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Select item 100819201.

Biallelic mutation of FBXL7 suggests a novel form of Hennekam syndrome

Philip M. Boone, Scott Paterson, Kiana Mohajeri, Wenmiao Zhu, Casie A. Genetti, Derek J. C. Tai, Neeharika Nori, Pankaj B. Agrawal, Carlos A. Bacino, Weimin Bi, Michael E. Talkowski, Benjamin M. Hogan, Lance H. Rodan

Am J Med Genet A. Author manuscript; available in PMC 2023 Apr 7.

Published in final edited form as: Am J Med Genet A. 2020 Jan; 182(1): 189–194. Published online 2019 Oct 21. doi: 10.1002/ajmg.a.61392

PMCID:: PMC10081920

Abstract Article PDF–289K

Select item 93166352.

FBXL7 Body Hypomethylation Is Frequent in Tumors from the Digestive and Respiratory Tracts and Is Associated with Risk-Factor Exposure

Diego Camuzi, Luisa Aguirre Buexm, Simone de Queiroz Chaves Lourenço, Rachele Grazziotin, Simone Guaraldi, Priscila Valverde, Davy Rapozo, Jill M. Brooks, Hisham Mehanna, Luis Felipe Ribeiro Pinto, Sheila Coelho Soares-Lima

Int J Mol Sci. 2022 Jul; 23(14): 7801. Published online 2022 Jul 15. doi: 10.3390/ijms23147801

PMCID:: PMC9316635

Abstract Article PDF–14M

Select item 74844253.

Epigenetic silencing of the ubiquitin ligase subunit FBXL7 impairs c-SRC degradation and promotes epithelial-to-mesenchymal transition and metastasis

Loredana Moro, Daniele Simoneschi, Emma Kurz, Arnaldo A. Arbini, Shaowen Jang, Nicoletta Guaragnella, Sergio Giannattasio, Wei Wang, Yu-An Chen, Geoffrey Pires, Andrew Dang, Elizabeth Hernandez, Payal Kapur, Ankita Mishra, Aristotelis Tsirigos, George Miller, Jer-Tsong Hsieh, Michele Pagano

Nat Cell Biol. Author manuscript; available in PMC 2021 Feb 24.

Published in final edited form as: Nat Cell Biol. 2020 Sep; 22(9): 1130–1142. Published online 2020 Aug 24. doi: 10.1038/s41556-020-0560-6

PMCID:: PMC7484425

Abstract Article PDF–7.6M

Select item 41123834.

Genetic predictors associated with improvement of asthma symptoms in response to inhaled corticosteroids

Heung-Woo Park, Amber Dahlin, Szeman Tse, Qing Ling Duan, Brooke Schuemann, Fernando D. Martinez, Stephen P. Peters, Stanley J. Szefler, John J. Lima, Michiaki Kubo, Mayumi Tamari, Kelan G. Tantisira

J Allergy Clin Immunol. Author manuscript; available in PMC 2015 Mar 1.

Published in final edited form as: J Allergy Clin Immunol. 2014 Mar; 133(3): 664–9.e5. Published online 2014 Jan 31. doi: 10.1016/j.jaci.2013.12.1042

PMCID:: PMC4112383

Abstract Article PDF–142K

Select item 97126195.

Butein promotes ubiquitination-mediated survivin degradation inhibits tumor growth and overcomes chemoresistance

Xin Dong, Wenbin Liu, Xiaoying Li, Yu Gan, Li Zhou, Wei Li, Li Xie

Sci Rep. 2022; 12: 20644. Published online 2022 Nov 30. doi: 10.1038/s41598-022-21839-4

Correction in:: Sci Rep. 2023; 13: 1780.

PMCID:: PMC9712619

Abstract Article PDF–5.5M

Select item 82645916.

Downregulated F-Box/LRR-Repeat Protein 7 Facilitates Pancreatic Cancer Metastasis by Regulating Snail1 for Proteasomal Degradation

Liang Tang, Meng Ji, Xing Liang, Danlei Chen, Anan Liu, Guang Yang, Ligang Shi, Zhiping Fu, Chenghao Shao

Front Genet. 2021; 12: 650090. Published online 2021 Jun 24. doi: 10.3389/fgene.2021.650090

PMCID:: PMC8264591

Abstract Article PDF–4.2M

Select item 71768897.

miR‐152‐5p suppresses glioma progression and tumorigenesis and potentiates temozolomide sensitivity by targeting FBXL7

Shiqi Kong, Yanwei Fang, Bingqian Wang, Yingxiao Cao, Runzhi He, Zongmao Zhao

J Cell Mol Med. 2020 Apr; 24(8): 4569–4579. Published online 2020 Mar 9. doi: 10.1111/jcmm.15114

PMCID:: PMC7176889

Abstract Article PDF–1.4M

Select item 28938068.

Common variants associated with breast cancer in genome-wide association studies are modifiers of breast cancer risk in BRCA1 and BRCA2 mutation carriers

Xianshu Wang, V. Shane Pankratz, Zachary Fredericksen, Robert Tarrell, Mary Karaus, Lesley McGuffog, Paul D.P. Pharaoh, Bruce A.J. Ponder, Alison M. Dunning, Susan Peock, Margaret Cook, Clare Oliver, Debra Frost, EMBRACE, Olga M. Sinilnikova, Dominique Stoppa-Lyonnet, Sylvie Mazoyer, Claude Houdayer, GEMO, Frans B.L. Hogervorst, Maartje J. Hooning, Marjolijn J. Ligtenberg, HEBON, Amanda Spurdle, Georgia Chenevix-Trench, kConFab, Rita K. Schmutzler, Barbara Wappenschmidt, Christoph Engel, Alfons Meindl, Susan M. Domchek, Katherine L. Nathanson, Timothy R. Rebbeck, Christian F. Singer, Daphne Gschwantler-Kaulich, Catherina Dressler, Anneliese Fink, Csilla I. Szabo, Michal Zikan, Lenka Foretova, Kathleen Claes, Gilles Thomas, Robert N. Hoover, David J. Hunter, Stephen J. Chanock, Douglas F. Easton, Antonis C. Antoniou, Fergus J. Couch

Hum Mol Genet. 2010 Jul 15; 19(14): 2886–2897. Published online 2010 Apr 23. doi: 10.1093/hmg/ddq174

PMCID:: PMC2893806

Abstract Article PDF–307K

Select item 46697929.

F-box protein Fbxl18 mediates polyubiquitylation and proteasomal degradation of the pro-apoptotic SCF subunit Fbxl7

Y Liu, T Lear, Y Zhao, J Zhao, C Zou, B B Chen, R K Mallampalli

Cell Death Dis. 2015 Feb; 6(2): e1630. Published online 2015 Feb 5. doi: 10.1038/cddis.2014.585

PMCID:: PMC4669792

Abstract Article PDF–1.7M

Select item 331810610.

Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrest

Tiffany A Coon, Jennifer R Glasser, Rama K Mallampalli, Bill B Chen

Cell Cycle. 2012 Feb 15; 11(4): 721–729. Published online 2012 Feb 15. doi: 10.4161/cc.11.4.19171

PMCID:: PMC3318106

Abstract Article PDF–18M

Select item 442432511.

The Proapoptotic F-box Protein Fbxl7 Regulates Mitochondrial Function by Mediating the Ubiquitylation and Proteasomal Degradation of Survivin

Yuan Liu, Travis Lear, Olivia Iannone, Sruti Shiva, Catherine Corey, Shristi Rajbhandari, Jacob Jerome, Bill B. Chen, Rama K. Mallampalli

J Biol Chem. 2015 May 8; 290(19): 11843–11852. Published online 2015 Mar 16. doi: 10.1074/jbc.M114.629931

PMCID:: PMC4424325

Abstract Article PDF–2.5M

Select item 244715212.

Downregulation of Vertebrate Tel (ETV6) and Drosophila Yan Is Facilitated by an Evolutionarily Conserved Mechanism of F-Box-Mediated Ubiquitination

M. Guy Roukens, Mariam Alloul-Ramdhani, Setareh Moghadasi, Marjolein Op den Brouw, David A. Baker

Mol Cell Biol. 2008 Jul; 28(13): 4394–4406. Published online 2008 Apr 21. doi: 10.1128/MCB.01914-07

PMCID:: PMC2447152

Abstract Article PDF–1.0M

Select item 38476213.

M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCF^β-TrCP

Nobumoto Watanabe, Harumi Arai, Yoshifumi Nishihara, Makoto Taniguchi, Naoko Watanabe, Tony Hunter, Hiroyuki Osada

Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13): 4419–4424. Published online 2004 Mar 22. doi: 10.1073/pnas.0307700101

PMCID:: PMC384762

Abstract Article PDF–526K

Select item 562796914.

PTEN counteracts FBXL2 to promote IP3R3– and Ca²⁺–mediated apoptosis limiting tumour growth

Shafi Kuchay, Carlotta Giorgi, Daniele Simoneschi, julia Pagan, Sonia Missiroli, Anita Saraf, Laurence Florens, Michael P. Washburn, Ana Collazo-Lorduy, Mireia Castillo-Martin, Carlos Cordon-Cardo, Said M. Sebti, Paolo Pinton, Michele Pagano

Nature. Author manuscript; available in PMC 2017 Oct 4.

Published in final edited form as: Nature. 2017 Jun 22; 546(7659): 554–558. Published online 2017 Jun 14. doi: 10.1038/nature22965

PMCID:: PMC5627969

Abstract Article PDF–1.3M

Select item 336143615.

The genetic architecture of economic and political preferences

Daniel J. Benjamin, David Cesarini, Matthijs J. H. M. van der Loos, Christopher T. Dawes, Philipp D. Koellinger, Patrik K. E. Magnusson, Christopher F. Chabris, Dalton Conley, David Laibson, Magnus Johannesson, Peter M. Visscher

Proc Natl Acad Sci U S A. 2012 May 22; 109(21): 8026–8031. Published online 2012 May 7. doi: 10.1073/pnas.1120666109

PMCID:: PMC3361436

Abstract Article PDF–128K

Select item 398146816.

Parallel SCF Adaptor Capture Proteomics Reveals a Role for SCF^FBXL17 in NRF2 Activation via BACH1 Repressor Turnover

Meng-Kwang Marcus Tan, Hui-Jun Lim, Eric J. Bennett, Yang Shi, J. Wade Harper

Mol Cell. Author manuscript; available in PMC 2014 Oct 10.

Published in final edited form as: Mol Cell. 2013 Oct 10; 52(1): 9–24. Published online 2013 Sep 12. doi: 10.1016/j.molcel.2013.08.018

PMCID:: PMC3981468

Abstract Article PDF–5.8M

Select item 533762117.

Aurora kinase A regulates Survivin stability through targeting FBXL7 in gastric cancer drug resistance and prognosis

M Kamran, Z-J Long, D Xu, S-S Lv, B Liu, C-L Wang, J Xu, E W-F Lam, Q Liu

Oncogenesis. 2017 Feb; 6(2): e298. Published online 2017 Feb 20. doi: 10.1038/oncsis.2016.80

PMCID:: PMC5337621

Abstract Article PDF–2.8M

Select item 334973418.

Genome-Wide Association for Abdominal Subcutaneous and Visceral Adipose Reveals a Novel Locus for Visceral Fat in Women

Caroline S. Fox, Yongmei Liu, Charles C. White, Mary Feitosa, Albert V. Smith, Nancy Heard-Costa, Kurt Lohman, GIANT Consortium, MAGIC Consortium, GLGC Consortium, Andrew D. Johnson, Meredith C. Foster, Danielle M. Greenawalt, Paula Griffin, Jinghong Ding, Anne B. Newman, Fran Tylavsky, Iva Miljkovic, Stephen B. Kritchevsky, Lenore Launer, Melissa Garcia, Gudny Eiriksdottir, J. Jeffrey Carr, Vilmunder Gudnason, Tamara B. Harris, L. Adrienne Cupples, Ingrid B. Borecki

PLoS Genet. 2012 May; 8(5): e1002695. Published online 2012 May 10. doi: 10.1371/journal.pgen.1002695

PMCID:: PMC3349734

Abstract Article PDF–377K

Select item 760600819.

BCAR1 promotes proliferation and cell growth in lung adenocarcinoma via upregulation of POLR2A

Chun‐guo Mao, Sha‐sha Jiang, Cheng Shen, Tan Long, Hua Jin, Qun‐You Tan, Bo Deng

Thorac Cancer. 2020 Nov; 11(11): 3326–3336. Published online 2020 Oct 1. doi: 10.1111/1759-7714.13676

PMCID:: PMC7606008

Abstract Article PDF–2.5M

Select item 933831320.

HSF1 phosphorylation establishes an active chromatin state via the TRRAP–TIP60 complex and promotes tumorigenesis

Mitsuaki Fujimoto, Ryosuke Takii, Masaki Matsumoto, Mariko Okada, Keiich I. Nakayama, Ryuichiro Nakato, Katsunori Fujiki, Katsuhiko Shirahige, Akira Nakai

Nat Commun. 2022; 13: 4355. Published online 2022 Jul 29. doi: 10.1038/s41467-022-32034-4

PMCID:: PMC9338313

Abstract Article PDF–2.8M

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