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Select item 104119731.

TPL2 kinase activity regulates microglial inflammatory responses and promotes neurodegeneration in tauopathy mice

Yuanyuan Wang, Tiffany Wu, Ming-Chi Tsai, Mitchell G Rezzonico, Alyaa M Abdel-Haleem, Luke Xie, Vineela D Gandham, Hai Ngu, Kimberly Stark, Caspar Glock, Daqi Xu, Oded Foreman, Brad A Friedman, Morgan Sheng, Jesse E Hanson

eLife. 2023; 12: e83451. Published online 2023 Aug 9. doi: 10.7554/eLife.83451

PMCID:: PMC10411973

Article PDF–13M

Select item 96040452.

Tumor Progression Locus 2 Protects against Acute Respiratory Distress Syndrome in Influenza A Virus-Infected Mice

Krishna Latha, Sanjana Rao, Kaori Sakamoto, Wendy T. Watford

Microbiol Spectr. 2022 Sep-Oct; 10(5): e01136-22. Published online 2022 Aug 18. doi: 10.1128/spectrum.01136-22

PMCID:: PMC9604045

Article PDF–3.1M

Select item 87755643.

Influenza-induced Tpl2 expression within alveolar epithelial cells is dispensable for host viral control and anti-viral immunity

Kara D. Wyatt, Demba Sarr, Kaori Sakamoto, Wendy T. Watford

PLoS One. 2022; 17(1): e0262832. Published online 2022 Jan 20. doi: 10.1371/journal.pone.0262832

PMCID:: PMC8775564

Article PDF–1.4M

Select item 85291114.

Tpl2 Ablation Leads to Hypercytokinemia and Excessive Cellular Infiltration to the Lungs During Late Stages of Influenza Infection

Krishna Latha, Katelyn F. Jamison, Wendy T. Watford

Front Immunol. 2021; 12: 738490. Published online 2021 Oct 7. doi: 10.3389/fimmu.2021.738490

PMCID:: PMC8529111

Article PDF–3.2M

Select item 78217525.

Foot-and-Mouth Disease Virus Capsid Protein VP1 Antagonizes TPL2-Mediated Activation of the IRF3/IFN-β Signaling Pathway to Facilitate the Virus Replication

Junhong Hao, Chaochao Shen, Nannan Wei, Minghao Yan, Xuegang Zhang, Guowei Xu, Dajun Zhang, Jing Hou, Weijun Cao, Ye Jin, Keshan Zhang, Haixue Zheng, Xiangtao Liu

Front Immunol. 2020; 11: 580334. Published online 2021 Jan 8. doi: 10.3389/fimmu.2020.580334

Correction in:: Front Immunol. 2021; 12: 686494.

PMCID:: PMC7821752

Article PDF–5.4M

Select item 65483146.

Severe fever with thrombocytopenia syndrome phlebovirus non-structural protein activates TPL2 signalling pathway for viral immunopathogenesis

Younho Choi, Su-Jin Park, Yinyan Sun, Ji-Seung Yoo, Raghavendra Sumanth Pudupakam, Suan-Sin Foo, Woo-Jin Shin, Sally B. Chen, Philip N. Tsichlis, Won-Ja Lee, Jong-Soo Lee, Wenhui Li, Benjamin Brennan, Young-Ki Choi, Jae U. Jung

Nat Microbiol. Author manuscript; available in PMC 2019 Jun 4.

Published in final edited form as: Nat Microbiol. 2019 Mar; 4(3): 429–437. Published online 2019 Jan 7. doi: 10.1038/s41564-018-0329-x

PMCID:: PMC6548314

Article PDF–1009K

Select item 60568507.

TPL2 Is a Key Regulator of Intestinal Inflammation in Clostridium difficile Infection

Yuanguo Wang, Shaohui Wang, Ciaran P. Kelly, Hanping Feng, Andrew Greenberg, Xingmin Sun

Infect Immun. 2018 Aug; 86(8): e00095-18. Prepublished online 2018 May 29. Published online 2018 Jul 23. doi: 10.1128/IAI.00095-18

PMCID:: PMC6056850

Article PDF–2.8M

Select item 59191688.

The Murine cot Proto‐oncogene: Genome Structure and Tissue‐specific Expression

Reiko Ohara, Jun Miyoshi, Masahiro Aoki, Kumao Toyoshima

Jpn J Cancer Res. 1993 May; 84(5): 518–525. doi: 10.1111/j.1349-7006.1993.tb00170.x

PMCID:: PMC5919168

Article PDF–479K

Select item 56074299.

Tpl2 Promotes Innate Cell Recruitment and Effector T Cell Differentiation To Limit Citrobacter rodentium Burden and Dissemination

Nicole V. Acuff, Xin Li, Krishna Latha, Tamas Nagy, Wendy T. Watford

Infect Immun. 2017 Oct; 85(10): e00193-17. Prepublished online 2017 Jul 31. Published online 2017 Sep 20. doi: 10.1128/IAI.00193-17

PMCID:: PMC5607429

Article PDF–1.5M

Select item 550393610.

Map3k8 controls granulocyte colony-stimulating factor production and neutrophil precursor proliferation in lipopolysaccharide-induced emergency granulopoiesis

Ángela Sánchez, Carlos Relaño, Araceli Carrasco, Constanza Contreras-Jurado, Antonio Martín-Duce, Ana Aranda, Susana Alemany

Sci Rep. 2017; 7: 5010. Published online 2017 Jul 10. doi: 10.1038/s41598-017-04538-3

PMCID:: PMC5503936

Article PDF–6.5M

Select item 543385811.

Tpl2 promotes neutrophil trafficking, oxidative burst, and bacterial killing

Nicole V. Acuff, Xin Li, Jessica Elmore, Balázs Rada, Wendy T. Watford

J Leukoc Biol. 2017 Jun; 101(6): 1325–1333. Published online 2017 Mar 29. doi: 10.1189/jlb.3A0316-146R

PMCID:: PMC5433858

Article

Select item 436356612.

Tumor Progression Locus 2 Differentially Regulates IFNγ and IL-17 Production by Effector CD4⁺ T Cells in a T Cell Transfer Model of Colitis

Nicole V. Acuff, Xin Li, Rebecca Kirkland, Tamas Nagy, Wendy T. Watford

PLoS One. 2015; 10(3): e0119885. Published online 2015 Mar 17. doi: 10.1371/journal.pone.0119885

PMCID:: PMC4363566

Article PDF–1.1M

Select item 395167013.

THE ROLE OF TUMOR PROGRESSION LOCUS 2 (TPL-2) PROTEIN KINASE IN GLIAL INFLAMMATORY RESPONSE

Joshua Hirschhorn, Sangeeta Mohanty, Narayan R. Bhat

J Neurochem. Author manuscript; available in PMC 2015 Mar 1.

Published in final edited form as: J Neurochem. 2014 Mar; 128(6): 919–926. Published online 2013 Nov 21. doi: 10.1111/jnc.12522

PMCID:: PMC3951670

Article PDF–2.1M

Select item 384589714.

Tpl2 knockout keratinocytes have increased biomarkers for invasion and metastasis

Kathleen L. DeCicco-Skinner, Sarah A. Jung, Tracy Tabib, J.Curtis Gwilliam, Hepzibha Alexander, Sarah E. Goodheart, Anand S. Merchant, Mengge Shan, Caroline Garber, Jonathan S. Wiest

Carcinogenesis. 2013 Dec; 34(12): 2789–2798. Published online 2013 Sep 25. doi: 10.1093/carcin/bgt319

PMCID:: PMC3845897

Article PDF–2.7M

Select item 376988315.

Tpl2 Inhibitors Thwart Endothelial Cell Function in Angiogenesis and Peritoneal Dissemination

Wen-Jane Lee, Keng-Hsin Lan, Chiang-Ting Chou, Yu-Chiao Yi, Wei-Chih Chen, Hung-Chuan Pan, Yen-Chun Peng, Keh-Bin Wang, Yi-Ching Chen, Te-Hsin Chao, Hsing-Ru Tien, Wayne Huey Herng Sheu, Meei-Ling Sheu

Neoplasia. 2013 Sep; 15(9): 1036–1048. doi: 10.1593/neo.121914

PMCID:: PMC3769883

Article PDF–2.7M

Select item 366355316.

Sterile Inflammation in Acetaminophen-induced Liver Injury Is Mediated by Cot/tpl2

Carlos Sanz-Garcia, Gemma Ferrer-Mayorga, Águeda González-Rodríguez, Ángela M. Valverde, Antonio Martín-Duce, Juan P. Velasco-Martín, Javier Regadera, Margarita Fernández, Susana Alemany

J Biol Chem. 2013 May 24; 288(21): 15342–15351. Published online 2013 Apr 9. doi: 10.1074/jbc.M112.439547