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Select item 109546171.

Heterozygous missense variant in GLI2 impairs human endocrine pancreas development

Laura M. Mueller, Abigail Isaacson, Heather Wilson, Anna Salowka, Isabel Tay, Maolian Gong, Nancy Samir Elbarbary, Klemens Raile, Francesca M. Spagnoli

Nat Commun. 2024; 15: 2483. Published online 2024 Mar 20. doi: 10.1038/s41467-024-46740-8

PMCID:: PMC10954617

Article PDF–3.3M

Select item 107814912.

Anoikis regulator GLI2 promotes NC cell immunity escape by TGF-β-mediated non-classic hedgehog signaling in colorectal cancer: based on artificial intelligence and big data analysis

Zhang Shanshan, Ding Fanfei, Sun Xuan, Lu Huina, Zhang Ye, Li Jiayu, Zhao Shuo, Pan Xue, Pu Yingye, Jin Chengjun, Pan Hang, Li Li

Aging (Albany NY) 2023 Dec 31; 15(24): 14733–14748. Published online 2023 Dec 29. doi: 10.18632/aging.205283

PMCID:: PMC10781491

Article PDF–2.7M

Select item 83740603.

Constitutive Hedgehog/GLI2 signaling drives extracutaneous basaloid squamous cell carcinoma development and bone remodeling

Marina Grachtchouk, Jianhong Liu, Mark E Hutchin, Paul W Harms, Dafydd Thomas, Lebing Wei, Aiqin Wang, Donelle Cummings, Lori Lowe, Jonathan Garlick, James Sciubba, Arul M Chinnaiyan, Monique E Verhaegen, Andrzej A Dlugosz

Carcinogenesis. 2021 Aug; 42(8): 1100–1109. Published online 2021 Jun 12. doi: 10.1093/carcin/bgab050

PMCID:: PMC8374060

Article PDF–1.3M

Select item 78600014.

GLI2 but not GLI1/GLI3 plays a central role in the induction of malignant phenotype of gallbladder cancer

Shu Ichimiya, Hideya Onishi, Shinjiro Nagao, Satoko Koga, Kukiko Sakihama, Kazunori Nakayama, Akiko Fujimura, Yasuhiro Oyama, Akira Imaizumi, Yoshinao Oda, Masafumi Nakamura

Oncol Rep. 2021 Mar; 45(3): 997–1010. Published online 2021 Jan 22. doi: 10.3892/or.2021.7947

PMCID:: PMC7860001

Article PDF–1.5M

Select item 74991315.

Ectopic Posterior Pituitary, Polydactyly, Midfacial Hypoplasia and Multiple Pituitary Hormone Deficiency due to a Novel Heterozygous IVS11-2A>C(c.1957-2A>C) Mutation in the GLI2 Gene

Meliha Demiral, Hüseyin Demirbilek, Edip Unal, Ceren Damla Durmaz, Serdar Ceylaner, Mehmet Nuri Özbek

J Clin Res Pediatr Endocrinol. 2020 Sep; 12(3): 319–328. Published online 2020 Sep 2. doi: 10.4274/jcrpe.galenos.2019.2019.0142

PMCID:: PMC7499131

Article PDF–664K

Select item 72524616.

Gli2 mediates the development of castration-resistant prostate cancer

Lu Xia, Hakim Bouamar, Xiang Gu, Carla Zeballos, Tai Qin, Bingzhi Wang, You Zhou, Yuhui Wang, Junhua Yang, Haiyan Zhu, Weishe Zhang, Peter J. Houghton, Lu-Zhe Sun

Int J Oncol. 2020 Jul; 57(1): 100–112. Published online 2020 Apr 13. doi: 10.3892/ijo.2020.5044

PMCID:: PMC7252461

Article PDF–1.5M

Select item 64174297.

Pathogenic mutations in GLI2 cause a specific phenotype that is distinct from holoprosencephaly

Kelly A Bear, Benjamin D Solomon, Sonir Antonini, Ivo J P Arnhold, Marcela M França, Erica H Gerkes, Dorothy K Grange, Donald W Hadley, Jarmo Jääskeläinen, Sabrina S Paulo, Patrick Rump, Constantine A Stratakis, Elizabeth M Thompson, Mary Willis, Thomas L Winder, Alexander A L Jorge, Erich Roessler, Maximilian Muenke

J Med Genet. Author manuscript; available in PMC 2019 Mar 14.

Published in final edited form as: J Med Genet. 2014 Jun; 51(6): 413–418. Published online 2014 Apr 17. doi: 10.1136/jmedgenet-2013-102249

PMCID:: PMC6417429

Article PDF–436K

Select item 63281678.

A novel truncating variant of GLI2 associated with Culler-Jones syndrome impairs Hedgehog signalling

Fabiola Valenza, Davide Cittaro, Elia Stupka, Donatella Biancolini, Maria Grazia Patricelli, Dario Bonanomi, Dejan Lazarević

PLoS One. 2019; 14(1): e0210097. Published online 2019 Jan 10. doi: 10.1371/journal.pone.0210097

PMCID:: PMC6328167

Article PDF–1.2M

Select item 63266989.

BCAR4 activates GLI2 signaling in prostate cancer to contribute to castration resistance

Zhiping Cai, Yapei Wu, Yao Li, Jizhong Ren, Linhui Wang

Aging (Albany NY) 2018 Dec; 10(12): 3702–3712. Published online 2018 Dec 4. doi: 10.18632/aging.101664

PMCID:: PMC6326698

Article PDF–3.7M

Select item 589613710.

GLI2 promoter hypermethylation in saliva of children with a respiratory allergy

Sabine A. S. Langie, Matthieu Moisse, Katarzyna Szarc vel Szic, Ellen Van Der Plas, Gudrun Koppen, Sofie De Prins, Tijs Louwies, Vera Nelen, Guy Van Camp, Diether Lambrechts, Greet Schoeters, Wim Vanden Berghe, Patrick De Boever

Clin Epigenetics. 2018; 10: 50. Published online 2018 Apr 11. doi: 10.1186/s13148-018-0484-1

PMCID:: PMC5896137

Article PDF–1.4M

Select item 534017711.

Hedgehog and TGFβ signaling converge on Gli2 to control bony invasion and bone destruction in oral squamous cell carcinoma

Shellese A. Cannonier, Cara B. Gonzales, Kim Ely, Scott A. Guelcher, Julie A. Sterling

Oncotarget. 2016 Nov 15; 7(46): 76062–76075. Published online 2016 Oct 12. doi: 10.18632/oncotarget.12584

PMCID:: PMC5340177

Article PDF–5.3M

Select item 496791912.

HCV derived from sera of HCV-infected patients induces pro-fibrotic effects in human primary fibroblasts by activating GLI2

M. Granato, C. Zompetta, E. Vescarelli, C. Rizzello, A. Cardi, S. Valia, G. Antonelli, C. Marchese, M. R. Torrisi, A. Faggioni, M. Cirone

Sci Rep. 2016; 6: 30649. Published online 2016 Aug 1. doi: 10.1038/srep30649

PMCID:: PMC4967919

Article PDF–1.2M

Select item 462298413.

Gli2 silencing enhances TRAIL-induced apoptosis and reduces tumor growth in human hepatoma cells in vivo

Da-wei Zhang, Hai-yan Li, Wan-yee Lau, Liang-qi Cao, Yue Li, Xiao-feng Jiang, Xue-wei Yang, Ping Xue

Cancer Biol Ther. 2014 Dec; 15(12): 1667–1676. Published online 2014 Dec 23. doi: 10.4161/15384047.2014.972286

PMCID:: PMC4622984

Article PDF–1.0M

Select item 441437514.

GLI2 inhibition abrogates human leukemia stem cell dormancy

Anil Sadarangani, Gabriel Pineda, Kathleen M Lennon, Hye-Jung Chun, Alice Shih, Annelie E Schairer, Angela C Court, Daniel J Goff, Sacha L Prashad, Ifat Geron, Russell Wall, John D McPherson, Richard A Moore, Minya Pu, Lei Bao, Amy Jackson-Fisher, Michael Munchhof, Todd VanArsdale, Tannishtha Reya, Sheldon R Morris, Mark D Minden, Karen Messer, Hanna KA Mikkola, Marco A Marra, Thomas J Hudson, Catriona HM Jamieson

J Transl Med. 2015; 13: 98. Published online 2015 Mar 21. doi: 10.1186/s12967-015-0453-9

PMCID:: PMC4414375

Article PDF–3.6M

Select item 413674815.

HEDGEHOG-GLI signaling inhibition suppresses tumor growth in squamous lung cancer

Lingling Huang, Vonn Walter, D. Neil Hayes, Mark Onaitis

Clin Cancer Res. Author manuscript; available in PMC 2015 Mar 15.

Published in final edited form as: Clin Cancer Res. 2014 Mar 15; 20(6): 1566–1575. Published online 2014 Jan 14. doi: 10.1158/1078-0432.CCR-13-2195

PMCID:: PMC4136748

Article PDF–931K

Select item 404066016.

GLI2 induces genomic instability in human keratinocytes by inhibiting apoptosis

E Pantazi, E Gemenetzidis, G Trigiante, G Warnes, L Shan, X Mao, M Ikram, M-T Teh, Y-J Lu, M P Philpott

Cell Death Dis. 2014 Jan; 5(1): e1028. Published online 2014 Jan 30. doi: 10.1038/cddis.2013.535

PMCID:: PMC4040660

Article PDF–2.0M

Select item 359047817.

Functional Characterization of a Heterozygous GLI2 Missense Mutation in Patients With Multiple Pituitary Hormone Deficiency

G. M. C. Flemming, J. Klammt, G. Ambler, Y. Bao, W. F. Blum, C. Cowell, K. Donaghue, N. Howard, A. Kumar, J. Sanchez, H. Stobbe, R. W. Pfäffle

J Clin Endocrinol Metab. 2013 Mar; 98(3): E567–E575. Published online 2013 Feb 13. doi: 10.1210/jc.2012-3224

PMCID:: PMC3590478

Article

Select item 356594618.

Expression of glioma-associated oncogene 2 (Gli 2) is correlated with poor prognosis in patients with hepatocellular carcinoma undergoing hepatectomy

Dawei Zhang, Liangqi Cao, Yue Li, Haiwu Lu, Xuewei Yang, Ping Xue

World J Surg Oncol. 2013; 11: 25. Published online 2013 Jan 29. doi: 10.1186/1477-7819-11-25

PMCID:: PMC3565946

Article PDF–1.5M

Select item 313566219.

Clinical findings in patients with GLI2 mutations – phenotypic variability

Claudia Danielli Pereira Bertolacini, Lucilene Arilho Ribeiro-Bicudo, Aline da Silva Petrin, Antonio Richieri-Costa, Jeffrey C. Murray

Clin Genet. Author manuscript; available in PMC 2013 Jan 1.

Published in final edited form as: Clin Genet. 2012 Jan; 81(1): 70–75. Published online 2011 Jan 19. doi: 10.1111/j.1399-0004.2010.01606.x

PMCID:: PMC3135662

Article PDF–704K

Select item 291476320.

GLI2-Mediated Melanoma Invasion and Metastasis

Vasileia-Ismini Alexaki, Delphine Javelaud, Leon C. L. Van Kempen, Khalid S. Mohammad, Sylviane Dennler, Flavie Luciani, Keith S. Hoek, Patricia Juàrez, James S. Goydos, Pierrick J. Fournier, Claire Sibon, Corine Bertolotto, Franck Verrecchia, Simon Saule, Veronique Delmas, Robert Ballotti, Lionel Larue, Philippe Saiag, Theresa A. Guise, Alain Mauviel

J Natl Cancer Inst. 2010 Aug 4; 102(15): 1148–1159. doi: 10.1093/jnci/djq257

PMCID:: PMC2914763

Article PDF–2.0M

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Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase [Rattus norvegicus]
Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase [Rattus norvegicus]
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