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Select item 109508041.

Adipose tissue peroxisomal lipid synthesis orchestrates obesity and insulin resistance through LXR-dependent lipogenesis

Brian Kleiboeker, Anyuan He, Min Tan, Dongliang Lu, Donghua Hu, Xuejing Liu, Parniyan Goodarzi, Fong-Fu Hsu, Babak Razani, Clay F. Semenkovich, Irfan J. Lodhi

Mol Metab. 2024 Apr; 82: 101913. Published online 2024 Mar 7. doi: 10.1016/j.molmet.2024.101913

PMCID:: PMC10950804

Abstract Article PDF–4.3M

Select item 108002692.

Enhanced liver X receptor signalling reduces brain injury and promotes tissue regeneration following experimental intracerebral haemorrhage: roles of microglia/macrophages

Ruiyi Zhang, Yifei Dong, Yang Liu, Dorsa Moezzi, Samira Ghorbani, Reza Mirzaei, Brian M Lozinski, Jeff F Dunn, V Wee Yong, Mengzhou Xue

Stroke Vasc Neurol. 2023 Dec; 8(6): 486–502. Published online 2023 May 3. doi: 10.1136/svn-2023-002331

PMCID:: PMC10800269

Abstract Article PDF–9.0M

Select item 79256323.

Administration of GDF3 Into Septic Mice Improves Survival via Enhancing LXRα-Mediated Macrophage Phagocytosis

Peng Wang, Xingjiang Mu, Hongyan Zhao, Yutian Li, Lu Wang, Vivian Wolfe, Shu-Nan Cui, Xiaohong Wang, Tianqing Peng, Basilia Zingarelli, Chunting Wang, Guo-Chang Fan

Front Immunol. 2021; 12: 647070. Published online 2021 Feb 17. doi: 10.3389/fimmu.2021.647070

PMCID:: PMC7925632

Abstract Article PDF–4.0M

Select item 71992944.

Stigmasterol stimulates transintestinal cholesterol excretion independent of liver X receptor activation in the small intestine

Hannah C. Lifsey, Rupinder Kaur, Bradley H Thompson, Lisa Bennett, Ryan E. Temel, Gregory A. Graf

J Nutr Biochem. Author manuscript; available in PMC 2021 Feb 1.

Published in final edited form as: J Nutr Biochem. 2020 Feb; 76: 108263. Published online 2019 Nov 9. doi: 10.1016/j.jnutbio.2019.108263

PMCID:: PMC7199294

Abstract Article PDF–1.1M

Select item 67032245.

Critical Role of Astroglial Apolipoprotein E and Liver X Receptor-α Expression for Microglial Aβ Phagocytosis

Dick Terwel, Knut R. Steffensen, Philip B. Verghese, Markus P. Kummer, Jan-Åke Gustafsson, David M. Holtzman, Michael T. Heneka

J Neurosci. 2011 May 11; 31(19): 7049–7059. doi: 10.1523/JNEUROSCI.6546-10.2011

PMCID:: PMC6703224

Abstract Article PDF–2.6M

Select item 63443426.

Impaired LXRα Phosphorylation Attenuates Progression of Fatty Liver Disease

Natalia Becares, Matthew C. Gage, Maud Voisin, Elina Shrestha, Lucia Martin-Gutierrez, Ning Liang, Rikah Louie, Benoit Pourcet, Oscar M. Pello, Tu Vinh Luong, Saioa Goñi, Cesar Pichardo-Almarza, Hanne Røberg-Larsen, Vanessa Diaz-Zuccarini, Knut R. Steffensen, Alastair O’Brien, Michael J. Garabedian, Krista Rombouts, Eckardt Treuter, Inés Pineda-Torra

Cell Rep. 2019 Jan 22; 26(4): 984–995.e6. Published online 2019 Jan 22. doi: 10.1016/j.celrep.2018.12.094

PMCID:: PMC6344342

Abstract Article

Select item 53964337.

Liver X Receptor Agonist TO901317 Attenuates Paraquat-Induced Acute Lung Injury through Inhibition of NF-κB and JNK/p38 MAPK Signal Pathways

Xiao Hu, Haitao Shen, Yu Wang, Min Zhao

Biomed Res Int. 2017; 2017: 4652695. Published online 2017 Apr 5. doi: 10.1155/2017/4652695

PMCID:: PMC5396433

Abstract Article PDF–4.0M

Select item 53130698.

Liver X receptor α mediates hepatic triglyceride accumulation through upregulation of G0/G1 Switch Gene 2 expression

Bradlee L. Heckmann, Xiaodong Zhang, Alicia M. Saarinen, Gabriele Schoiswohl, Erin E. Kershaw, Rudolf Zechner, Jun Liu

JCI Insight. 2017 Feb 23; 2(4): e88735. Published online 2017 Feb 23. doi: 10.1172/jci.insight.88735

PMCID:: PMC5313069

Abstract Article PDF–2.4M

Select item 51227859.

Ozone-derived Oxysterols Affect Liver X Receptor (LXR) Signaling: A POTENTIAL ROLE FOR LIPID-PROTEIN ADDUCTS

Adam M. Speen, Hye-Young H. Kim, Rebecca N. Bauer, Megan Meyer, Kymberly M. Gowdy, Michael B. Fessler, Kelly E. Duncan, Wei Liu, Ned A. Porter, Ilona Jaspers

J Biol Chem. 2016 Nov 25; 291(48): 25192–25206. Published online 2016 Oct 4. doi: 10.1074/jbc.M116.732362

PMCID:: PMC5122785

Abstract Article PDF–2.2M

Select item 508732610.

Promiscuous activity of the LXR antagonist GSK2033 in a mouse model of fatty liver disease

Kristine Griffett, Thomas P. Burris

Biochem Biophys Res Commun. Author manuscript; available in PMC 2016 Oct 31.

Published in final edited form as: Biochem Biophys Res Commun. 2016 Oct 21; 479(3): 424–428. Published online 2016 Sep 25. doi: 10.1016/j.bbrc.2016.09.036

PMCID:: PMC5087326

Abstract Article PDF–1.5M

Select item 477729511.

Sexual Dimorphism in Circadian Physiology Is Altered in LXRα Deficient Mice

Céline Feillet, Sophie Guérin, Michel Lonchampt, Catherine Dacquet, Jan-Åke Gustafsson, Franck Delaunay, Michèle Teboul

PLoS One. 2016; 11(3): e0150665. Published online 2016 Mar 3. doi: 10.1371/journal.pone.0150665

PMCID:: PMC4777295

Abstract Article PDF–1.2M

Select item 475804412.

Liver X receptor α is essential for the capillarization of liver sinusoidal endothelial cells in liver injury

Yan Xing, Tingting Zhao, Xiaoyan Gao, Yuzhang Wu

Sci Rep. 2016; 6: 21309. Published online 2016 Feb 18. doi: 10.1038/srep21309

PMCID:: PMC4758044

Abstract Article PDF–1.8M

Select item 474249113.

LXRα improves myocardial glucose tolerance and reduces cardiac hypertrophy in a mouse model of obesity-induced type 2 diabetes

Megan V. Cannon, Herman H. W. Silljé, Jürgen W. A. Sijbesma, Mohsin A. F. Khan, Knut R. Steffensen, Wiek H. van Gilst, Rudolf A. de Boer

Diabetologia. 2016; 59: 634–643. Published online 2015 Dec 18. doi: 10.1007/s00125-015-3827-x

PMCID:: PMC4742491

Abstract Article PDF–852K

Select item 450988114.

Age-dependent therapeutic effects of liver X receptor-α activation in murine polymicrobial sepsis

Gabriela Botez, Giovanna Piraino, Paul W Hake, John R Ledford, Michael O’Connor, James A Cook, Basilia Zingarelli

Innate Immun. 2015 Aug; 21(6): 609–618. doi: 10.1177/1753425915569367

PMCID:: PMC4509881

Abstract Article PDF–1004K

Select item 400442515.

Activation of Liver X Receptor Alleviates Ocular Inflammation in Experimental Autoimmune Uveitis

Hongxia Yang, Shijie Zheng, Yiguo Qiu, Yan Yang, Chaokui Wang, Peizeng Yang, Qiuhong Li, Bo Lei

Invest Ophthalmol Vis Sci. 2014 Apr; 55(4): 2795–2804. Published online 2014 Apr 28. doi: 10.1167/iovs.13-13323

PMCID:: PMC4004425

Abstract Article PDF–1.0M

Select item 388666316.

LXRα fuels fatty acid-stimulated oxygen consumption in white adipocytes

Lea Dib, Anne Bugge, Sheila Collins

J Lipid Res. 2014 Feb; 55(2): 247–257. doi: 10.1194/jlr.M043422

PMCID:: PMC3886663

Abstract Article PDF–1.5M

Select item 342820517.

Liver X receptor-activating ligands modulate renal and intestinal sodium–phosphate transporters

Yupanqui A. Caldas, Hector Giral, Michael A. Cortázar, Eileen Sutherland, Kayo Okamura, Judith Blaine, Victor Sorribas, Hermann Koepsell, Moshe Levi

Kidney Int. Author manuscript; available in PMC 2012 Aug 27.

Published in final edited form as: Kidney Int. 2011 Sep; 80(5): 535–544. Published online 2011 Jun 15. doi: 10.1038/ki.2011.159

PMCID:: PMC3428205

Abstract Article PDF–4.2M

Select item 333178218.

Liver X Receptor α Is Involved in the Transcriptional Regulation of the 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase Gene

Li-Feng Zhao, Yasumasa Iwasaki, Mitsuru Nishiyama, Takafumi Taguchi, Makoto Tsugita, Mizuho Okazaki, Shuichi Nakayama, Machiko Kambayashi, Shimpei Fujimoto, Koshi Hashimoto, Koji Murao, Yoshio Terada

Diabetes. 2012 May; 61(5): 1062–1071. Published online 2012 Apr 13. doi: 10.2337/db11-1255

PMCID:: PMC3331782

Abstract Article PDF–1.4M

Select item 323077019.

Activation of LXR Increases Acetaminophen Clearance and Prevents Its Toxicity

Simrat P.S. Saini, Bin Zhang, Yongdong Niu, Mengxi Jiang, Jie Gao, Yonggong Zhai, Jung Hoon Lee, Hirdesh Uppal, Hui Tian, Michael A. Tortorici, Samuel M. Poloyac, Wenxin Qin, Raman Venkataramanan, Wen Xie

Hepatology. Author manuscript; available in PMC 2012 Dec 1.

Published in final edited form as: Hepatology. 2011 Dec; 54(6): 2208–2217. doi: 10.1002/hep.24646

PMCID:: PMC3230770

Abstract Article PDF–1.0M

Select item 279033020.

Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis

Ebru Erbay, Vladimir R. Babaev, Jared R. Mayers, Liza Makowski, Khanichi N. Charles, Melinda Snitow, Sergio Fazio, Michelle M. Wiest, Steven M. Watkins, MacRae F. Linton, Gökhan S. Hotamisligil

Nat Med. Author manuscript; available in PMC 2010 Jun 1.

Published in final edited form as: Nat Med. 2009 Dec; 15(12): 1383–1391. Published online 2009 Nov 29. doi: 10.1038/nm.2067