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Select item 109045601.

Yap/Taz activity is associated with increased expression of phosphoglycerate dehydrogenase that supports myoblast proliferation

Marius Meinhold, Sander Verbrugge, Andi Shi, Martin Schönfelder, Lore Becker, Richard T. Jaspers, Peter S. Zammit, Henning Wackerhage

Cell Tissue Res. 2024; 395(3): 271–283. Published online 2024 Jan 6. doi: 10.1007/s00441-023-03851-w

PMCID:: PMC10904560

Article PDF–5.3M

Select item 106248472.

Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate

Yu-Qing Wu, Chen-Song Zhang, Jinye Xiong, Dong-Qi Cai, Chen-Zhe Wang, Yu Wang, Yan-Hui Liu, Yu Wang, Yiming Li, Jian Wu, Jianfeng Wu, Bin Lan, Xuefeng Wang, Siwei Chen, Xianglei Cao, Xiaoyan Wei, Hui-Hui Hu, Huiling Guo, Yaxin Yu, Abdul Ghafoor, Changchuan Xie, Yaying Wu, Zheni Xu, Cixiong Zhang, Mingxia Zhu, Xi Huang, Xiufeng Sun, Shu-Yong Lin, Hai-Long Piao, Jianyin Zhou, Sheng-Cai Lin

Cell Res. 2023 Nov; 33(11): 835–850. Published online 2023 Sep 19. doi: 10.1038/s41422-023-00874-4

PMCID:: PMC10624847

Article PDF–5.8M

Select item 41691733.

Requirement of the expression of 3-phosphoglycerate dehydrogenase for traversing S phase in murine T lymphocytes following polyclonal activation

Do Youn Jun, Dennis Taub, Francis J. Chrest, Sang Kook Kim, Byung Jo Moon, Wan Park, Young Ho Kim

Cell Immunol. Author manuscript; available in PMC 2014 Sep 19.

Published in final edited form as: Cell Immunol. 2014 Feb; 287(2): 78–85. Published online 2013 Dec 18. doi: 10.1016/j.cellimm.2013.12.003

PMCID:: PMC4169173

Article PDF–356K

Select item 30098644.

Brain-specific Phgdh Deletion Reveals a Pivotal Role for l-Serine Biosynthesis in Controlling the Level of d-Serine, an N-methyl-d-aspartate Receptor Co-agonist, in Adult Brain

Jung Hoon Yang, Akira Wada, Kazuyuki Yoshida, Yurika Miyoshi, Tomoko Sayano, Kayoko Esaki, Masami O. Kinoshita, Shozo Tomonaga, Norihiro Azuma, Masahiko Watanabe, Kenji Hamase, Kiyoshi Zaitsu, Takeo Machida, Albee Messing, Shigeyoshi Itohara, Yoshio Hirabayashi, Shigeki Furuya

J Biol Chem. 2010 Dec 31; 285(53): 41380–41390. Published online 2010 Oct 21. doi: 10.1074/jbc.M110.187443

PMCID:: PMC3009864

Article PDF–1.8M

Select item 104693925.

ZEB1 Transcriptionally Activates PHGDH to Facilitate Carcinogenesis and Progression of HCC

Huihui Wang, Furong Lin, Zhenzhen Xu, Shengnan Yu, Guannan Li, Shan Liao, Wentao Zhao, Fengqiong Zhang, Jinyang Wang, Shijie Wang, Cong Ouyang, Cixiong Zhang, Hailong Xia, Yufei Wu, Bin Jiang, Qinxi Li

Cell Mol Gastroenterol Hepatol. 2023; 16(4): 541–556. Published online 2023 Jun 17. doi: 10.1016/j.jcmgh.2023.06.006

PMCID:: PMC10469392

Article PDF–5.7M

Select item 100062326.

Phosphoglycerate dehydrogenase activates PKM2 to phosphorylate histone H3T11 and attenuate cellular senescence

Yinsheng Wu, Lixu Tang, Han Huang, Qi Yu, Bicheng Hu, Gang Wang, Feng Ge, Tailang Yin, Shanshan Li, Xilan Yu

Nat Commun. 2023; 14: 1323. Published online 2023 Mar 10. doi: 10.1038/s41467-023-37094-8

PMCID:: PMC10006232

Article PDF–5.5M

Select item 37218497.

d-Serine in Glia and Neurons Derives from 3-Phosphoglycerate Dehydrogenase

Jeffrey T. Ehmsen, Ting Martin Ma, Hagit Sason, Dina Rosenberg, Tadashi Ogo, Shigeki Furuya, Solomon H. Snyder, Herman Wolosker

J Neurosci. 2013 Jul 24; 33(30): 12464–12469. doi: 10.1523/JNEUROSCI.4914-12.2013

PMCID:: PMC3721849

Article PDF–2.8M

Select item 3596588.

A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Krüppel family of nuclear proteins.

I J Miller, J J Bieker

Mol Cell Biol. 1993 May; 13(5): 2776–2786. doi: 10.1128/mcb.13.5.2776

PMCID:: PMC359658

Summary Page Browse PDF–3.0M

Select item 90576079.

PHGDH is required for germinal center formation and is a therapeutic target in MYC-driven lymphoma

Annalisa D’Avola, Nathalie Legrave, Mylène Tajan, Probir Chakravarty, Ryan L. Shearer, Hamish W. King, Katarina Kluckova, Eric C. Cheung, Andrew J. Clear, Arief S. Gunawan, Lingling Zhang, Louisa K. James, James I. MacRae, John G. Gribben, Dinis P. Calado, Karen H. Vousden, John C. Riches

J Clin Invest. 2022 May 2; 132(9): e153436. Published online 2022 May 2. doi: 10.1172/JCI153436

Correction in:: J Clin Invest. 2024 Feb 15; 134(4): e179917.

PMCID:: PMC9057607

Article PDF–15M

Select item 700306410.

Inverse Data-Driven Modeling and Multiomics Analysis Reveals Phgdh as a Metabolic Checkpoint of Macrophage Polarization and Proliferation

Jayne Louise Wilson, Thomas Nägele, Monika Linke, Florian Demel, Stephanie D. Fritsch, Hannah Katharina Mayr, Zhengnan Cai, Karl Katholnig, Xiaoliang Sun, Lena Fragner, Anne Miller, Arvand Haschemi, Alexandra Popa, Andreas Bergthaler, Markus Hengstschläger, Thomas Weichhart, Wolfram Weckwerth

Cell Rep. 2020 Feb 4; 30(5): 1542–1552.e7. Published online 2019 Feb 4. doi: 10.1016/j.celrep.2020.01.011

PMCID:: PMC7003064

Article

Select item 310785511.

3-Phosphoglycerate dehydrogenase expression is regulated by HOXA10 in murine endometrium and human endometrial cells

Hongling Du, Danielle Vitiello, Jennifer L Sarno, Hugh S Taylor

Reproduction. Author manuscript; available in PMC 2011 Jun 3.

Published in final edited form as: Reproduction. 2010 Jan; 139(1): 237–245. doi: 10.1530/REP-08-0376

PMCID:: PMC3107855

Article PDF–1022K

Select item 664726912.

Increased PHGDH expression promotes aberrant melanin accumulation

Katherine R. Mattaini, Mark R. Sullivan, Allison N. Lau, Brian P. Fiske, Roderick T. Bronson, Matthew G. Vander Heiden

BMC Cancer. 2019; 19: 723. Published online 2019 Jul 22. doi: 10.1186/s12885-019-5933-5

PMCID:: PMC6647269

Article PDF–1.1M

Select item 330540113.

Mouse Genetics Suggests Cell-Context Dependency for Myc-Regulated Metabolic Enzymes during Tumorigenesis

Lisa M. Nilsson, Tacha Zi Plym Forshell, Sara Rimpi, Christiane Kreutzer, Walter Pretsch, Georg W. Bornkamm, Jonas A. Nilsson

PLoS Genet. 2012 Mar; 8(3): e1002573. Published online 2012 Mar 15. doi: 10.1371/journal.pgen.1002573

PMCID:: PMC3305401

Article PDF–640K

Select item 676288414.

3-Phosphoglycerate Dehydrogenase, a Key Enzyme forl-Serine Biosynthesis, Is Preferentially Expressed in the Radial Glia/Astrocyte Lineage and Olfactory Ensheathing Glia in the Mouse Brain

Miwako Yamasaki, Keiko Yamada, Shigeki Furuya, Junya Mitoma, Yoshio Hirabayashi, Masahiko Watanabe

J Neurosci. 2001 Oct 1; 21(19): 7691–7704. doi: 10.1523/JNEUROSCI.21-19-07691.2001

PMCID:: PMC6762884

Article PDF–6.4M

Select item 655125515.

Increased serine synthesis provides an advantage for tumors arising in tissues where serine levels are limiting

Mark R. Sullivan, Katherine R. Mattaini, Emily A. Dennstedt, Anna A. Nguyen, Montana F. Reilly, Katrina Meeth, Alexander Muir, Alicia M. Darnell, Marcus W. Bosenberg, Caroline A. Lewis, Matthew G. Vander Heiden

Cell Metab. Author manuscript; available in PMC 2020 Jun 4.

Published in final edited form as: Cell Metab. 2019 Jun 4; 29(6): 1410–1421.e4. Published online 2019 Mar 21. doi: 10.1016/j.cmet.2019.02.015

PMCID:: PMC6551255

Article PDF–1.6M

Select item 674189116.

Neutral Amino Acid Transporter ASCT1 Is Preferentially Expressed in l-Ser-Synthetic/Storing Glial Cells in the Mouse Brain with Transient Expression in Developing Capillaries

Kazuhisa Sakai, Hidemi Shimizu, Tatsuro Koike, Shigeki Furuya, Masahiko Watanabe

J Neurosci. 2003 Jan 15; 23(2): 550–560. doi: 10.1523/JNEUROSCI.23-02-00550.2003

PMCID:: PMC6741891

Article PDF–2.1M

Select item 330296317.

STRAIN-SPECIFIC MODIFIER GENES GOVERNING CRANIOFACIAL PHENOTYPES

Partha Mukhopadhyay, Guy Brock, Cynthia Webb, M. Michele Pisano, Robert M Greene

Birth Defects Res A Clin Mol Teratol. Author manuscript; available in PMC 2013 Mar 1.

Published in final edited form as: Birth Defects Res A Clin Mol Teratol. 2012 Mar; 94(3): 162–175. Published online 2012 Feb 28. doi: 10.1002/bdra.22890

PMCID:: PMC3302963

Article PDF–554K

Select item 952349118.

Mitochondrial stress induces an HRI-eIF2α pathway protective for cardiomyopathy

Siting Zhu, Anh Nguyen, Jing Pang, Jun Zhao, Ze’e Chen, Zhengyu Liang, Yusu Gu, Helen Huynh, Yutong Bao, Sharon Lee, Yuval Kluger, Kunfu Ouyang, Sylvia M Evans, Xi Fang

Circulation. Author manuscript; available in PMC 2023 Sep 27.

Published in final edited form as: Circulation. 2022 Sep 27; 146(13): 1028–1031. Published online 2022 Sep 26. doi: 10.1161/CIRCULATIONAHA.122.059594

PMCID:: PMC9523491

Article PDF–1016K

Select item 1038723719.

DELE1 is protective for mitochondrial cardiomyopathy

Helen Huynh, Siting Zhu, Sharon Lee, Yutong Bao, Jing Pang, Anh Nguyen, Yusu Gu, Chao Chen, Kunfu Ouyang, Sylvia M. Evans, Xi Fang

J Mol Cell Cardiol. Author manuscript; available in PMC 2023 Jul 30.

Published in final edited form as: J Mol Cell Cardiol. 2023 Feb; 175: 44–48. Published online 2022 Dec 17. doi: 10.1016/j.yjmcc.2022.12.003

PMCID:: PMC10387237

Article PDF–661K

Select item 456367820.

Steroid receptor coactivators 1 and 2 mediate fetal-to-maternal signaling that initiates parturition

Lu Gao, Elizabeth H. Rabbitt, Jennifer C. Condon, Nora E. Renthal, John M. Johnston, Matthew A. Mitsche, Pierre Chambon, Jianming Xu, Bert W. O’Malley, Carole R. Mendelson

J Clin Invest. 2015 Jul 1; 125(7): 2808–2824. Published online 2015 Jun 22. doi: 10.1172/JCI78544

PMCID:: PMC4563678

Article PDF–3.5M

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