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Items: 1 to 20 of 33

1.
The Energy Status of Astrocytes Is the Achilles’ Heel of eIF2B-Leukodystrophy
Melisa Herrero, Maron Daw, Andrea Atzmon, Orna Elroy-Stein
Cells. 2021 Aug; 10(8): 1858. Published online 2021 Jul 22. doi: 10.3390/cells10081858
PMCID:
PMC8393801
AbstractArticlePDF–5.3M
2.
TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation
Xiaochen Fan, V Pragathi Masamsetti, Jane QJ Sun, Kasper Engholm-Keller, Pierre Osteil, Joshua Studdert, Mark E Graham, Nicolas Fossat, Patrick PL Tam
eLife. 2021; 10: e62873. Published online 2021 Feb 8. doi: 10.7554/eLife.62873
PMCID:
PMC7968925
AbstractArticlePDF–4.0M
3.
eIF2B activator prevents neurological defects caused by a chronic integrated stress response
Yao Liang Wong, Lauren LeBon, Ana M Basso, Kathy L Kohlhaas, Arthur L Nikkel, Holly M Robb, Diana L Donnelly-Roberts, Janani Prakash, Andrew M Swensen, Nimrod D Rubinstein, Swathi Krishnan, Fiona E McAllister, Nicole V Haste, Jonathon J O'Brien, Margaret Roy, Andrea Ireland, Jennifer M Frost, Lei Shi, Stephan Riedmaier, Kathleen Martin, Michael J Dart, Carmela Sidrauski
eLife. 2019; 8: e42940. Published online 2019 Jan 9. doi: 10.7554/eLife.42940
PMCID:
PMC6326728
AbstractArticlePDF–3.8M
4.
Adult mouse eIF2Bε Arg191His astrocytes display a normal integrated stress response in vitro
Lisanne E. Wisse, Timo J. ter Braak, Malu-Clair van de Beek, Carola G. M. van Berkel, Joke Wortel, Vivi M. Heine, Chris G. Proud, Marjo S. van der Knaap, Truus E. M. Abbink
Sci Rep. 2018; 8: 3773. Published online 2018 Feb 28. doi: 10.1038/s41598-018-21885-x
PMCID:
PMC5830650
AbstractArticlePDF–1.3M
5.
Proteomics-level analysis of myelin formation and regeneration in a mouse model for Vanishing White Matter disease
Irit Gat-Viks, Tamar Geiger, Mali Barbi, Gali Raini, Orna Elroy-Stein
J Neurochem. Author manuscript; available in PMC 2016 Aug 1.
Published in final edited form as: J Neurochem. 2015 Aug; 134(3): 513–526. Published online 2015 May 14. doi: 10.1111/jnc.13142
PMCID:
PMC4499455
AbstractArticlePDF–814K
6.
Pridopidine subtly ameliorates motor skills in a mouse model for vanishing white matter
Ellen Oudejans, Diede Witkamp, Gino V Hu-A-Ng, Leoni Hoogterp, Gemma van Rooijen-van Leeuwen, Iris Kruijff, Pleun Schonewille, Zeinab Lalaoui El Mouttalibi, Imke Bartelink, Marjo S van der Knaap, Truus EM Abbink
Life Sci Alliance. 2024 Mar; 7(3): e202302199. Published online 2024 Jan 3. doi: 10.26508/lsa.202302199
PMCID:
PMC10765115
AbstractArticlePDF–2.1M
7.
Vanishing white matter: deregulated integrated stress response as therapy target
Truus E. M. Abbink, Lisanne E. Wisse, Ermelinda Jaku, Michiel J. Thiecke, Daniel Voltolini‐González, Hein Fritsen, Sander Bobeldijk, Timo J. ter Braak, Emiel Polder, Nienke L. Postma, Marianna Bugiani, Eduard A. Struijs, Mark Verheijen, Nina Straat, Sophie van der Sluis, Adri A. M. Thomas, Douwe Molenaar, Marjo S. van der Knaap
Ann Clin Transl Neurol. 2019 Aug; 6(8): 1407–1422. Published online 2019 Jul 18. doi: 10.1002/acn3.50826
PMCID:
PMC6689685
AbstractArticlePDF–14M
8.
Astrocytes are central in the pathomechanisms of vanishing white matter
Stephanie Dooves, Marianna Bugiani, Nienke L. Postma, Emiel Polder, Niels Land, Stephen T. Horan, Anne-Lieke F. van Deijk, Aleid van de Kreeke, Gerbren Jacobs, Caroline Vuong, Jan Klooster, Maarten Kamermans, Joke Wortel, Maarten Loos, Lisanne E. Wisse, Gert C. Scheper, Truus E.M. Abbink, Vivi M. Heine, Marjo S. van der Knaap
J Clin Invest. 2016 Apr 1; 126(4): 1512–1524. Published online 2016 Mar 14. doi: 10.1172/JCI83908
PMCID:
PMC4811153
AbstractArticlePDF–3.5M
9.
DYRK2 Negatively Regulates Cardiomyocyte Growth by Mediating Repressor Function of GSK-3β on eIF2Bε
Celine S. Weiss, Marco M. Ochs, Marco Hagenmueller, Marcus R. Streit, Pratima Malekar, Johannes H. Riffel, Sebastian J. Buss, Karl H. Weiss, Junichi Sadoshima, Hugo A. Katus, Stefan E. Hardt
PLoS One. 2013; 8(9): e70848. Published online 2013 Sep 4. doi: 10.1371/journal.pone.0070848
PMCID:
PMC3762802
AbstractArticlePDF–1.7M
10.
Poor Cerebral Inflammatory Response in eIF2B Knock-In Mice: Implications for the Aetiology of Vanishing White Matter Disease
Yuval Cabilly, Mali Barbi, Michal Geva, Liraz Marom, David Chetrit, Marcelo Ehrlich, Orna Elroy-Stein
PLoS One. 2012; 7(10): e46715. Published online 2012 Oct 4. doi: 10.1371/journal.pone.0046715
PMCID:
PMC3464276
AbstractArticlePDF–921K
11.
A Point Mutation in Translation Initiation Factor eIF2B Leads to Function- and Time-Specific Changes in Brain Gene Expression
Liraz Marom, Igor Ulitsky, Yuval Cabilly, Ron Shamir, Orna Elroy-Stein
PLoS One. 2011; 6(10): e26992. Published online 2011 Oct 31. doi: 10.1371/journal.pone.0026992
PMCID:
PMC3205039
AbstractArticlePDF–964K
12.
Eukaryotic initiation factor 2B epsilon induces cap-dependent translation and skeletal muscle hypertrophy
David L Mayhew, Troy A Hornberger, Hannah C Lincoln, Marcas M Bamman
J Physiol. 2011 Jun 15; 589(Pt 12): 3023–3037. Published online 2011 Apr 11. doi: 10.1113/jphysiol.2010.202432
PMCID:
PMC3139084
AbstractArticlePDF–716K
13.
Glycogen Synthase Kinase 3β Is a Novel Regulator of High Glucose- and High Insulin-induced Extracellular Matrix Protein Synthesis in Renal Proximal Tubular Epithelial Cells
Meenalakshmi M. Mariappan, Megan Shetty, Kavithalakshmi Sataranatarajan, Goutam Ghosh Choudhury, Balakuntalam S. Kasinath
J Biol Chem. 2008 Nov 7; 283(45): 30566–30575. doi: 10.1074/jbc.M801756200
PMCID:
PMC2576557
AbstractArticlePDF–801K
14.
Oligodendrocytes depend on MCL-1 to prevent spontaneous apoptosis and white matter degeneration
Abigail H. Cleveland, Alejandra Romero-Morales, Laurent Alfonso Azcona, Melisa Herrero, Viktoriya D. Nikolova, Sheryl Moy, Orna Elroy-Stein, Vivian Gama, Timothy R. Gershon
Cell Death Dis. 2021 Dec; 12(12): 1133. Published online 2021 Dec 6. doi: 10.1038/s41419-021-04422-z
PMCID:
PMC8648801
AbstractArticlePDF–7.7M
15.
GSK3β regulates AKT-induced central nervous system axon regeneration via an eIF2Bε-dependent, mTORC1-independent pathway
Xinzheng Guo, William D Snider, Bo Chen
eLife. 2016; 5: e11903. Published online 2016 Mar 14. doi: 10.7554/eLife.11903
PMCID:
PMC4805534
AbstractArticlePDF–6.7M
16.
Identification of ubiquitin-modified lysine residues and novel phosphorylation sites on eukaryotic initiation factor 2B epsilon
Alexander P. Tuckow, Abid A. Kazi, Scot R. Kimball, Leonard S. Jefferson
Biochem Biophys Res Commun. Author manuscript; available in PMC 2014 Jun 21.
Published in final edited form as: Biochem Biophys Res Commun. 2013 Jun 21; 436(1): 41–46. Published online 2013 May 21. doi: 10.1016/j.bbrc.2013.05.053
PMCID:
PMC3744827
AbstractArticlePDF–708K
17.
Toll-like receptor activation suppresses endoplasmic reticulum stress-induced CHOP and translation inhibition through activation of eIF2B
Connie W. Woo, Lydia Kutzler, Scot R. Kimball, Ira Tabas
Nat Cell Biol. Author manuscript; available in PMC 2012 Aug 1.
Published in final edited form as: Nat Cell Biol. 2012 Feb; 14(2): 192–200. Published online 2012 Jan 8. doi: 10.1038/ncb2408
PMCID:
PMC3271190
AbstractArticlePDF–5.7M
18.
A MYC/GCN2/eIF2α negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer
Stefanie Schmidt, David Gay, Friedrich Wilhelm Uthe, Sarah Denk, Madelon Paauwe, Niels Matthes, Markus Elmar Diefenbacher, Sheila Bryson, Fiona Clare Warrander, Florian Erhard, Carsten Patrick Ade, Apoorva Baluapuri, Susanne Walz, Rene Jackstadt, Catriona Ford, Georgios Vlachogiannis, Nicola Valeri, Christoph Otto, Christina Schülein-Völk, Katja Maurus, Werner Schmitz, John Raymond Philip Knight, Elmar Wolf, Douglas Strathdee, Almut Schulze, Christoph-Thomas Germer, Andreas Rosenwald, Owen James Sansom, Martin Eilers, Armin Wiegering
Nat Cell Biol. Author manuscript; available in PMC 2020 May 4.
Published in final edited form as: Nat Cell Biol. 2019 Nov; 21(11): 1413–1424. Published online 2019 Nov 4. doi: 10.1038/s41556-019-0408-0
PMCID:
PMC6927814
AbstractArticlePDF–6.9M
19.
Expression, purification, and crystallization of Schizosaccharomyces pombe eIF2B
Kazuhiro Kashiwagi, Tomoaki Shigeta, Hiroaki Imataka, Takuhiro Ito, Shigeyuki Yokoyama
J Struct Funct Genomics. 2016; 17: 33–38. Published online 2016 Mar 29. doi: 10.1007/s10969-016-9203-3
PMCID:
PMC4833825
AbstractArticlePDF–1.0M
20.
Affected astrocytes in the spinal cord of the leukodystrophy vanishing white matter
Prisca S. Leferink, Nicole Breeuwsma, Marianna Bugiani, Marjo S. van der Knaap, Vivi M. Heine
Glia. 2018 Apr; 66(4): 862–873. Published online 2017 Dec 29. doi: 10.1002/glia.23289
PMCID:
PMC5838785
AbstractArticlePDF–2.2M

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