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Select item 107118311.

Tumor cell-intrinsic SETD2 inactivation sensitizes cancer cells to immune checkpoint blockade through the NR2F1-STAT1 pathway

Xufen Zheng, Yuxiang Luo, Yangjie Xiong, Xiaoxiao Liu, Chunling Zeng, Xiaojing Lu, Xiaofang Wang, Yumei Cheng, Simin Wang, Haoqi Lan, Kai Wang, Zhonghui Weng, Wenbo Bi, Xinxin Gan, Xiaona Jia, Linhui Wang, Yuexiang Wang

J Immunother Cancer. 2023; 11(12): e007678. Published online 2023 Dec 6. doi: 10.1136/jitc-2023-007678

PMCID:: PMC10711831

Abstract Article PDF–11M

Select item 106635092.

SETD2 deficiency accelerates sphingomyelin accumulation and promotes the development of renal cancer

Hanyu Rao, Changwei Liu, Aiting Wang, Chunxiao Ma, Yue Xu, Tianbao Ye, Wenqiong Su, Peijun Zhou, Wei-Qiang Gao, Li Li, Xianting Ding

Nat Commun. 2023; 14: 7572. Published online 2023 Nov 21. doi: 10.1038/s41467-023-43378-w

PMCID:: PMC10663509

Abstract Article PDF–3.8M

Select item 99775083.

SETD2 regulates chromatin accessibility and transcription to suppress lung tumorigenesis

Yuchen Xie, Merve Sahin, Toru Wakamatsu, Akane Inoue-Yamauchi, Wanming Zhao, Song Han, Amrita M. Nargund, Shaoyuan Yang, Yang Lyu, James J. Hsieh, Christina S. Leslie, Emily H. Cheng

JCI Insight. 2023 Feb 22; 8(4): e154120. Published online 2023 Feb 22. doi: 10.1172/jci.insight.154120

PMCID:: PMC9977508

Abstract Article PDF–15M

Select item 84410594.

Intra‐heterogeneity in transcription and chemoresistant property of leukemia‐initiating cells in murine Setd2^−/− acute myeloid leukemia

Jiachun Song, Longting Du, Ping Liu, Fuhui Wang, Bo Zhang, Yinyin Xie, Jing Lu, Yi Jin, Yan Zhou, Gang Lv, Jianmin Zhang, Saijuan Chen, Zhu Chen, Xiaojian Sun, Yuanliang Zhang, Qiuhua Huang

Cancer Commun (Lond) 2021 Sep; 41(9): 867–888. Published online 2021 Jul 1. doi: 10.1002/cac2.12189

PMCID:: PMC8441059

Abstract Article PDF–6.5M

Select item 84183475.

Neuronal SETD2 activity links microtubule methylation to an anxiety-like phenotype in mice

Matthias Koenning, Xianlong Wang, Menuka Karki, Rahul Kumar Jangid, Sarah Kearns, Durga Nand Tripathi, Michael Cianfrocco, Kristen J Verhey, Sung Yun Jung, Cristian Coarfa, Christopher Scott Ward, Brian Thomas Kalish, Sandra L Grimm, W Kimryn Rathmell, Ricardo Mostany, Ruhee Dere, Matthew Neil Rasband, Cheryl Lyn Walker, In Young Park

Brain. 2021 Aug; 144(8): 2527–2540. Published online 2021 May 20. doi: 10.1093/brain/awab200

PMCID:: PMC8418347

Abstract Article PDF–1.2M

Select item 67853656.

SETD2 mutations confer chemoresistance in acute myeloid leukemia partly through altered cell cycle checkpoints

Yunzhu Dong, Xinghui Zhao, Xiaomin Feng, Yile Zhou, Xiaomei Yan, Ya Zhang, Jiachen Bu, Di Zhan, Yoshihiro Hayashi, Yue Zhang, Zefeng Xu, Rui Huang, Jieyu Wang, Taoran Zhao, Zhijian Xiao, Zhenyu Ju, Paul R. Andreassen, Qian-fei Wang, Wei Chen, Gang Huang

Leukemia. Author manuscript; available in PMC 2019 Nov 9.

Published in final edited form as: Leukemia. 2019 Nov; 33(11): 2585–2598. Published online 2019 Apr 9. doi: 10.1038/s41375-019-0456-2

PMCID:: PMC6785365

Abstract Article PDF–3.3M

Select item 64387147.

Histone H3 trimethylation at lysine 36 guides m⁶A RNA modification co-transcriptionally

Huilin Huang, Hengyou Weng, Keren Zhou, Tong Wu, Boxuan Simen Zhao, Mingli Sun, Zhenhua Chen, Xiaolan Deng, Gang Xiao, Franziska Auer, Lars Klemm, Huizhe Wu, Zhixiang Zuo, Xi Qin, Yunzhu Dong, Yile Zhou, Hanjun Qin, Shu Tao, Juan Du, Jun Liu, Zhike Lu, Hang Yin, Ana Mesquita, Celvie L. Yuan, Yueh-Chiang Hu, Wenju Sun, Rui Su, Lei Dong, Chao Shen, Chenying Li, Ying Qing, Xi Jiang, Xiwei Wu, Miao Sun, Jun-Lin Guan, Lianghu Qu, Minjie Wei, Markus Müschen, Gang Huang, Chuan He, Jianhua Yang, Jianjun Chen

Nature. Author manuscript; available in PMC 2019 Sep 13.

Published in final edited form as: Nature. 2019 Mar; 567(7748): 414–419. Published online 2019 Mar 13. doi: 10.1038/s41586-019-1016-7

PMCID:: PMC6438714

Abstract Article PDF–6.2M

Select item 62339198.

H3K36 trimethylation mediated by SETD2 regulates the fate of bone marrow mesenchymal stem cells

Lijun Wang, Ningning Niu, Li Li, Rui Shao, Huiling Ouyang, Weiguo Zou

PLoS Biol. 2018 Nov; 16(11): e2006522. Published online 2018 Nov 13. doi: 10.1371/journal.pbio.2006522

PMCID:: PMC6233919

Abstract Article PDF–4.5M

Select item 60295249.

Setd2 regulates quiescence and differentiation of adult hematopoietic stem cells by restricting RNA polymerase II elongation

Yile Zhou, Xiaomei Yan, Xiaomin Feng, Jiachen Bu, Yunzhu Dong, Peipei Lin, Yoshihiro Hayashi, Rui Huang, Andre Olsson, Paul R. Andreassen, H. Leighton Grimes, Qian-fei Wang, Tao Cheng, Zhijian Xiao, Jie Jin, Gang Huang

Haematologica. 2018 Jul; 103(7): 1110–1123. Prepublished online 2018 Apr 12. doi: 10.3324/haematol.2018.187708

PMCID:: PMC6029524

Abstract Article PDF–4.3M

Select item 593904710.

Setd2 deficiency impairs hematopoietic stem cell self-renewal and causes malignant transformation

Yuan-Liang Zhang, Jie-Wen Sun, Yin-Yin Xie, Yan Zhou, Ping Liu, Jia-Chun Song, Chun-Hui Xu, Lan Wang, Dan Liu, Ai-Ning Xu, Zhu Chen, Sai-Juan Chen, Xiao-Jian Sun, Qiu-Hua Huang

Cell Res. 2018 Apr; 28(4): 476–490. Published online 2018 Mar 12. doi: 10.1038/s41422-018-0015-9

PMCID:: PMC5939047

Abstract Article PDF–3.3M

Select item 573108411.

SETD2 alterations impair DNA damage recognition and lead to resistance to chemotherapy in leukemia

Brenton G. Mar, S. Haihua Chu, Josephine D. Kahn, Andrei V. Krivtsov, Richard Koche, Cecilia A. Castellano, Jacob L. Kotlier, Rebecca L. Zon, Marie E. McConkey, Jonathan Chabon, Ryan Chappell, Peter V. Grauman, James J. Hsieh, Scott A. Armstrong, Benjamin L. Ebert

Blood. 2017 Dec 14; 130(24): 2631–2641. Prepublished online 2017 Oct 10. doi: 10.1182/blood-2017-03-775569

PMCID:: PMC5731084

Abstract Article

Select item 1062915512.

SETD2 deficiency promotes renal fibrosis through the TGF‐β/Smad signalling pathway in the absence of VHL

Changwei Liu, Li Ni, Xiaoxue Li, Hanyu Rao, Wenxin Feng, Yiwen Zhu, Wei Zhang, Chunxiao Ma, Yue Xu, Liming Gui, Ziyi Wang, Rebiguli Aji, Jin Xu, Wei‐Qiang Gao, Li Li

Clin Transl Med. 2023 Nov; 13(11): e1468. Published online 2023 Nov 7. doi: 10.1002/ctm2.1468

PMCID:: PMC10629155

Abstract Article PDF–24M

Select item 816841113.

SETD2 epidermal deficiency promotes cutaneous wound healing via activation of AKT/mTOR Signalling

Xiaoxue Li, Changwei Liu, Yiwen Zhu, Hanyu Rao, Min Liu, Liming Gui, Wenxin Feng, Huayuan Tang, Jin Xu, Wei‐Qiang Gao, Li Li

Cell Prolif. 2021 Jun; 54(6): e13045. Published online 2021 May 5. doi: 10.1111/cpr.13045

PMCID:: PMC8168411

Abstract Article PDF–1.6M

Select item 814192814.

The histone methyltransferase SETD2 modulates oxidative stress to attenuate experimental colitis

Min Liu, Hanyu Rao, Jing Liu, Xiaoxue Li, Wenxin Feng, Liming Gui, Huayuan Tang, Jin Xu, Wei-Qiang Gao, Li Li

Redox Biol. 2021 Jul; 43: 102004. Published online 2021 May 13. doi: 10.1016/j.redox.2021.102004

PMCID:: PMC8141928

Abstract Article PDF–8.8M

Select item 799366615.

SEDT2/METTL14-mediated m6A methylation awakening contributes to hypoxia-induced pulmonary arterial hypertension in mice

Xue-Liang Zhou, Feng-Jian Huang, Yang Li, Huang Huang, Qi-Cai Wu

Aging (Albany NY) 2021 Mar 15; 13(5): 7538–7548. Published online 2021 Feb 26. doi: 10.18632/aging.202616

PMCID:: PMC7993666

Abstract Article PDF–1.1M

Select item 665970316.

The histone methyltransferase Setd2 is indispensable for V(D)J recombination

Zhongzhong Ji, Yaru Sheng, Juju Miao, Xiaoxia Li, Huifang Zhao, Jinming Wang, Chaping Cheng, Xue Wang, Kaiyuan Liu, Kai Zhang, Longmei Xu, Jufang Yao, Lijing Shen, Jian Hou, Wenhao Zhou, Jinqiao Sun, Li Li, Wei-Qiang Gao, Helen He Zhu

Nat Commun. 2019; 10: 3353. Published online 2019 Jul 26. doi: 10.1038/s41467-019-11282-x

PMCID:: PMC6659703

Abstract Article PDF–3.3M

Select item 627702917.

SETD2-mediated crosstalk between H3K36me3 and H3K79me2 in MLL-rearranged leukemia

J Bu, A Chen, X Yan, F He, Y Dong, Y Zhou, J He, D Zhan, P Lin, Y Hayashi, Y Sun, Y Zhang, Z Xiao, HL Grimes, QF Wang, G Huang

Leukemia. Author manuscript; available in PMC 2018 Dec 3.

Published in final edited form as: Leukemia. 2018 Apr; 32(4): 890–899. Published online 2017 Nov 29. doi: 10.1038/leu.2017.339

PMCID:: PMC6277029

Abstract Article PDF–1021K

Select item 600425818.

SETD2 Haploinsufficiency for Microtubule Methylation is an Early Driver of Genomic Instability in Renal Cell Carcinoma

Yun-Chen Chiang, In-Young Park, Esteban A. Terzo, Durga N. Tripathi, Frank M. Mason, Catherine C. Fahey, Menuka Karki, Charles B. Shuster, Bo-Hwa Sohn, Pratim Chowdhury, Reid T. Powell, Ryoma Ohi, Yihsuan S. Tsai, Aguirre A. de Cubas, Abid Khan, Ian J. Davis, Brian D. Strahl, Joel S. Parker, Ruhee Dere, Cheryl L. Walker, W. K. Rathmell

Cancer Res. Author manuscript; available in PMC 2019 Jun 15.

Published in final edited form as: Cancer Res. 2018 Jun 15; 78(12): 3135–3146. Published online 2018 May 3. doi: 10.1158/0008-5472.CAN-17-3460

PMCID:: PMC6004258

Abstract Article PDF–1.5M

Select item 541332419.

Enteropathy-associated T cell lymphoma subtypes are characterized by loss of function of SETD2

Andrea B. Moffitt, Sarah L. Ondrejka, Matthew McKinney, Rachel E. Rempel, John R. Goodlad, Chun Huat Teh, Sirpa Leppa, Susanna Mannisto, Panu E. Kovanen, Eric Tse, Rex K.H. Au-Yeung, Yok-Lam Kwong, Gopesh Srivastava, Javeed Iqbal, Jiayu Yu, Kikkeri Naresh, Diego Villa, Randy D. Gascoyne, Jonathan Said, Magdalena B. Czader, Amy Chadburn, Kristy L. Richards, Deepthi Rajagopalan, Nicholas S. Davis, Eileen C. Smith, Brooke C. Palus, Tiffany J. Tzeng, Jane A. Healy, Patricia L. Lugar, Jyotishka Datta, Cassandra Love, Shawn Levy, David B. Dunson, Yuan Zhuang, Eric D. Hsi, Sandeep S. Dave

J Exp Med. 2017 May 1; 214(5): 1371–1386. doi: 10.1084/jem.20160894

PMCID:: PMC5413324

Abstract Article PDF–2.0M

Select item 825757620.

α-TubK40me3 is required for neuronal polarization and migration by promoting microtubule formation

Xuan Xie, Shaogang Wang, Mingyi Li, Lei Diao, Xingyu Pan, Jijun Chen, Weiguo Zou, Xu Zhang, Wenfeng Feng, Lan Bao

Nat Commun. 2021; 12: 4113. Published online 2021 Jul 5. doi: 10.1038/s41467-021-24376-2

PMCID:: PMC8257576

Abstract Article PDF–11M

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