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Select item 90468871.

Hypothalamic Irak4 is a genetically controlled regulator of hypoglycemia-induced glucagon secretion

Alexandre Picard, Xavier Berney, Judit Castillo-Armengol, David Tarussio, Maxime Jan, Ana Rodriguez Sanchez-Archidona, Sophie Croizier, Bernard Thorens

Mol Metab. 2022 Jul; 61: 101479. Published online 2022 Mar 24. doi: 10.1016/j.molmet.2022.101479

PMCID:: PMC9046887

Abstract Article PDF–2.7M

Select item 61621512.

IRAK4 Activity Controls Immune Responses to Intracellular Bacteria Listeria monocytogenes and Mycobacterium smegmatis

Goutham Pattabiraman, Michael Murphy, Federica Agliano, Keaton Karlinsey, Andrei E. Medvedev

J Leukoc Biol. Author manuscript; available in PMC 2019 Oct 1.

Published in final edited form as: J Leukoc Biol. 2018 Oct; 104(4): 811–820. Published online 2018 May 11. doi: 10.1002/JLB.2A1117-449R

PMCID:: PMC6162151

Abstract Article PDF–1.0M

Select item 55758293.

Deficiency in Interleukin-1 receptor-associated kinase (IRAK) 4 activity attenuates manifestations of murine Lupus

Michael Murphy, Goutham Pattabiraman, Tissa T. Manavalan, Andrei E. Medvedev

Eur J Immunol. Author manuscript; available in PMC 2018 May 1.

Published in final edited form as: Eur J Immunol. 2017 May; 47(5): 880–891. Published online 2017 Mar 31. doi: 10.1002/eji.201646641

PMCID:: PMC5575829

Abstract Article PDF–1.3M

Select item 42944964.

Interleukin-1 Receptor-associated Kinase-4 (IRAK4) Promotes Inflammatory Osteolysis by Activating Osteoclasts and Inhibiting Formation of Foreign Body Giant Cells

Eri Katsuyama, Hiroya Miyamoto, Tami Kobayashi, Yuiko Sato, Wu Hao, Hiroya Kanagawa, Atsuhiro Fujie, Toshimi Tando, Ryuichi Watanabe, Mayu Morita, Kana Miyamoto, Yasuo Niki, Hideo Morioka, Morio Matsumoto, Yoshiaki Toyama, Takeshi Miyamoto

J Biol Chem. 2015 Jan 9; 290(2): 716–726. Published online 2014 Nov 17. doi: 10.1074/jbc.M114.568360

PMCID:: PMC4294496

Abstract Article PDF–3.9M

Select item 37145655.

IRAK4 kinase activity is not required for induction of endotoxin tolerance but contributes to TLR2-mediated tolerance

Yanbao Xiong, Meghan Pennini, Stefanie N. Vogel, Andrei E. Medvedev

J Leukoc Biol. 2013 Aug; 94(2): 291–300. doi: 10.1189/jlb.0812401

PMCID:: PMC3714565

Abstract Article

Select item 36382606.

IRAK4 kinase Activity is Required for Th17 Differentiation and Th17-mediated Disease

Kirk A. Staschke, Sucai Dong, Joy Saha, Jingyong Zhao, Nathan A. Brooks, Deena L. Hepburn, Jinqi Xia, Muhammet F. Gulen, Zizhen Kang, Cengiz Z. Altuntas, Vincent K. Tuohy, Raymond Gilmour, Xiaoxia Li, Songqing Na

J Immunol. Author manuscript; available in PMC 2013 Apr 29.

Published in final edited form as: J Immunol. 2009 Jul 1; 183(1): 568–577. doi: 10.4049/jimmunol.0802361

PMCID:: PMC3638260

Abstract Article PDF–1.6M

Select item 21185907.

A critical role for IRAK4 kinase activity in Toll-like receptor–mediated innate immunity

Tae Whan Kim, Kirk Staschke, Katarzyna Bulek, Jianhong Yao, Kristi Peters, Keun-Hee Oh, Yvonne Vandenburg, Hui Xiao, Wen Qian, Tom Hamilton, Booki Min, Ganes Sen, Raymond Gilmour, Xiaoxia Li

J Exp Med. 2007 May 14; 204(5): 1025–1036. doi: 10.1084/jem.20061825

PMCID:: PMC2118590

Abstract Article PDF–2.4M

Select item 40115598.

MicroRNA-302b augments host defense to bacteria by regulating inflammatory responses via feedback to TLR/IRAK4 circuits

Xikun Zhou, Xuefeng Li, Yan Ye, Kelei Zhao, Yan Zhuang, Yi Li, Yuquan Wei, Min Wu

Nat Commun. Author manuscript; available in PMC 2014 Oct 10.

Published in final edited form as: Nat Commun. 2014; 5: 3619. Published online 2014 Apr 10. doi: 10.1038/ncomms4619

Correction in:: Nat Commun. 2015; 6: 8679.

PMCID:: PMC4011559

Abstract Article PDF–2.3M

Select item 35058809.

Loss of Interleukin Receptor-Associated Kinase 4 Signaling Suppresses Amyloid Pathology and Alters Microglial Phenotype in a Mouse Model of Alzheimer's Disease

Brent Cameron, Wayne Tse, Raza Lamb, Xiaoxia Li, Bruce T. Lamb, Gary E. Landreth

J Neurosci. 2012 Oct 24; 32(43): 15112–15123. doi: 10.1523/JNEUROSCI.1729-12.2012

PMCID:: PMC3505880

Abstract Article PDF–2.8M

Select item 349741810.

Impaired Innate Immunity in Mice Deficient in Interleukin-1 Receptor-Associated Kinase 4 Leads to Defective Type 1 T Cell Responses, B Cell Expansion, and Enhanced Susceptibility to Infection with Toxoplasma gondii

Samantha R. Béla, Míriam S. Dutra, Ernest Mui, Alexandre Montpetit, Fernanda S. Oliveira, Sérgio C. Oliveira, Rosa M. E. Arantes, Lis R. Antonelli, Rima McLeod, Ricardo T. Gazzinelli

Infect Immun. 2012 Dec; 80(12): 4298–4308. doi: 10.1128/IAI.00328-12

PMCID:: PMC3497418

Abstract Article PDF–3.1M

Select item 326175511.

The critical role of IRAK4-mediated NFκB activation in modified-LDL-induced atherosclerosis

Tae Whan Kim, Maria Febbraio, Peggy Robinet, Brandon DuGar, Diane Greene, Anna Cerny, Eicke Latz, Raymond Gilmour, Kirk Staschke, Guy Chisolm, Paul L Fox, Paul E DiCorleto, Jonathan D. Smith, Xiaoixa Li

J Immunol. Author manuscript; available in PMC 2012 Mar 1.

Published in final edited form as: J Immunol. 2011 Mar 1; 186(5): 2871–2880. Published online 2011 Jan 28. doi: 10.4049/jimmunol.1002242

PMCID:: PMC3261755

Abstract Article PDF–1.1M

Select item 325794712.

Interleukin-1 Receptor-Associated Kinase 4 Is Essential for Initial Host Control of Brucella abortus Infection

Fernanda S. Oliveira, Natália B. Carvalho, Ana Paula M. S. Brandão, Marco Túlio R. Gomes, Leonardo A. de Almeida, Sérgio C. Oliveira

Infect Immun. 2011 Nov; 79(11): 4688–4695. doi: 10.1128/IAI.05289-11

PMCID:: PMC3257947

Abstract Article PDF–1.0M

Select item 271210713.

Signalling mechanisms for Toll-like receptor-activated neutrophil exocytosis: key roles for interleukin-1-receptor-associated kinase-4 and phosphatidylinositol 3-kinase but not Toll/IL-1 receptor (TIR) domain-containing adaptor inducing IFN-β (TRIF)

Agnieszka A Brzezinska, Jennifer L Johnson, Daniela B Munafo, Beverly A Ellis, Sergio D Catz

Immunology. 2009 Jul; 127(3): 386–397. doi: 10.1111/j.1365-2567.2008.02980.x

PMCID:: PMC2712107

Abstract Article PDF–454K

Select item 258157314.

The Kinase Activity of IL-1 Receptor-associated Kinase 4 Is Required for Interleukin-1 Receptor/Toll-like Receptor-induced TAK1-dependent NFκB Activation

Jerzy Frączek, Tae Whan Kim, Hui Xiao, Jianhong Yao, Qian Wen, Yali Li, Jean-Laurent Casanova, Juliusz Pryjma, Xiaoxia Li

J Biol Chem. 2008 Nov 14; 283(46): 31697–31705. doi: 10.1074/jbc.M804779200

PMCID:: PMC2581573

Abstract Article PDF–663K

Select item 679541115.

IRAK4 mediates colitis-induced tumorigenesis and chemoresistance in colorectal cancer

Qiong Li, Yali Chen, Daoxiang Zhang, Julie Grossman, Lin Li, Namrata Khurana, Hongmei Jiang, Patrick M. Grierson, John Herndon, David G. DeNardo, Grant A. Challen, Jingxia Liu, Marianna B. Ruzinova, Ryan C. Fields, Kian-Huat Lim

JCI Insight. 2019 Oct 3; 4(19): e130867. Published online 2019 Oct 3. doi: 10.1172/jci.insight.130867

PMCID:: PMC6795411

Abstract Article PDF–18M

Select item 616671416.

Interleukin-1 receptor–associated kinase 4 (IRAK4) plays a dual role in myddosome formation and Toll-like receptor signaling

Dominic De Nardo, Katherine R. Balka, Yamel Cardona Gloria, Vikram R. Rao, Eicke Latz, Seth L. Masters

J Biol Chem. 2018 Sep 28; 293(39): 15195–15207. Published online 2018 Aug 3. doi: 10.1074/jbc.RA118.003314

PMCID:: PMC6166714

Abstract Article PDF–2.2M

Select item 538172617.

Comprehensive siRNA-based screening of human and mouse TLR pathways identifies species-specific preferences in signaling protein use

Jing Sun, Ning Li, Kyu-Seon Oh, Bhaskar Dutta, Sharat J. Vayttaden, Bin Lin, Thomas S. Ebert, Dominic De Nardo, Joie Davis, Rustam Bagirzadeh, Nicolas W. Lounsbury, Chandrashekhar Pasare, Eicke Latz, Veit Hornung, Iain D. C. Fraser

Sci Signal. Author manuscript; available in PMC 2017 Apr 5.

Published in final edited form as: Sci Signal. 2016 Jan 5; 9(409): ra3. Published online 2016 Jan 5. doi: 10.1126/scisignal.aab2191

PMCID:: PMC5381726

Abstract Article PDF–1.5M

Select item 511488218.

Suppression of IRAK1 or IRAK4 Catalytic Activity, but Not Type 1 IFN Signaling, Prevents Lupus Nephritis in Mice Expressing a Ubiquitin Binding–Defective Mutant of ABIN1

Sambit K. Nanda, Marta Lopez-Pelaez, J. Simon C. Arthur, Francesco Marchesi, Philip Cohen

J Immunol. 2016 Dec 1; 197(11): 4266–4273. Published online 2016 Nov 2. doi: 10.4049/jimmunol.1600788

PMCID:: PMC5114882

Abstract Article PDF–1.9M

Select item 395174319.

A promiscuous lipid-binding protein diversifies the subcellular sites of Toll-like Receptor signal transduction

Kevin S. Bonham, Megan H. Orzalli, Kachiko Hayashi, Amaya I. Wolf, Christoph Glanemann, Wolfgang Weninger, Akiko Iwasaki, David M. Knipe, Jonathan C. Kagan

Cell. Author manuscript; available in PMC 2015 Feb 13.

Published in final edited form as: Cell. 2014 Feb 13; 156(4): 705–716. doi: 10.1016/j.cell.2014.01.019

PMCID:: PMC3951743

Article PDF–2.0M

Select item 389616720.

IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation

Keng-Mean Lin, Wei Hu, Ty Dale Troutman, Michelle Jennings, Travis Brewer, Xiaoxia Li, Sambit Nanda, Philip Cohen, James A. Thomas, Chandrashekhar Pasare

Proc Natl Acad Sci U S A. 2014 Jan 14; 111(2): 775–780. Published online 2013 Dec 30. doi: 10.1073/pnas.1320294111