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Select item 109023471.

Tim4 deficiency reduces CD301b⁺ macrophage and aggravates periodontitis bone loss

Ziming Wang, Hao Zeng, Can Wang, Jiaolong Wang, Jing Zhang, Shuyuan Qu, Yue Han, Liu Yang, Yueqi Ni, Wenan Peng, Huan Liu, Hua Tang, Qin Zhao, Yufeng Zhang

Int J Oral Sci. 2024; 16: 20. Published online 2024 Feb 28. doi: 10.1038/s41368-023-00270-z

PMCID:: PMC10902347

Abstract Article PDF–6.1M

Select item 73781892.

Tim-4 functions as a scavenger receptor for phagocytosis of exogenous particles

Chanhyuk Min, Jeongjun Park, Gayoung Kim, Hyunji Moon, Sang-Ah Lee, Deokhwan Kim, Byeongjin Moon, Susumin Yang, Juyeon Lee, Kwanhyeong Kim, Hyeokjin Cho, Jihwan Park, Dae-Hee Lee, Gwangrog Lee, Daeho Park

Cell Death Dis. 2020 Jul; 11(7): 561. Published online 2020 Jul 23. doi: 10.1038/s41419-020-02773-7

PMCID:: PMC7378189

Abstract Article PDF–3.3M

Select item 59879253.

Tissue-resident macrophages in the intestine are long lived and defined by Tim-4 and CD4 expression

Tovah N. Shaw, Stephanie A. Houston, Kelly Wemyss, Hayley M. Bridgeman, Thomas A. Barbera, Tamsin Zangerle-Murray, Patrick Strangward, Amanda J.L. Ridley, Ping Wang, Samira Tamoutounour, Judith E. Allen, Joanne E. Konkel, John R. Grainger

J Exp Med. 2018 Jun 4; 215(6): 1507–1518. doi: 10.1084/jem.20180019

PMCID:: PMC5987925

Abstract Article PDF–1.8M

Select item 55654444.

Mouse macrophages show different requirements for phosphatidylserine receptor Tim4 in efferocytosis

Yuichi Yanagihashi, Katsumori Segawa, Ryota Maeda, Yo-ichi Nabeshima, Shigekazu Nagata

Proc Natl Acad Sci U S A. 2017 Aug 15; 114(33): 8800–8805. Published online 2017 Aug 2. doi: 10.1073/pnas.1705365114

PMCID:: PMC5565444

Abstract Article PDF–1.3M

Select item 53401185.

TIM-4 is expressed on invariant NKT cells but dispensable for their development and function

Xilin Zhang, Jun Gu, Li Zhou, Qing-Sheng Mi

Oncotarget. 2016 Nov 1; 7(44): 71099–71111. Published online 2016 Sep 20. doi: 10.18632/oncotarget.12153

PMCID:: PMC5340118

Abstract Article PDF–5.3M

Select item 51223276.

TIM-4 is differentially expressed in the distinct subsets of dendritic cells in skin and skin-draining lymph nodes and controls skin Langerhans cell homeostasis

Xilin Zhang, Queping Liu, Jie Wang, Guihua Li, Matthew Weiland, Fu-Shin Yu, Qing-Sheng Mi, Jun Gu, Li Zhou

Oncotarget. 2016 Jun 21; 7(25): 37498–37512. Published online 2016 May 21. doi: 10.18632/oncotarget.9546

PMCID:: PMC5122327

Abstract Article PDF–2.4M

Select item 44081207.

Tim-4 Inhibits NO Generation by Murine Macrophages

Li-yun Xu, Jian-ni Qi, Xiao Liu, Hong-xin Ma, Wei Yuan, Pei-qing Zhao, Xiao-hong Liang, Yong Xu, Hong-xing Wang, Xiao-yan Xu, Wei Wang, Chun-hong Ma, Li-fen Gao

PLoS One. 2015; 10(4): e0124771. Published online 2015 Apr 23. doi: 10.1371/journal.pone.0124771

PMCID:: PMC4408120

Abstract Article PDF–461K

Select item 43969878.

T-Cell Immunoglobulin and Mucin Domain 4 (TIM-4) Signaling in Innate Immune-Mediated Liver Ischemia-Reperfusion Injury

Haofeng Ji, Yuanxing Liu, Yu Zhang, Xiu-da Shen, Feng Gao, Ronald W. Busuttil, Vijay K. Kuchroo, Jerzy W. Kupiec-Weglinski

Hepatology. Author manuscript; available in PMC 2015 Dec 1.

Published in final edited form as: Hepatology. 2014 Dec; 60(6): 2052–2064. Published online 2014 Oct 29. doi: 10.1002/hep.27334

PMCID:: PMC4396987

Abstract Article PDF–4.3M

Select item 42305699.

TIM-4, expressed by medullary macrophages, regulates respiratory tolerance by mediating phagocytosis of antigen-specific T cells

Lee A Albacker, Sanhong Yu, Denis Bedoret, Wan-Ling Lee, Sarah E Umetsu, Sheena Monahan, Gordon J Freeman, Dale T Umetsu, Rosemarie H DeKruyff

Mucosal Immunol. Author manuscript; available in PMC 2014 Nov 13.

Published in final edited form as: Mucosal Immunol. 2013 May; 6(3): 580–590. Published online 2012 Nov 14. doi: 10.1038/mi.2012.100

PMCID:: PMC4230569

Abstract Article PDF–404K

Select item 400459910.

The phosphatidylserine receptor TIM4 utilizes integrins as coreceptors to effect phagocytosis

Ronald S. Flannagan, Johnathan Canton, Wendy Furuya, Michael Glogauer, Sergio Grinstein

Mol Biol Cell. 2014 May 1; 25(9): 1511–1522. doi: 10.1091/mbc.E13-04-0212

PMCID:: PMC4004599

Abstract Article PDF–4.4M

Select item 399265611.

Molecular mechanism for differential recognition of membrane phosphatidylserine by the immune regulatory receptor Tim4

Gregory T. Tietjen, Zhiliang Gong, Chiu-Hao Chen, Ernesto Vargas, James E. Crooks, Kathleen D. Cao, Charles T. R. Heffern, J. Michael Henderson, Mati Meron, Binhua Lin, Benoît Roux, Mark L. Schlossman, Theodore L. Steck, Ka Yee C. Lee, Erin J. Adams

Proc Natl Acad Sci U S A. 2014 Apr 15; 111(15): E1463–E1472. Published online 2014 Mar 31. doi: 10.1073/pnas.1320174111

PMCID:: PMC3992656

Abstract Article PDF–1.1M

Select item 294896512.

“Tim-4 expressed on antigen-presenting cells induces T cell expansion and survival”

Roselynn Rodriguez-Manzanet, Jennifer Hartt Meyers, Savithri Balasubramanian, Jacqueline Slavik, Nasim Kassam, Valerie Dardalhon, Edward A. Greenfield, Ana C. Anderson, Raymond A. Sobel, David A. Hafler, Terry B. Strom, Vijay K. Kuchroo

J Immunol. Author manuscript; available in PMC 2010 Oct 4.

Published in final edited form as: J Immunol. 2008 Apr 1; 180(7): 4706–4713. doi: 10.4049/jimmunol.180.7.4706

PMCID:: PMC2948965

Abstract Article PDF–1.2M

Select item 288935513.

Phosphatidylserine receptor Tim-4 is essential for the maintenance of the homeostatic state of resident peritoneal macrophages

Kit Wong, Patricia A. Valdez, Christine Tan, Sherry Yeh, Jo-Anne Hongo, Wenjun Ouyang

Proc Natl Acad Sci U S A. 2010 May 11; 107(19): 8712–8717. Published online 2010 Apr 26. doi: 10.1073/pnas.0910929107

PMCID:: PMC2889355

Abstract Article PDF–637K

Select item 288934914.

T and B cell hyperactivity and autoimmunity associated with niche-specific defects in apoptotic body clearance in TIM-4-deficient mice

Roselynn Rodriguez-Manzanet, Miguel A. Sanjuan, Henry Y. Wu, Francisco J. Quintana, Sheng Xiao, Ana C. Anderson, Howard L. Weiner, Douglas R. Green, Vijay K. Kuchroo

Proc Natl Acad Sci U S A. 2010 May 11; 107(19): 8706–8711. Published online 2010 Apr 5. doi: 10.1073/pnas.0910359107

PMCID:: PMC2889349

Abstract Article PDF–939K

Select item 829538915.

Role of Tim4 in the regulation of ABCA1⁺ adipose tissue macrophages and post-prandial cholesterol levels

M. S. Magalhaes, P. Smith, J. R. Portman, L. H. Jackson-Jones, C. C. Bain, P. Ramachandran, Z. Michailidou, R. H. Stimson, M. R. Dweck, L. Denby, N. C. Henderson, S. J. Jenkins, C. Bénézech

Nat Commun. 2021; 12: 4434. Published online 2021 Jul 21. doi: 10.1038/s41467-021-24684-7