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Items: 1 to 20 of 403

1.
A conserved isoleucine in the binding pocket of RIG-I controls immune tolerance to mitochondrial RNA
Ann Kristin de Regt, Kanchan Anand, Katrin Ciupka, Felix Bender, Karl Gatterdam, Bastian Putschli, David Fusshöller, Daniel Hilbig, Alexander Kirchhoff, Charlotte Hunkler, Steven Wolter, Agathe Grünewald, Christina Wallerath, Christine Schuberth-Wagner, Janos Ludwig, Katrin Paeschke, Eva Bartok, Gregor Hagelueken, Gunther Hartmann, Thomas Zillinger, Matthias Geyer, Martin Schlee
Nucleic Acids Res. 2023 Nov 27; 51(21): 11893–11910. Published online 2023 Oct 13. doi: 10.1093/nar/gkad835
PMCID:
PMC10681732
ArticlePDF–1.5M
2.
Functional comparisons of the virus sensor RIG-I from humans, the microbat Myotis daubentonii, and the megabat Rousettus aegyptiacus, and their response to SARS-CoV-2 infection
Andreas Schoen, Martin Hölzer, Marcel A. Müller, Kai B. Wallerang, Christian Drosten, Manja Marz, Benjamin Lamp, Friedemann Weber
J Virol. 2023 Oct; 97(10): e00205-23. Published online 2023 Sep 20. doi: 10.1128/jvi.00205-23
PMCID:
PMC10653997
ArticlePDF–8.7M
3.
RIG-I recognizes metabolite-capped RNAs as signaling ligands
Brandon D Schweibenz, Mihai Solotchi, Pranita Hanpude, Swapnil C Devarkar, Smita S Patel
Nucleic Acids Res. 2023 Aug 25; 51(15): 8102–8114. Published online 2023 Jun 16. doi: 10.1093/nar/gkad518
PMCID:
PMC10450190
ArticlePDF–1.5M
4.
Influenza A Infection Stimulates RIG-I and Enhances Effector Function of Primary Human NK Cells
Adham Abuelola Mohamed, Sofía Soler, Julia Wegner, Eva Bartok, Sanda Stankovic, Andrew G. Brooks, Martin Schlee
Int J Mol Sci. 2023 Aug; 24(15): 12220. Published online 2023 Jul 30. doi: 10.3390/ijms241512220
PMCID:
PMC10419028
ArticlePDF–4.3M
5.
Transposable elements potentiate radiotherapy-induced cellular immune reactions via RIG-I-mediated virus-sensing pathways
Junyan Du, Shun-Ichiro Kageyama, Riu Yamashita, Kosuke Tanaka, Masayuki Okumura, Atsushi Motegi, Hidehiro Hojo, Masaki Nakamura, Hidenari Hirata, Hironori Sunakawa, Daisuke Kotani, Tomonori Yano, Takashi Kojima, Yamato Hamaya, Motohiro Kojima, Yuka Nakamura, Ayako Suzuki, Yutaka Suzuki, Katsuya Tsuchihara, Tetsuo Akimoto
Commun Biol. 2023; 6: 818. Published online 2023 Aug 5. doi: 10.1038/s42003-023-05080-x
PMCID:
PMC10404237
ArticlePDF–2.4M
6.
DDX58 Is Associated With Susceptibility to Severe Influenza Virus Infection in Children and Adolescents
Sanghun Lee, Yu Zhang, Margaret Newhams, Tanya Novak, Paul G Thomas, Peter M Mourani, Mark W Hall, Laura L Loftis, Natalie Z Cvijanovich, Keiko M Tarquinio, Adam J Schwarz, Scott L Weiss, Neal J Thomas, Barry Markovitz, Melissa L Cullimore, Ronald C Sanders, Jr, Matt S Zinter, Janice E Sullivan, Natasha B Halasa, Melania M Bembea, John S Giuliano, Jr, Katri V Typpo, Ryan A Nofziger, Steven L Shein, Michele Kong, Bria M Coates, Scott T Weiss, Christoph Lange, Helen C Su, Adrienne G Randolph, for the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Pediatric Intensive Care Influenza (PICFlu) Investigators and the Trans-Omics for Precision Medicine (TOPMed) Investigators
J Infect Dis. 2022 Dec 1; 226(11): 2030–2036. Published online 2022 Aug 20. doi: 10.1093/infdis/jiac350
PMCID:
PMC10205622
ArticlePDF–499K
7.
Intrinsic RIG-I restrains STAT5 activation to modulate antitumor activity of CD8+ T cells
Xinyi Jiang, Jian Lin, Chengfang Shangguan, Xiaoyao Wang, Bin Xiang, Juan Chen, Hezhou Guo, Wu Zhang, Jun Zhang, Yan Shi, Jiang Zhu, Hui Yang
J Clin Invest. 2023 May 1; 133(9): e160790. Published online 2023 May 1. doi: 10.1172/JCI160790
PMCID:
PMC10145944
ArticlePDF–9.7M
8.
Rhinovirus-induced epithelial RIG-I inflammasome suppresses antiviral immunity and promotes inflammation in asthma and COVID-19
Urszula Radzikowska, Andrzej Eljaszewicz, Ge Tan, Nino Stocker, Anja Heider, Patrick Westermann, Silvio Steiner, Anita Dreher, Paulina Wawrzyniak, Beate Rückert, Juan Rodriguez-Coira, Damir Zhakparov, Mengting Huang, Bogdan Jakiela, Marek Sanak, Marcin Moniuszko, Liam O’Mahony, Marek Jutel, Tatiana Kebadze, David J. Jackson, Michael R. Edwards, Volker Thiel, Sebastian L. Johnston, Cezmi A. Akdis, Milena Sokolowska
Nat Commun. 2023; 14: 2329. Published online 2023 Apr 22. doi: 10.1038/s41467-023-37470-4
Correction in:
Nat Commun. 2023; 14: 3493.
PMCID:
PMC10122208
ArticlePDF–6.2M
9.
Mechanisms of length-dependent recognition of viral double-stranded RNA by RIG-I
Jung Hyun Im, Ivana Duic, Shige H. Yoshimura, Koji Onomoto, Mitsutoshi Yoneyama, Hiroki Kato, Takashi Fujita
Sci Rep. 2023; 13: 6318. Published online 2023 Apr 18. doi: 10.1038/s41598-023-33208-w
Correction in:
Sci Rep. 2024; 14: 835.
PMCID:
PMC10113236
ArticlePDF–4.7M
10.
Clinical Implications of a New DDX58 Pathogenic Variant That Causes Lupus Nephritis due to RIG-I Hyperactivation
Jiahui Peng, Yusha Wang, Xu Han, Changming Zhang, Xiang Chen, Ying Jin, Zhaohui Yang, Yu An, Jiahui Zhang, Zhengzhao Liu, Yinghua Chen, Erzhi Gao, Yangyang Zhang, Feng Xu, Chunxia Zheng, Qing Zhou, Zhihong Liu
J Am Soc Nephrol. 2023 Feb; 34(2): 258–272. Published online 2022 Oct 19. doi: 10.1681/ASN.2022040477
PMCID:
PMC10103098
Article
11.
The molecular mechanism of RIG‐I activation and signaling
Daniel Thoresen, Wenshuai Wang, Drew Galls, Rong Guo, Ling Xu, Anna Marie Pyle
Immunol Rev. 2021 Nov; 304(1): 154–168. Published online 2021 Sep 12. doi: 10.1111/imr.13022
PMCID:
PMC9293153
ArticlePDF–1.0M
12.
MAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I
Johannes Brägelmann, Carina Lorenz, Sven Borchmann, Kazuya Nishii, Julia Wegner, Lydia Meder, Jenny Ostendorp, David F. Ast, Alena Heimsoeth, Takamasa Nakasuka, Atsuko Hirabae, Sachi Okawa, Marcel A. Dammert, Dennis Plenker, Sebastian Klein, Philipp Lohneis, Jianing Gu, Laura K. Godfrey, Jan Forster, Marija Trajkovic-Arsic, Thomas Zillinger, Mareike Haarmann, Alexander Quaas, Stefanie Lennartz, Marcel Schmiel, Joshua D’Rozario, Emily S. Thomas, Henry Li, Clemens A. Schmitt, Julie George, Roman K. Thomas, Silvia von Karstedt, Gunther Hartmann, Reinhard Büttner, Roland T. Ullrich, Jens T. Siveke, Kadoaki Ohashi, Martin Schlee, Martin L. Sos
Nat Commun. 2021; 12: 5505. Published online 2021 Sep 17. doi: 10.1038/s41467-021-25728-8
PMCID:
PMC8448826
ArticlePDF–2.0M
13.
The Endogenous RIG-I Ligand Is Generated in Influenza A-Virus Infected Cells
Julia Steinberg, Timo Wadenpohl, Stephanie Jung
Viruses. 2021 Aug; 13(8): 1564. Published online 2021 Aug 7. doi: 10.3390/v13081564
PMCID:
PMC8402674
ArticlePDF–3.2M
14.
Mechanism of Nucleic Acid Sensing in Retinal Pigment Epithelium (RPE): RIG-I Mediates Type I Interferon Response in Human RPE
Joshua Schustak, Michael Twarog, Xiaoqiu Wu, Henry Y. Wu, Qian Huang, Yi Bao
J Immunol Res. 2021; 2021: 9975628. Published online 2021 Jun 18. doi: 10.1155/2021/9975628
PMCID:
PMC8235977
ArticlePDF–1.5M
15.
Regulation of RIG-I-like receptor-mediated signaling: interaction between host and viral factors
Koji Onomoto, Kazuhide Onoguchi, Mitsutoshi Yoneyama
Cell Mol Immunol. 2021 Mar; 18(3): 539–555. Published online 2021 Jan 18. doi: 10.1038/s41423-020-00602-7
PMCID:
PMC7812568
ArticlePDF–2.0M
16.
Effect of Strain Variations on Lassa Virus Z Protein-Mediated Human RIG-I Inhibition
Qinfeng Huang, Xiaoying Liu, Morgan Brisse, Hinh Ly, Yuying Liang
Viruses. 2020 Sep; 12(9): 907. Published online 2020 Aug 19. doi: 10.3390/v12090907
PMCID:
PMC7551410
ArticlePDF–1.9M
17.
Foot-and-Mouth Disease Virus 3B Protein Interacts with Pattern Recognition Receptor RIG-I to Block RIG-I–Mediated Immune Signaling and Inhibit Host Antiviral Response
Xiangle Zhang, Zixiang Zhu, Congcong Wang, Fan Yang, Weijun Cao, Pengfei Li, Xiaoli Du, Furong Zhao, Xiangtao Liu, Haixue Zheng
J Immunol. 2020 Oct 15; 205(8): 2207–2221. Published online 2020 Sep 11. doi: 10.4049/jimmunol.1901333
PMCID:
PMC7533709
ArticlePDF–2.0M
18.
N6-Methyladenosine modification of hepatitis B and C viral RNAs attenuates host innate immunity via RIG-I signaling
Geon-Woo Kim, Hasan Imam, Mohsin Khan, Aleem Siddiqui
J Biol Chem. 2020 Sep 11; 295(37): 13123–13133. Published online 2020 Jul 27. doi: 10.1074/jbc.RA120.014260
PMCID:
PMC7489896
ArticlePDF–2.5M
19.
Targeting the innate immunoreceptor RIG-I overcomes melanoma-intrinsic resistance to T cell immunotherapy
Lina Such, Fang Zhao, Derek Liu, Beatrice Thier, Vu Thuy Khanh Le-Trilling, Antje Sucker, Christoph Coch, Natalia Pieper, Sebastian Howe, Hilal Bhat, Halime Kalkavan, Cathrin Ritter, Robin Brinkhaus, Selma Ugurel, Johannes Köster, Ulrike Seifert, Ulf Dittmer, Martin Schuler, Karl S. Lang, Thomas A. Kufer, Gunther Hartmann, Jürgen C. Becker, Susanne Horn, Soldano Ferrone, David Liu, Eliezer M. Van Allen, Dirk Schadendorf, Klaus Griewank, Mirko Trilling, Annette Paschen
J Clin Invest. 2020 Aug 3; 130(8): 4266–4281. Published online 2020 Jul 13. doi: 10.1172/JCI131572
PMCID:
PMC7410049
ArticlePDF–11M
20.
RIG-I Plays a Dominant Role in the Induction of Transcriptional Changes in Zika Virus-Infected Cells, which Protect from Virus-Induced Cell Death
Mirjam Schilling, Anne Bridgeman, Nicki Gray, Jonny Hertzog, Philip Hublitz, Alain Kohl, Jan Rehwinkel
Cells. 2020 Jun; 9(6): 1476. Published online 2020 Jun 16. doi: 10.3390/cells9061476
PMCID:
PMC7349056
ArticlePDF–3.1M

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