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Items: 1 to 20 of 43

1.
Cell volume controlled by LRRC8A-formed volume-regulated anion channels fine-tunes T cell activation and function
Yuman Wang, Zaiqiao Sun, Jieming Ping, Jianlong Tang, Boxiao He, Teding Chang, Qian Zhou, Shijie Yuan, Zhaohui Tang, Xin Li, Yan Lu, Ran He, Ximiao He, Zheng Liu, Lei Yin, Ning Wu
Nat Commun. 2023; 14: 7075. Published online 2023 Nov 4. doi: 10.1038/s41467-023-42817-y
Correction in:
Nat Commun. 2024; 15: 309.
PMCID:
PMC10625614
AbstractArticlePDF–5.2M
2.
Identification of the chloride channel, leucine-rich repeat-containing protein 8, subfamily a (LRRC8A), in mouse cholangiocytes
Nikolay Shcheynikov, Kristy Boggs, Anthony Green, Andrew P. Feranchak
Hepatology. Author manuscript; available in PMC 2023 Apr 25.
Published in final edited form as: Hepatology. 2022 Nov; 76(5): 1248–1258. Published online 2022 May 19. doi: 10.1002/hep.32536
PMCID:
PMC10126881
AbstractArticlePDF–2.5M
3.
Adipose-targeted SWELL1 deletion exacerbates obesity- and age-related nonalcoholic fatty liver disease
Susheel K. Gunasekar, John Heebink, Danielle H. Carpenter, Ashutosh Kumar, Litao Xie, Haixia Zhang, Joel D. Schilling, Rajan Sah
JCI Insight. 2023 Mar 8; 8(5): e154940. Published online 2023 Mar 8. doi: 10.1172/jci.insight.154940
PMCID:
PMC10077479
AbstractArticlePDF–16M
4.
Inhibition of the LRRC8A channel promotes microglia/macrophage phagocytosis and improves outcomes after intracerebral hemorrhagic stroke
Jing Liu, Danmin Shen, Chao Wei, Weihua Wu, Zhaoli Luo, Liye Hu, Zhongnan Xiao, Tingting Hu, Qingyu Sun, Xiaotong Wang, Yumeng Ding, Meng Liu, Miaoyi Pang, Kaiyuan Gai, Yiran Ma, Yichen Tian, Yan Yu, Peipei Wang, Yun Guan, Meng Xu, Fei Yang, Qian Li
iScience. 2022 Dec 22; 25(12): 105527. Published online 2022 Nov 13. doi: 10.1016/j.isci.2022.105527
PMCID:
PMC9708789
AbstractArticlePDF–5.9M
5.
LRRC8A is dispensable for a variety of microglial functions and response to acute stroke
James R. Cook, Anna L. Gray, Eloise Lemarchand, Ingo Schiessl, Jack P. Green, Mary C. Newland, Douglas P. Dyer, David Brough, Catherine B. Lawrence
Glia. 2022 Jun; 70(6): 1068–1083. Published online 2022 Feb 12. doi: 10.1002/glia.24156
PMCID:
PMC9304177
AbstractArticlePDF–5.1M
6.
Late adolescence mortality in mice with brain-specific deletion of the volume-regulated anion channel subunit LRRC8A
Corinne S. Wilson, Preeti Dohare, Shaina Orbeta, Julia W. Nalwalk, Yunfei Huang, Russell J. Ferland, Rajan Sah, Annalisa Scimemi, Alexander A. Mongin
FASEB J. Author manuscript; available in PMC 2022 Oct 1.
Published in final edited form as: FASEB J. 2021 Oct; 35(10): e21869. doi: 10.1096/fj.202002745R
PMCID:
PMC8639177
AbstractArticlePDF–3.4M
7.
Allosteric modulation of LRRC8 channels by targeting their cytoplasmic domains
Dawid Deneka, Sonja Rutz, Cedric A. J. Hutter, Markus A. Seeger, Marta Sawicka, Raimund Dutzler
Nat Commun. 2021; 12: 5435. Published online 2021 Sep 14. doi: 10.1038/s41467-021-25742-w
PMCID:
PMC8440666
AbstractArticlePDF–6.4M
8.
Chronic ethanol consumption and HBV induce abnormal lipid metabolism through HBx/SWELL1/arachidonic acid signaling and activate Tregs in HBV-Tg mice
Zixian Liu, Jiapei Wang, Lei Liu, Hongfeng Yuan, Yanan Bu, Jinyan Feng, Yunxia Liu, Guang Yang, Man Zhao, Ying Yuan, Huihui Zhang, Haolin Yun, Xiaodong Zhang
Theranostics. 2020; 10(20): 9249–9267. Published online 2020 Jul 23. doi: 10.7150/thno.46005
PMCID:
PMC7415795
AbstractArticlePDF–3.4M
9.
LRRC8A-dependent volume-regulated anion channels contribute to ischemia-induced brain injury and glutamatergic input to hippocampal neurons
Jing-Jing Zhou, Yi Luo, Shao-Rui Chen, Jian-Ying Shao, Rajan Sah, Hui-Lin Pan
Exp Neurol. Author manuscript; available in PMC 2021 Oct 1.
Published in final edited form as: Exp Neurol. 2020 Oct; 332: 113391. Published online 2020 Jun 27. doi: 10.1016/j.expneurol.2020.113391
Correction in:
Exp Neurol. 2021 Dec 26 : 113956.
PMCID:
PMC7398854
AbstractArticlePDF–1.9M
10.
The LRRC8/VRAC anion channel facilitates myogenic differentiation of murine myoblasts by promoting membrane hyperpolarization
Lingye Chen, Thorsten M. Becker, Ursula Koch, Tobias Stauber
J Biol Chem. 2019 Sep 27; 294(39): 14279–14288. Published online 2019 Aug 6. doi: 10.1074/jbc.RA119.008840
PMCID:
PMC6768655
AbstractArticlePDF–3.1M
11.
Cryo-EM structures of the DCPIB-inhibited volume-regulated anion channel LRRC8A in lipid nanodiscs
David M Kern, SeCheol Oh, Richard K Hite, Stephen G Brohawn
eLife. 2019; 8: e42636. Published online 2019 Feb 18. doi: 10.7554/eLife.42636
PMCID:
PMC6395065
AbstractArticlePDF–5.7M
12.
Leucine-rich repeat containing 8A (LRRC8A)–dependent volume-regulated anion channel activity is dispensable for T-cell development and function
Craig D. Platt, Janet Chou, Patrick Houlihan, Yousef R. Badran, Lalit Kumar, Wayne Bainter, P. Luigi Poliani, Carlos J. Perez, Sharon Y. R. Dent, David E. Clapham, Fernando Benavides, Raif S. Geha
J Allergy Clin Immunol. Author manuscript; available in PMC 2018 Oct 3.
Published in final edited form as: J Allergy Clin Immunol. 2017 Dec; 140(6): 1651–1659.e1. Published online 2017 Feb 10. doi: 10.1016/j.jaci.2016.12.974
PMCID:
PMC6170198
AbstractArticlePDF–957K
13.
LRRC8/VRAC anion channels are required for late stages of spermatid development in mice
Jennifer C. Lück, Dmytro Puchkov, Florian Ullrich, Thomas J. Jentsch
J Biol Chem. 2018 Jul 27; 293(30): 11796–11808. Published online 2018 Jun 7. doi: 10.1074/jbc.RA118.003853
PMCID:
PMC6066314
AbstractArticlePDF–6.7M
14.
Induction of adipose and hepatic SWELL1 expression is required for maintaining systemic insulin-sensitivity in obesity
Litao Xie, Yanhui Zhang, Susheel K. Gunasekar, Anil Mishra, Lei Cao, Rajan Sah
Channels (Austin) 2017; 11(6): 673–677. Published online 2017 Oct 5. doi: 10.1080/19336950.2017.1373225
PMCID:
PMC5786185
AbstractArticlePDF–558K
15.
The LRRC8A Mediated “Swell Activated” Chloride Conductance Is Dispensable for Vacuolar Homeostasis in Neutrophils
Philippe Behe, Juliet R. Foote, Adam P. Levine, Craig D. Platt, Janet Chou, Fernando Benavides, Raif S. Geha, Anthony W. Segal
Front Pharmacol. 2017; 8: 262. Published online 2017 May 12. doi: 10.3389/fphar.2017.00262
PMCID:
PMC5427109
AbstractArticlePDF–4.7M
16.
The volume-regulated anion channel (LRRC8) in nodose neurons is sensitive to acidic pH
Runping Wang, Yongjun Lu, Susheel Gunasekar, Yanhui Zhang, Christopher J. Benson, Mark W. Chapleau, Rajan Sah, François M. Abboud
JCI Insight. 2017 Mar 9; 2(5): e90632. Published online 2017 Mar 9. doi: 10.1172/jci.insight.90632
PMCID:
PMC5333957
AbstractArticlePDF–2.1M
17.
Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function
Lalit Kumar, Janet Chou, Christina S.K. Yee, Arturo Borzutzky, Elisabeth H. Vollmann, Ulrich H. von Andrian, Shin-Young Park, Georg Hollander, John P. Manis, P. Luigi Poliani, Raif S. Geha
J Exp Med. 2014 May 5; 211(5): 929–942. doi: 10.1084/jem.20131379
PMCID:
PMC4010910
AbstractArticlePDF–4.0M
18.
LRRC8A anion channels modulate vascular reactivity via association with Myosin Phosphatase Rho Interacting Protein (MPRIP)
Hyehun Choi, Michael R. Miller, Nguyen Hong-Ngan, Jeffrey C. Rohrbough, Stephen R. Koch, Naoko Boatwright, Michael T. Yarboro, Rajan Sah, W. Hayes McDonald, J. Jeffrey Reese, Ryan J. Stark, Fred S. Lamb
FASEB J. Author manuscript; available in PMC 2023 Oct 23.
Published in final edited form as: FASEB J. 2023 Jul; 37(7): e23028. doi: 10.1096/fj.202300561R
PMCID:
PMC10591482
AbstractArticlePDF–2.8M
19.
ATP-releasing SWELL1 channel in spinal microglia contributes to neuropathic pain
Jiachen Chu, Junhua Yang, Yuan Zhou, Jianan Chen, Kevin Hong Chen, Chi Zhang, Henry Yi Cheng, Nicholas Koylass, Jun O. Liu, Yun Guan, Zhaozhu Qiu
Sci Adv. 2023 Mar; 9(13): eade9931. Published online 2023 Mar 29. doi: 10.1126/sciadv.ade9931
PMCID:
PMC10058245
AbstractArticlePDF–1.9M
20.
Structure of a volume-regulated heteromeric LRRC8A/C channel
Sonja Rutz, Dawid Deneka, Antje Dittmann, Marta Sawicka, Raimund Dutzler
Nat Struct Mol Biol. 2023; 30(1): 52–61. Published online 2022 Dec 15. doi: 10.1038/s41594-022-00899-0
PMCID:
PMC9851909
AbstractArticlePDF–20M

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