho, Pyung-Lim Han, Kong-Joo Lee

Mol Cell Proteomics. 2018 Sep; 17(9): 1803–1823. Published online 2018 Jun 29. doi: 10.1074/mcp.RA118.000835

PMCID:: PMC6126396

Abstract Article PDF–4.6M

Select item 591313615.

The deubiquitinating enzyme UCHL1 negatively regulates the immunosuppressive capacity and survival of multipotent mesenchymal stromal cells

Yuting Gu, Xinyuan Ding, Jiefang Huang, Mingxing Xue, Jie Zhang, Qiwei Wang, Hongshuang Yu, Yanan Wang, Fang Zhao, Hui Wang, Min Jin, Yeming Wu, Yanyun Zhang

Cell Death Dis. 2018 May; 9(5): 459. Published online 2018 Apr 23. doi: 10.1038/s41419-018-0532-y

PMCID:: PMC5913136

Abstract Article PDF–2.7M

Select item 558458416.

Ubiquitin C-Terminal Hydrolase L1 regulates myoblast proliferation and differentiation

Hongbo Gao, Sigurd Hartnett, Yifan Li

Biochem Biophys Res Commun. Author manuscript; available in PMC 2018 Oct 7.

Published in final edited form as: Biochem Biophys Res Commun. 2017 Oct 7; 492(1): 96–102. Published online 2017 Aug 10. doi: 10.1016/j.bbrc.2017.08.027